Role of sex steroids in fish sex determination and differentiation as revealed by gene editing

Estrogen receptor 2b is the major determinant of sex-typical mating behavior and sexual preference in medaka

(2021) Yuji Nishiike et al.   CURRENT BIOLOGY

Germline sexual fate is determined by the antagonistic action of dmrt1 and foxl3/foxl2 in tilapia

(2021) Shengfei Dai et al.   DEVELOPMENT

Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone

(2020) Qiaoyuan Zheng et al.   JOURNAL OF ENDOCRINOLOGY

Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction

(2020) Qifeng Zhang et al.   ENDOCRINOLOGY

foxl3, a sexual switch in germ cells, initiates two independent molecular pathways for commitment to oogenesis in medaka

(2020) Mariko Kikuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation

(2020) Tingting Shu et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Sex determination, gonadal sex differentiation, and plasticity in vertebrate species

(2020) Yoshitaka Nagahama et al.   PHYSIOLOGICAL REVIEWS

Star and LH are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish

(2019) Guohui Shang et al.   BIOLOGY OF REPRODUCTION

Establishment of three estrogen receptors (esr1, esr2a, esr2b) knockout lines for functional study in Nile tilapia

(2019) Longxia Yan et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mutation of cyp19a1b results in sterile males due to efferent duct obstruction in Nile tilapia

(2019) Xianbo Zhang et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Characterization and expression profiles of cyp19a1a in the schizothoracine fish Schizothorax prenanti

(2019) Taiming Yan et al.   TISSUE & CELL

Gene knockout analysis reveals essentiality of estrogen receptor β1 (Esr2a) for female reproduction in medaka

(2019) Daichi Kayo et al.   Scientific Reports

Estrogen Receptor β2 Oversees Germ Cell Maintenance and Gonadal Sex Differentiation in Medaka, Oryzias latipes

(2019) Tapas Chakraborty et al.   Stem Cell Reports

The P450 side chain cleavage enzyme Cyp11a2 facilitates steroidogenesis in zebrafish

(2019) Nan Li et al.   JOURNAL OF ENDOCRINOLOGY

Nuclear progestin receptor (Pgr) knockouts resulted in subfertility in male tilapia ( Oreochromis niloticus )

(2018) Xuelian Fang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Steroidogenic enzymes, their products and sex steroid receptors during testis development and spermatogenesis in the domestic cat ( Felis catus )

(2018) Beate C. Braun et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement

(2018) Xiaoyu Tu et al.   Reproductive Biology and Endocrinology

Fertility Enhancement but Premature Ovarian Failure in esr1-Deficient Female Zebrafish

(2018) Yu Chen et al.   Frontiers in Endocrinology

Roles of estrogens in fish sexual plasticity and sex differentiation

(2018) Minghui Li et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Targeted Disruption of Aromatase Reveals Dual Functions of cyp19a1a During Sex Differentiation in Zebrafish

(2017) Yike Yin et al.   ENDOCRINOLOGY

Functional Analysis of Nuclear Estrogen Receptors in Zebrafish Reproduction by Genome Editing Approach

(2017) Huijie Lu et al.   ENDOCRINOLOGY

From molecule to behavior: Brain aromatase ( cyp19a1b ) characterization, expression analysis and its relation with social status and male agonistic behavior in a Neotropical cichlid fish

(2017) Martín R. Ramallo et al.   HORMONES AND BEHAVIOR

Blockage of androgen and administration of estrogen induce transdifferentiation of testis into ovary

(2017) Hongjuan Shi et al.   JOURNAL OF ENDOCRINOLOGY

Vertebrate sex determination: evolutionary plasticity of a fundamental switch

(2017) Blanche Capel   NATURE REVIEWS GENETICS

Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-related protein SOX9A

(2017) Gang Zhai et al.   Science Bulletin

Gene editing nuclease and its application in tilapia

(2017) Minghui Li et al.   Science Bulletin

11-Ketotestosterone Is a Major Androgen Produced in Human Gonads

(2016) Yoshitaka Imamichi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Simultaneous exposure to estrogen and androgen resulted in feminization and endocrine disruption

(2016) Lili Chen et al.   JOURNAL OF ENDOCRINOLOGY

Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution

(2016) Jared V. Goldstone et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

gsdf is a downstream gene of dmrt1 that functions in the male sex determination pathway of the Nile tilapia

