Article
Substance Abuse
Monja Hoven, Renee S. Schluter, Arnt F. Schellekens, Ruth J. van Holst, Anna E. Goudriaan
Summary: This study examined the effects of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) on alcohol use and craving by targeting the right dorsolateral pre-frontal cortex. The results showed no significant impact of HF-rTMS on abstinent days and craving.
Review
Neurosciences
Silvano Gallus, Alessandra Lugo, Elisa Borroni, Teo Vignoli, Lisa Lungaro, Giacomo Caio, Roberto De Giorgio, Giorgio Zoli, Fabio Caputo
Summary: This systematic review summarizes literature on major symptoms of protracted alcohol withdrawal in patients with alcohol use disorder. The pharmacological approach to manage protracted alcohol withdrawal ensures a more rapid reduction of symptoms (craving in particular), achieving in three weeks similar results obtained only after almost 6 months without treatment.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Maarten Belgers, Philip Van Eijndhoven, Wiebren Markus, Aart H. Schene, Arnt Schellekens
Summary: This study demonstrated that high-frequency rTMS over the right dorsolateral prefrontal cortex, combined with standard treatment, significantly reduced alcohol craving and use in recently detoxified patients with AUD, with the most significant effects observed in the first month post-detoxification.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Psychiatry
Charlotte E. Goldfine, Jeremiah J. Tom, Dana D. Im, Benjamin Yudkoff, Amit Anand, Joseph J. Taylor, Peter R. R. Chai, Joji Suzuki
Summary: Alcohol use disorder (AUD) is a common substance use disorder (SUD), and current treatment options have limited success. Recent studies have shown that intravenous ketamine infusions may be a safe adjunct treatment for alcohol withdrawal syndrome (AWS) and can increase alcohol abstinence. The use of ketamine in AUD has been found to reduce cravings, alcohol consumption, and promote longer abstinence rates, while in AWS it helps in the resolution of delirium tremens and reduces the need for intensive care and intubation. However, further evidence is needed to recommend its broader clinical use.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Ming-Fen Ho, Cheng Zhang, Irene Moon, Brandon J. J. Coombes, Joanna Biernacka, Michelle Skime, Doo-Sup Choi, Paul E. E. Croarkin, Mark A. A. Frye, Quyen Ngo, Cedric Skillon, Tyler S. S. Oesterle, Victor M. M. Karpyak, Hu Li, Richard M. M. Weinshilboum
Summary: This study aimed to identify biomarkers associated with acamprosate treatment response in patients with alcohol use disorder (AUD) using proteomics and RNA sequencing. The findings suggest that baseline plasma TNFSF10 concentration is associated with alcohol craving intensity and acamprosate treatment outcomes. In addition, inflammation-related pathways are highly associated with relapse during acamprosate treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Psychology, Clinical
Victoria Paulus, Joel Billieux, Amine Benyamina, Laurent Karila
Summary: This systematic review suggests that CBD may have promising therapeutic potential for the treatment of substance use disorders, especially nicotine, cannabis, and opioid use disorders. However, the available research evidence is still limited and more human studies are needed.
ADDICTIVE BEHAVIORS
(2022)
Article
Psychiatry
Wenhan Yang, Shicong Wang, Jing Luo, Cui Yan, Fei Tang, Yanyao Du, Li Fan, Min Zhang, Jun Zhang, Kai Yuan, Jun Liu
Summary: This study found that there were changes in the functional connectivity of the insular cortex in individuals with opioid use disorder after protracted abstinence, and these changes were correlated with changes in craving. This finding provides novel evidence for future abstinence therapies and rehabilitation procedures for patients with substance use disorders.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Claudia B. Padula, Annika Hansen, Rachel L. Hughes, M. Windy McNerney
Summary: The study found a significant interaction between COMT genotype and craving in predicting relapse. Different genetic profiles were associated with craving and relapse in individuals with AUD.
