Article
Chemistry, Physical
Wei Quan, Guihua Zhang, Ling Huang, Wenhui Song, Weiying Lin
Summary: Studies have shown that changes in mitochondrial viscosity are closely related to its state, but existing probes cannot accurately image under depolarization conditions. To address this issue, researchers developed the MF-V1 probe, which effectively monitors changes in mitochondrial viscosity and successfully detected changes in viscosity in zebrafish and mice.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Seonyoung Jo, Sihyun Kim, Yena Lee, Gayoung Kim, Sehoon Kim, Soojin Lee, Taek Seung Lee
Summary: A pyrene-based fluorescent molecular probe, Py2-5EG, was synthesized for optical detection of viscosity variation. The probe showed blue fluorescence in high viscosity medium and greenish blue fluorescence in low viscosity medium. The fluorescence colors were used to observe microscopic changes in cellular viscosity.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Spectroscopy
Feng-Tao Yu, Ze Huang, Jia-Xiang Yang, Long-Mei Yang, Xian-Yun Xu, Jian-Yan Huang, Lin Kong
Summary: Two viscosity-sensitive fluorescent probes were designed and synthesized to localize in lysosome and mitochondria in living HeLa cells, respectively. The fluorescence quantum yield and two-photon absorption cross section of the probes were significantly increased with the increase of viscosity. Fluorescence lifetime imaging of the cells stained with the probes revealed the viscosity range of lysosome and mitochondria. This type of probe is of great importance for monitoring diseases associated with abnormal viscosity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Lijuan Liang, Yimeng Sun, Chang Liu, Xiaojie Jiao, Ye Shang, Xianshun Zeng, Liancheng Zhao, Jianlong Zhao
Summary: Water-soluble and fast-responsive fluorescent probes PTZ-TPP and PTZ-MP based on phenothiazine moiety were developed for accurate analysis and detection of changes in HOCl and viscosity, with low detection limits. Furthermore, PTZ-MP probe can also be used for viscosity detection, and is expected to be utilized for simultaneous determination of intracellular HOCl and viscosity.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Analytical
Zihong Li, Jie Cheng, Ping Huang, Wenhui Song, Li Nong, Ling Huang, Weiying Lin
Summary: Hepatocellular carcinoma is a highly invasive malignant tumor of the liver, and studying the change in hepatocyte viscosity is crucial for the detection and treatment of liver cancer. Researchers have designed and synthesized the first hepatocyte-specific fluorescent probe for viscosity detection, which can be used for imaging liver cancer at both cellular and organ levels.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wen-Jing Shi, Jinrong Yang, Yong-Feng Wei, Xiao-Tong Li, Xu-Hui Yan, Yuxuan Wang, Huaxiang Leng, Liyao Zheng, Jin-wu Yan
Summary: Two novel meso-CF3 BODIPY-based fluorescent rotors were rationally prepared and found to sensitively respond to viscosity in living cells with a fluorescence turn-on effect, which can be attributed to the special restricted rotation of meso-CF3 group in viscous environments. Interestingly, a monostyryl probe with one cationic group exhibited good mitochondrial localization and aggregation-induced emission (AIE) property.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Wen-Jing Shi, Ru Chen, Jinrong Yang, Yong-Feng Wei, Yuhui Guo, Zi-Zhou Wang, Jin-wu Yan, Li Niu
Summary: This study reported a new fluorescent probe with viscosity-responsive and aggregation-induced emission (AIE) properties. The probe successfully sensed changes in lysosomal viscosity and could be applied for autophagy monitoring.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xingzong Wang, Lei Wang, Tengda Jin, Keju Sun, Jingyue Yang
Summary: Two dual-mode fluorescent probes responding to both pH and viscosity were designed and synthesized in this study based on inhibited intramolecular charge transfer (ICT) and twisted intramolecular charge transfer (TICT) processes. The fluorescence intensity of the probes would be doubly amplified at low pH and high viscosity, providing excellent contrast for biological imaging. Fluorescence imaging in living cells, tissue, and organs further demonstrated the selective visualization of cancer by the synthesized probes.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Hua Wei, Xiaochan Tang, Qingxian Chen, Tao Yue, Baoli Dong
Summary: In this study, an ER-targeting fluorescent probe was developed to detect viscosity changes in the endoplasmic reticulum (ER) during ferroptosis. The results showed that erastin-induced ferroptosis led to an increase in ER viscosity, which could be inhibited by Fer-1 and VE.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Tomislav Suhina, Daniel Bonn, Bart Weber, Albert M. Brouwer
Summary: Fluorescent molecular rotors have been utilized for measurements of local mobility and contact visualization. This study delves into the excited-state deactivation kinetics and mechanics of dicyanodihydrofuran-based molecular rotors, revealing that fluorescence quantum yield is influenced by both rigidity and polarity of the environment. The findings suggest potential implications for the application of molecular rotors as local mobility probes.
