Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR

Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors

(2020) Ehab M. Gedawy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophenes

(2020) Nermeen A. Qandeel et al.   BIOORGANIC CHEMISTRY

Anti-inflammatory and anti-nociceptive activities of Alpinia Oxyphylla Miquel extracts in animal models

(2020) Su Hyun Yu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

(2020) Nathaniel C. Gilbert et al.   Nature Chemical Biology

Design, synthesis, and biological evaluation of new pyrazoloquinazoline derivatives as dual COX‐2/5‐LOX inhibitors

(2020) Mohamed A. Shaaban et al.   ARCHIV DER PHARMAZIE

Identification and development of thiazole leads as COX-2/5-LOX inhibitors through in-vitro and in-vivo biological evaluation for anti-inflammatory activity

(2020) Jaismy Jacob P et al.   BIOORGANIC CHEMISTRY

Conjugated linoleic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice through dual inhibition of COX-2/5-LOX and TLR4/NF-κB signaling

(2020) Liu Tang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core

(2020) Miroslav Sisa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Computational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways

(2020) Francisco das Chagas Pereira de Andrade et al.   Scientific Reports

Dual COX and 5-LOX inhibition by clerodane diterpenes from seeds of Polyalthia longifolia (Sonn.) Thwaites

(2020) Ha Thi Nguyen et al.   Scientific Reports

Dendropanax dentiger (Harms) Merr. root and its major constituents exert therapeutic effect on adjuvant-induced arthritis in rats

(2020) Li Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents

(2019) Zhang Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Albizia anthelmintica: HPLC-MS/MS profiling and in vivo anti-inflammatory, pain killing and antipyretic activities of its leaf extract

(2019) Mansour Sobeh et al.   BIOMEDICINE & PHARMACOTHERAPY

Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors

(2019) Ehab S. Taher et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids

(2019) Veronika Leláková et al.   FOOD CHEMISTRY

Design, synthesis, biological evaluation and docking study of novel indole-2-amide as anti-inflammatory agents with dual inhibition of COX and 5-LOX

(2019) Yuanzheng Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes

(2019) Nhu Ngoc Quynh Vo et al.   JOURNAL OF NATURAL PRODUCTS

Design, synthesis, and biological evaluation of novel 1,2-diaryl-4-substituted-benzylidene-5(4H )-imidazolone derivatives as cytotoxic agents and COX-2/LOX inhibitors

(2018) Phoebe F. Lamie et al.   ARCHIV DER PHARMAZIE

Novel N -substituted 5-aminosalicylamides as dual inhibitors of cyclooxygenase and 5-lipoxygenase enzymes: Synthesis, biological evaluation and docking study

(2018) Mohamed K.S. El-Nagar et al.   BIOORGANIC CHEMISTRY

Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies

(2018) Mohamed A. Abdelgawad et al.   BIOORGANIC CHEMISTRY

Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

(2018) Jaismy Jacob P et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Specialized oxygenated heterocyclics from Villorita cyprinoides with cyclooxygenase-2 and 5-lipoxygenase inhibitory properties

(2018) Minju Joy et al.   FOOD RESEARCH INTERNATIONAL

Focused library design and synthesis of 2-mercapto benzothiazole linked 1,2,4-oxadiazoles as COX-2/5-LOX inhibitors

(2018) Satayanarayana Yatam et al.   JOURNAL OF MOLECULAR STRUCTURE

Effects of phenidone (DuCLOX-2/5 inhibitor) against N -methyl- N -nitrosourea induced mammary gland carcinoma in albino rats

(2018) Swetlana Gautam et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity

(2018) Fatima Naaz et al.   BIOORGANIC CHEMISTRY

Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly

(2018) John J. McNeil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Indole and 2,4-Thiazolidinedione conjugates as potential anticancer modulators

(2018) Domenica M. Corigliano et al.   PeerJ

Evaluation of anti-inflammatory and immunomodulatory effects of Premna integrifolia extracts and assay-guided isolation of a COX-2/5-LOX dual inhibitor

(2018) Rajaram Azad et al.   FITOTERAPIA

Inflammation and cancer

(2018) Mariko Murata   Environmental Health and Preventive Medicine

Synthesis, characterization and molecular docking studies of substituted 4-coumarinylpyrano[2,3-c]pyrazole derivatives as potent antibacterial and anti-inflammatory agents

(2017) Bahubali M. Chougala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazole: A Review on Chemistry, Synthesis and Therapeutic Importance of its Derivatives

(2016) Mahesh T. Chhabria et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Novel N -substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study

(2016) Phoebe F. Lamie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy

(2016) Hao Cai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indoles — A promising scaffold for drug development

(2016) T.V. Sravanthi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

FDA labeling of NSAIDs: Review of nonsteroidal anti-inflammatory drugs in cardiovascular disease

(2016) Preethi Pirlamarla et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Crystal structure of rofecoxib bound to human cyclooxygenase-2

(2016) Benjamin J. Orlando et al.   Acta Crystallographica Section F-Structural Biology Communications

