BMP3 is a novel locus involved in the causality of ocular coloboma

Optic cup morphogenesis requires neural crest-mediated basement membrane assembly

(2020) Chase D. Bryan et al.   DEVELOPMENT

In Vivo Analysis of Optic Fissure Fusion in Zebrafish: Pioneer Cells, Basal Lamina, Hyaloid Vessels, and How Fissure Fusion is Affected by BMP

(2020) Priska Eckert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

nkx3.2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish

(2020) Tetsuto Miyashita et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves

(2020) Masanari Takamiya et al.   PLoS Genetics

Ocular coloboma: Genetic variants reveal a dynamic model of eye development

(2020) Kevin H. Yoon et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

An update on the genetics of ocular coloboma

(2019) Aisha S. ALSomiry et al.   HUMAN GENETICS

Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion

(2019) Holly Hardy et al.   eLife

Structural biology of the TGFβ family

(2019) Erich J Goebel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The cellular bases of choroid fissure formation and closure

(2018) Cassidy S. Bernstein et al.   DEVELOPMENTAL BIOLOGY

Cell Behaviors during Closure of the Choroid Fissure in the Developing Eye

(2018) Gaia Gestri et al.   Frontiers in Cellular Neuroscience

TGFβ-facilitated optic fissure fusion and the role of bone morphogenetic protein antagonism

(2018) Max D. Knickmeyer et al.   Open Biology

Genes and pathways in optic fissure closure

(2017) Aara Patel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Comparison of Zebrafish tmem88a mutant and morpholino knockdown phenotypes

(2017) Alexander M. J. Eve et al.   PLoS One

Roles of Wnt pathway geneswls,wnt9a,wnt5b,frzbandgpc4in regulating convergent-extension during zebrafish palate morphogenesis

(2016) Lucie Rochard et al.   DEVELOPMENT

Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling

(2016) Hyuna Noh et al.   DEVELOPMENT

The hyaloid vasculature facilitates basement membrane breakdown during choroid fissure closure in the zebrafish eye

(2016) Andrea James et al.   DEVELOPMENTAL BIOLOGY

Molecular mechanism of CHRDL1-mediated X-linked megalocornea in humans and in Xenopus model

(2015) Thorsten Pfirrmann et al.   HUMAN MOLECULAR GENETICS

CRIM1 haploinsufficiency causes defects in eye development in human and mouse

(2015) F. Beleggia et al.   HUMAN MOLECULAR GENETICS

FORGE Canada Consortium: Outcomes of a 2-Year National Rare-Disease Gene-Discovery Project

(2014) Chandree L. Beaulieu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The genetic architecture of microphthalmia, anophthalmia and coloboma

(2014) Kathleen A. Williamson et al.   European Journal of Medical Genetics

Inappropriate p53 activation during development induces features of CHARGE syndrome

(2014) Jeanine L. Van Nostrand et al.   NATURE

Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs

(2014) James A. Gagnon et al.   PLoS One

Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8, CRYGC, PAX6 and CYP1B1

(2013) Ivan Prokudin et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata

(2013) Jiwoon Lee et al.   HUMAN MOLECULAR GENETICS

Sma- and Mad-related Protein 7 (Smad7) Is Required for Embryonic Eye Development in the Mouse

(2013) Rui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development

(2012) Ishaq A. Viringipurampeer et al.   HUMAN MOLECULAR GENETICS

Defective neural crest migration revealed by a Zebrafish model of Alx1-related frontonasal dysplasia

(2012) C. T. Dee et al.   HUMAN MOLECULAR GENETICS

Identification of a Novel Oligomerization Disrupting Mutation inCRYΑAAssociated with Congenital Cataract in a South Australian Family

(2012) Kate J. Laurie et al.   HUMAN MUTATION

Variation of BMP3 Contributes to Dog Breed Skull Diversity

(2012) Jeffrey J. Schoenebeck et al.   PLoS Genetics

A complex choreography of cell movements shapes the vertebrate eye

(2011) K. M. Kwan et al.   DEVELOPMENT

Organogenesis of mild ocular coloboma in FLS mice: Failure of basement membrane disintegration at optic fissure margins

(2011) Naho Tsuji et al.   EXPERIMENTAL EYE RESEARCH

BMP4 loss-of-function mutations in developmental eye disorders including SHORT syndrome

(2011) Linda M. Reis et al.   HUMAN GENETICS

Class 5 Transmembrane Semaphorins Control Selective Mammalian Retinal Lamination and Function

(2011) Ryota L. Matsuoka et al.   NEURON

Anophthalmos, Microphthalmos, and Coloboma in the United Kingdom: Clinical Features, Results of Investigations, and Early Management

(2011) Shaheen P. Shah et al.   OPHTHALMOLOGY

Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme

(2011) G. Lupo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SMOC1 Is Essential for Ocular and Limb Development in Humans and Mice

(2010) Ippei Okada et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in the SPARC-Related Modular Calcium-Binding Protein 1 Gene, SMOC1, Cause Waardenburg Anophthalmia Syndrome

(2010) Hana Abouzeid et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation

(2010) Rachel LOCKRIDGE Mueller et al.   BMC GENOMICS

The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis

(2010) Laura M. Pillay et al.   DEVELOPMENTAL BIOLOGY

Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies

(2010) Alexander W. Wyatt et al.   HUMAN MUTATION

BMP-3 promotes mesenchymal stem cell proliferation through the TGF-β/activin signaling pathway

(2010) Aaron Stewart et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CHD7 cooperates with PBAF to control multipotent neural crest formation

(2010) Ruchi Bajpai et al.   NATURE

Mutations in BMP4 Are Associated with Subepithelial, Microform, and Overt Cleft Lip

(2009) Satoshi Suzuki et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gdf6a is required for the initiation of dorsal–ventral retinal patterning and lens development

(2009) Curtis R. French et al.   DEVELOPMENTAL BIOLOGY

Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish

(2009) Carrie McMahon et al.   DEVELOPMENTAL BIOLOGY

Reduced TFAP2A function causes variable optic fissure closure and retinal defects and sensitizes eye development to mutations in other morphogenetic regulators

(2009) Gaia Gestri et al.   HUMAN GENETICS

Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes

(2009) M. Asai-Coakwell et al.   HUMAN MOLECULAR GENETICS

Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies

(2009) M. Ye et al.   HUMAN MOLECULAR GENETICS

An essential role for Radar (Gdf6a) in inducing dorsal fate in the zebrafish retina

(2009) N. J. Gosse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in BMP4 Cause Eye, Brain, and Digit Developmental Anomalies: Overlap between the BMP4 and Hedgehog Signaling Pathways

(2008) Preeti Bakrania et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Clinical variability of autosomal dominant cataract, microcornea and corneal opacity and novel mutation in the alpha A crystallin gene (CRYAA)

(2008) Leslie Richter et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The eye organizes neural crest cell migration

(2008) Tobias Langenberg et al.   DEVELOPMENTAL DYNAMICS

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols