Article
Medicine, General & Internal
Ghazi Alshumrani, Ali Al bshabshe, Wesam Faried Mousa
Summary: This study aimed to estimate the diagnostic yield of CTPA in clinically suspected PE patients at a tertiary care hospital in Saudi Arabia. The study found that CTPA had a higher positive detection rate for PE among clinically suspected cases than its published diagnostic yield. Adequate clinical evaluation when selecting patients for CTPA is emphasized to minimize unjustified exposure of the patients to radiation and contrast.
Article
Radiology, Nuclear Medicine & Medical Imaging
Giovanni Foti, Ronaldo Silva, Niccolo Faccioli, Alessandro Fighera, Rossella Menghini, Arianna Campagnola, Giovanni Carbognin
Summary: In a selected, high-prevalence population, VP-DECT is considered an accurate imaging tool for diagnosing PE compared to CTPA. The sensitivity of VP-DECT images in per-patient analysis was 90.0%, with 100% specificity; while in per-lobe analysis, sensitivity ranged from 100% for the right lower lobe to 50% for the left upper lobe.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ilaria Vittoria de Martini, Adrian Raoul Kobe, Christian Roeren, Robert Manka, Andre Euler, Dagmar Keller, Frank Ruschitzka, Hatem Alkadhi, Matthias Eberhard
Summary: This study evaluated the feasibility and accuracy of using CT pulmonary angiography (CTPA) for diagnosing acute heart failure (HF) in emergency department patients. The results showed that both HUratio and HUdiff had a high sensitivity for diagnosing HF, indicating their potential as viable diagnostic markers.
EUROPEAN RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Angelo Porfidia, Carolina Mosoni, Rosa Talerico, Enrica Porceddu, Andrea Lupascu, Paolo Tondi, Francesco Landi, Roberto Pola
Summary: PE is a common complication in COVID-19 patients, but there is a lack of clear guidelines for diagnosing PE. While many COVID-19 patients may have indications for CTPA, only a small percentage actually undergo this examination, and there are no significant clinical differences between those who do and those who do not.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rocio Perez-Johnston, Andrew J. Plodkowski, Darragh F. Halpenny, Sara A. Hayes, Marinela Capanu, J. A. B. Araujo-Filho, Jonathan W. Weinsaft, Michelle S. Ginsberg
Summary: This study evaluated the utility of perfusion defects on dual-energy CT angiograms in assessing the clinical severity of pulmonary embolism, finding significant correlations between the presence of perfusion defects and parameters evaluating PE severity. Presence of a perfusion defect and higher perfusion defect score were associated with lower survival rates.
EUROPEAN RADIOLOGY
(2021)
Article
Emergency Medicine
Jakrin Kewcharoen, Paresh Giri, M. Reza Amini, Laren Tan, Dafne Moretta, Emily Barrett, E. Lea Walters, Dmitry Abramov
Summary: There is limited evidence on the impact of pre-existing heart failure (HF) on the diagnostic yield of pulmonary embolism (PE) evaluation in the Emergency Department (ED). This study found that patients with pre-existing HF had a lower incidence of PE on computed tomography pulmonary angiogram (CTPA) compared to patients without HF.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xuechun Guan, Qiaoqing Lan, Yi Liang, Honghong Ke, Siqi Chen, Liling Long
Summary: This study compared the efficacy of single phase-computed tomography pulmonary angiography (SP-CTPA) and dual phase-computed tomography pulmonary angiography (DP-CTPA) for the diagnosis of pulmonary embolism (PE). The results showed that DP-CTPA had high diagnostic efficiency, while SP-CTPA may misdiagnose certain artifacts as PE.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Lukas Lambert, Pavel Michalek, Andrea Burgetova
Summary: This study aims to examine the diagnostic performance of CT of the pulmonary artery (CTPA) as a potential first-choice imaging modality in patients with pulmonary arterial hypertension and suspected chronic thromboembolic pulmonary hypertension (CTEPH). A systematic review and meta-analysis were conducted to evaluate the diagnostic performance of CTPA in adult patients. The results indicate that CTPA has high sensitivity and specificity in the detection of CTEPH.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guillaume Chassagnon, Mostafa El Hajjam, Samia Boussouar, Marie-Pierre Revel, Ralph Khoury, Benoit Ghaye, Sebastien Bommart, Mathieu Lederlin, Stephane Tran Ba, Constance De Margerie-Mellon, Laure Fournier, Lucie Cassagnes, Mickael Ohana, Carole Jalaber, Gael Dournes, Nicolas Cazeneuve, Gilbert Ferretti, Pauline Talabard, Victoria Donciu, Emma Canniff, Marie-Pierre Debray, Bernard Crutzen, Jeremy Charriot, Valentin Rabeau, Philippe Khafagy, Richard Chocron, Ian Leonard Lorant, Loic Metairy, Lea Ruez-Lantuejoul, Sebastien Beaune, Pierre Hausfater, Jennifer Truchot, Antoine Khalil, Andrea Penaloza, Thibaut Affole, Pierre-Yves Brillet, Catherine Roy, Julien Pucheux, Jordan Zbili, Olivier Sanchez, Raphael Porcher
