Article
Obstetrics & Gynecology
Yin-Li Zhang, Wei Zheng, Peipei Ren, Jiamin Jin, Zhanhong Hu, Qing Liu, Heng-Yu Fan, Fei Gong, Guang-Xiu Lu, Ge Lin, Songying Zhang, Xiaomei Tong
Summary: The study identified rare variants in the MOS gene that are responsible for abnormal oocyte morphology and large PB1 extrusion, leading to female infertility. The findings expand our understanding of the genetic basis and phenotypic spectrum of MOS variants in female infertility and facilitate early genetic diagnosis.
HUMAN REPRODUCTION
(2022)
Article
Chemistry, Multidisciplinary
Jing Guo, Hailian Zhao, Jue Zhang, Xiangjiang Lv, Shen Zhang, Ruibao Su, Wei Zheng, Jing Dai, Fei Meng, Fei Gong, Guangxiu Lu, Yuanchao Xue, Ge Lin
Summary: This research reveals the importance of eIF4E1B in selective translation activation in mammalian oocytes. Maternal deletion of Eif4e1b leads to defects in oogenesis and embryonic developmental competence. The study identifies a distinct subset of mRNA targeted by eIF4E1B and its binding sites within the 5' untranslated region (UTR) using LACE-seq.
Article
Biochemistry & Molecular Biology
Jan Tesarik, Raquel Mendoza-Tesarik
Summary: Mitochondria in human sperm and oocytes play important roles in human fertility and infertility. Sperm mitochondria are involved in providing energy for sperm movement, capacitation, and fusion with oocytes, while oocyte mitochondria are essential for oocyte meiotic division and calcium metabolism. Abnormalities in these mitochondria can lead to aneuploidy in oocytes and embryos, as well as hereditary diseases in offspring. Accumulation of mitochondrial DNA abnormalities can also contribute to ovarian aging. Mitochondrial substitution therapy and mitochondrial DNA editing are being explored as potential treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Weijie Wang, Jing Guo, Juanzi Shi, Qun Li, Biaobang Chen, Zhiqi Pan, Ronggui Qu, Jing Fu, Rong Shi, Xia Xue, Jian Mu, Zhihua Zhang, Tianyu Wu, Wenjing Wang, Lin Zhao, Qiaoli Li, Lin He, Xiaoxi Sun, Qing Sang, Ge Lin, Lei Wang
Summary: PABPC1L gene variants are responsible for female infertility characterized by oocyte maturation arrest. These variants result in truncated proteins, reduced abundance, altered localization, and decreased mRNA translational activation. PABPC1L plays an important role in human oocyte maturation and could be a potential candidate gene for infertility causes.
EMBO MOLECULAR MEDICINE
(2023)
Review
Endocrinology & Metabolism
Tahir Muhammad, Yanling Wan, Yue Lv, Hanzhen Li, Wasifa Naushad, Wai-Yee Chan, Gang Lu, Zi-Jiang Chen, Hongbin Liu
Summary: Currently, obesity in reproductive-aged women has reached an epidemic level, leading to various consequences. It has been found that obesity can cause reproductive complications, particularly affecting fertility rates. These complications arise from the poor quality of oocytes in obese mothers, which results in increased chances of chromosomal abnormalities, high production of reactive oxygen species, impaired embryonic development, and ultimately reduced fertility. Maternal obesity is also associated with pregnancy complications such as implantation errors, abortion, miscarriage, and early pregnancy loss. This review emphasizes the negative effects of maternal obesity on female fertility, focusing on the mechanistic link between maternal obesity and oocyte quality, and proposing possible measures to reduce associated risks.
