Stronger together: Analytical techniques for recombinant adeno associated virus

AAV Joins the Rank of Genotoxic Vectors

(2021) Utpal P. Davé et al.   MOLECULAR THERAPY

The clinical landscape for AAV gene therapies

(2021) Dmitry A. Kuzmin et al.   NATURE REVIEWS DRUG DISCOVERY

Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies

(2021) Andreas L. Gimpel et al.   Molecular Therapy-Methods & Clinical Development

Quantitation of Trace Levels of DNA Released from Disrupted Adeno-Associated Virus Gene Therapy Vectors

(2021) Jared S. Bee et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Quantification of Adeno-Associated Virus with Safe Nucleic Acid Dyes

(2020) Jian Xu et al.   HUMAN GENE THERAPY

Methods Matter -- Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors

(2020) Neil G. Rumachik et al.   Molecular Therapy-Methods & Clinical Development

Capillary Electrophoresis-Sodium Dodecyl Sulfate with Laser-Induced Fluorescence Detection as a Highly Sensitive and QC-Friendly Method for Monitoring Adeno-Associated Virus Capsid Protein Purity

(2020) ZICHUAN ZHANG et al.   HUMAN GENE THERAPY

Quality Control Testing, Characterization and Critical Quality Attributes of Adeno‐Associated Virus Vectors Used for Human Gene Therapy

(2020) J. Fraser Wright   Biotechnology Journal

A qPCR Method for AAV Genome Titer with ddPCR-Level of Accuracy and Precision

(2020) Yu Wang et al.   Molecular Therapy-Methods & Clinical Development

Chemically Defined, High-Density Insect Cell-Based Expression System for Scalable AAV Vector Production

(2020) James H. Kurasawa et al.   Molecular Therapy-Methods & Clinical Development

Adeno-associated virus vector as a platform for gene therapy delivery

(2019) Dan Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Recombinant Adeno-Associated Virus Gene Therapy in Light of Luxturna (and Zolgensma and Glybera): Where Are We, and How Did We Get Here?

(2019) Allison M. Keeler et al.   Annual Review of Virology

Analytical Strategies for Quantification of Adeno-Associated Virus Empty Capsids to Support Process Development

(2019) Xiaotong Fu et al.   Human Gene Therapy Methods

Pharmacology of Recombinant Adeno-associated Virus Production

(2018) Magalie Penaud-Budloo et al.   Molecular Therapy-Methods & Clinical Development

Accurate Titration of Infectious AAV Particles Requires Measurement of Biologically Active Vector Genomes and Suitable Controls

(2018) Achille François et al.   Molecular Therapy-Methods & Clinical Development

Gene therapy for RPE65-related retinal disease

(2018) Virginia Miraldi Utz et al.   OPHTHALMIC GENETICS

Health outcomes in spinal muscular atrophy type 1 following AVXS‐101 gene replacement therapy

(2018) Samiah Al‐Zaidy et al.   PEDIATRIC PULMONOLOGY

Direct Head-to-Head Evaluation of Recombinant Adeno-associated Viral Vectors Manufactured in Human versus Insect Cells

(2017) Oleksandr Kondratov et al.   MOLECULAR THERAPY

Practical utilization of recombinant AAV vector reference standards: focus on vector genomes titration by free ITR qPCR

(2016) Susan D'Costa et al.   Molecular Therapy-Methods & Clinical Development

Capillary electrophoresis applied to DNA: determining and harnessing sequence and structure to advance bioanalyses (2009–2014)

(2015) Brandon C. Durney et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors

(2015) Brenda Burnham et al.   Human Gene Therapy Methods

Development of a Rapid, Robust, and Universal PicoGreen-Based Method to Titer Adeno-Associated Vectors

(2015) Jose Piedra et al.   Human Gene Therapy Methods

Biophysical and Ultrastructural Characterization of Adeno-Associated Virus Capsid Uncoating and Genome Release

(2012) E. D. Horowitz et al.   JOURNAL OF VIROLOGY

Seeing Engineered Loops in a Gene Delivery Vehicle by cryoEM

(2012) Z. Hong Zhou   STRUCTURE

Systemic Errors in Quantitative Polymerase Chain Reaction Titration of Self-Complementary Adeno-Associated Viral Vectors and Improved Alternative Methods

(2012) Paolo Fagone et al.   Human Gene Therapy Methods

Production, Purification and Characterization of Adeno-Associated Vectors

(2010) Eduard Ayuso et al.   CURRENT GENE THERAPY

Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors

(2010) Sylvie Boutin et al.   HUMAN GENE THERAPY

Adeno-Associated Virus Site-Specific Integration Is Mediated by Proteins of the Nonhomologous End-Joining Pathway

(2009) S. Daya et al.   JOURNAL OF VIROLOGY

Effect of Genome Size on AAV Vector Packaging

(2009) Zhijian Wu et al.   MOLECULAR THERAPY