Summary: The objective of this study was to define a safe strategy to exclude pulmonary embolism (PE) in COVID-19 outpatients without performing CT pulmonary angiogram (CTPA). The study evaluated COVID-19 outpatients from 15 university hospitals who had undergone a CTPA. Different PE rule-out strategies, including D-Dimer tests with different thresholds, the revised Geneva and Wells scores, and a COVID-19 PE prediction model, were compared. The results showed that D-Dimer > 500 mu g/l and the age-adjusted D-Dimer level, as well as the revised Geneva and Wells scores, had good performance in excluding PE.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benedikt H. Heidinger, Dominique DaBreo, Rachae Kirkbride, Mario Santos, Brett J. Carroll, Stephanie A. Feldman, Donya Mohebali, Ian McCormick, Jason D. Matos, Warren J. Manning, Diana E. Litmanovich
Summary: This study evaluated the relationship between CAC on non-ECG-gated CTPA and short-term mortality in patients with acute PE. The results showed that CAC is common and associated with mortality in these patients. Visual assessment of CAC may be an easy tool for early risk stratification.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eline Langius-Wiffen, Pim A. A. de Jong, Firdaus A. Mohamed Hoesein, Lisette Dekker, Andor F. F. van den Hoven, Ingrid M. M. Nijholt, Martijn F. F. Boomsma, Wouter B. B. Veldhuis
Summary: By using an AI algorithm to analyze CT pulmonary angiography of patients suspected of acute pulmonary embolism, the detection accuracy of PE can be improved, reducing the risk of missed diagnosis in clinical practice.
INSIGHTS INTO IMAGING
(2023)
Review
Medicine, General & Internal
Emily S. L. Martens, Menno V. Huisman, Frederikus A. Klok
Summary: Venous thromboembolism (VTE), especially acute pulmonary embolism (PE), is a common and potentially fatal complication of COVID-19. Diagnostic strategies for suspected PE in COVID-19 patients are still controversial. This article discusses the current state-of-the-art diagnostic algorithms for acute PE and summarizes the resolution of PE in patients with COVID-19 under anticoagulant treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Koehler, Ann-Kathrin Ozga, Isabel Molwitz, Hanna Maria Goerich, Sarah Keller, Ulrich Mayer-Runge, Gerhard Adam, Jin Yamamura
Summary: This retrospective study aimed to analyze the distribution of demand and the duration of diagnostic workup of suspected pulmonary embolism using CTPA. The results showed that the demand for CTPA varied depending on the sector of patient care, and processing time differed substantially throughout the day. Time series analysis can reveal such coherences and may help optimize workflows in radiology departments.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ghazaleh Mehdipoor, David Jimenez, Laurent Bertoletti, Jorge Del Toro, Carmen Fernandez-Capitan, Alessandra Bura-Riviere, Cristina Amado, Beatriz Valero, Angeles Blanco-Molina, Remedios Otero, Egidio Imbalzano, Ramin Khorasani, Martin R. Prince, Behnood Bikdeli, Manuel Monreal
Summary: The study found that CTPA was the primary modality for confirming PE in all trimesters of pregnancy, with a higher proportional use in later stages of pregnancy.
EUROPEAN RADIOLOGY
(2022)
Article
Obstetrics & Gynecology
Jack Fitzsimmons, Laura Hart, Emily Oliver, Wadia Mulla
Summary: Pulmonary embolism is a significant cause of obstetric morbidity and mortality, but excessive use of diagnostic testing can lead to overdiagnosis and long-term health issues. Accurate diagnosis depends on understanding the prevalence of PE in pregnant women, the probability based on specific findings, and the accuracy of computed tomography pulmonary angiography. Refining the probability through scoring systems and D-dimer measurements can decrease utilization and limit false positive diagnoses without increasing morbidity or mortality.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Rheumatology
Silvia Sartorelli, Guillaume Chassagnon, Pascal Cohen, Bertrand Dunogue, Xavier Puechal, Alexis Regent, Luc Mouthon, Loic Guillevin, Benjamin Terrier
Summary: Specific cardiomyopathy is frequent in EGPA, especially in ANCA-negative patients with high eosinophil counts. Long-term outcome was better than previously reported. Abnormal ECG and LGE on CMRI were associated with the occurrence of MACEs.
