Review
Microbiology
Kunyu Zhang, Lei Chen, Chenyu Zhu, Meng Zhang, Chaozhao Liang
Summary: T helper 22 (Th22) cells, characterized by their distinct cytokine profile, play variable roles in human immunity. The main effector molecule secreted by Th22 cells is IL-22, which has both protective and deleterious effects on infectious diseases. Th22/IL-22 may be a promising therapeutic target and an effective treatment strategy for various infections.
Article
Immunology
Wenzhe Zhang, Shiru Xu, Rongrong Zhang, Zhuqing Li, Nianyu Li, Xiruo Zhang, Yueshuang Lu, Yuehong Bian, Ping Yang, Fang Fang, Yingying Qin, Xue Jiao
Summary: This study found that deficiency of IL-22 was associated with premature ovarian insufficiency (POI). The levels of IL-22 and IL-22BP were measured and compared among different groups, and it was discovered that IL-22 levels were significantly lower in the POI group. The study also identified a correlation between IL-22 and ovarian reserve markers, providing new insights into the autoimmune disturbance in POI and suggesting potential intervention strategies.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Viva J. Rase, Reid Hayward, James M. Haughian, Nicholas A. Pullen
Summary: Immunotherapies relying on type 1 immunity have shown limited effectiveness in solid breast tumors. This study investigated the role of type 3 immunity in breast cancer and found that IL-6 depletion combined with immunotherapy could improve outcomes by expanding T(h)17 cell populations and reducing T(h)22 cells and MDSC. This suggests that targeting IL-6 could be a potential strategy to overcome immunotherapy resistance in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Emily R. Webb, Georgia L. Dodd, Michaela Noskova, Esme Bullock, Morwenna Muir, Margaret C. Frame, Alan Serrels, Valerie G. Brunton
Summary: The over-expression of Kindlin-1 in breast cancer is associated with metastasis-free survival, but the mechanisms are poorly understood. This study reveals that Kindlin-1 promotes immune evasion in breast cancer mouse models. Deletion of Kindlin-1 led to tumor regression and reduced tumor infiltrating Tregs, which was associated with increased IL-6 secretion. Conditioned media from Kindlin-1-depleted cells resulted in decreased suppression of CD8(+) T cells by Tregs, dependent on IL-6.
Review
Oncology
Bhalchandra Mirlekar, Yuliya Pylayeva-Gupta
Summary: The IL-12 family cytokines are crucial in regulating tumor immune contexture and activating anti-tumor immune responses. Different family members have distinct roles, encompassing both promoting effector responses and inhibitory functions. These cytokines hold promise as candidates for developing immunomodulatory therapeutic approaches.
Review
Immunology
Lauren A. Zenewicz
Summary: Cytokines, including IL-22, play crucial roles in inflammation, with their activity regulated by factors like IL-22BP. IL-22BP, a soluble receptor homolog, binds to IL-22 with greater affinity, impacting the biological functions of IL-22, yet further research is needed to fully understand its role and regulation mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Berengere Villeret, Reem Ghinnagow, Saade Kheir, Maelys Born-Bony, Jay K. Kolls, Ignacio Garcia-Verdugo, Jean-Michel Sallenave
Summary: This study reveals the importance of lymphocytes in fighting against Pseudomonas aeruginosa infection. The bacterium down-regulates IL-23 and IL-22 protein accumulation in the lungs, but up-regulates their RNA production. Adenovirus-mediated over-expression of IL-1, IL-23, and IL-7 can rescue mice from Pseudomonas aeruginosa-induced lethality, suggesting its potential value in locally immunosuppressed individuals like cystic fibrosis patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Kewei Liu, Ai Huang, Jun Nie, Jun Tan, Shijie Xing, Yue Qu, Ke Jiang
Summary: IL-35, a heterodimeric cytokine, plays important roles in the tumor microenvironment by promoting tumor growth, metastasis, and exhibiting immunosuppressive activity. Regulating immune cells can impact tumor-related phenotypes, and targeting IL-35 may offer potential strategies for inhibiting tumor growth.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yuhan Sun, Alexander James Sedgwick, Md Abdullah-Al-Kamran Khan, Yaseelan Palarasah, Stefano Mangiola, Alexander David Barrow
Summary: The activation of NK cell function in bladder cancer is regulated by cytokines and secreted factors. IL-2-expanded NK cell phenotype is associated with improved prognosis, while PDGF-DD-activated NK cell phenotype is associated with poor prognosis. High expression of activating NK cell receptors correlates with IL-2-expanded NK cell phenotype and improved prognosis in bladder cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yashgin Hassanzadeh, Ramin Yaghobi, Parviz Pakzad, Bita Geramizadeh
Summary: This study found that the frequency of Th22 cells and the production of IL-22 cytokine were reduced in transplant recipients with active HCMV infection. This suggests that Th22 cells may play a protective role in controlling HCMV infection.