Review
Biochemistry & Molecular Biology
Yi Luan, Pauline Xu, Seok-Yeong Yu, So-Youn Kim
Summary: The p63 transcription factor is crucial in female reproduction, serving as a genomic guardian in the ovaries and its mutations are increasingly associated with female infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Jian Han, Nana Zhang, Qiqi Cao, Xiaodan Shi, Congjing Wang, Ximan Rui, Jie Ding, Chun Zhao, Junqiang Zhang, Xiufeng Ling, Hong Li, Yichun Guan, Qingxia Meng, Ran Huo
Summary: Successful human reproduction requires normal oocyte maturation, fertilization, and early embryo development. NLRP7 variants were found to be associated with early embryo arrest, and this study identified five heterozygous variants of NLRP7 in infertile patients who experienced early embryo arrest. The study also demonstrated that NLRP7 variants can influence oocyte quality and early embryo development, providing a new genetic marker for clinical early embryo arrest patients.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Biochemistry & Molecular Biology
Yang-Ching Chen, Yen-Chia Yeh, Yu-Fang Lin, Heng-Kien Au, Shih-Min Hsia, Yue-Hwa Chen, Rong-Hong Hsieh
Summary: Frequent consumption of diet drinks, specifically those with aspartame, is associated with negative effects on fertility, including oocyte dysmorphism and decreased embryo quality. Aspartame consumption leads to disrupted estrus cycle, reduced anti-Mullerian hormone level, increased oxidative stress in the ovaries, and decline in mitochondrial function, which affects follicle preservation and steroidogenesis in granulosa cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Ling Wang, Jinhua Tang, Lei Wang, Feng Tan, Huibin Song, Jiawei Zhou, Fenge Li
Summary: Oxidative stress plays a significant role in oocyte aging, leading to a gradual decrease in oocyte quantity and quality, as well as various reproductive pathologies. Strategies to delay oocyte aging include targeting oxidative stress through autophagy antioxidant pathways and antioxidants, along with creating a hypoxic culture environment for oocytes in vitro.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biology
Sin-Yeon Kim, Violette Chiara, Nayade Alvarez-Quintero, Alberto Velando
Summary: The high level of mtDNA content in animal oocytes helps prevent the transmission of detrimental mutations to the next generation. Variation in oocyte mtDNA levels can impact offspring development and viability.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Developmental Biology
Zhihua Zhang, Ruyi Liu, Hongbin Zhou, Qun Li, Ronggui Qu, Weijie Wang, Zhou Zhou, Ran Yu, Yang Zeng, Jian Mu, Biaobang Chen, Xuejiang Guo, Qing Sang, Lei Wang
Summary: PATL2 is an oocyte-specific RNA-binding protein that regulates maternal mRNA expression in immature oocytes. Its phosphorylation at S279 site affects its protein levels and leads to subfertility in mice.
Review
Genetics & Heredity
Zahra Anvar, Imen Chakchouk, Hannah Demond, Momal Sharif, Gavin Kelsey, Ignatia B. Van den Veyver
Summary: Genomic imprinting is an epigenetic process affecting development, with multi-locus imprinting disturbances possibly leading to disorders. Pathogenic gene variants can cause rare embryonic and reproductive issues.
Article
Cell Biology
Naoki Okamoto, Yorino Sato, Yuta Kawagoe, Takahiko Shimizu, Kazuhiro Kawamura
Summary: Resveratrol treatment improves oocyte quality and restores fertility in aging mice by enhancing mitochondrial functions, without adverse effects on animals and offspring.
Article
Biotechnology & Applied Microbiology
Erin Chille, Emma Strand, Mayaan Neder, Valeria Schmidt, Madeleine Sherman, Tali Mass, Hollie Putnam
Summary: In the Pacific rice coral, four expression peaks were identified, representing maternal complement, two waves of the MZT, and adult expression. Maternal transcripts are dominated by functions related to cell division, methylation, biosynthesis, metabolism, and protein/RNA processing and transport. The two waves of the MZT involve functions related to biosynthesis, cell division, transcription, ion/peptide transport, and cell signaling. Adult expression is enriched for functions related to signaling, metabolism, and ion/peptide transport.
Article
Reproductive Biology
Atefeh Abedini, David A. Landry, Angus D. Macaulay, Het Vaishnev, Ashna Parbhakar, Dalia Ibrahim, Reza Salehi, Vincent Maranda, Elizabeth Macdonald, Barbara C. Vanderhyden
Summary: The study investigates the role of BRG1 in female fertility using mutant mice. Depletion of Brg1 in granulosa cells causes sterility, while depletion in oocytes results in subfertility. These findings highlight the importance of BRG1 in regulating granulosa and oocyte functions during follicle growth and its necessity for oocyte developmental competence.
