Review
Medicine, General & Internal
Brett D. M. Jones, Cory R. Weissman, Lais B. Razza, M. Ishrat Husain, Andre R. Brunoni, Zafiris J. Daskalakis
Summary: This study aims to understand the placebo response in treatment-resistant depression patients. The research will quantitatively analyze the placebo response for each treatment modality through meta-analyses and explore contributing factors through regression analysis.
Review
Clinical Neurology
Nicolas A. Nunez, Boney Joseph, Mehak Pahwa, Rakesh Kumar, Manuel Gardea Resendez, Larry J. Prokop, Marin Veldic, Ashok Seshadri, Joanna M. Biernacka, Mark A. Frye, Zhen Wang, Balwinder Singh
Summary: This study compared the efficacy and discontinuation of augmentation agents in adult patients with treatment-resistant depression through a systematic review and network meta-analyses. The findings suggest that certain adjunctive atypical antipsychotics, thyroid hormones, dopamine compounds, and lithium are superior in terms of efficacy. However, ziprasidone, mirtazapine, and cariprazine had higher discontinuation rates. Further research and head-to-head studies are needed to strengthen treatment options for treatment-resistant depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medicine, General & Internal
Keyi Zhou, Jiarui Chen, Chongmei Huang, Siyuan Tang
Summary: This systematic review aims to summarize the current evidence of the prevalence of and factors influencing depression and anxiety among Chinese adolescents. The researchers will conduct a comprehensive search of English and Chinese databases to identify eligible studies and extract data. The results will be published in a peer-reviewed journal or disseminated at relevant conferences.
Review
Medicine, General & Internal
Philippa Clery, Alexander Royston, Katie Driver, Jasmine Bailey, Esther Crawley, Maria Loades
Summary: Children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) have a higher prevalence of depression and anxiety. Previous reviews have found limited evidence for effective treatment for children with CFS/ME and comorbid depression and/or anxiety. This updated review does not significantly add to what is known and the evidence is of poor quality to conclude which interventions are effective for treating comorbid anxiety and/or depression in pediatric CFS/ME.
Review
Medicine, General & Internal
Anna Wrobel, Samantha E. Russell, Olivia M. Dean, Sue Cotton, Michael Berk, Alyna Turner
Summary: Despite available treatments, remission rates for bipolar disorder are low. Childhood trauma may moderate treatment outcomes for individuals with bipolar disorder. This systematic review aims to analyze the impact of childhood trauma on the efficacy of pharmacological and psychological interventions for bipolar disorder patients.
Article
Medicine, General & Internal
Marije van Dalen, Suzanne G. M. A. Pasmans, Marie-Louise Aendekerk, Irene Mathijssen, Maarten Koudstaal, Reinier Timman, Heidi Williamson, Manon Hillegers, Elisabeth M. W. J. Utens, Jolanda Okkerse
Summary: The Dutch YP Face IT Study aims to test whether an online psychotherapeutic intervention can effectively reduce appearance-related distress and improve body esteem among adolescents with visible differences. The study is a two-armed randomized controlled trial involving adolescents aged 12-18 with visible differences and experiencing appearance-related distress.
Article
Psychiatry
Roger S. McIntyre, Joshua D. Rosenblat, Nelson B. Rodrigues, Orly Lipsitz, David Chen-Li, Jung Goo Lee, Flora Nasri, Mehala Subramaniapillai, Kevin Kratiuk, Andrew Wang, Hartej Gill, Rodrigo B. Mansur, Roger Ho, Kangguang Lin, Yena Lee
Summary: The study found that intravenous ketamine can significantly improve cognitive function in TRD patients, especially in tests like DSST and PDQ-5-D. This improvement is mainly mediated by reduced depressive symptoms, indicating that ketamine has independent and rapid effects in promoting cognition.
PSYCHIATRY RESEARCH
(2021)
Article
Medicine, General & Internal
Eva Szigethy, David Wolfson, Keneisha Sinclair-McBride, Kelly Williams, Grace Jhe, Erica H. Lee, Mario Bialostozky, Meredith Wallace, Sonika Bhatnagar, Dr Demaso, Donald M. Yealy, Kathryn Hollenbach
Summary: This study aims to evaluate how a coach-enhanced digital cognitive behavioral intervention (dCBI) improves usual care for depressed adolescents and young adults in paediatric practices with minority enriched samples. A total of 750 participants aged 16-22 will be recruited and randomized to receive 12 weeks of dCBI+usual treatment or usual treatment alone. The primary outcome is improvement in clinician-rated and self-reported depressive severity, and the secondary outcomes include self-reported suicidal ideation, anxiety severity, general quality of life, and general functioning. The study results will be published within 2 years and disseminated through peer-reviewed journals, professional conferences, and reports to participating entities and stakeholders.
