Journal
FUTURE MEDICINAL CHEMISTRY
Volume 13, Issue 21, Pages 1885-1906Publisher
Newlands Press Ltd
DOI: 10.4155/fmc-2021-0096
Keywords
apoptosis; cancer; cancer stem cells; carcinogenesis; metastasis; miR-21; miRNA
Categories
Funding
- Science and Engineering Research Board grant, India [SB/S2/RJN-072/2015, ECR/2017/00092]
- seed grant under the Institute of Eminence Scheme, BHU
- Excellence Project grant [PrF UHK 2011/2021-2022]
- MH CZ - DRO (UHHK) [00179906]
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miRNAs are small noncoding RNAs that play important roles in various cancers, with miR-21 being a potential clinical target and biomarker for early cancer detection. Its upregulation is associated with high oncogenic properties and chemotherapy resistance in multiple cancers.
MicroRNAs (miRNAs), a class of small noncoding RNA, posttranscriptionally regulate the expression of genes. Aberrant expression of miRNA is reported in various types of cancer. Since the first report of oncomiR-21 involvement in the glioma, its upregulation was reported in multiple cancers and was allied with high oncogenic property. In addition to the downregulation of tumor suppressor genes, the miR-21 is also associated with cancer resistance to various chemotherapy. The recent research is appraising miR-21 as a promising cancer target and biomarker for early cancer detection. In this review, we briefly explain the biogenesis and regulation of miR-21 in cancer cells. Additionally, the review features the assorted genes/pathways regulated by the miR-21 in various cancer and cancer stem cells.
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