Article
Biochemistry & Molecular Biology
Yuan Zhang, Aurore Devocelle, Christophe Desterke, Lucas Eduardo Botelho de Souza, Eva Hadadi, Herve Acloque, Adlen Foudi, Yao Xiang, Annabelle Ballesta, Yunhua Chang, Julien Giron-Michel
Summary: The study demonstrates that BMAL1 plays a crucial role in maintaining the balance between epithelial and mesenchymal properties of CRC cell lines, influencing their capacities for adhesion, migration, invasion, and chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lei Na, Zhuo Wang, Yu Bai, Yu Sun, Dan Dong, Wei Wang, Chenghai Zhao
Summary: This study identified that WNT7B is downregulated in high-grade bladder urothelial carcinomas, and its low expression is associated with poor prognosis. WNT7B inhibits bladder urothelial carcinoma progression by suppressing EMT, stem-like properties, and chemoresistance.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Oncology
Kaibo Guo, Yuqian Feng, Xueer Zheng, Leitao Sun, Harpreet S. Wasan, Shanming Ruan, Minhe Shen
Summary: Resveratrol and its analogs can reverse EMT through diverse mechanisms, inhibit tumor invasion and migration, potentially serving as novel anti-tumor agents. They can also reverse chemoresistance and improve the antiproliferative effects of conventional treatments.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Sekaran Balaji, Usha Kim, Veerappan Muthukkaruppan, Ayyasamy Vanniarajan
Summary: The interactions between cancer and non-cancerous cells in the TME through exosomes play a significant role in influencing tumor progression, therapeutic resistance, and metastasis. Wnt signaling, which is often involved in exosomal transport, represents a potential therapeutic target in inhibiting these processes.
Review
Oncology
Wenrong Mu, Zubang Zhou, Liping Shao, Qi Wang, Wanxue Feng, Yuling Tang, Yizong He, Yuanlin Wang
Summary: The study found that there is a close interaction between ferroptosis and EMT. The EMT process can promote the accumulation of iron ions, providing conditions for ferroptosis. Conversely, ferroptosis may impact the regulatory network of EMT by modulating transcription factors, signaling pathways, and cell adhesion molecules. Genes, signaling pathways, and oxidative homeostasis related to ferroptosis play important roles in the regulation of EMT.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Tengteng Zou, Meng Lan, Fengjie Liu, Lihong Li, Tiange Cai, Huaqin Tian, Yu Cai
Summary: The study highlights the crucial role of EMT in breast cancer drug resistance, but inhibiting EMT with E-PLNs can enhance the sensitivity of breast cancer cells to chemotherapy drug DOX. This offers a new approach to prevent or delay clinical drug resistance in breast cancer.
CANCER NANOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mehrdad Hashemi, Fatemeh Ghadyani, Sahar Hasani, Yeganeh Olyaee, Behnaz Raei, Marzieh Khodadadi, Maryam Fallah Ziyarani, Fatemeh A. Basti, Alireza Tavakolpournegari, Arash Matinahmadi, Shokooh Salimimoghadam, Amir Reza Aref, Afshin Taheriazam, Maliheh Entezari, Yavuz Nuri Ertas
Summary: Cancer is a life-threatening disease characterized by abnormal proliferation and metastasis of cancer cells. Chemotherapy, the use of anti-cancer drugs, is a common treatment for cancer, but drug resistance can lead to treatment failure. To overcome this, nano-scale delivery systems like liposomes have been developed to reverse drug resistance and enhance the effectiveness of chemotherapy agents.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Tianzhu Sun, Dengyang Zhang, Zehao Wang, Bingyu Zhao, Yaping Li, Xiuli Sun, Jia Liu, Xuanjun Wang, Jun Sheng
Summary: Studies have shown that cervical cancer cells develop an EMT phenotype partly through activation of the Notch1 signaling pathway, leading to resistance to paclitaxel. Targeting the Notch1 signaling pathway may be a strategy to reverse the EMT phenotype and increase sensitivity of cervical cancer cells to paclitaxel treatment.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Adriana Martinez Turtos, Francesca Napoli, Yasmin Antonelli, Aldo Leal-Egana, Jesper Foged Havelund, Simon Toftholm Jakobsen, Elisa Le Boiteux, Marco Volante, Nils Joakim Faergeman, Ole N. Jensen, Rasmus Siersbaek, Kumar Somyajit, Paolo Ceppi
Summary: This study found an inverse association between short-chain fatty acids and EMT in non-small cell lung cancer patients. In vitro experiments showed that propionate treatment enhanced the epithelial transcriptional program and reduced the EMT phenotype in lung cancer cell lines. Animal experiments also confirmed that propionate can reduce lung cancer metastasis and lymph node spread. Further mechanistic investigation revealed that propionate treatment caused chromatin remodeling through p300-mediated histone acetylation.
