Article
Immunology
Bing Yu, Xiao-Qing Jin, Wen-Ying Yu, Ying-Ying Dong, Hua-Zhong Ying, Chen-Huan Yu
Summary: One of the main compounds in I. Flos, 1 beta-hydroxy alantolactone (HAL), exhibited remarkable inhibitory activity on TGF-beta 1-induced fibroblast activation, inducing apoptosis and suppressing proliferation of fibroblast cells. Additionally, HAL showed potential in improving lung fibrosis in rats by inhibiting the JNK/FOXO1/ NF-kappa B pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Daisuke Tsukui, Yoshitaka Kimura, Hajime Kono
Summary: Atherosclerosis complicates chronic inflammatory diseases by involving a shared physiological pathway regulated by spleen tyrosine kinase (SYK). SYK is found to be involved in atherosclerosis via the inflammatory response. Knockout of SYK gene in atherosclerosis-prone mice reduces atherosclerosis in vivo and ameliorates cell migration in macrophages. CD11c expression on SYK-knockout monocytes and macrophages is regulated by forkhead box protein O1 (FOXO1) through granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulation, mediated by c-Jun amino-terminal kinase (JNK) signaling to FOXO1. Inhibiting FOXO1 alleviates atherosclerosis in mice, suggesting GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling and FOXO1 as potential therapeutic targets for atherosclerosis and inflammatory diseases.
Article
Chemistry, Analytical
Xinyue Zhao, Lulu Ning, Xiaoman Zhou, Zhihui Song, Jianjian Zhang, Feng Guan, Xiao-Feng Yang
Summary: Hydrogen sulfide (H2S) is a vital endogenous signal molecule with critical physiological functions, but its site-specific delivery and release in biological systems remains a challenge. The newly developed Pro-S donor shows excellent release efficiency and live-cell compatibility, allowing real-time capturing of H2S and demonstrating anti-inflammatory effects in cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Mengyang Wang, Jinfeng Sun, Tianxiang Yu, Minxiu Wang, Leiming Jin, Shiqi Liang, Wu Luo, Yi Wang, Gao Li, Guang Liang
Summary: This study evaluates the pharmacological effects and potential mechanisms of Diacerin in APAP-induced liver injury. The results show that Diacerin can protect the liver from APAP-induced damage by inhibiting JNK kinase phosphorylation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Zhuo-Fan Liu, Kuan Liu, Zhi-Qi Liu, Lin Cong, Meng -Yu Lei, Jing Li, Zhuo Ma, Yu Deng, Wei Liu, Bin Xu
Summary: Excessive manganese exposure can lead to manganese toxicity, which can be alleviated by melatonin through regulating the Mst1-JNK signaling pathway, reducing manganese-induced mitochondrial fragmentation, and maintaining mitochondrial network.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Chemistry, Inorganic & Nuclear
Ruksana Shaik, Roopa Kishore Kampara, Amit Kumar, Chandra Shekhar Sharma, Mahesh Kumar
Summary: With industrial escalation, air toxicity increases, leading to a decline in air quality. Monitoring environmental pollutants is essential for protecting animals and humans, as dangerous gases like NH3, H2S, CO2, etc., can cause fatal diseases.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Engineering, Chemical
Sylvie Neyertz, Nieck E. Benes, David Brown
Summary: Molecular dynamics simulations have shown that hybrid inorganic-organic membranes based on POSS or OAPS silsesquioxanes can maintain good selectivity for CO2/N2 and CO2/CH4 separation at high temperatures and pressures. PolyPOSS-imides degrade above 300 degrees C, while polyOAPSimides can resist up to above 400 degrees C. PolyOAPS/POSS-imide networks have been further tested for their gas separation abilities of H2S-containing mixtures, and it has been found that H2S has a high solubility in the networks at 300 degrees C. The denser polyPOSS-imides show better sieving properties than the more open polyOAPS-imides.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Xuan Zhang, Dingding Zhang, Hongmin Li, Zhaojun Liu, Yatong Yang, Jiameng Li, Lishiyuan Tang, Jingli Tao, Honglin Liu, Ming Shen
Summary: This study reveals an innovative protective mechanism of melatonin against hypoxia-induced granulosa cell (GC) apoptosis by selectively inhibiting mitochondrial ROS (mtROS) generation. Melatonin activates MTNR1B to promote SOD2 expression, effectively suppressing mtROS-JNK-FOXO1-mediated apoptosis.
Article
Neurosciences
Hui Yang, Zhenqian Liu, Xiaomei Liu, Xiaowei Cao, Mo Chen, Shiying Lou, Liangqun Rong, Yun Xu, Qingxiu Zhang
Summary: This study demonstrates that Tat-SynGAP (670-685aa) reduces neuronal apoptosis and cerebral infarction volume by inhibiting MST1/JNK signaling pathway, while maintaining vascular stability and blood-brain barrier integrity.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Eui Kyun Jeong, Baskar Selvaraj, Shyaka Clovis, Yun Jeong Son, Tae Hoo Park, Ashokkumar Veeramanoharan, Hoe-In Kim, Ki-Yeon Yoo, Jae Wook Lee, Chung-Min Park
Summary: Hydrogen sulfide (H2S) functions as an endogenous signaling molecule in various physiological and pathological processes in human cells. A study has developed hybrid molecules combining a slow-releasing H2S donor with powerful antioxidant natural products, exhibiting complementary neuroprotective effects against oxidative stress-induced neuronal damage.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiaodong Zhang, Shuangjie Li, Xiaolei Ren, Peng Xiang, Yankun Zhang, Tixiao Wang, Qinghua Qin, Fengkai Sun, Jingkang Liu, Lifen Gao, Chunhong Ma, Xuetian Yue, Xiaoyun Yang, Shuang Han, Xiaohong Liang
Summary: TIPE1 plays a crucial role in liver regeneration by finely regulating oxidative stress and autophagy to promote hepatocyte proliferation, making it a potential target for medical intervention in liver regeneration.
