Review
Biochemistry & Molecular Biology
Donghui Zhu, Axel Montagne, Zhen Zhao
Summary: AD is a neurodegenerative disease, with studies showing gender differences in risk and progression. The higher risk and progression of AD in women are largely attributed to distinct biological mechanisms, such as deviations in brain structure and biomarkers, psychosocial stress responses, genetic background, and more.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Environmental Sciences
Xihui Zhu, Yancen Meng, Yaru Ju, Yanjing Yang, Su'e Zhang, Liye Miao, Zhan Liu
Summary: This study examined the relationship between exposure to polycyclic aromatic hydrocarbons (PAH) metabolites and sex hormones in pre- and postmenopausal women. The results showed that PAH metabolites were inversely associated with testosterone and estradiol levels. The Bayesian kernel machine regression analysis revealed that higher concentrations of chemical combinations were negatively correlated with estrogen, testosterone, and free androgen index, but positively correlated with sex hormone-binding globulin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Clinical Neurology
Rob Molenberg, Chris H. L. Thio, Marlien W. Aalbers, Maarten Uyttenboogaart, Susanna C. Larsson, Mark K. Bakker, Ynte M. Ruigrok, Harold Snieder, J. Marc C. van Dijk
Summary: Using a 2-sample MR study, we found that genetic predisposition to elevated SHBG levels, with secondary lower BioT levels, is associated with an increased risk of aSAH in women.
Article
Obstetrics & Gynecology
E. O. Adewuyi, D. Mehta, D. R. Nyholt
Summary: The study confirms a significant association between endometriosis and asthma, suggesting a shared genetic susceptibility and biological pathways. The findings provide insights into the underlying mechanisms of both disorders and their relationship.
HUMAN REPRODUCTION
(2022)
Article
Oncology
Raneem Yaseen Hammouz, Magdalena Orzechowska, Dorota Anusewicz, Andrzej K. K. Bednarek
Summary: Sex differences in lung cancer are evident, but studies on this topic are not widely considered. In this study, various methods were used to analyze lung adenocarcinoma data, revealing key differences in immune system regulation and metabolic processes between male and female patients. The study also found different energy production preferences and hormonal effects between the two sexes. Further research is needed to investigate sex-specific gene regulatory networks and the impact of lifestyle factors on metabolic pathways.
Article
Health Care Sciences & Services
Georgianna Lin, Rumsha Siddiqui, Zixiong Lin, Joanna M. Blodgett, Shwetak N. Patel, Khai N. Truong, Alex Mariakakis
Summary: Previous studies on blood glucose levels during the menstrual cycle have produced inconsistent results based on limited blood samples. This study used continuous glucose monitors and smartwatches to collect data from 49 individuals over an average duration of 79.3 ± 21.2 days, resulting in 149 cycles and 554 phases in the dataset. The results showed a biphasic pattern of blood glucose levels, with the highest levels during the luteal phase and lowest levels during the late-follicular phase. Factors such as estrogen levels, step count, fatigue, and food cravings were found to be associated with variations in blood glucose levels. The findings suggest that blood glucose could be an important parameter in understanding menstrual health and warrant further investigation into its relationship with the menstrual cycle.
NPJ DIGITAL MEDICINE
(2023)
Article
Ophthalmology
Donel S. Kelly, Sabhyta Sabharwal, David J. Ramsey, Melina I. Morkin
Summary: This review examines the effects of female sex hormone changes on corneal structure and function, including the hormonal milestones of menarche, pregnancy, and menopause, as well as the consequences of using exogenous sex hormones for fertility control and replacement therapy. Articles were identified through a search of PubMed, and the primary outcomes evaluated were changes in central corneal thickness, intraocular pressure, and tear film quality. The potential impact of hormone-associated changes on the diagnosis and surgical management of common eye diseases, as well as the potential use of sex hormones as therapeutic agents, is also discussed. Understanding the physiological effects of female sex hormones on the cornea is important for guiding management decisions related to ocular health throughout a woman's life stages.