EMBO MOLECULAR MEDICINE
(2023)
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Cell Biology
Zhongjian Yu, Xiongjie Zhu, Ying Li, Min Liang, Meijun Liu, Zhile Liu, Lingyu Qin, Xiaoran Wu, Kunpeng Du, Lu Liu, Yong Wang, Yanfang Zheng
Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Anastasios Goulioumis, Kostis Gyftopoulos
Summary: Epithelial-to-mesenchymal transition (EMT) is a molecular phenomenon that occurs in epithelial neoplasms, such as laryngeal carcinoma. EMT leads to the loss of epithelial traits and acquisition of mesenchymal traits by tumor cells, enhancing their migratory capacity. EMT is mediated by complex molecular pathways and involves various changes, including loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, etc. Partial EMT models have been accepted to explain the cell plasticity associated with invasion and metastasis of tumors.
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anda Huna, Beatrice Nawrocki-Raby, Teresita Padilla-Benavides, Julie Gavard, Sylvie Coscoy, David Bernard, Mathieu Boissan
Summary: NME1, not NME2, acts specifically to inhibit EMT and prevent the earliest stages of metastasis. Loss of NME1 leads to a hybrid phenotype associated with higher metastatic potential, while overexpression of NME1 results in a more epithelial phenotype. Additionally, NME1 inhibits key intracellular signaling pathways involved in inducing EMT, such as AKT and MAPK pathways, and affects the distribution and cell-cell adhesion of E-cadherin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Babak Roshanravan, Shahnaz Yousefizadeh, Betul Apaydin Yildirim, Tahereh Farkhondeh, Alireza Amirabadizadeh, Milad Ashrafizadeh, Marjan Talebi, Saeed Samarghandian
Summary: Berberis vulgaris L. and Berberis aristata L. have beneficial effects in patients with metabolic syndrome, reducing LDL, total cholesterol, and triglyceride levels, and increasing HDL levels.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Neurosciences
Erica Costantini, Srinivas Jarlapoodi, Federica Serra, Lisa Aielli, Haroon Khan, Tarun Belwal, Katia Falasca, Marcella Reale
Summary: This study evaluates the anti-inflammatory and regenerative properties of Bacopa monnieri extract (BME) in an in vitro model of neuroinflammation. The results show that BME protects neuronal cells from cytotoxicity and reduces the expression of inflammatory genes, while accelerating wound healing. Therefore, BME may be a promising candidate for the treatment of neuroinflammation.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Microbiology
Arianna Pompilio, Marco Scocchi, Maria Luisa Mangoni, Samira Shirooie, Annalisa Serio, Ygor Ferreira Garcia da Costa, Maria Silvana Alves, Gokce Seker Karatoprak, Ipek Suntar, Haroon Khan, Giovanni Di Bonaventura
Summary: Most human infectious diseases are caused by microorganisms in biofilms, which have increased resistance to antibiotics and the immune system. Therefore, there is a need for new strategies to control biofilm-associated infections. Natural products with a wide range of chemical structures and biological activities have been explored as potential biofilm inhibitors. This review discusses the bioactive compounds isolated from various natural sources that have the potential to inhibit biofilm formation and disperse established biofilms. However, the exact mechanism of action of these compounds is often unclear.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sepideh Mirzaei, Mohammad Hossein Gholami, Amirhossein Zabolian, Hossein Saleki, Morteza Bagherian, Seyed Mohammadreza Torabi, Seyed Omid Sharifzadeh, Kiavash Hushmandi, Kaila R. Fives, Haroon Khan, Milad Ashrafizadeh, Ali Zarrabi, Anupam Bishayee
