The year in cardiovascular medicine 2021: heart failure and cardiomyopathies

Gaps in Evidence for Risk Stratification for Sudden Cardiac Death in Hypertrophic Cardiomyopathy

(2021) Francesco Pelliccia et al.   CIRCULATION

Cell-Free DNA to Detect Heart Allograft Acute Rejection

(2021) Sean Agbor-Enoh et al.   CIRCULATION

Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK)

(2021) A. Yilmaz et al.   Clinical Research in Cardiology

Circulating cardiovascular microRNAs in critically ill COVID ‐19 patients Short title: microRNA signatures in COVID ‐19

(2021) Ankita Garg et al.   EUROPEAN JOURNAL OF HEART FAILURE

Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19

(2021) Renato D. Lopes et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis

(2021) Rika Kawakami et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

(2021) Chaolin Huang et al.   LANCET

Continuation versus discontinuation of renin–angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial

(2021) Jordana B Cohen et al.   Lancet Respiratory Medicine

Electrocardiographic features and their echocardiographic correlates in peripartum cardiomyopathy: results from the ESC EORP PPCM registry

(2021) Amam C. Mbakwem et al.   ESC Heart Failure

All-cause mortality and location of death in patients with established cardiovascular disease before, during, and after the COVID-19 lockdown: a Danish Nationwide Cohort Study

(2021) Jawad H Butt et al.   EUROPEAN HEART JOURNAL

The novel cystatin C, lactate, interleukin-6, and N-terminal pro-B-type natriuretic peptide (CLIP)-based mortality risk score in cardiogenic shock after acute myocardial infarction

(2021) Uta Ceglarek et al.   EUROPEAN HEART JOURNAL

Quality of life in EMPEROR-Reduced: emphasizing what is important to patients while identifying strategies to support more patient-centred care

(2021) John A Spertus   EUROPEAN HEART JOURNAL

Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance

(2021) Tushar Kotecha et al.   EUROPEAN HEART JOURNAL

Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23

(2021) Sophie Garnier et al.   EUROPEAN HEART JOURNAL

Five-year outcomes of patients supported with HeartMate 3: a single-centre experience

(2021) Jan D Schmitto et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction

(2021) Rebecca J. Woolley et al.   EUROPEAN JOURNAL OF HEART FAILURE

Sodium–glucose co‐transporter 2 inhibition in patients hospitalized for acute decompensated heart failure: rationale for and design of the EMPULSE trial

(2021) Jasper Tromp et al.   EUROPEAN JOURNAL OF HEART FAILURE

Risk stratification and management of women with cardiomyopathy/heart failure planning pregnancy or presenting during/after pregnancy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on Peripartum Cardiomyopathy

(2021) Karen Sliwa et al.   EUROPEAN JOURNAL OF HEART FAILURE

Universal definition and classification of heart failure: A report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure

(2021) Biykem Bozkurt et al.   EUROPEAN JOURNAL OF HEART FAILURE

The Heart Failure Association Atlas : Heart Failure Epidemiology and Management Statistics 2019

(2021) Petar M. Seferović et al.   EUROPEAN JOURNAL OF HEART FAILURE

Real-world effectiveness and safety of sacubitril/valsartan in heart failure: A systematic review

(2021) Clare Proudfoot et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure

(2021) Michael J. Mack et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Association of Effective Regurgitation Orifice Area to Left Ventricular End-Diastolic Volume Ratio With Transcatheter Mitral Valve Repair Outcomes

(2021) JoAnn Lindenfeld et al.   JAMA Cardiology

Prevalence of Inflammatory Heart Disease Among Professional Athletes With Prior COVID-19 Infection Who Received Systematic Return-to-Play Cardiac Screening

(2021) Matthew W. Martinez et al.   JAMA Cardiology

The Effect of Neprilysin Inhibition on Left Ventricular Remodeling in Patients with Asymptomatic Left Ventricular Systolic Dysfunction Late After Myocardial Infarction

(2021) Kieran F. Docherty et al.   CIRCULATION

Development and Validation of Machine Learning-Based Race-Specific Models to Predict 10-Year Risk of Heart Failure: A Multi-Cohort Analysis

(2021) Matthew W. Segar et al.   CIRCULATION

Efficacy and Safety of Sacubitril/Valsartan in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction　― Results From the PARALLEL-HF Study ―

(2021) Hiroyuki Tsutsui et al.   CIRCULATION JOURNAL

Implications of Atrial Fibrillation on the Mechanisms of Mitral Regurgitation and Response to MitraClip in the COAPT Trial