Editorial Material
Immunology
Jinzhi Duan, Juan D. Matute, Richard S. Blumberg
Summary: The research discovered that interleukin-22 (IL-22) has a regulatory effect on MHC class II expression in epithelial cells, with opposite impacts on chronic inflammatory disease and viral infection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Jia Zhang, Zhou Liu, Lingpeng Liu, Mingwen Huang, Yong Huang
Summary: T helper cell 22 (Th22) and its main cytokine interleukin 22 (IL-22) play a crucial role in the progression of Hepatitis B Virus-related hepatocellular carcinoma (HCC). In this study, it was found that Th22 cells promoted the proliferation and inhibited the apoptosis of HCC cells. Furthermore, the overexpression of IL-22 triggered the over-activation of STAT3, leading to the progression of HCC.
Article
Oncology
Xudong Zhu, Rongpu Liang, Tianyun Lan, Dongbing Ding, Shengxin Huang, Jun Shao, Zongheng Zheng, Tufeng Chen, Yong Huang, Jianpei Liu, Janak L. Pathak, Hongbo Wei, Bo Wei
Summary: This study found that the specific localization of CD155(+) TAMs in CRC tissue could become a potential therapeutic target for CRC treatment, as it is responsible for M2-phenotype transition, immunosuppression, and tumor progression in CRC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Lujun Chen, Hao Huang, Xiao Zheng, Yuan Li, Junjun Chen, Bo Tan, Yingting Liu, Runzi Sun, Bin Xu, Min Yang, Bin Li, Changping Wu, Binfeng Lu, Jingting Jiang
Summary: This study reveals the critical role of IL1 signaling in inhibiting Treg-mediated tumor immune suppression by modulating the interaction between Tregs and CAFs. These findings provide a theoretical basis for developing new anti-tumor immunotherapy strategies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Yangyang Zhang, Lingxiu Zeng, Meng Wang, Zhenwei Yang, Hailin Zhang, Liping Gao, Ranran Zhang, Jialong Liu, Wenqing Shan, Ying Chang, Lan Liu, Qiu Zhao, Yong Li, Jing Liu
Summary: The study found that RIG-I plays an important role in the immunotherapy of colon cancer by maintaining the stability of PD-L1 to promote immune evasion. Silencing RIG-I increases the sensitivity of tumor cells to T cell killing and slows down the growth of colon tumors. High expression of RIG-I promotes tumor progression and enhances the sensitivity to PD-1 therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Sara Hashemi, Kazem Karami, Zeinab Saberi Dehkordi, Amir Abbas Momtazi-Borojeni, Seyed Alireza Esmaeili
Summary: Novel Pd(II) complexes were prepared and characterized. The stability of the complexes in biological media was confirmed, and their interaction with DNA and BSA was investigated. The complexes showed selectivity against cancer cells and binding to specific sites of BSA.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Endocrinology & Metabolism
Abbas Samadi-Khouzani, Payam Kheirmand Parizi, Fatemeh Ghafari, Seyed-Alireza Esmaeili, Maryam Peymani, Amir Abbas Momtazi-Borojeni
Summary: The study did not find an association between the rs619586 (A/G) polymorphism in the gene encoding lncRNA-MALAT1 and susceptibility to T2DM in the Isfahan population.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2022)
Article
Immunology
Bita Mohammadi, Mohammadreza Saghafi, Tola Abdulsattar Faraj, Ramiar Kamal Kheder, Hadi Sajid Abdulabbas, Seyed-Alireza Esmaeili
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by an imbalance between effector and regulatory immune responses. Inflammatory dendritic cells (inflDC) play a role in promoting inflammation in SLE, while tolerogenic dendritic cells (tolDC) suppress immune cell overreaction in SLE. Recent studies show the potential of tolDC therapy in treating autoimmune diseases including SLE, by inducing regulatory T cells and maintaining self tolerance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Akram Hoseinzadeh, Zahra Rezaieyazdi, Mahmoud Mahmoudi, Jalil Tavakol Afshari, Fahimeh Lavi Arab, Seyed-Alireza Esmaeili, Arezoo Faridzadeh, Amin Rezaeian, Sara Hoseini, Mehdi Barati, Ali Mahmoudi, Nafiseh Sadat Tabasi
