Article
Immunology
Kanza M. Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Govindhasamy Pushpavathi Selvakumar, Ruixiang Wang, Suzanne Mason, Michael E. Dailey, Catherine A. Marcinkiewcz
Summary: Adolescent alcohol use can permanently alter brain function and lead to poor health outcomes in adulthood. Emerging evidence suggests that alcohol use can predispose individuals to pain disorders or exacerbate existing pain conditions, but the underlying neural mechanisms are currently unknown.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Clinical Neurology
Maya Kuperberg, Douglas Katz, Sophie L. A. Greenebaum, Nevita George, Louisa G. Sylvia, Gustavo Kinrys, Astrid Desrosiers, Andrew A. Nierenberg
Summary: This study examined the relationship between psychotic symptoms during bipolar depressive episodes and suicidal ideation among outpatients with bipolar disorder. The results indicated that patients with psychotic symptoms were more likely to report active suicidal thoughts, including specific plans and methods.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Ao Li, Rui Li, Pengrong Ouyang, Huihui Li, Sa Wang, Xinxin Zhang, Dan Wang, Mingzi Ran, Guangchao Zhao, Qianzi Yang, Zhenghua Zhu, Hailong Dong, Haopeng Zhang
Summary: The dorsal raphe nucleus serotonergic neurons play a regulatory role in general anesthesia, as activation can facilitate emergence from anesthesia partly through 5-HT 1A and 2C receptors. By assessing neuronal activities, researchers found that Fos expression and calcium activity are significantly decreased during general anesthesia.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Alessio Simonetti, Mario Luciano, Gaia Sampogna, Bianca Della Rocca, Emiliana Mancuso, Pasquale De Fazio, Marco Di Nicola, Giorgio Di Lorenzo, Maria Pepe, Fabio Sambataro, Maria Salvina Signorelli, Alexia Emilia Koukopoulos, Roberto Delle Chiaie, Andrea Fiorillo, Gabriele Sani
Summary: This multicentric observational study aimed to investigate the relationship between affective temperaments and bipolar disorder (BD) or major depressive disorder (MDD), as well as their influence on the severity and course of the diseases. The results revealed that specific affective temperaments were associated with certain disease characteristics. Evaluating affective temperaments may contribute to a better understanding of mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Iltan Aklan, Nilufer Sayar-Atasoy, Fei Deng, Hyojin Kim, Yavuz Yavuz, Jacob Rysted, Connor Laule, Debbie Davis, Yulong Li, Deniz Atasoy
Summary: This study investigated the role of downstream neural circuits of serotonergic neurons in regulating feeding in rats. Using optogenetics and other methods, the researchers found that these circuits interact with satiety hormones, revealing the regulatory mechanisms of these hormones.
MOLECULAR METABOLISM
(2023)
Article
Neurosciences
Tomonobu Kato, Yasue Mitsukura, Keitaro Yoshida, Masaru Mimura, Norio Takata, Kenji F. Tanaka
Summary: Dorsal raphe (DR) 5-HT neurons play a crucial role in regulating sleep-wake transitions. The activity of these neurons fluctuates during the sleep-wake cycle, with slow oscillatory signals during non-rapid eye movement (NREM) sleep and cessation during rapid eye movement (REM) sleep. The oscillatory activity of DR 5-HT neurons is associated with EEG power fluctuation, and optogenetic manipulation of these neurons can induce or prolong specific sleep states.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Heming Cheng, Yingbei Qi, Nanxi Lai, Lin Yang, Cenglin Xu, Shuang Wang, Yi Guo, Zhong Chen, Yi Wang
Summary: Inhibition of hyperactivity of DR 5-HTergic neuron may present promising anti-seizure effect, and DR may be a potential DBS target for the therapy of TLE.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Engineering, Biomedical
Yiyue Zhu, Jiaru He, Canwen Wu, Junwei Wu, Zhongwen Cheng, Yan Chen, Maodan Yuan, Lvming Zeng, Xuanrong Ji