(2021) Zachary M. Gertz et al.   Circulation-Cardiovascular Interventions

Clinical characteristics and outcomes in childhood-onset hypertrophic cardiomyopathy

(2021) Nicholas A Marston et al.   EUROPEAN HEART JOURNAL

An automated computational image analysis pipeline for histological grading of cardiac allograft rejection

(2021) Eliot G Peyster et al.   EUROPEAN HEART JOURNAL

Association between prophylactic angiotensin-converting enzyme inhibitors and overall survival in Duchenne muscular dystrophy—analysis of registry data

(2021) Raphaël Porcher et al.   EUROPEAN HEART JOURNAL

Leveraging clinical epigenetics in heart failure with preserved ejection fraction: a call for individualized therapies

(2021) Nazha Hamdani et al.   EUROPEAN HEART JOURNAL

Effects of dapagliflozin on mortality in patients with chronic kidney disease: a pre-specified analysis from the DAPA-CKD randomized controlled trial

(2021) Hiddo J L Heerspink et al.   EUROPEAN HEART JOURNAL

The management of secondary mitral regurgitation in patients with heart failure: a joint position statement from the Heart Failure Association (HFA), European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA), and European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC

(2021) Andrew J S Coats et al.   EUROPEAN HEART JOURNAL

A call to action for new global approaches to cardiovascular disease drug solutions

(2021) Gemma A Figtree et al.   EUROPEAN HEART JOURNAL

The struggle towards a Universal Definition of Heart Failure—how to proceed?

(2021) John G F Cleland et al.   EUROPEAN HEART JOURNAL

Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position statement on endomyocardial biopsy

(2021) Petar M. Seferović et al.   EUROPEAN JOURNAL OF HEART FAILURE

Diagnostic recommendations and phenotyping for heart failure with preserved ejection fraction: knowing more and understanding less?

(2021) Alan G. Fraser et al.   EUROPEAN JOURNAL OF HEART FAILURE

Prospective ARNI vs. ACE inhibitor trial to DetermIne Superiority in reducing heart failure Events after Myocardial Infarction (PARADISE‐MI): design and baseline characteristics

(2021) Karola S. Jering et al.   EUROPEAN JOURNAL OF HEART FAILURE

The combination of PICP blood levels and LGE at CMR provides additional prognostic information in idiopathic Dilated Cardiomyopathy

(2021) Anne G. Raafs et al.   EUROPEAN JOURNAL OF HEART FAILURE

Patients profiling in Heart Failure for tailoring medical therapy A consensus document of the Heart Failure Association of the European Society of Cardiology

(2021) Giuseppe M.C. Rosano et al.   EUROPEAN JOURNAL OF HEART FAILURE

Renal Function and the Effects of Vericiguat in Patients with Worsening Heart Failure with Reduced Ejection Fraction: Insights from VICTORIA ( VerICiguaT Global Study in Subjects with HFrEF ) Trial

(2021) Adriaan A. Voors et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cardiac Rehabilitation for Patients With Heart Failure

(2021) Biykem Bozkurt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of Ejection Fraction on Clinical Outcomes in Patients treated with Omecamtiv Mecarbil in GALACTIC-HF

(2021) John R. Teerlink et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2020 ACC/AHA guideline for the management of patients with valvular heart disease

(2021) Catherine M. Otto et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial

(2021) John A Spertus et al.   LANCET

Physical Rehabilitation for Older Patients Hospitalized for Heart Failure

(2021) Dalane W. Kitzman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Spot urine sodium in acute heart failure: differences in prognostic value on admission and discharge

(2021) Jan Biegus et al.   ESC Heart Failure

Myocarditis With COVID-19 mRNA Vaccines

(2021) Biykem Bozkurt et al.   CIRCULATION

Implantable Cardioverter-Defibrillator Eligibility After Initiation of Sacubitril/Valsartan in Chronic Heart Failure: Insights From PROVE-HF

(2021) G. Michael Felker et al.   CIRCULATION

From Studying Heart Disease and Cancer Simultaneously to Reverse Cardio-Oncology

(2021) Sanne de Wit et al.   CIRCULATION

Cerebrovascular Events in Patients With Centrifugal-Flow Left Ventricular Assist Devices: Propensity Score–Matched Analysis From the Intermacs Registry

(2021) Sung-Min Cho et al.   CIRCULATION

Relationship Between Residual Mitral Regurgitation and Clinical and Quality-of-Life Outcomes After Transcatheter and Medical Treatments in Heart Failure

(2021) Saibal Kar et al.   CIRCULATION

What can heart failure trialists learn from oncology trialists?