Letter
Respiratory System
Guillaume Chassagnon, Alienor Campredon, Maria Vakalopoulou, Pierre-Regis Burgel
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Alienor Campredon, Enzo Battistella, Clemence Martin, Isabelle Durieu, Laurent Mely, Christophe Marguet, Chantal Belleguic, Marlene Murris-Espin, Raphael Chiron, Annlyse Fanton, Stephanie Bui, Martine Reynaud-Gaubert, Philippe Reix, Trieu-Nghi Hoang-Thi, Maria Vakalopoulou, Marie-Pierre Revel, Jennifer Da Silva, Pierre-Regis Burgel, Guillaume Chassagnon
Summary: The study evaluated lung structural changes after 1 year of lumacaftor-ivacaftor treatment and identified morphological phenotypes associated with treatment response using unsupervised machine learning. The results showed significant improvement in bronchial disease on chest CT after 1-year treatment with lumacaftor-ivacaftor, and radiomics features on pre-therapeutic CT scans may help predict lung function response to the medication.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Letter
Critical Care Medicine
Clemence Martin, Lucile Regard, Guillaume Chassagnon, Pierre-Regis Burgel
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Arnaud Tual, Marie-Pierre Revel, Emma Canniff, Alexandre Garin, Guillaume Chassagnon
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2022)
Review
Pharmacology & Pharmacy
Philippe Icard, Luca Simula, Ludovic Fournel, Karen Leroy, Audrey Lupo, Diane Damotte, Marie Christine Charpentier, Catherine Durdux, Mauro Loi, Olivier Schussler, Guillaume Chassagnon, Antoine Coquerel, Hubert Lincet, Vincent De Pauw, Marco Alifano
Summary: NSCLC is the main cause of cancer mortality and poses a significant challenge in cancer therapy. Resistance to anticancer drugs is promoted by hypoxia and HIF-1?? in tumor cells. Chemoresistance is also influenced by the activation of various oncogenic signaling pathways.
DRUG RESISTANCE UPDATES
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Philippe Soyer, Elliot K. Fishman, Steven P. Rowe, Michael N. Patlas, Guillaume Chassagnon
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Elodie Gouhier, Emma Canniff, Ludovic Fournel, Marie-Pierre Revel, Guillaume Chassagnon
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2022)
Review
Health Care Sciences & Services
Trieu-Nghi Hoang-Thi, Guillaume Chassagnon, Hai-Dang Tran, Nhat-Nam Le-Dong, Anh Tuan Dinh-Xuan, Marie-Pierre Revel
Summary: Artificial intelligence plays a significant role in medicine and lung health by enabling automatic quantitative assessment of anatomical structures and disease detection/prognosis estimation through machine learning.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Guillaume Chassagnon, Constance De Margerie-Mellon, Maria Vakalopoulou, Rafael Marini, Trieu-Nghi Hoang-Thi, Marie-Pierre Revel, Philippe Soyer
Summary: AI has been widely applied in thoracic oncology, including pulmonary nodule detection, segmentation, characterization, and stratification. Some of the tools developed have already been commercially available.
JAPANESE JOURNAL OF RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Constance de Margerie-Mellon, Guillaume Chassagnon
Summary: Artificial intelligence has been applied in medical imaging, specifically in the detection, segmentation, and classification of lung nodules, as well as the characterization and prognosis prediction of lung cancer. However, the clinical implementation of AI tools is still in its early stages due to the lack of generalizability in published studies, limited understanding of the working mechanism, and insufficient data on the impact on radiologists' decision-making and patient outcomes.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2023)
Article
Oncology
Clara Vigneron, Othmane Laousy, Guillaume Chassagnon, Maria Vakalopoulou, Julien Charpentier, Jerome Alexandre, Matthieu Jamme, Frederic Pene
Summary: This study evaluated the impact of daily activities, nutritional status, and muscle surface on the prognosis of critically ill cancer patients in the intensive care unit (ICU). The results showed that muscle surface, the ability to perform daily activities, and the six-month course of nutritional parameters could predict short- and long-term prognosis. This information is crucial for solid cancer patients with life-threatening complications.
Article
Rheumatology
Carole Jalaber, Xavier Puechal, Ines Saab, Emma Canniff, Benjamin Terrier, Luc Mouthon, Eglantine Cabanne, Sandra Mghaieth, Marie-Pierre Revel, Guillaume Chassagnon
Summary: Chest CT can differentiate between GPA and RP, with subglottic tracheal involvement and extensive airway involvement being the most relevant features.
ARTHRITIS RESEARCH & THERAPY
(2022)