(2016) Dong-Neng Jiang et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Knockout of Zebrafish Ovarian Aromatase Gene (cyp19a1a) by TALEN and CRISPR/Cas9 Leads to All-male Offspring Due to Failed Ovarian Differentiation

(2016) Esther Shuk-Wa Lau et al.   Scientific Reports

Characterization and expression of cDNAs encoding P450c17-II (cyp17a2) in Japanese eel during induced ovarian development

(2015) Ting Su et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway

(2015) X Lei et al.   REPRODUCTION IN DOMESTIC ANIMALS

Nuclear Progestin Receptor (Pgr) Knockouts in Zebrafish Demonstrate Role for Pgr in Ovulation but Not in Rapid Non-Genomic Steroid Mediated Meiosis Resumption

(2015) Yong Zhu et al.   Frontiers in Endocrinology

Characterization of two paralogous StAR genes in a teleost, Nile tilapia (Oreochromis niloticus)

(2014) Xiangguo Yu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Misregulated Progesterone Secretion and Impaired Pregnancy in Cyp11a1 Transgenic Mice1

(2013) Yu Chien et al.   BIOLOGY OF REPRODUCTION

Polygenic sex determination

(2013) Emily C. Moore et al.   CURRENT BIOLOGY

Antagonistic Roles of Dmrt1 and Foxl2 in Sex Differentiation via Estrogen Production in Tilapia as Demonstrated by TALENs

(2013) Ming-Hui Li et al.   ENDOCRINOLOGY

Redefining the Initiation and Maintenance of Zebrafish Interrenal Steroidogenesis by Characterizing the Key Enzyme Cyp11a2

(2013) Silvia Parajes et al.   ENDOCRINOLOGY

Characterization of Gonadal Transcriptomes from Nile Tilapia (Oreochromis niloticus) Reveals Differentially Expressed Genes

(2013) Wenjing Tao et al.   PLoS One

Induction of Female-to-Male Sex Change in Adult Zebrafish by Aromatase Inhibitor Treatment

(2013) Kanae Takatsu et al.   Scientific Reports

Cytochrome P450 17α-hydroxylase/C(17,20)-lyase immunoreactivity and molecular expression in the cerebellar nuclei of adult male rats

(2012) Paolo Manca et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Anatomical distribution of sex steroid hormone receptors in the brain of female medaka

(2012) Buntaro Zempo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Molecular cloning, characterization expression of P450c17-I and P450c17-II and their functions analysis during the reproductive cycle in males of barfin flounder (Verasper moseri)

(2011) Guo X. Jin et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Aromatase inhibitors in pediatrics

(2011) Jan M. Wit et al.   Nature Reviews Endocrinology

Cloning and expression of medaka cholesterol side chain cleavage cytochrome P450 during gonadal development

(2010) Masatoshi Nakamoto et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Functional Significance of Nuclear Estrogen Receptor Subtypes in the Liver of Goldfish

(2010) Erik R. Nelson et al.   ENDOCRINOLOGY

Cortisol Is Involved in Temperature-Dependent Sex Determination in the Japanese Flounder

(2010) Toshiya Yamaguchi et al.   ENDOCRINOLOGY

Cloning and expression of P450c17-I (17α-hydroxylase/17,20-lyase) in brain and ovary during gonad development in Cynoglossus semilaevis

(2010) Cai F. Chen et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Aromatase in the brain of teleost fish: Expression, regulation and putative functions

(2010) Nicolas Diotel et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Differential expression of three estrogen receptor subtype mRNAs in gonads and liver from embryos to adults of the medaka, Oryzias latipes

(2010) Tapas Chakraborty et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Two distinct types of theca cells in the medaka gonad: Germ cell-dependent maintenance ofcyp19a1-expressing theca cells

(2009) Shuhei Nakamura et al.   DEVELOPMENTAL DYNAMICS

Ovarian aromatase and estrogens: A pivotal role for gonadal sex differentiation and sex change in fish

(2009) Yann Guiguen et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Rainbow Trout Gonadal Masculinization Induced by Inhibition of Estrogen Synthesis Is More Physiological Than Masculinization Induced by Androgen Supplementation1

(2008) Denise Vizziano et al.   BIOLOGY OF REPRODUCTION

Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)

(2008) Nicole Maninger et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Cyp11b1Null Mouse, a Model of Congenital Adrenal Hyperplasia

(2008) Linda J. Mullins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Novel Mutantsclof the Medaka Fish, Oryzias latipes, Shows No Secondary Sex Characters

(2008) Tadashi Sato et al.   ZOOLOGICAL SCIENCE