BIOLOGY OF REPRODUCTION
(2023)
Article
Materials Science, Multidisciplinary
M. H. Nie, S. Zhang, Z. Y. Wang, T. Y. Yin, C. H. Zhang, C. L. Wu, D. X. Zhang
Summary: Laser cladding technology is an advanced material surface modification technique used for preparing high-performance coatings and repairing failed parts. This study investigated the effect of laser power on the microstructure, texture characterization, and corrosion resistance of a 17-4 PH stainless steel cladding layer. The results showed that the presence of defects such as pores in the cladding layer was influenced by the laser power. A model was established to explain the generation of pores and the Marangoni effect in laser cladding. The sample fabricated with a laser power of 2200 W exhibited better corrosion resistance due to fewer defects.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Materials Science, Multidisciplinary
C. L. Wu, T. Zhao, S. Zhang, Z. Y. Wang, C. H. Zhang, J. Z. Tan
Summary: Surface machining techniques such as cutting, rolling, and grinding were used to machine 304 austenitic stainless steels in order to enhance the hardening layer and corrosion resistance. Among the tested samples, the rolling sample exhibited the best surface quality with the lowest surface roughness and fewest defects. The rolling sample also displayed the highest degree of work hardening and corrosion resistance, attributed to the residual compressive stress and fewer micro-defects.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Materials Science, Multidisciplinary
Guangyan Wang, Sugui Tian, Ning Tian, Xinjie Zhu, Shunke Zhang, Song Zhang
Summary: This study investigated the stacking fault energy and creep mechanism of a single-crystal nickel-based superalloy at different temperatures. The results revealed that the stacking fault energy increased with temperature and that the presence of element Ru significantly reduced the stacking fault energy compared to other elements in the alloy. The creep mechanism involved <110> super-dislocation shearing into the gamma ' phase below 850 degrees C, which could be decomposed into (a/3) <112> partial dislocations and super-lattice intrinsic stacking fault. However, above 850 degrees C, the resistance to dislocation decomposition increased, and the a <110> super-dislocation did not decompose when it cut into the gamma ' phase along the {111} plane.
MATERIALS SCIENCE AND TECHNOLOGY
(2023)
Article
Optics
Binxun Li, Jin Du, Yujing Sun, Song Zhang, Qing Zhang
Summary: In this study, a three-dimensional finite element heat transfer model is developed using different heat source models to accurately predict the temperature distribution and melt pool geometry in selective laser melting (SLM). The experimental results show that the hybrid heat source model incorporating both surface and volumetric heat models can accurately simulate the peak temperature and melt pool geometry.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Chemistry, Organic
Cong-Cong Feng, Song-Lin Zhang
Summary: A convenient method for preparing aryl formates using difluorocarbene as a CO surrogate is described. This reaction proceeds through sequential O-difluoromethylation of phenol, followed by alpha-C-F bond functionalization of the resulting aryl difluoromethyl ether intermediate by phenol or moisture through fluorosemiacetal or orthoformate intermediates. Late-stage modification of biologically and materially active compounds is demonstrated.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Materials Science, Multidisciplinary
Ying Sun, Wenchao Hu, Chenliang Wu, Hai Kuang, Jie Wang, Song Zhang, Tingting Yan, Qiang Wang
Summary: This paper reviews the research progress of 3D printing titanium alloys, focusing on the basic phases, alloying elements and mechanical properties of titanium alloys, and discusses the effects of defects, microstructures and surface roughness on fatigue properties. It also introduces the research progress of mechanical properties of porous titanium alloys, including the influence of structural design, microstructure and surface roughness on fatigue properties. Finally, future development trends and potential research topics are pointed out.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Oncology
Yongdong Dai, Xiang Lin, Na Liu, Libing Shi, Feng Zhuo, Qianmeng Huang, Weijia Gu, Fanxuan Zhao, Yi Zhang, Yinli Zhang, Yinbin Pan, Songying Zhang
Summary: Endometriosis is a common gynecological disorder that causes female infertility. Excessive oxidative stress in ovaries of endometriosis patients induced senescence of cumulus granulosa cells. Our research analyzed the transcriptomic and metabolomic profiles of follicles in a mouse model of endometriosis and in patients with endometriosis, and investigated the potential function of changed metabolites in granulosa cells.
JOURNAL OF PATHOLOGY
(2023)
Article
Chemistry, Physical
Chao Wang, Maomao Gong, Yongjun Cheng, Victor Kimberg, Xiao-Jing Liu, Oriol Vendrell, Kiyoshi Ueda, Song Bin Zhang
Summary: We suggest using a femtosecond X-ray pulse to trigger Resonant Auger scattering (RAS) in a distorted molecule, which provides information on the core-valence electronic transition and impresses a rich fingerprint of the electronic structure and nuclear configuration. By controlling the amount of molecular distortion with varied time delay, the RAS measurements imprint both their electronic structures and changing geometries. This work showcases a new alternative pump-probe technique for mapping the core and valence dynamics with ultrashort X-ray probe pulses.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Materials Science, Coatings & Films
H. F. Zhang, S. Zhang, C. L. Wu, C. H. Zhang, X. L. Bai, X. Y. Sun, J. Chen
Summary: An investigation was conducted to study the impact of molybdenum (Mo) content on the microstructure and properties of ferritic stainless steel (FSS) produced using laser melting deposition (LMD). Stainless steel specimens with varying Mo content were manufactured with LMD, and their microstructures, microhardness, wear resistance, and corrosion resistance were evaluated. The results showed that the phase composition remained the same, consisting of α-Fe and carbide M7C3. The addition of Mo resulted in refined grains, increased microhardness, improved wear resistance, and enhanced electrochemical corrosion performance.