Review
Endocrinology & Metabolism
Annalisa Geraci, Riccardo Calvani, Evelyn Ferri, Emanuele Marzetti, Beatrice Arosio, Matteo Cesari
Summary: During aging and menopausal transition, women experience progressive muscle degeneration, leading to an increased risk of sarcopenia. Estradiol plays a crucial role in skeletal muscle function by stimulating satellite cell proliferation and limiting inflammatory stress damage. Estradiol Replacement Therapy, combined with nutrition and physical activity programs, can be a valuable tool in treating sarcopenia in women.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Victoria Persky, Chibuzor Abasilim, Konstantina Tsintsifas, Tessa Day, Robert M. Sargis, Martha L. Daviglus, Jianwen Cai, Sally Freels, Terry Unterman, Noel Chavez, Robert Kaplan, Carmen R. Isasi, Amber Pirzada, Michelle L. Meyer, Gregory A. Talavera, Bharat Thyagarajan, Brandilyn A. Peters, Jessica M. Madrigal, Arielle Grieco, Mary E. Turyk
Summary: This study examined the associations between endogenous sex hormones and diabetes progression. It found an inverse association between testosterone levels in men and conversion from prediabetes to diabetes, and an inverse association between SHBG levels in women and various glycemic measures as well as prediabetes to diabetes conversion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Health Care Sciences & Services
Alexandre Gonzalez-Rodriguez, Armand Guardia, Jose Antonio Monreal
Summary: Premenopausal women show better response to antipsychotic drugs, caution is needed in using hormone replacement therapy for postmenopausal women with schizophrenia, and raloxifene combined with antipsychotics can effectively improve psychotic and cognitive symptoms in postmenopausal women with schizophrenia and related disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hao Wei, Annie Lee, Qing Zhang, Melanie A. Felmlee
Summary: This study evaluated the effects of exogenous sex hormones and cross-sex hormones on the expression of renal monocarboxylate transporters, finding that different hormones had different regulatory effects on the expression of MCT1, MCT4, and SMCT1.
Article
Pharmacology & Pharmacy
M. M. Elsayed, A. Rabiee, G. E. Elrefaye, H. F. Elsis
Summary: This study aimed to investigate the effect of aerobic training and diet program versus diet only on sex hormones and coagulation biomarkers in obese postmenopausal women. The results showed that aerobic exercise along with a balanced diet significantly improved sex hormone levels and coagulation markers, reducing the potential risk of cardiovascular disease.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Psychology, Clinical
Kristen M. Culbert, Katharine N. Thakkar, Kelly L. Klump
Summary: This narrative review examines the theories behind the heightened risk for psychosis in midlife women and looks at the potential role of ovarian hormones. Studies indicate that the peak ages of midlife psychosis risk in women overlap with the age range of key menopausal stages, especially the perimenopausal transition. However, there is a lack of direct research on menopausal stage. Studies on ovarian hormone effects have mostly focused on earlier developmental stages and events, showing increases in psychotic symptoms during periods of lower estradiol levels. Future research is needed to fill the gaps in our knowledge.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Angelo Cagnacci, Anjeza Xholli
Summary: The study found opposing trends in COVID-19 infection and death rates among women of different age groups. Specifically, women aged 20 to 59 had higher infection rates but lower mortality rates compared to men, while women aged 60 to 89 had lower infection rates but higher mortality rates.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Fabio Rinaldi, Anna Trink, Giorgia Mondadori, Giammaria Giuliani, Daniela Pinto
Summary: This article explores the relationship between menopause and changes in the hair follicle lifecycle, focusing on hormone and metabolic dynamics. Hormonal fluctuations and aging during menopause can affect the hair follicles, leading to thinning, reduction in volume, and changes in hair texture. These changes are primarily caused by a decrease in estrogen levels. However, not all women experience significant hair changes during menopause, and the extent of transformations can vary greatly due to genetic factors, stress, diet, and other elements. Additionally, menopause affects metabolism and blood flow to the hair follicles, affecting the availability of essential nutrients. The article also discusses the role of energy metabolism in the hair follicle lifecycle and the impact of hormones, especially estrogens, on metabolic efficiency. The concept of a possible menopause clinically independent of menopause is introduced, which is related to changes in hair follicle metabolism, highlighting the importance of individual factors such as estrogen receptor responses, genetics, and the microbiota in determining these dynamics.
Review
Oncology
Cameron B. Haas, Larissa Nekhlyudov, Janie M. Lee, Sara H. Javid, Mary Bush, Dianne Johnson, Timothy Gleason, Cary Kaufman, Jennifer Specht, Sean Stitham, Karen J. Wernli
BREAST CANCER RESEARCH AND TREATMENT
(2020)
Article
Genetics & Heredity
Chethan Jujjavarapu, Jeevan Anandasakaran, Laura M. Amendola, Cameron Haas, Elizabeth Zampino, Nora B. Henrikson, Gail P. Jarvik, Sean D. Mooney
Summary: Genetic testing enables individuals to understand hereditary disease risks, and the ShareDNA smartphone app allows for secure sharing of these results with relatives while providing educational support for better understanding. Participants found the app to be comfortable to use, but suggested improvements to make the interface more intuitive and provide more explanations on the app's security features.