Article
Psychology, Clinical
Brianna R. Altman, Tosca D. Braun, Cynthia L. Battle, Sydney Iacoi, Michael D. Stein, Ana M. Abrantes
Summary: Women with alcohol use disorder often have heightened negative emotionality, which may impact their confidence in remaining sober during treatment. This study found that negative emotionality indirectly influenced alcohol abstinence self-efficacy through alcohol craving. Further research is needed to determine if teaching coping skills for alcohol craving in the context of negative emotionality could lead to better treatment outcomes.
ADDICTIVE BEHAVIORS
(2022)
Article
Psychiatry
Soundarya Soundararajan, Pratima Murthy
Summary: This study aimed to capture craving and explore its association with relapse in an outpatient facility. High craving was found to be associated with shorter time to relapse. Baseline craving was negatively associated with proximal percentage of days abstinent, and cravings at follow-ups were negatively correlated with cross-sectional abstinent days. Craving reduced significantly over time, regardless of the drinking status during follow-ups.
INDIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Gastroenterology & Hepatology
Lauren Carrique, Jill Quance, Adrienne Tan, Susan Abbey, Isabel Sales, Les Lilly, Mamatha Bhat, Zita Galvin, Mark Cattral, Anand Ghanekar, Ian McGilvray, Trevor Reichman, Gonzalo Sapisochin, Blayne Sayed, Markus Selzner, Marie-Josee Lynch, Nazia Selzner
Summary: The study team conducted a pilot program challenging the traditional 6-month abstinence rule for ALD patients, providing in-depth assessment and addiction treatment, resulting in a reduction in post-transplantation return to drinking without significant impact on survival rates.
Article
Multidisciplinary Sciences
Ida Fredriksson, Pei-Jung Tsai, Aniruddha Shekara, Ying Duan, Sarah Applebey, Hanbing Lu, Jennifer M. Bossert, Yavin Shaham, Yihong Yang
Summary: Through experiments, it was found that both opioid self-administration and voluntary abstinence can induce changes in functional connectivity between the orbitofrontal cortex and dorsal striatum, as well as related circuits in rats. These connectivity changes can predict individual differences in the incubation of opioid craving.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Celine M. Laffont, Eliford Ngaimisi, Mathangi Gopalakrishnan, Vijay Ivaturi, Malcolm Young, Mark K. Greenwald, Christian Heidbreder
Summary: This study analyzes the relationship between buprenorphine plasma exposure and clinical efficacy in individuals with opioid use disorder (OUD). The findings suggest that maintaining buprenorphine plasma concentrations at 2-3 ng/ml optimizes treatment outcomes in most patients, while certain subgroups may require higher concentrations. The study also identifies demographic, genetic, and social factors that modulate treatment response and retention.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Substance Abuse
Pablo Barrio, Nuria Baldaqui, Magali Andreu, Carolin Kilian, Juergen Rehm, Antoni Gual, Jakob Manthey
Summary: This study found a significant increase in alcohol use among AUD patients during the COVID-19 lockdown compared to before, as well as an association with testing positive for other drugs and length of treatment. Addiction healthcare systems may face challenges ahead in responding to the needs of patients with AUD during the pandemic.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Medicine, General & Internal
Jing-Li Yue, Kai Yuan, Yan-Ping Bao, Shi-Qiu Meng, Le Shi, Qing Fang, Xiao-Jie Guo, Lu Cao, Ye-Kun Sun, Tang-Sheng Lu, Na Zeng, Wei Yan, Ying Han, Jie Sun, Jie Shi, Thomas R. Kosten, Yan-Xue Xue, Ping Wu, Lin Lu
Summary: The study found that MRUP conducted within about 10 minutes to 1 hour after methadone injection decreased reinstatement of heroin seeking in rats. In the human experimental study, MRUP promoted sustained abstinence from heroin, reduced experimental cue-induced heroin craving and blood pressure increases.