(2021) Faiez Zannad et al.   EUROPEAN HEART JOURNAL

2021 ESC/EACTS Guidelines for the management of valvular heart disease

(2021) Alec Vahanian et al.   EUROPEAN HEART JOURNAL

Statin associated lower cancer risk and related mortality in patients with heart failure

(2021) Qing-Wen Ren et al.   EUROPEAN HEART JOURNAL

AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial

(2021) Michele Brignole et al.   EUROPEAN HEART JOURNAL

Regional and ethnic influences on the response to empagliflozin in patients with heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial

(2021) Carolyn S P Lam et al.   EUROPEAN HEART JOURNAL

Sacubitril–valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction

(2021) Alice M Jackson et al.   EUROPEAN HEART JOURNAL

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2021) Theresa A McDonagh et al.   EUROPEAN HEART JOURNAL

Dapagliflozin in heart failure with preserved and mildly reduced ejection fraction: rationale and design of the DELIVER trial

(2021) Scott D. Solomon et al.   EUROPEAN JOURNAL OF HEART FAILURE

Prevalence and clinical outcomes of dystrophin‐associated dilated cardiomyopathy without severe skeletal myopathy

(2021) Maria A. Restrepo‐Cordoba et al.   EUROPEAN JOURNAL OF HEART FAILURE

Vericiguat in patients with atrial fibrillation and heart failure with reduced ejection fraction: insights from the VICTORIA trial

(2021) Piotr Ponikowski et al.   EUROPEAN JOURNAL OF HEART FAILURE

Effect of sacubitril/valsartan vs. enalapril on changes in heart failure therapies over time: the PARADIGM‐HF trial

(2021) Ankeet S. Bhatt et al.   EUROPEAN JOURNAL OF HEART FAILURE

Baseline characteristics of patients in the PARALLAX trial: insights into quality of life and exercise capacity in heart failure with preserved ejection fraction

(2021) Sanjiv J. Shah et al.   EUROPEAN JOURNAL OF HEART FAILURE

Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry

(2021) Alice M. Jackson et al.   EUROPEAN JOURNAL OF HEART FAILURE

Iron deficiency contributes to resistance to endogenous erythropoietin in anaemic heart failure patients

(2021) Michał Tkaczyszyn et al.   EUROPEAN JOURNAL OF HEART FAILURE

Contemporary Left Ventricular Assist Device Outcomes in an Aging Population

(2021) Dominic Emerson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial

(2021) JoAnn Lindenfeld et al.   LANCET

Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes

(2021) Bertram Pitt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

(2021) Stefan D. Anker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock

(2021) Rebecca Mathew et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial

(2021) Mikhail N Kosiborod et al.   Lancet Diabetes & Endocrinology

Optimising clinical trials in acute myocardial infarction complicated by cardiogenic shock: a statement from the 2020 Critical Care Clinical Trialists Workshop

(2021) Mattia Arrigo et al.   Lancet Respiratory Medicine

Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial

(2021) Axel Bauer et al.   Lancet Respiratory Medicine

Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor–Associated Myocarditis

(2021) Lorenz H. Lehmann et al.   JAMA Cardiology

Long-term 5-year outcome of the randomized IMPRESS in severe shock trial: percutaneous mechanical circulatory support vs. intra-aortic balloon pump in cardiogenic shock after acute myocardial infarction

(2021) Mina Karami et al.   European Heart Journal-Acute Cardiovascular Care

Prediction of right heart failure after left ventricular assist implantation: external validation of the EUROMACS right-sided heart failure risk score

(2021) Mercedes Rivas-Lasarte et al.   European Heart Journal-Acute Cardiovascular Care

Admission NT‐proBNP and outcomes in patients without history of heart failure hospitalized with COVID‐19

(2021) Jeanwoo Yoo et al.   ESC Heart Failure

Sacubitril/valsartan in real‐life European patients with heart failure and reduced ejection fraction: a systematic review and meta‐analysis

(2021) Stefano Giovinazzo et al.   ESC Heart Failure

Peripartum cardiomyopathy in Iraq: initial registry‐based data and 6 month outcomes

(2021) Hasan Ali Farhan et al.   ESC Heart Failure

Effect of Dapagliflozin in Patients With HFrEF Treated With Sacubitril/Valsartan

(2020) Scott D. Solomon et al.   JACC-Heart Failure

Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine

(2020) Rajiv Agarwal et al.   EUROPEAN HEART JOURNAL

Clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy: an ESC EORP registry

(2020) Karen Sliwa et al.   EUROPEAN HEART JOURNAL

Mechanical circulatory support does not reduce advanced myocardial fibrosis in patients with terminal heart failure

