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Chemistry, Medicinal
Futoon Abedrabbu Al-Rawashde, Abdullah Saleh Al-wajeeh, Mansoureh Nazari Vishkaei, Hanan Kamel M. Saad, Muhammad Farid Johan, Wan Rohani Wan Taib, Imilia Ismail, Hamid Ali Nagi Al-Jamal
Summary: This study explores the inhibitory effect of thymoquinone (TQ) on the JAK/STAT and PI3K/Akt/mTOR pathways in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) cells. TQ showed a dose and time dependent inhibition of cell proliferation and downregulated PI3K, Akt, and mTOR genes while upregulating PTEN gene expression. TQ also inhibited JAK/STAT and PI3K/Akt/mTOR signaling pathways. These findings suggest that TQ has potential anti-leukemic effects on both AML and CML cells.
Article
Oncology
Sime Brkic, Simona Stivala, Alice Santopolo, Jakub Szybinski, Sarah Jungius, Jakob R. Passweg, Dimitrios Tsakiris, Stefan Dirnhofer, Gregor Hutter, Katharina Leonards, Heidi E. L. Lischer, Matthias S. Dettmer, Benjamin G. Neel, Ross L. Levine, Sara C. Meyer
Summary: Dual targeting of JAK2 and ERK1/2 shows enhanced therapeutic efficacy for myeloproliferative neoplasms (MPN), mitigating disease features and promoting clone control.
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Plant Sciences
Yuan Wu, Qiong Li, Ling-ling Lv, Jing-xian Chen, Hai-feng Ying, Ming Ruan, Wen-hua Zhu, Jia-yue Xu, Chen-yiyu Zhang, Kai-yuan Zhang, Yuan-biao Guo, Wei-rong Zhu, Lan Zheng
Summary: This study aimed to evaluate the inhibitory effect of nobiletin on breast cancer and elucidate potential mechanisms against invasion and migration. The results showed that nobiletin can inhibit the invasion and migration of breast cancer cells by suppressing the ERK and JNK signaling pathways. In addition, nobiletin inhibited liver metastasis of breast cancer in vivo. Therefore, nobiletin has the potential to be used as an anticancer agent.
Review
Immunology
Shuang Liu, Hongxing Ma, Huaxi Zhang, Chengjie Deng, Ping Xin
Summary: Rheumatoid arthritis is characterized by systemic synovitis and joint destruction due to imbalances in pro-inflammatory and anti-inflammatory cytokines. Understanding the signaling pathways and inhibitors is crucial for the development of therapeutic targets and new drugs for RA.
CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pei-Shan Wu, Chih-Yang Wang, Pin-Shern Chen, Jui-Hsiang Hung, Jui-Hung Yen, Ming-Jiuan Wu
Summary: 8-OHD exerts anti-CML effects by downregulating JAK/STAT, PI3K/AKT, MMP, and OXPHOS pathways, as well as MYC expression. These findings shed new light on the development of 8-OHD for CML therapy.
Review
Genetics & Heredity
Sumit Kumar, Sidharth Mehan, Acharan S. Narula
Summary: The JAK-STAT, mTOR, and PPAR gamma signaling pathways play important roles in neuronal activity and brain development, and their overactivation or inhibition can lead to neurocomplications. Even minor disruptions in cellular and molecular processes can have significant consequences as neurological and neuropsychiatric diseases. Therefore, modulators of these signaling pathways may serve as potential therapeutic targets for preventing neuronal dysfunctions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Biochemistry & Molecular Biology
Nazia Afroze, Sreepoorna Pramodh, Jasmin Shafarin, Khuloud Bajbouj, Mawieh Hamad, Madhumitha Kedhari Sundaram, Shafiul Haque, Arif Hussain
Summary: Fisetin inhibits cell proliferation, promotes apoptosis, and improves oxidative stress and inflammation through regulating various signaling pathways, suggesting its potential therapeutic value in cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Chan Gao, Xiao Fei, Ming Wang, Qi Chen, Ning Zhao
Summary: This study investigated the role of cardamonin (CAD) in diabetes-induced kidney damage in rats. The results showed that CAD protects against diabetes-induced kidney damage by modulating the PI3K/AKT and JAK/STAT signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amir Barzegar Behrooz, Zahra Talaie, Fatemeh Jusheghani, Marek J. Los, Thomas Klonisch, Saeid Ghavami
Summary: Glioblastoma (GBM) is a devastating type of brain tumor, and targeting the Wnt/β-catenin and PI3K/Akt/mTOR (PAM) signaling pathways, which play crucial roles in GBM progression and invasion, may provide important advancements in alternative treatment strategies for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Thomas Gabriel Mhone, Ming-Cheng Chen, Chia-Hua Kuo, Tzu-Ching Shih, Chung-Min Yeh, Tso-Fu Wang, Ray-Jade Chen, Yu-Chun Chang, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study aimed to explore a tumor suppressive compound that can enhance the efficacy of Gefitinib treatment in lung cancer. Through in vitro and in vivo experiments, it was found that the combination of Daidzein and Gefitinib synergistically induced apoptosis and cell cycle arrest, effectively inhibiting lung cancer growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Ildiko M. L. Somorjai, Matthias T. Ehebauer, Hector Escriva, Jordi Garcia-Fernandez
Summary: The study demonstrates that pharmacological inhibition of JNK signaling in cephalochordate embryos results in morphological abnormalities such as notochord elongation defects, cell delamination, and altered gene expression. This suggests a conserved role of JNK signaling in regulating cellular behavior and tissue differentiation during cephalochordate morphogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Bojie Cong, Mai Nakamura, Yukari Sando, Takefumi Kondo, Shizue Ohsawa, Tatsushi Igaki
Summary: Identifying a common oncogenesis pathway among tumors with different oncogenic mutations is critical for developing anti-cancer strategies. Using fruit fly Drosophila as a model organism, researchers discovered a common oncogenesis pathway in malignant tumors and suppressed their growth using LAT1 inhibitors.