Article
Biochemistry & Molecular Biology
Yu Chen, Ping Li, Yueting Peng, Xiaoxue Xie, Yixi Zhang, Ying Jiang, Tingting Li, Xiang Qin, Shun Li, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu
Summary: The study demonstrates that the soft substrate-induced ROS/JNK signaling increases cell apoptosis and protective autophagy by promoting the interaction of Bcl-2 and Beclin-1 and suppressing the interaction of Bcl-2 and Beclin-1, respectively, in human breast cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Linda de Bont, Xiujie Mu, Bo Wei, Yi Han
Summary: Hydrogen sulfide (H2S) plays an important role in plant growth and adaptation to abiotic stress. It functions in defense by activating plant hormones and is involved in oxidative stress responses. Additionally, H2S interacts with nitric oxide and reactive oxygen species, regulating oxidative stress responses.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Engineering, Chemical
Lucas de Oliveira Carneiro, Suenia Fernandes de Vasconcelos, Gilvan Wanderley de Farias Neto, Romildo Pereira Brito, Karoline Dantas Brito
Summary: Coke oven gas is an important byproduct used as an energy substitute for natural gas in the steel industry, but it requires treatment to remove impurities like ammonia and hydrogen sulfide. Developing a more efficient absorption process is crucial due to the increasing use of coke oven gas and stricter emission regulations. A model was created to evaluate solutions for greater hydrogen sulfide removal, with the best configuration showing a 5% increase in efficiency. This aligns with efforts towards environmentally responsible solutions and also resulted in a 15% reduction in raw materials costs.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuexia Zhang, Yushi Zhang, Jiapeng Xing, Yajun Li, Yan Yang, Yubin Wang, Linjian Jiang, Mingcai Zhang, Zhaohu Li
Summary: In vitro dodder shoots actively grow for over 10 days, utilizing starch as an energy source in the basal stems and relying on glycolysis, TCA cycle, and pentose phosphate pathway for energy supply in shoot tip elongation. Efficient nutrient recycling and ROS modulation facilitate the parasitism of dodder by promoting shoot elongation growth to reach the host.
Article
Environmental Sciences
Qianru Chi, Tianqi Liu, Zhepeng Sun, Siran Tan, Shiping Li, Shu Li
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2017)
Article
Environmental Sciences
Qianru Chi, Xin Chi, Xueyuan Hu, Shuang Wang, Hongfu Zhang, Shu Li
ENVIRONMENTAL RESEARCH
(2018)
Article
Cell Biology
Qianru Chi, Dongxu Wang, Xueyuan Hu, Shiping Li, Shu Li
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Engineering, Environmental
Chi Qianru, Hu Xueyuan, Zhao Bing, Zhang Qing, Zhang Kaixin, Li Shu
Summary: The study investigates the mechanism of immune injury induced by H2S, revealing the important role of miR-15b-5p in necroptosis and inflammation through its targeting relationship with TGFBR3. The research provides a new perspective on the regulation of necroptosis by the miR-15b-5p/TGFBR3 axis and unveils a new form of inflammation regulation in immune diseases.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Qianru Chi, Qing Zhang, Yiming Lu, Yiming Zhang, Shiwen Xu, Shu Li
Summary: Selenium deficiency induces arteritis by reducing SelS levels and promotes disease progression by regulating neutrophil recruitment and NET formation. The formation of NETs in arteritis is dependent on ROS bursts and the PPAR pathway. Silencing SelS exacerbates arteritis through its effects on NET formation.
Article
Engineering, Environmental
Nuan Song, Xiaojing Li, Yuan Cui, Tianyi Zhang, Shiwen Xu, Shu Li
Summary: H2S regulates pyroptosis in broilers trachea through the circRNA-IGLL1-17828/miR-6631-5p/DUSP6 axis, influencing ROS production and pyroptosis indicators.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Environmental
Qianru Chi, Tong Xu, Yujiao He, Zhe Li, Xinyu Tang, Xue Fan, Shu Li
Summary: The use of plastics and nanotechnology has brought convenience to our lives, but it also increases the environmental burden and the risk of exposure to nanoparticles. This study reveals that exposure to polystyrene nanoparticles (PSNPs) leads to neutrophil infiltration and neutrophil extracellular trap (NET) formation in the liver. Further research shows that NET formation is associated with the reactive oxygen species (ROS)-NLRP3 axis. Inhibition of ROS and NLRP3 can alleviate PSNP-induced NET formation. Moreover, the use of DNase I-coated PSNPs can disassemble NET, reduce neutrophil infiltration in the liver, inhibit the ROS-NLRP3 axis, and decrease cytokine expression.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Qianru Chi, Yilin Luan, Yiming Zhang, Xueyuan Hu, Shu Li