Discovery of substituted indole derivatives as allosteric inhibitors of m 6 A‐RNA methyltransferase, METTL3 ‐14 complex

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

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METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes

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Small‐Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer

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METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification

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Regulatory Role of N6 -methyladenosine (m6 A) Methylation in RNA Processing and Human Diseases

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Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

(2017) Isaia Barbieri et al.   NATURE

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

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Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

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Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

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m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

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N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

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Chemical, Target, and Bioactive Properties of Allosteric Modulation

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RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

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A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

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Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

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Drugs for Allosteric Sites on Receptors

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Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A2α Inhibitors∥

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Indole Cytosolic Phospholipase A2α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib

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