Article
Medicine, General & Internal
Gustavo Vazquez, Gilmar Gutierrez, Joshua Rosenblat, Ayal Schaffer, Jennifer Swainson, Ganapathy Karthikeyan, Nisha Ravindran, Raymond W. Lam, Andre Do, Peter Giacobbe, Emily Hawken, Roumen Milev
Summary: This observational study aims to investigate the association of intranasal esketamine with outcomes and side effects in the management of treatment-resistant major depressive disorder. Patients will be evaluated using depression rating scales and side effect tracking tools. The study will also analyze the impact of site and demographic variables on treatment outcomes.
Review
Medicine, General & Internal
Jan Jacobus Muit, Philip F. P. van Eijndhoven, Andrea Cipriani, Iris Dalhuisen, Suzanne van Bronswijk, Toshi A. Furukawa, Henricus G. Ruhe
Summary: This article presents a protocol for a systematic review and network meta-analysis aiming to summarize and rank treatments for treatment-resistant depression. By considering the variations in treatment resistance levels and population characteristics, the study aims to identify the most effective treatment strategies.
Article
Clinical Neurology
Giovanni Martinotti, Antonio Vita, Andrea Fagiolini, Giuseppe Maina, Alessandro Bertolino, Bernardo Dell'Osso, Alberto Siracusano, Massimo Clerici, Antonello Bellomo, Gabriele Sani, Giacomo d'Andrea, Roberto Delle Chiaie, Andreas Conca, Stefano Barlati, Giorgio Di Lorenzo, Pasquale De Fazio, Sergio De Filippis, Giuseppe Nicolo, Gianluca Rosso, Alessandro Valchera, Domenica Nucifora, Stefania Di Mauro, Roberta Bassetti, W. Vassilis Martiadis, Miriam Olivola, Sandro Belletti, Ileana Andriola, Marco Di Nicola, Mauro Pettorruso, Roger S. McIntyre, Massimo di Giannantonio, REAL ESK Study Grp
Summary: This study evaluated the effectiveness and safety of esketamine nasal spray in the treatment of TRD patients in several Italian mental health services. The results show that esketamine significantly reduces depressive symptoms and is well tolerated. Additionally, esketamine is equally effective in patients with comorbidities.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
J. J. E. Rovers, P. Vissers, D. Loef, J. A. van Waarde, J. P. A. J. Verdijk, B. F. P. Broekman, A. C. M. Vergouwen, M. L. Oudega, E. van Exel, R. Coenen, D. S. Everaerd, I. Tendolkar, A. Dols, P. F. P. van Eijndhoven
Summary: This study investigates the association between treatment resistance and the outcome and course of electroconvulsive therapy (ECT) in major depressive disorder (MDD). The results showed that higher levels of treatment resistance were associated with smaller reductions in depression symptoms and lower chances of response. Furthermore, patients with lower treatment resistance required fewer ECT sessions and had fewer switches to bilaterally electrode placement, potentially reducing the risk of cognitive side effects.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Biochemistry & Molecular Biology
Vjekoslav Peitl, Antonia Puljic, Mislav Skrobo, Sergej Nadalin, Lidija Fumic Dunkic, Dalibor Karlovic
Summary: This study aimed to evaluate the effectiveness of clozapine in treating patients with treatment-resistant schizophrenia (TRS) and the efficacy of electroconvulsive therapy (ECT) augmentation of clozapine in patients with ultra-treatment-resistant schizophrenia (UTRS). The results suggest that both clozapine and ECT are effective treatment options for TRS and UTRS patients.
Review
Psychology, Developmental
Susan Kim, Brittany S. Rush, Timothy R. Rice
Summary: Suicide is the second leading cause of death among individuals aged 10-24 in the United States, and ketamine has been shown to be effective in reducing depressive symptoms in adults. However, studies on ketamine use in youth are limited. Ketamine generally improves depressive symptoms, reduces acute suicidality, and mood lability in youth, although some individuals still show resistance to its treatment. Further longitudinal studies are needed to investigate ketamine's long-term safety, efficacy, and abuse potential in youth.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Neurosciences
Manpreet K. Singh, Cynthia Siu, Michael Tocco, Andrei Pikalov, Antony Loebel
Summary: This study investigated the influence of mixed symptoms on treatment outcomes in pediatric bipolar depression and found that sleep disturbances and irritability are key symptoms that bridge between depressive and manic symptom clusters and influence treatment outcomes.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Ethnic Studies
Timothy D. Becker, Ohemaa B. Poku, Xinlin Chen, Jeffrey Wong, Amar Mandavia, Minda Huang, Yuqi Chen, Debbie Huang, Hong Ngo, Lawrence H. Yang
Summary: HIV stigma in China is characterized by the loss of moral status and limited social network opportunities, while structural vulnerabilities shift upon immigration to the US, enabling the maintenance of moral status and formation of new social networks, thereby ameliorating aspects of stigma.
ETHNICITY & HEALTH
(2022)
Review
Pediatrics
Timothy D. Becker, Timothy R. Rice
Summary: Youth electronic cigarette use has significantly increased worldwide in the past decade, leading to public health concerns. Recent research shows that there are physical and behavioral health risks associated with youth vaping, emphasizing the importance for clinicians to pay close attention and intervene.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Psychology, Clinical
Naomi Liang, Timothy D. Becker, Timothy Rice
Summary: Children and adolescents who lose a parent or caretaker are at increased risk of anxiety, depression, and substance use disorders, with the COVID-19 pandemic potentially exacerbating these issues. Youth with adverse childhood experiences, as well as boys and young men, may require special considerations. Tailored pediatric care based on evidence can advance accurate formulations and effective interventions for youth facing such losses.