Summary: This study investigated the potential of MSCs in the treatment of refractory SLE. The results showed that MSCs can reduce inflammation, modulate immune function, and repair damaged tissues. Animal experiments demonstrated that MSCs transplantation can decrease proteinuria and anti-dsDNA antibody levels, reduce serum creatinine levels, and attenuate lupus renal pathology.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Parisa Ahmadi, Mahmoud Mahmoudi, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Samaneh Mollazadeh, Hadi Sajid Abdulabbas, Seyed-Alireza Esmaeili
Summary: In patients with rheumatoid arthritis (RA), certain citrullinated proteins can be targeted by ACCPAs in the synovial sites. Extra-articular sites may be the origin of primary auto-immunization against these proteins. There is a significant association between P. gingivalis periodontitis, anti-P. gingivalis antibodies, and RA. P. gingivalis can degrade proteins such as fibrin and alpha-enolase into citrullinated peptides, and induce inflammation and immune cell attraction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Gholamreza Karimi, Sina Fatemi, Bahram Memar, Mohammad-Bagher Khorrami, Arian Amali, Mahmood Sadeghi, Seyed-Alireza Esmaeili, Bamdad Riahi-Zanjani
Summary: Our study showed that melittin had no significant pathological effects on the spleen and bone marrow, as well as no impact on hematological parameters. Additionally, melittin did not affect proliferation response of splenocytes, spleen cellularity, DTH response, and the production of anti-SRBC antibodies in the mice immune system.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Obstetrics & Gynecology
Malihe Soltani, Maryam Moghimian, Seyed-Hosein Abtahi-Evari, Seyed-Alireza Esmaeili, Ramin Mahdipour, Majid Shokoohi
Summary: This study aimed to determine whether clove could help PCOS rats. The results showed that clove improved oxidative stress, apoptosis, and excessive autophagy in PCOS rats, thereby improving pathological parameters and hormone levels.
INTERNATIONAL JOURNAL OF FERTILITY & STERILITY
(2023)
Review
Medicine, Research & Experimental
Davood Bahadorian, Samaneh Mollazadeh, Hosein Mirazi, Tola Abdulsattar Faraj, Ramiar Kamal Kheder, Seyed-Alireza Esmaeili
Summary: NK cells play a vital role in defending against tumors and viral infections and regulating innate and adaptive immunity. They can be divided into CD56dim NK and CD56bright NK subsets, with CD56bright NK cells known as regulatory NK cells. Their activation can suppress autologous CD4+ T cells and prevent the initiation of autoimmunity. This review summarizes the roles of regulatory NK cells in autoimmune diseases and suggests targeting NK cells as a promising therapeutic approach.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Review
Oncology
Seyed Hossein Abtahi Eivary, Ramiar Kamal Kheder, Soran K. Najmaldin, Nahid Kheradmand, Seyed-Alireza Esmaeili, Jafar Hajavi
Summary: Cancer, a deadly disease, is a recent global dilemma. The use of cytokine IL-21 shows potential in manipulating the immune system to fight solid tumors, as it enhances NK and CTL functions and stimulates IgG antibody production. Combining IL-21 with other agents is found to further enhance its antitumor activity. Promising preclinical results have led to the initiation of clinical trials in cancer patients. This review focuses on the function of IL-21 in solid tumor immunotherapy.