(2020) Astrid Kassner et al.   EUROPEAN JOURNAL OF HEART FAILURE

Common Mechanistic Pathways in Cancer and Heart Failure

(2020) Rudolf A. Boer et al.   EUROPEAN JOURNAL OF HEART FAILURE

How Should We Sequence the Treatments for Heart Failure and a Reduced Ejection Fraction? A Redefinition of Evidence-Based Medicine

(2020) John J.V. McMurray et al.   CIRCULATION

COVID-19 Myocardial Pathology Evaluation in AthleTEs with Cardiac Magnetic Resonance (COMPETE CMR)

(2020) Daniel E. Clark et al.   CIRCULATION

Characteristics and Outcome of COAPT-Eligible Patients in the MITRA-FR Trial

(2020) Bernard Iung et al.   CIRCULATION

Dapagliflozin and the Incidence of Type 2 Diabetes in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis From DAPA-HF

(2020) Silvio E. Inzucchi et al.   DIABETES CARE

Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations

(2020) Birgit Assmus et al.   EUROPEAN HEART JOURNAL

Fighting HFpEF in women: taking aim at belly fat

(2020) Coenraad Withaar et al.   EUROPEAN HEART JOURNAL

Pathophysiologic importance of visceral adipose tissue in women with heart failure and preserved ejection fraction

(2020) Hidemi Sorimachi et al.   EUROPEAN HEART JOURNAL

Are we underestimating the potential for cardiotoxicity related to immune checkpoint inhibitors?

(2020) Matthias Totzeck et al.   EUROPEAN HEART JOURNAL

Antagonism of miRNA in heart failure: first evidence in human

(2020) Andrew H Baker et al.   EUROPEAN HEART JOURNAL

Effect of empagliflozin on exercise ability and symptoms in heart failure patients with reduced and preserved ejection fraction, with and without type 2 diabetes

(2020) William T Abraham et al.   EUROPEAN HEART JOURNAL

The risk of cardiac events in patients receiving immune checkpoint inhibitors: a nationwide Danish study

(2020) Maria D’Souza et al.   EUROPEAN HEART JOURNAL

Empagliflozin and health-related quality of life outcomes in patients with heart failure with reduced ejection fraction: the EMPEROR-Reduced trial

(2020) Javed Butler et al.   EUROPEAN HEART JOURNAL

Heart failure drug treatment: the fantastic four

(2020) Johann Bauersachs   EUROPEAN HEART JOURNAL

Influence of neprilysin inhibition on the efficacy and safety of empagliflozin in patients with chronic heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial

(2020) Milton Packer et al.   EUROPEAN HEART JOURNAL

A current and future outlook on upcoming technologies in remote monitoring of patients with heart failure

(2020) Tarek Bekfani et al.   EUROPEAN JOURNAL OF HEART FAILURE

Intravenous immunoglobulin therapy in adult patients with idiopathic chronic cardiomyopathy and cardiac parvovirus B19 persistence: a prospective, double‐blind, randomized, placebo‐controlled clinical trial

(2020) Mark R. Hazebroek et al.   EUROPEAN JOURNAL OF HEART FAILURE

Sacubitril/valsartan for the management of heart failure: A perspective viewpoint on current evidence

(2020) Massimo Volpe et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease

(2020) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure

(2020) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insights into heart failure hospitalizations, management, and services during and beyond COVID‐19

(2020) Sarah J. Charman et al.   ESC Heart Failure

Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling

(2020) Kieran F. Docherty et al.   ESC Heart Failure

Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank

(2020) Mengying Wang et al.   EUROPEAN HEART JOURNAL

How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)

(2019) Burkert Pieske et al.   EUROPEAN HEART JOURNAL

Evaluation of the effects of sodium–glucose co‐transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a preserved ejection fraction: rationale for and design of the EMPEROR‐Preserved Trial

(2019) Stefan D. Anker et al.   EUROPEAN JOURNAL OF HEART FAILURE

Effects of Dapagliflozin on Symptoms, Function and Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction: Results from the DAPA-HF Trial

(2019) Mikhail N. Kosiborod et al.   CIRCULATION

The Dapagliflozin And Prevention of Adverse outcomes in Heart Failure trial (DAPA-HF) in context

(2019) John J V McMurray et al.   EUROPEAN HEART JOURNAL