Summary: This review focuses on the therapeutic impacts of resveratrol (Res) in enhancing the antitumor activities of doxorubicin (DOX) and cisplatin (CP) while reducing their side effects. Co-administration of Res can overcome chemoresistance, induce apoptosis and cell cycle arrest in cancer cells, and enhance the sensitivity of cancer cells to DOX and CP chemotherapy. Additionally, Res ameliorates the adverse impacts of DOX and CP on normal cells and organs, and nanoformulations have been developed to improve its bioavailability and therapeutic effects.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Aditi Sharma, Lalit Sharma, Shouvik Kumar Nandy, Nazrana Payal, Shivam Yadav, Celia Vargas-De-La-Cruz, Md. Khalid Anwer, Haroon Khan, Tapan Behl, Simona Gabriela Bungau
Summary: Due to genetic changes, cancer remains a major cause of death. Anticancer research faces challenges in targeting healthy cells while addressing the importance of target function. Cancer cells undergo various mutations and abnormalities that affect the efficacy of anticancer drugs. With low clinical success rates, finding alternative herbal-based therapies to attenuate resistance and protect against chemotherapy side effects is crucial. This review updates the understanding of common cancer types and presents key compounds that may enhance cancer treatment efficacy.
Article
Pharmacology & Pharmacy
Mehrdad Hashemi, Motahare Sadat Ayat Mirdamadi, Yasmin Talebi, Nasrin Khaniabad, Gooya Banaei, Pouria Daneii, Sadaf Gholami, Amin Ghorbani, Alireza Tavakolpournegari, Zoheir Mohammadian Farsani, Ali Zarrabi, Noushin Nabavi, Mohammad Arad Zandieh, Mohsen Rashidi, Afshin Taheriazam, Maliheh Entezari, Haroon Khan
Summary: The field of non-coding RNA has made significant progress in cancer research, and miR-21 plays a crucial role in tumor progression, metabolism reprogramming, metastasis, and drug resistance.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Seyed Hossein Shahcheraghi, Fateme Salemi, Shlomo Small, Suliman Syed, Farzam Salari, Waqas Alam, Wai San Cheang, Luciano Saso, Haroon Khan
Summary: Oxidative stress refers to the auxiliary damage of natural materials such as nucleic acids, proteins, and lipids by reactive oxygen/nitrogen species in aerobic metabolism. Resveratrol, a natural polyphenol found in red wine and peanuts, is known for its anti-aging properties. Studies have shown that resveratrol can inhibit the destructive effects of inflammation and reactive oxygen radicals. The nuclear erythroid 2-related factor 2 (Nrf2) is a transcription factor with anti-inflammatory and antioxidant properties, involved in enzyme biotransformation and the biosynthesis of lipids and carbohydrates. This review provides current understanding and information about the role of resveratrol in combating oxidative stress and regulating inflammation through the Nrf2 signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Review
Cell Biology
Maryam Boshtam, Ilnaz Rahimmanesh, Laleh Shariati, Malihe Najaflu, Hossein Khanahmad, Mina Mirian, Atefeh Zarepour, Ali Zarrabi, Shirin Kouhpayeh
Summary: MicroRNAs (miRNAs) play a role in post-transcriptional gene expression regulation and contribute to the regulation of different steps in the differentiation, maturation, and activation of various cell subsets. They also play a key role in modulating the adaptive immune responses by directly targeting hallmark genes or regulating signaling pathways and transcription factors involved in T-cell subset development and B-cell differentiation. This review discusses the regulatory role of miRNAs and transcription factors in the differentiation and maturation processes of T-cell subsets and B-cells.