Review
Chemistry, Inorganic & Nuclear
Xiaojing Nan, Yuchen Huyan, Hongjuan Li, Shiguo Sun, Yongqian Xu
Summary: Transition metal ions play crucial roles in medicine, life sciences, and environmental science, but some like mercury, copper, and iron ions pose serious health and environmental risks due to biomagnification. Monitoring metal ion levels in organisms and the environment is urgent, and reaction-based fluorescent probes offer higher sensitivity and selectivity than traditional methods. Research on these probes for Hg2+, Cu2+, and Fe2+/Fe2+ detection has advanced in the past decade, with potential for interdisciplinary development in the future.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Engineering, Environmental
Yue Wang, Li Zhang, Xiaoyue Han, Liangwei Zhang, Xiaoyan Wang, Lingxin Chen
Summary: This article reviews recent advances in fluorescent probes for Hg2+ analysis, focusing on different response modes and design strategies, highlighting their applications in environmental detection and in vivo analysis. Challenges and prospects for fluorescent probes are proposed to guide new design strategies and applications expansion in the future.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Tong-Tong Jia, Yuanyuan Zhang, Ji-Ting Hou, Huawei Niu, Shan Wang
Summary: Hydrogen sulfide (H2S) as an important endogenous signaling molecule, has a vital role in physiological processes. Monitoring changes in hydrogen sulfide can help pre-warning and treating pathophysiological processes. Fluorescence imaging techniques can be used to observe real-time changes in analyte concentration in organisms. This review focuses on the design and sensing mechanisms of hydrogen sulfide-based fluorescent probes and their imaging applications in various pathophysiological processes. It demonstrates the value of these probes in preclinical studies and their potential application in clinical diagnostics.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Analytical
Peiyao Xie, Jianfei Liu, Xiaopeng Yang, Weimin Zhu, Yong Ye
Summary: This study developed a novel fluorescent probe, TPA-SO2, which can detect both the polarity and SO2 of lipid droplets. The probe exhibited sensitivity to polarity decrease and SO2 and specifically targeted cellular lipid droplets.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Gui-Qin Fu, Qin-Ting Liao, Zhi-Qing Wang, Zhi-Ke Tan, Guo-Jiang Mao, Bin Yang, Chun-Yan Li
Summary: Viscosity is an important parameter related to diseases such as acute inflammation. In this study, a fluorescent probe named HPQ-BI-V was developed to monitor viscosity changes in biological systems. The probe showed high sensitivity, excellent selectivity, and outstanding photostability and response capability in the physiological pH range. It was successfully used to detect viscosity changes in HepG2 cells and zebrafish, as well as visualize viscosity changes in acute inflammatory mice induced by LPS and assess anti-inflammatory drugs.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Zihong Li, Mingguang Ren, Li Wang, Lixuan Dai, Weiying Lin
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Applied
Tiange Zhang, Linlin Zhu, Weiying Lin
Summary: The probe PBT, with near-infrared, ratiometric detection, high selectivity, low detection limit (0.11 nM), and large Stokes shift (200 nm), can be effectively used for detecting hydrazine vapor and imaging hydrazine in HepG(2) cells and zebrafish.
Article
Chemistry, Applied
Bingli Lu, Junling Yin, Cong Liu, Weiying Lin
Summary: A new viscosity-sensitive fluorescent probe was designed to visualize the viscosity level of tumors at different growth stages, showing a high dependence on tumor growth period. This probe also proved to be useful in monitoring viscosity changes in inflammatory mice.
Article
Chemistry, Applied
Bingli Lu, Junling Yin, Cong Liu, Weiying Lin
Summary: A new fluorescent probe ABI-V was synthesized to detect viscosity changes of lipid droplets in complex biological systems, showing increased viscosity of lipid droplets in diabetic pathology and decreased fluorescence intensity in metformin-treated diabetic liver injury, indicating the potential of ABI-V in monitoring diabetes treatment efficacy.
