Article
Immunology
Riguo Lan, Zhixin Wan, Yuanyuan Xu, Zhenglei Wang, Shaodong Fu, Yuanyuan Zhou, Xinguang Lin, Xiangan Han, Zhenhua Luo, Jinfeng Miao, Yulong Yin
Summary: Streptococcus uberis is an important pathogen causing mastitis, and metabolic reprogramming during host immune responses is associated with infection-driven inflammation. The use of taurine can restore metabolic homeostasis and alleviate inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhenglei Wang, Riguo Lan, Yuanyuan Xu, Jiakun Zuo, Xiangan Han, Vanhnaseng Phouthapane, Zhenhua Luo, Jinfeng Miao
Summary: Taurine enhances PTEN activity, inhibits Akt/mTOR signaling, and activates autophagy to degrade intracellular S. uberis, reducing bacterial load, inhibiting over-activation of the NF-kappa B pathway, and alleviating inflammation and damage caused by S. uberis infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Petr Slama, Terezie Zavadilova, Ales Pavlik, Pavel Horky, Sylvie Skalickova, Jiri Skladanka, Shubhadeep Roychoudhury, Simona Baldovska, Adriana Kolesarova, Roman Konecny, Vladimir Tancin, Monika Zouharova
Summary: Bovine mastitis is a significant issue for dairy farmers with antibiotic treatment needing to be minimized due to resistance. Streptococcus uberis is a common pathogen, with research indicating that gamma delta T cells may play a key role in resolving inflammation in mammary glands.
Article
Chemistry, Multidisciplinary
Yongwoo Jang, Taegyu Park, Eunyoung Kim, Jong Woo Park, Dong Yeop Lee, Seon Jeong Kim
Summary: By utilizing the cellular redox system, a CNT yarn supercapacitor with maximum area capacitance was developed and demonstrated excellent performance under physiological conditions. Implanted NAD/BQ/CNT yarn electrodes in a rat's abdominal cavity showed stable in vivo electrical performance of a supercapacitor. These findings suggest a promising platform for implantable energy storage devices using redox biomolecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Nutrition & Dietetics
Andrea Benzi, Alessia Grozio, Sonia Spinelli, Laura Sturla, Andreas H. Guse, Antonio De Flora, Elena Zocchi, Joerg Heeren, Santina Bruzzone
Summary: Nicotinamide adenine dinucleotide (NAD(+)) plays a critical role in energy metabolism regulation as both a coenzyme and substrate for various enzymes. CD38, as an enzyme synthesizing Ca2+-mobilizing second messenger and a major NAD(+)-consumer, can impact NAD(+) levels. This review explores recent studies on the modulation of CD38 expression and activity, and the resulting changes in NAD(P)(H) levels in adipose tissue.
Article
Biochemistry & Molecular Biology
Cuiting Liao, Li Zhang, Rong Jiang, Juanjuan Xu, Jiarui Tang, Kai Hu, Shifang Jiang, Longhui Li, Yongqiang Yang, Jiayi Huang, Li Tang, Longjiang Li
Summary: The expression of NADK is positively correlated with APAP-induced acute liver injury, and inhibition of NADK can alleviate liver injury by increasing hepatic NAD(+) level and improving antioxidant capacity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Mariajose Metcalfe, Brian T. David, Brett C. Langley, Caitlin E. Hill
Summary: Spinal cord injury leads to tissue damage and functional deficits. Administering NR can increase NAD+ levels in the injured spinal cord, protect tissue, and improve motor function.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Pharmacology & Pharmacy
Yumeng Zhu, Ping Xu, Xuan Huang, Wen Shuai, Li Liu, Shuai Zhang, Rui Zhao, Xiuying Hu, Guan Wang
Summary: Nicotinamide phosphoribosyltransferase (NAMPT) plays a significant role in mammals by synthesizing nicotinamide mononucleotide (NMN) for metabolic homeostasis and cell survival, serving as a key protein in the host's defense mechanism. Neurodegenerative diseases pose a serious threat to human health, but effective drugs are limited. NAMPT has active biological functions in neurogenesis, making it a powerful therapeutic target for neurodegenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Qin Song, Xiaofeng Zhou, Kexin Xu, Sishi Liu, Xinqiang Zhu, Jun Yang
Summary: Nicotinamide mononucleotide (NMN) is a precursor for NAD+ biosynthesis, and supplementation has shown to increase NAD+ concentration and alleviate aging-related disorders. While most studies have been conducted in cell or animal models, several human clinical trials are currently evaluating the safety and physiological effects of NMN supplementation.
ADVANCES IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
JuKyung Lee, Han Na Suh, Saeyoung Ahn, Hye Bin Park, Jeong Yoon Lee, Hyung Jin Kim, Sang Hee Kim
Summary: This study developed electrocatalytic sensors for analyzing NADH in whole blood, which exhibited stability and a limit of detection of 3.5 μM. These sensors have the potential for extensive applications.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Peleg Schneider, Hagit Salamon, Nathalie Weizmann, Einat Nissim-Eliraz, Inna Lysnyansky, Nahum Y. Shpigel
Summary: Mastitis is a common and economically important disease in dairy animals, caused by bacterial infection. The recruitment of neutrophils into the milk spaces is a characteristic of acute mammary infection. The understanding of the molecular mechanisms underlying the pathogenesis of mastitis is still limited.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemical Research Methods
Ryo Matsuyama, Tomoyo Omata, Michiharu Kageyama, Ryota Nakajima, Masanobu Kanou, Kei Yamana
Summary: Nicotinamide adenine dinucleotide (NAD(+)) is an essential coenzyme for energy production. Associations between NAD(+) and aging-related diseases have been reported, and NAD(+) precursors are acknowledged as anti-aging supplements. However, there have been few studies on the link between aging or aging-related diseases and human blood NAD(+) concentration due to the instability and difficulty in measuring NAD(+). This study aimed to develop a simpler quantitative NAD(+) measurement method.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Veterinary Sciences
Niels Vander Elst, Julie Bellemans, Jonas Steenbrugge, Chloe Geeroms, Koen Breyne, Sofie Piepers, Bruno Toledo-Silva, Fernando Nogueira de Souza, Freddy Haesebrouck, Sarne De Vliegher, Evelyne Meyer
Summary: Bovine mastitis, caused by Streptococcus uberis, has significant economic consequences. In this study, priming the murine mammary gland with Staphylococcus chromogenes IM was able to reduce the growth of S. uberis, potentially through the activation of the innate immune system by increasing IL-8 and LCN2.
VETERINARY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chengting Luo, Changmei Yang, Xueying Wang, Yuling Chen, Xiaohui Liu, Haiteng Deng
Summary: Research showed that nicotinamide supplementation can reduce fat mass in obese mice, improve glucose tolerance, and enhance mitochondrial function in adipose tissue. Nicotinamide activates NAMPT and increases cellular NAD(+) levels to reprogram cellular metabolism for better adipose tissue function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Immunology
Anna Dobrut, Dagmara Wojcik-Grzybek, Agata Mlodzinska, Dorota Pietras-Ozga, Katarzyna Michalak, Aleksander Tabacki, Urszula Mroczkowska, Monika Brzychczy-Wloch
Summary: This study aimed to detect immunoreactive proteins related to bovine mastitis through in silico and in vitro methods. Thirteen proteins were identified, which showed immunoreactivity to antibodies present in serum from cows with diagnosed mastitis. These proteins have the potential to be used as targets in rapid immunodiagnostic assays for bovine mastitis, but further research is needed due to the limited sample size.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)