Article
Pharmacology & Pharmacy
Zahra Mohammadpour, Mahshid Kharaziha, Ali Zarrabi
Summary: The main challenge in extrusion 3D bioprinting is the development of bioinks with desired properties for creating complex and patient-specific scaffolds. This study focuses on non-synthetic bioinks based on alginate and silk nanofibrils (SNF) and their optimization for soft tissue engineering. The addition of SNF improved the mechanical and biological performance of the bioink, with 2 wt.% SNF showing the best results. Overall, this study highlights the favorable properties of the Alg-2SNF bioink for extrusion-based bioprinting.
Article
Materials Science, Multidisciplinary
Gokcen Yasayan, Omid Nejati, Asli F. Ceylan, Cimen Karasu, Pelin Kelicen Ugur, Ayca Bal-Ozturk, Atefeh Zarepour, Ali Zarrabi, Ebrahim Mostafavi
Summary: Chronic wounds, particularly in diabetes patients, are a major health challenge with high economic costs. Nanomaterials have shown promising results in treating chronic wounds by acting as carriers for therapeutic agents or directly as the therapeutic compound. This review provides the latest research progress and prospects on the application of different nanomaterials in chronic wound healing, with a focus on their effects on intracellular factors.
APPLIED MATERIALS TODAY
(2023)
Review
Oncology
Zhenli Guo, Milad Ashrafizadeh, Wei Zhang, Rongjun Zou, Gautam Sethi, Xianbin Zhang
Summary: Metastasis is a multistep process where a small proportion of cancer cells detach from the primary site and enter the bloodstream to find new sites for metastasis and proliferation. Cancer metastasis and cell plasticity contribute to increased malignancy of cancer cells and poorer prognosis for patients. Pancreatic cancer (PC) is one of the most aggressive gastrointestinal tumors, and along with lifestyle factors and genomic changes, it is associated with PC progression. The stimulation of epithelial-mesenchymal transition (EMT) in PC cells leads to increased metastasis and chemoresistance. Molecular pathways such as STAT3, PTEN, PI3K/Akt, and Wnt play a crucial role in regulating the metastasis of PC cells. Tumor microenvironment components, including macrophages, neutrophils, and cancer-associated fibroblasts, can modulate PC progression and the response to chemotherapy through communication facilitated by exosomes.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Hazal Ezgi Gultekin, Gokcen Yasayan, Ayca Bal-Ozurk, Ashkan Bigham, Abdolreza (Arash) Simchi, Atefeh Zarepour, Siavash Iravani, Ali Zarrabi
Summary: Wound healing is a complex process that requires effective management. Upconversion nanoparticles (UCNPs) have emerged as promising materials for wound dressing due to their unique properties. Functionalized with antibacterial agents, UCNPs have enhanced antibacterial properties and can deliver therapeutic agents to the wound site. They can also convert near-infrared light for therapy and diagnosis. However, the use of UCNPs in wound dressing faces challenges of stability, biocompatibility, efficient incorporation, scalability, and cost-effectiveness.
MATERIALS HORIZONS
(2023)
Review
Oncology
Samira Hassani, Fahimeh Ghanbari, Marzieh Lotfi, Waqas Alam, Michael Aschner, Jelena Popovic-Djordjevic, Seyed Hossein Shahcheraghi, Haroon Khan
Summary: This review discusses the potential of gallic acid (GA), a phenolic compound, in cancer treatment and its anti-tumor properties. GA can inhibit cancer progression by targeting different molecular pathways and can be an effective complement to chemotherapy drugs and combat multidrug resistance.
Review
Materials Science, Biomaterials
Atefeh Zarepour, Cimen Karasu, Yousof Mir, Mohammad Hadi Nematollahi, Siavash Iravani, Ali Zarrabi
Summary: MXenes and graphene have gained attention in neuroscience for their potential applications in sensing, theranostics, and biomedical engineering. They have been used to develop advanced nanosystems for diagnosis and therapy, and have shown promise in treating neurological disorders. However, there are challenges and limitations to their use, and further research is needed to optimize their properties and understand their potential in neuroscience.
BIOMATERIALS SCIENCE
(2023)