Article
Immunology
Maryam Rastin, Mahmoud Mahmoudi, Nafiseh Tabasi, Nadia Kia, Jafar Hajavi, Seyed-Alireza Esmaeili
Summary: The immunomodulatory effect of Lactobacillus rhamnosus and Lactobacillus delbrueckii on the differentiation and maturation of myeloid dendritic cells was evaluated. The probiotic-treated dendritic cells exhibited significant immunomodulatory properties, indicating their potential for immune response regulation.
IRANIAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Oncology
Vahideh Keyvani, Nahid Kheradmand, Zahra Nasrpour Navaei, Samaneh Mollazadeh, Seyed-Alireza Esmaeili
Summary: Gynecological cancers, the most common among women worldwide, have a significant impact on reproductive system function and quality of life. The epidemiological patterns of these cancers vary across regions and change over time. Improving patient outcomes requires addressing the challenges and evaluating reported risk factors in gynecological cancers. Preventive measures, modifiable lifestyles, and early detection in high-risk groups are effective strategies for reducing mortality rates. This review provides a summary of the epidemiology, global risk factors, and management approaches for gynecological cancers to improve the quality of life in affected patients.
Review
Biochemistry & Molecular Biology
Zahra Darvish, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Soran K. Najmaldin, Samaneh Mollazadeh, Reza Nosratabadi, Seyed-Alireza Esmaeili
Summary: Autoimmune diseases are caused by disturbed regulatory mechanisms of the immune response, and investigating the CTLA4-CD80/86 axis may provide insights for treatment strategies.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Cell & Tissue Engineering
Akram Hoseinzadeh, Zahra Rezaieyazdi, Jalil Tavakol Afshari, Ali Mahmoudi, Sahar Heydari, Reza Moradi, Seyed-Alireza Esmaeili, Mahmoud Mahmoudi
Summary: The breakdown of self-tolerance in the immune response can cause autoimmune diseases like systemic lupus erythematosus (SLE), which is more prevalent in women of childbearing age and influenced by ethnicity. Dysregulation in B cell subsets and hyperactive T helper cells play a major role in SLE's pathogenesis. New treatment strategies using mesenchymal stem cells (MSCs) as immune modulators show promise in controlling autoimmune responses without suppressing the immune system.
STEM CELL REVIEWS AND REPORTS
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Darshan Chakrabarti, John P. Dickerson, Seyed A. Esmaeili, Aravind Srinivasan, Leonidas Tsepenekas
Summary: This paper introduces a novel definition of individual fairness for clustering problems and answers questions regarding the combinatorial structure and Price of Fairness (PoF) behavior. Efficient and easily-implementable approximation algorithms are provided for the well-defined region of alpha, with bounded-PoF guarantees in certain cases. Extensive experiments validate the effectiveness of the theoretical results.
INTERNATIONAL CONFERENCE ON ARTIFICIAL INTELLIGENCE AND STATISTICS, VOL 151
(2022)
Article
Biotechnology & Applied Microbiology
Vahid Bagheri, Seyed-Alireza Esmaeili, Mehran Gholamin, Mohammad Reza Abbaszadegan
Summary: This study successfully generated spherical colonies from cancerous cell suspensions isolated from patients with GC under serum-free conditions, which were able to form xenograft tumors in immunodeficient nude mice. The spheroid-forming single cells upregulated stemness transcription factors associated with pluripotency and self-renewal, as well as CD44 isoforms, indicating their stem-like properties. The rapid isolation of cancer cells with certain stem-like properties may be important for targeted CSC therapy, especially in advanced disease patients.
IRANIAN JOURNAL OF BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