CLINICAL CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Health Policy & Services
Timothy Rice, Aaron Reliford, Chiara Calov, James Rodriguez
Summary: Children and adolescents with psychiatric disorders, especially those from disadvantaged communities, have faced exacerbated challenges and disparities in accessing behavioral health resources during the COVID-19 pandemic. This article reviews the factors contributing to these disparities and provides policy proposals to address them.
JOURNAL OF PEDIATRIC HEALTH CARE
(2023)
Editorial Material
Psychology, Developmental
Kaitlin Hanss, Rebecca Carcana, Timothy Rice
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Timothy Rice
Summary: The death of a parent or caretaker is a significant loss and challenge for children, adolescents, and young adults. In the context of the COVID-19 pandemic, parental deaths related to the virus can lead to traumatic grief and disrupted mourning. Social distancing measures, travel restrictions, and changes in funeral practices have affected the grieving process for young people. The pandemic has also resulted in economic, social, and educational changes that impact the support available to children mourning a parent.
PSYCHOANALYTIC STUDY OF THE CHILD
(2023)
Article
Public, Environmental & Occupational Health
Ohemaa B. Poku, Evan L. Eschliman, Patlo Entaile, Shathani Rampa, Haitisha Mehta, Danielle Tal, Lea Silvert, Tingyu Li, Timothy D. Becker, Darshini Govindasamy, Melissa A. Stockton, Adebola Adedimeji, Ari Ho-Foster, Michael B. Blank, Derek T. Dangerfield II, Lawrence H. Yang, Sarah M. Murray
Summary: This study qualitatively explores the role of HIV-related gossip in driving HIV-related stigma and its negative impact on HIV outcomes. The findings suggest that HIV-related gossip can diminish community standing and worsen psychosocial well-being of individuals living with HIV. Protective factors, such as appearing healthy and community education about the harms of gossip, can help mitigate these negative effects.
Article
Psychiatry
Timothy D. Becker, Drew Blasco, Maria Soledad Burrone, Gabriella Dishy, Paola Velasco, Gabriel Reginatto, Franco Mascayano, Maximillian S. Wu, Cindy Hu, Simran Bharadwaj, Shivangi Khattar, Liz Calderon, Cynthia Filgueira, Ruben Alvarado, Ezra S. Susser, Lawrence H. Yang
Summary: In urban Chile, traditional values and capitalist variations of those values have a significant impact on individuals with psychotic disorders, increasing stigma in the fulfillment of personal goals and recovery. However, mental health services that align with cultural values and engage users in services such as pharmacotherapy, education/vocational rehabilitation, and family-centered care can mitigate stigma and facilitate recovery.
PSYCHIATRIC REHABILITATION JOURNAL
(2023)
Article
Psychology, Clinical
Andreas Walther, Timothy Rice, Lukas Eggenberger
Summary: The notion of precarious manhood beliefs (PMB) states that manhood is difficult to attain, easy to lose, and needs to be proven through public action. This concept is associated with erectile dysfunction (ED) in cisgender men, as higher levels of PMB endorsement can lead to increased sexual pressure and a higher risk of developing ED.
ARCHIVES OF SEXUAL BEHAVIOR
(2023)
Letter
Education & Educational Research
Timothy Rice
ACADEMIC PSYCHIATRY
(2023)
Review
Psychology, Developmental
Timothy D. Becker, Santiago Castaneda Ramirez, Adriana Bruges Boude, Alicia Leong, Iliyan Ivanov, Timothy R. Rice
Summary: Most substance use begins during adolescence, and childhood trauma and PTSD increase the risk of early substance use. Co-occurring PTSD and SUD can worsen each other, necessitating integrated treatment approaches. A systematic review identified several interventions for preventing or treating SUDs among adolescents with a history of trauma, including individual therapy based on cognitive-behavioral principles and exposure-based interventions with positive results. Further research is needed to understand the differential response to SUD treatments among youth with and without trauma history.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Timothy D. Becker, Evan L. Eschliman, Ashish P. Thakrar, Lawrence H. Yang
Summary: Stigma toward people using opioid medication is harmful, but emerging MOUD service models have the potential to reduce this stigma and empower patients to pursue their life goals through community outreach, clinical evaluation and induction of MOUD, and outpatient care.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Developmental
Dalton Martin, Sean Lynch, Timothy D. Becker, Parul Shanker, Paige Staudenmaier, Alicia Leong, Timothy Rice
Summary: This retrospective study compares psychiatric admissions between cisgender and transgender/gender nonconforming (TGNC) youth, finding that TGNC youth have higher rates of mood disorders, self-injurious behavior, and suicide attempts. The study suggests that TGNC youth may be more vulnerable to mental health crises during pandemic-related stressors.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)