Summary: This study investigates whether transcranial ultrasound stimulation (TUS) can improve depression-like behaviors by restoring serotonin levels. TUS treatment is performed on depression model mice, and the effects on depression-like behaviors are evaluated. The results show that TUS significantly improves depression-like behaviors, increases serotonin levels, and does not cause brain tissue damage. These findings suggest that DRN-TUS can safely and effectively improve depression-like behaviors, potentially by restoring serotonin levels.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Behavioral Sciences
Emma K. Stapp, Vadim Zipunnikov, Andrew Leroux, Lihong Cui, Mathilde M. Husky, Debangan Dey, Kathleen R. Merikangas
Summary: In this study, the dynamics of the four dimensions of the circumplex model of affect were examined using ecological momentary assessment (EMA) in individuals with bipolar disorder (BD) and major depressive disorder (MDD). The results showed that all mood disorder subtypes were associated with higher levels of sad and anxious mood and lower energy. Bipolar-I was characterized by lower activation and independent lower energy compared to MDD or controls. Bipolar-II was characterized by higher lability of sad and anxious mood compared to bipolar-I and controls but not MDD. MDD was characterized by cross-augmentation of sadness and anxiety, and sadness blunted energy.
BRAIN AND BEHAVIOR
(2023)
Review
Clinical Neurology
Enze Tang, Minyue Zhang, Yu Chen, Yi Lin, Hongwei Ding
Summary: This study aimed to evaluate the impairment of affective prosody recognition (APR) in patients with bipolar and depressive disorders, identify moderators for inconsistent results, and highlight trends in this field. The meta-analysis of 16 studies revealed a medium-to-large overall impairment of APR in patients, with depression severity and task complexity as significant moderators. Future research should incorporate neuroimaging approaches and investigate the effects of tonal language stimuli and clinical interventions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biology
Zachary A. Grieb, Joseph S. Lonstein
Summary: The interaction between oxytocin and central dopamine and serotonin systems is crucial for behavioral adaptations during the postpartum period. Oxytocin-dopamine interaction regulates maternal motivation and active caregiving behaviors, while oxytocin-serotonin interaction influences other aspects such as nursing, aggression, anxiety-like behavior, and stress coping strategy.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Jacqueline K. Khamma, Daniel S. Copeland, Holly S. Hake, Stephanie C. Gantz
Summary: The activity of dorsal raphe neurons is controlled by noradrenaline afferents, which activate α1-adrenergic receptors to produce EPSC. The amplitude of the EPSC is influenced by the amount of noradrenaline released, while the decay time is not affected. The termination of EPSC is primarily mediated by reuptake via transporters.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychiatry
Hao Tang, Tingting Xiong, Jiabo Shi, Yu Chen, Xiaoxue Liu, Siqi Zhang, Huan Wang, Qing Lu, Zhijian Yao
Summary: The study aimed to investigate the relationship between rumination and suicide attempts, finding that both global rumination levels and reflection were higher in suicide attempters than non-suicide attempters; the results suggest that rumination may be a risk factor for suicide attempts.
Article
Psychiatry
Lu Yin, Tian-He Song, Yan-Yan Wei, Li-Gang Zhang, Shuang-Jiang Zhou, Jian-Jin Yu, Li-Ye Zhang, Hong-Juan Li, Jing-Xu Chen
Summary: There is a relationship between affective temperaments and suicide risk in patients with major depressive disorder, with those having severe depression symptoms and cyclothymic or dysthymic temperaments being at higher risk.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Behavioral Sciences
Ross A. McDevitt, Rosa Anna M. Marino, Hugo A. Tejeda, Antonello Bonci
Summary: Serotonin plays a crucial role in cue-reward learning in mice, as serotonin reuptake inhibitors can reduce lever pressing behavior, and alterations in serotonin levels in different brain regions can impact behavioral responses.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