Article
Psychology, Clinical
Jessica L. Martin, Joaquim Armando Ferreira, Richard F. Haase, Jorge Martins, Mariana Coelho
ADDICTIVE BEHAVIORS
(2016)
Article
Psychology, Biological
Bruce D. Bartholow, Kimberly A. Fleming, Phillip K. Wood, Nelson Cowan, J. Scott Saults, Lee Altamirano, Akira Miyake, Jorge Martins, Kenneth J. Sher
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2018)
Article
Substance Abuse
Jorge S. Martins, Bruce D. Bartholow, M. Lynne Cooper, Kelsey M. Irvin, Thomas M. Piasecki
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Psychiatry
Alex P. Miller, Ian R. Gizer, William A. Fleming, Jacqueline M. Otto, Joseph D. Deak, Jorge S. Martins, Bruce D. Bartholow
PSYCHIATRY RESEARCH
(2019)
Article
Substance Abuse
Roberto U. Cofresi, Ashley L. Watts, Jorge S. Martins, Phillip K. Wood, Kenneth J. Sher, Nelson Cowan, Akira Miyake, Bruce D. Bartholow
Summary: The study found that acute alcohol consumption has limited impact on working memory updating, but alcohol may dampen practice effects and interfere with the completion of novel tasks.
Article
Substance Abuse
Seungju Hwang, Jorge S. Martins, Ryan J. Douglas, Justin J. Choi, Rajita Sinha, Dongju Seo
Summary: This study aimed to explore the neural correlates of ANS activity in AUD and its role in AUD pathology using fMRI and ECG. Results showed that AUD patients exhibited higher overall heart rate and ApEn levels compared to social drinkers, and increased HR was associated with greater drinking volume. Additionally, higher ApEn levels were related to both increased drinking volume and decreased right VmPFC response to stress in all participants. These findings suggest that ANS disruption, indexed by HR and ApEn, may modulate drinking behavior through interactions with neural regions involved in emotion regulation.
ALCOHOL AND ALCOHOLISM
(2022)
Article
Biochemistry & Molecular Biology
Jorge S. Martins, Keanan J. Joyner, Denis M. McCarthy, David H. Morris, Christopher J. Patrick, Bruce D. Bartholow
Summary: Research indicates that the biased valuation of alcohol relative to natural rewards is associated with an increased risk for substance misuse and dependence. Differential P3 response to alcohol and natural reward cues serves as a neurophysiological indicator to distinguish high-risk from lower-risk drinkers.
Article
Substance Abuse
Stephanie E. Wemm, Max Golden, Jorge Martins, Nia Fogelman, Rajita Sinha
Summary: Chronic heavy alcohol use has a profound effect on the cardiovascular system. This study found that individuals with alcohol use disorder (AUD) have altered heart rate variability (HRV) metrics during waking and sleeping. It was observed that light social drinkers had higher parasympathetic activation during sleep compared to AUD patients. The HRV measures during sleep and waking were also correlated with patient-reported symptoms of depression and sleep difficulties in the AUD group.
ALCOHOL AND ALCOHOLISM
(2023)
Article
Psychology, Clinical
Jessica L. Martin, Joaquim Armando Ferreira, Richard F. Haase, Matthew P. Martens, Mariana Coelho, Jorge Martins, LaRae M. Jome, Eduardo R. Santos
EUROPEAN JOURNAL OF HEALTH PSYCHOLOGY
(2020)
Article
Psychology, Social
Curtis D. Von Gunten, Bruce D. Bartholow, Jorge S. Martins
EUROPEAN JOURNAL OF PERSONALITY
(2020)
Article
Substance Abuse
Jorge S. Martins, Bruce D. Bartholow, M. Lynne Cooper, Curtis D. Von Gunten, Phillip K. Wood
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2018)
Article
Behavioral Sciences
Marie-Eve Couture, Sherry H. Stewart, M. Lynne Cooper, Emmanuel Kuntsche, Roisin M. O'Connor, Sean P. Mackinnon
INTERNATIONAL JOURNAL OF ALCOHOL AND DRUG RESEARCH
(2017)
Article
Substance Abuse
Sean P. Mackinnon, Marie-Eve Couture, M. L. Cooper, Emmanuel Kuntsche, Roisin M. O'Connor, Sherry H. Stewart
DRUG AND ALCOHOL REVIEW
(2017)
Article
Public, Environmental & Occupational Health
M. Lynne Cooper, Ross E. O'Hara, Jorge Martins