BMC MEDICAL GENOMICS
(2021)
Article
Health Policy & Services
Cameron B. Haas, Aaron Scrol, Chethan Jujjavarapu, Gail P. Jarvik, Nora B. Henrikson
Summary: The study found that using a mobile app as a tool to communicate genetic test results to at-risk family members has potential usefulness, especially for relatives still in the family planning stage and family members with strained relationships. Most participants were willing to use a mobile app to share their genetic test results with younger relatives or family members they have limited contact with.
HEALTH POLICY AND TECHNOLOGY
(2021)
Article
Oncology
Cameron B. Haas, Erin J. Aiello Bowles, Janie M. Lee, Jennifer Specht, Diana S. M. Buist
Summary: Accounting for endocrine therapy use for breast cancer treatment is important for survivorship studies. This study evaluated the accuracy of SEER breast cancer endocrine therapy data compared with pharmacy dispensings and identified factors contributing to underascertainment.
CANCER CAUSES & CONTROL
(2022)
Article
Multidisciplinary Sciences
Cameron B. Haas, Yu-Ru Su, Paneen Petersen, Xiaoliang Wang, Stephanie A. Bien, Yi Lin, Demetrius Albanes, Stephanie J. Weinstein, Mark A. Jenkins, Jane C. Figueiredo, Polly A. Newcomb, Graham Casey, Loic Le Marchand, Peter T. Campbell, Victor Moreno, John D. Potter, Lori C. Sakoda, Martha L. Slattery, Andrew T. Chan, Li Li, Graham G. Giles, Roger L. Milne, Stephen B. Gruber, Gad Rennert, Michael O. Woods, Steven J. Gallinger, Sonja Berndt, Richard B. Hayes, Wen-Yi Huang, Alicja Wolk, Emily White, Hongmei Nan, Rami Nassir, Noralane M. Lindor, Juan P. Lewinger, Andre E. Kim, David Conti, W. James Gauderman, Daniel D. Buchanan, Ulrike Peters, Li Hsu
Summary: Observational studies have shown that higher folate consumption is associated with a lower risk of colorectal cancer. This study investigated the interaction between genetic risk factors and folate consumption on colorectal cancer risk. The results suggest that certain genes involved in preventing or repairing DNA damage may interact with folate consumption to alter the risk of colorectal cancer.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Cameron B. Haas, Eric A. Engels, Marie-Josephe Horner, Ruth M. Pfeiffer, Qianlai Luo, Aimee R. Kreimer, Joel M. Palefsky, Meredith S. Shiels
Summary: Treatment of screen-detected anal high-grade squamous intraepithelial lesions effectively reduces incidence of invasive anal cancer in people with HIV. Men who have sex with men are at the greatest risk, especially those with a diagnosis of AIDS. These estimates can guide prioritization of anal cancer screening and treatment.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Cameron B. Haas, Eric A. Engels, Joel M. Palefsky, Megan A. Clarke, Aimee R. Kreimer, Qianlai Luo, Ruth M. Pfeiffer, Baozhen Qiao, Karen S. Pawlish, Analise Monterosso, Meredith S. Shiels
Summary: Anal intraepithelial neoplasia grade III (AIN III) has a higher risk of squamous cell carcinoma of the anus in HIV-infected individuals, with a 20-fold higher rate compared to the general population in the United States. The diagnosis rate of AIN III has increased since 1996, especially among people with HIV, potentially due to increased screening. HIV-infected individuals with a prior AIDS diagnosis also have a higher risk of AIN III.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Immunology
Cameron B. Haas, Eric A. Engels, Marie-Josephe Horner, Neal Freedman, Qianlai Luo, Susan Gershman, Baozhen Qiao, Ruth M. Pfeiffer, Meredith S. Shiels
Summary: The study found that the risk of lung cancer decreased for people living with HIV aged 20-69 from 2001 to 2016, but remained higher compared to the general population, with increasing risk with age. For people living with HIV aged 60 and older, the risk of lung cancer exceeded that of two common AIDS-related cancers.
Article
Health Care Sciences & Services
Cameron B. Haas, Amanda I. Phipps, Anjum Hajat, Jessica Chubak, Karen J. Wernli
AMERICAN JOURNAL OF MANAGED CARE
(2019)