Article
Spectroscopy
Lixuan Dai, Mingguang Ren, Weiying Lin
Summary: A novel near-infrared fluorescent probe, NI-VD, with a large Stokes-shift and satisfactory response, was reported in this study. It can sensitively detect changes in cell and tissue viscosity, monitor mitochondrial viscosity, and potentially serve as a new approach for the diagnosis and treatment of diabetic nephropathy.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Applied
Minggang Tian, Dingyi Guo, Weiying Lin
Summary: A new fluorescent probe has been developed for ratiometric monitoring of lysosomal pH, showing optimized membrane permeability and the ability to stain lysosomes. The probe successfully visualized the pH increase induced by chloroquine in lysosomes, as well as the downregulation and subsequent up-regulation of lysosomal pH during starvation in a ratiometric manner. It is believed to be a desirable tool for investigating lysosomal pH and promoting studies in autophagy and related biological areas.
Article
Chemistry, Applied
Cong Liu, Junling Yin, Bingli Lu, Weiying Lin
Summary: In this study, a new near-infrared viscosity sensitive fluorescent probe was designed to detect the increased liver viscosity in hyperlipidemic mice and diagnose hyperlipidemia using blood viscosity as an indicator. Furthermore, the reduction in blood and liver viscosity after treatment with a lipid-lowering drug was tracked.
Article
Chemistry, Applied
Jingfen Yin, Qingyu Xu, Xiaocong Mo, Lixuan Dai, Mingguang Ren, Shoujuan Wang, Fangong Kong
Summary: Mitochondria play a vital role in cellular functions and abnormal viscosity is a key factor indicating mitochondrial dysfunction. Abnormal changes in mitochondrial viscosity are closely related to various diseases and dysfunctions. Developing a mitochondrial viscosity response probe can provide new insights into these diseases. This study introduces a novel near-infrared fluorescent probe for the detection of mitochondrial viscosity in live cells.
Article
Chemistry, Multidisciplinary
Rui Chen, Wenxiu Li, Rong Li, Sixin Ai, Huayong Zhu, Weiying Lin
Summary: A novel Cys-activated NIRF and PA dual-modality imaging probe (CDR) was developed for early diagnosis of drug-induced liver injury (DILI), which has high sensitivity and high-resolution imaging capability.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Analytical
Lixuan Dai, Mingguang Ren, Zihong Li, Li Wang, Weiying Lin
ANALYTICAL METHODS
(2019)
Article
Materials Science, Biomaterials
Zihong Li, Mingguang Ren, Li Wang, Lixuan Dai, Weiying Lin
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Chemistry, Applied
Leping Chen, Yanfen Wang, Tingyu Shi, Tiantian Ma, Yang Li, Huayu Qiu, Shouchun Yin, Meier Gu
Summary: This study successfully overcame the limitations of the heavy atom effect by introducing iodine atoms and innovatively enhancing the structure while weakening stacking behavior, achieving high efficiency and precision in photodynamic therapy and photothermal therapy.
Article
Chemistry, Applied
Bingpeng Guo, Honghan Sa, Peng Zhang, Guiwen Hao, Mengyu Li, Qingqing Jiang, Baoying Li, Wei Shu, Changxiang Shao
Summary: The design of ratiometric fluorescence probes with large Stokes shift is of great significance in detecting and imaging target substances in complex organisms. In this study, a novel fluorophore with a large Stokes shift was easily obtained, and a fluorescence probe based on it demonstrated rapid response, high selectivity, and sensitivity towards peroxynitrite. The probe also showed excellent biocompatibility and remarkable mitochondrial targeting ability, making it suitable for proportional imaging of peroxynitrite in living cells and zebrafish.
Review
Chemistry, Applied
Haidong Huang, Xiaohui Wang, Xinyang Li, Yichen Li, Guojin Liu, Lan Zhou, Jianzhong Shao
Summary: This article introduces the application of responsive photonic crystals in anti-counterfeiting technology, with a focus on the preparation principle, classification, and preparation methods.
Article
Chemistry, Applied
Yunpeng Wang, Tao Zhao, Xiaoye Bi, Chencheng Lv
Summary: In this study, three novel carbene dyes were designed to achieve environmentally friendly dyeing processes. The dyes formed covalent bonds with fibers and exhibited good dyeing performance and high color fastness. These findings highlight the potential of the novel carbene dyes in promoting green production in the textile industry.
Review
Chemistry, Applied
Yizhe Yan, Xiaopei Zhu, Jia-Xin Cao, Yuan He, Shaoqing Li, Jian-Yong Wang
Summary: In this paper, 1,3,5-triazine dyes were successfully synthesized and their photophysical properties were studied. Two probes were selected for further investigation, showing promising applications in various fields.