JOURNAL OF THERMAL SPRAY TECHNOLOGY
(2023)
Article
Genetics & Heredity
Jiamin Jin, Peipei Ren, Xiang Li, Yinyi Zhang, Weijie Yang, Yerong Ma, Mengru Lai, Chao Yu, Songying Zhang, Yin-Li Zhang
Summary: Histone deacetylation is observed in granulosa cells during the process of ovulation, which is mediated by FSH and hCG. This process is regulated by CK2 alpha-mediated HDAC2 phosphorylation and is essential for successful ovulation.
EPIGENETICS & CHROMATIN
(2023)
Article
Materials Science, Multidisciplinary
Zehua Wang, Zhengbin Wang, Hongxiang Hu, Chunhua Zhang, Song Zhang, Yugui Zheng
Summary: This study investigates the effects of fluid parameters - flow velocity, impact angle, and sand impact frequency - on the erosion-enhanced corrosion of 90/10 copper-nickel alloy. By combining computational fluid dynamics simulation, wire beam electrode technology, and electrochemical measurements, the researchers find that under different flow velocities, erosion-enhanced corrosion is dominated by either the impact angle or the flow velocity. However, at intermediate flow velocities, both parameters have noticeable effects. Furthermore, the addition of sand particles increases the corrosion current density without changing the effects of flow velocity and impact angle, indicating the significant influence of all three fluid parameters on the erosion-enhanced corrosion of the alloy.
Article
Materials Science, Ceramics
Rong Tu, Zhen Liu, Qingfang Xu, Song Zhang, Qizhong Li, Xian Zhang, Marina L. Kosinova, Takashi Goto
Summary: Silicon nitride films were fabricated using halide laser chemical vapor deposition (LCVD) for surface protection of electronic devices. The study investigated the effects of deposition parameters on the crystallinity, microstructure, deposition rate, Vickers microhardness, nano-hardness, and electrical resistivity. The highest deposition rate was achieved at a temperature of 1573 K and pressure of 10 kPa. The hardness of the films increased with temperature and the electrical resistivity decreased.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Obstetrics & Gynecology
Xiaomei Tong, Jiamin Jin, Yamei Xue, Lu Fang, Haiyan Zhu, Lingying Jiang, Songying Zhang
Summary: This study investigated the clinical outcomes of frozen-thawed blastocyst transfers derived from zygotes with no or one pronucleus (0PN or 1PN). The results showed that the developmental potential and clinical outcomes of 0PN and 1PN embryos were similar to those of 2PN embryos in both IVF and ICSI cycles. This suggests that 0PN and 1PN embryos from ICSI cycles can be transferred when there is an insufficient number of 2PN embryos.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Cell & Tissue Engineering
Ying-Yi Zhang, Weijie Yang, Yi Zhang, Zhanhong Hu, Yingyan Chen, Yerong Ma, Anran Yang, Zhan Shi, Hanjing Zhou, Peipei Ren, Libing Shi, Jiamin Jin, Yan Rong, Xiaomei Tong, Yin-Li Zhang, Songying Zhang
Summary: Follicle developmental capacity and oocyte quality decline with advanced maternal age. Extracellular vesicles from human umbilical cord mesenchymal stem cells (HucMSC-EVs) have potential therapeutic effects on age-related ovarian dysfunction. In vitro culture (IVC) of preantral follicles is a useful method for understanding follicle development and improving female fertility. This study demonstrated that HucMSC-EVs can improve the growth and quality of aged follicles and oocytes in vitro through gene transcription regulation.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Optics
Ya-Wei Liu, Shu-Xing Wang, Long-Quan Xu, Yi-Geng Peng, Song-Bin Zhang, Yong Wu, Jian-Guo Wang, Lin-Fan Zhu
Summary: The inelastic squared form factors of valence-shell excitations in D2 were studied using high-energy electron scattering and theoretical calculations. Discrepancies were found between the experimental results and theoretical calculations for the B1Eu+ state and vibronic states of C1 pi u and EF1 sigma g+. This can be attributed to electronic-vibrational coupling and the failure of the first Born approximation at an incident electron energy of 1500 eV. The inelastic squared form factors of D2 were in good agreement with H2 and HD, indicating no isotope effect for electronic matrix elements in the momentum space.