HNRNPU promotes the progression of hepatocellular carcinoma by enhancing CDK2 transcription

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Novel Cell-Penetrating Peptides Derived From Scaffold-Attachment- Factor A Inhibits Cancer Cell Proliferation and Survival

(2021) Pavan Kumar Puvvula et al.   Frontiers in Oncology

hnRNPU Functions as a Novel Therapeutic Target of c‐Myc in the Progression of Hepatocellular Carcinoma

(2020) Biao Zhang et al.   FEBS LETTERS

Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation

(2020) Marc A. J. Morgan et al.   NATURE GENETICS

Chromatin accessibility and the regulatory epigenome

(2019) Sandy L. Klemm et al.   NATURE REVIEWS GENETICS

Amplification of SMYD3 promotes tumorigenicity and intrahepatic metastasis of hepatocellular carcinoma via upregulation of CDK2 and MMP2

(2019) Yu Wang et al.   ONCOGENE

The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers

(2019) Lili Cao et al.   Cell Host & Microbe

Targeting CDK2 in cancer: challenges and opportunities for therapy

(2019) Solomon Tadesse et al.   DRUG DISCOVERY TODAY

SKA3 Promotes tumor growth by regulating CDK2/P53 phosphorylation in hepatocellular carcinoma

(2019) Yuchen Hou et al.   Cell Death & Disease

CDK2 positively regulates aerobic glycolysis by suppressing SIRT5 in gastric cancer

(2018) Zhenyong Tang et al.   CANCER SCIENCE

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

Kinase-independent function of E-type cyclins in liver cancer

(2018) Yan Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of nuclear matrix protein HNRNPU in maintaining the architecture of 3D genome

(2018) Linlin Zhang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update

(2018) Solomon Tadesse et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chromatin regulatory mechanisms and therapeutic opportunities in cancer

(2018) Alfredo M. Valencia et al.   NATURE CELL BIOLOGY

The nuclear matrix protein HNRNPU maintains 3D genome architecture globally in mouse hepatocytes

(2017) Hui Fan et al.   GENOME RESEARCH

Heterozygous HNRNPU variants cause early onset epilepsy and severe intellectual disability

(2017) Nuria C. Bramswig et al.   HUMAN GENETICS

CDK Substrate Phosphorylation and Ordering the Cell Cycle

(2016) Matthew P. Swaffer et al.   CELL

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Diverse Epigenetic Mechanisms of Human Disease

(2014) Emily Brookes et al.   Annual Review of Genetics

Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre

(2014) Ezgi Hacisuleyman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

H19 inhibits RNA polymerase II-mediated transcription by disrupting the hnRNP U–actin complex

(2013) Hai-shan Bi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

De novo mutations in epileptic encephalopathies

(2013) et al.   NATURE

Dynamic regulation of transcriptional states by chromatin and transcription factors

(2013) Ty C. Voss et al.   NATURE REVIEWS GENETICS

Histone acetylation: molecular mnemonics on the chromatin

(2013) Johannes Gräff et al.   NATURE REVIEWS NEUROSCIENCE

Nuclear Matrix Factor hnRNP U/SAF-A Exerts a Global Control of Alternative Splicing by Regulating U2 snRNP Maturation

(2012) Rui Xiao et al.   MOLECULAR CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

SAF-A Has a Role in Transcriptional Regulation of Oct4 in ES Cells Through Promoter Binding

(2011) Dzeneta Vizlin-Hodzic et al.   Cellular Reprogramming

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

SAF-A Forms a Complex with BRG1 and Both Components Are Required for RNA Polymerase II Mediated Transcription

(2011) Dzeneta Vizlin-Hodzic et al.   PLoS One

Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+breast cancer patients

(2011) Maurizio Scaltriti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRG1 helps RNA polymerase II to overcome a nucleosomal barrier during elongation, in vivo

(2010) Alicia Subtil-Rodríguez et al.   EMBO REPORTS

BRG1 directly regulates nucleosome structure and chromatin looping of the α globin locus to activate transcription

(2009) Shin-Il Kim et al.   NUCLEIC ACIDS RESEARCH

Overlapping euchromatin/heterochromatin- associated marks are enriched in imprinted gene regions and predict allele-specific modification

(2008) B. Wen et al.   GENOME RESEARCH

The Histone Acetyltransferase PCAF Associates with Actin and hnRNP U for RNA Polymerase II Transcription

(2008) A. Obrdlik et al.   MOLECULAR AND CELLULAR BIOLOGY