Article
Chemistry, Applied
Xin Hu, Tongsheng Huang, Lihua Chen, Weifeng Zhu, Fengjie Deng, Xiancai Li, Jianwen Tian, Meiying Liu, Xiaoyong Zhang, Yen Wei
Summary: This study presents the synthesis of fluorescent cyclomatrix polyphosphazene spheres with aggregation-induced emission (AIE) feature and biodegradable potential for controlled drug delivery. The resulting micelles exhibit high water dispersibility, desirable fluorescence performance, and high drug loading capacity. They can effectively release the encapsulated drug in physiological solution and show excellent biological imaging ability and cytotoxicity against cancer cells.
Article
Chemistry, Applied
Yanzhu Liu, Yanghui Lei, Dongyan Li, Guangkui Li, Dongping Li, Yongxiu Li
Summary: In this study, luminescent lanthanide nanoparticles were synthesized as a dual emission turn-off probe for detecting 2,6-pyridinedicarboxylic acid (DPA) in water. The nanoparticles showed good dispersion and water stability, and achieved low detection limits for DPA. They also exhibited high recoveries in various samples.
Article
Chemistry, Applied
Jung Jae Do, Jong Ryeol Kwon, Donghan Kim, Jae Woong Jung
Summary: This study presents a defect passivation approach using coumarin dye as a multi-functional passivating agent of perovskite films to boost power conversion efficiency and operating stability of PSCs. The incorporation of coumarin dye improves the film morphology, enhances carrier extraction/transport, and suppresses trap-assisted recombination in the perovskite films. The optimized device demonstrates impressive reliability and practical applicability, maintaining over 90% of its initial PCE after being exposed to continuous indoor lighting irradiation for 2000 hours.
Article
Chemistry, Applied
Gang Wang, Yu-Chang Wang, Jing Lu, Wen-Fu Yan, Juan Jin, Yuan-Peng Wang, Jia-Jia Zhang, Hui-Jie Zhang, Hao Dong, Xi-Guang Liu
Summary: A new Ni(II) compound with good solid-state fluorescence performance and stability was synthesized, and it showed outstanding detection properties for various substances in aqueous solutions. This compound has the potential to be a multifunctional sensor.
Article
Chemistry, Applied
Luyao Wei, Shenglong Shang, Yu Zheng, Jie Liu, Ping Zhu
Summary: This study developed a facile method to create high saturation and durable structural colors on cotton fabrics. The colors are regulated by adjusting the size of magnetic particles and can be conveniently printed on fabrics using photo masks on transparent films.
Article
Chemistry, Applied
Zhao Jiang, Qing Zhang, Zhaoyu Kong, Ruijie Qiao, Zichuan Liu, Linzhou Song, Senqiang Zhu, Rui Liu, Hongjun Zhu
Summary: Three heteroleptic Ir(III) complexes with different electron-donating aryl groups were synthesized and their optical properties were investigated. It was found that all three complexes exhibited aggregation-induced phosphorescence emission (AIPE) behaviors, and the relationship between the size of organic ligands and AIPE behaviors was characterized. Ir-PhCz showed the best imaging of latent fingerprints due to its green light emission and high quantum yield.
Article
Chemistry, Applied
Zhijun Ruan, Chunxia Fan, Xuanrong Wang, Dong Shao, Xiaodong Yang, Wentao He, Tao Xu, Junqi Lin, Zhengfang Tian
Summary: A novel thioketal-based probe has been designed for rapid and accurate detection of mercury (II) ions, showing different fluorescence characteristics in various states. The probe exhibits excellent selectivity and specificity, making it suitable for Hg2+ detection in water solutions.
Article
Chemistry, Applied
Jianjun Huang, Xuan Zhao, Daniel Escudero, Luc Van Meervelt, Dongbin Zheng, Yuyu Fang, Wim Dehaen
Summary: A series of BOAHY compounds were successfully synthesized and showed versatile applications as a platform for designing novel fluorescent probes, especially in selective recognition.
Article
Chemistry, Applied
Roman V. Larkovich, Victoria E. Shambalova, Savva A. Ponomarev, Alexander S. Aldoshin, Boris N. Tarasevich, Konstantin A. Lyssenko, Valentine G. Nenajdenko
Summary: An efficient synthetic protocol for the preparation of novel 1,7-difluorinated BODIPYs was elaborated. Their photophysical properties were studied and the effect of 2,6-substituents was evaluated using DFT calculations.
Article
Chemistry, Applied
Haneul Kim, Byungjin Koo
Summary: In this study, a lithium ion sensing methodology based on fluorinated naphthalene compounds using 19F NMR and UV-vis spectroscopy is reported. The binding of lithium ions to the compounds is confirmed by changes in chemical shifts and peak broadening. Additionally, the effect of different crown ether ring sizes on the binding ability is observed. This study provides a new method for lithium ion sensing using spectroscopy.