Identification of the Substrate Access Portal of 5-Lipoxygenase

(2015) Sunayana Mitra et al.   BIOCHEMISTRY

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

(2015) Sofia A. Santos et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes

(2015) Palwinder Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indole-based hydrazide-hydrazones and 4-thiazolidinones: synthesis and evaluation as antitubercular and anticancer agents

(2015) Gökçe Cihan-Üstündağ et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Triblock Conjugates: Identification of a Highly Potent Antiinflammatory Agent

(2015) Palwinder Singh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization and cytotoxic investigations of novel bis(indole) analogues besides antimicrobial study

(2015) Praveen Choppara et al.   Arabian Journal of Chemistry

Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents

(2014) Guangcheng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors

(2014) Sultan Nacak Baytas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and structure–activity analysis of diphenylpyrazolodiazene inhibitors of the HIV-1 Nef virulence factor

(2014) Prema C. Iyer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and identification of α-cyano bis(indolyl)chalcones as novel anticancer agents

(2014) Dalip Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, Molecular Docking, and Biological Evaluation of Some Novel Hydrazones and Pyrazole Derivatives as Anti-inflammatory Agents

(2014) Khaled O. Mohammed et al.   Chemical Biology & Drug Design

Synthesis, structure–activity relationships, and in vitro antibacterial and antifungal activity evaluations of novel pyrazole carboxylic and dicarboxylic acid derivatives

(2014) Samet Mert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cardiovascular events associated with the long-term use of NSAIDs: a review of randomized controlled trials and observational studies

(2014) Francesco Salvo et al.   Expert Opinion On Drug Safety

Synthesis, biological evaluation, and molecular docking studies of pyrazolyl-acylhydrazone derivatives as novel anticancer agents

(2014) Man Xing et al.   MEDICINAL CHEMISTRY RESEARCH

Anti-Inflammatory Effects of Triterpenoids; Naturally Occurring and Synthetic Agents

(2014) Gil-Saeng Jeong et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

2-(2-Arylphenyl)benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation

(2014) Kapileswar Seth et al.   ACS Medicinal Chemistry Letters

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin

(2013) Anja M. Schaible et al.   BIOCHEMICAL PHARMACOLOGY

Current Perspectives in NSAID-Induced Gastropathy

(2013) Mau Sinha et al.   MEDIATORS OF INFLAMMATION

Synthesis and antibacterial activity of 4,4′-(aryl or alkyl methylene)-bis(1H-pyrazol-5-ol) derivatives

(2013) S. Bhavanarushi et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives

(2012) Antonio Palumbo Piccionello et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

4-(1H-Pyrazol-1-yl) Benzenesulfonamide Derivatives: Identifying New Active Antileishmanial Structures for Use against a Neglected Disease

(2012) Roberta Marra et al.   MOLECULES

Synthesis and cytotoxic evaluation of thiourea and N-bis-benzothiazole derivatives: A novel class of cytotoxic agents

(2011) Ravindra M. Kumbhare et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents

(2011) Vikas N. Telvekar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

(2011) William L. Smith et al.   CHEMICAL REVIEWS

Endocannabinoid Oxygenation by Cyclooxygenases, Lipoxygenases, and Cytochromes P450: Cross-Talk between the Eicosanoid and Endocannabinoid Signaling Pathways

(2011) Carol A. Rouzer et al.   CHEMICAL REVIEWS

Synthesis, spectral, crystal structure and in vitro antimicrobial evaluation of imidazole/benzotriazole substituted piperidin-4-one derivatives

(2011) R. Ramachandran et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents

(2011) Sameena Bano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A facile green synthesis and in vitro antimicrobial activity 4H-pyrimido[2,1-b][1,3]benzothiazole derivatives using aluminum trichloride under solvent free conditions

(2011) Pramod K. Sahu et al.   MEDICINAL CHEMISTRY RESEARCH

Redox and Non-Redox Mechanism ofIn VitroCyclooxygenase Inhibition by Natural Quinones

(2011) Premysl Landa et al.   PLANTA MEDICA

Inflammation as “common soil” of the multifactorial diseases

(2010) Rossana Scrivo et al.   AUTOIMMUNITY REVIEWS

Homeostasis and Inflammation in the Intestine

(2010) Wendy S. Garrett et al.   CELL

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Convenient synthesis and biological profile of 5-amino-substituted 1,2,4-oxadiazole derivatives

(2010) Maria Ispikoudi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins

(2009) Charles Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 4-benzyl-1,3-thiazole derivatives as potential anti-inflammatory agents: An analogue-based drug design approach

(2009) Ritesh N. Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Boswellia resin: from religious ceremonies to medical uses; a review of in-vitro, in-vivo and clinical trials

(2009) Arieh Moussaieff et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors

(2008) M.V. Ramana Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cyclooxygenases: structural and functional insights

(2008) Carol A. Rouzer et al.   JOURNAL OF LIPID RESEARCH

Stereoselective cyclopropanation of serine- and threonine-derived oxazines to access new morpholine-based scaffolds

(2008) Filippo Sladojevich et al.   ORGANIC & BIOMOLECULAR CHEMISTRY