Review
Biochemistry & Molecular Biology
Nauf Bou Antoun, Athina-Myrto Chioni
Summary: Cancer is a leading cause of death worldwide. Drug resistance, whether intrinsic or acquired, plays a crucial role in cancer relapse. Various factors and signaling pathways are involved in the development of drug resistance, and a deeper understanding of these mechanisms is necessary to improve cancer treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Jingwangwei Liu, Yujia Lu, Min Tang, Fanghao Shao, Dongzi Yang, Shuchang Chen, Ziyi Xu, Leilei Zhai, Juanjuan Chen, Qian Li, Wei Wu, Haimin Chen
Summary: Fucoxanthin, extracted from seaweeds, has neuroprotective activity through its antioxidant properties. It can reduce cytotoxicity, inhibit cell apoptosis, and improve motor ability in Parkinson's disease patients with long-term l-DA administration.
Article
Chemistry, Medicinal
Belal Almajali, Muhammad Farid Johan, Abdullah Saleh Al-Wajeeh, Wan Rohani Wan Taib, Imilia Ismail, Maysa Alhawamdeh, Nafe M. Al-Tawarah, Wisam Nabeel Ibrahim, Futoon Abedrabbu Al-Rawashde, Hamid Ali Nagi Al-Jamal
Summary: This study found that thymoquinone (TQ) from Nigella sativa inhibits the activation of JAK/STAT and PI3K/AKT signaling pathways, leading to downregulation of c-Myc expression in HL60 leukemia cells. This potential inhibition of proliferation and induction of apoptosis highlights the therapeutic potential of TQ in treating leukemia.
Article
Clinical Neurology
Neha Singh, Sheekha Vijayanti, Lekha Saha, Alka Bhatia, Dibyajyoti Banerjee, Amitava Chakrabarti
Article
Pharmacology & Pharmacy
Puja Kumari, Neha Singh, Lekha Saha
INDIAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Neurosciences
Neha Singh, Sheekha Vijayanti, Lekha Saha
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Neha Singh, Lekha Saha, Puja Kumari, Jagjit Singh, Alka Bhatia, Dibyajyoti Banerjee, Amitava Chakrabarti
BRAIN RESEARCH BULLETIN
(2019)
Article
Pharmacology & Pharmacy
Jagjit Singh, Lekha Saha, Neha Singh, Puja Kumari, Alka Bhatia, Amitava Chakrabarti
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2019)
Review
Neurosciences
Kajal Rawat, Neha Singh, Puja Kumari, Lekha Saha
Summary: The gut microbiota plays a crucial role in neurological diseases through the gut-brain axis, with factors such as diet and stress affecting colonization patterns. Recent studies have shown that the ketogenic diet can remodel the gut microbiome and have protective effects on CNS disorders. Understanding the interaction between gut microbes and KD may provide novel therapeutic approaches for neurological disorders.
REVIEWS IN THE NEUROSCIENCES
(2021)
Review
Pharmacology & Pharmacy
Kajal Rawat, Puja Kumari, Lekha Saha
Summary: COVID-19, caused by a new strain of betacoronavirus named as SARS-CoV-2, poses a huge burden on public health and global economies due to its high transmission rate. Developing vaccines is essential for preventing the spread of the virus and reducing mortality.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Umashanker Navik, Kajal Rawat, Kulbhushan Tikoo
Summary: In this study, we investigated the effect of L-Methionine (L-Met) on streptozotocin-induced beta-cell damage model of diabetes mellitus in rats. Our results showed that L-Met improved plasma glucose and insulin levels, increased insulin expression, and inhibited the expression of Arx. Furthermore, L-Met regulated the expression of FOXO1 through histone methylation marks H3K27me3 and H3K4me3. These findings suggest that L-Met may be a potential therapeutic approach for preventing beta-cell injury in diabetes.
Review
Neurosciences
Sree Lalitha Bojja, Neha Singh, Kiran Kumar Kolathur, Chamallamudi Mallikarjuna Rao
Summary: Lithium is a well-known medication for bipolar and mood disorders, and recent studies have shown its neuroprotective and neurotrophic effects in various neurological diseases. However, the exact mechanisms of its actions, especially in epilepsy treatment, are still unknown.
CURRENT NEUROPHARMACOLOGY
(2022)