Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 72, Issue -, Pages 209-218Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2021.11.003
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- UNESCO-L'Oreal International Rising Talent Fellowship
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Proteins interact through interfaces and abnormal interactions may cause diseases. Discovering small molecules that modulate protein interactions is challenging but has high therapeutic potential. Hot spot prediction is crucial for drug design.
Proteins interact through their interfaces to fulfill essential functions in the cell. They bind to their partners in a highly specific manner and form complexes that have a profound effect on understanding the biological pathways they are involved in. Any abnormal interactions may cause diseases. Therefore, the identification of small molecules which modulate protein interactions through their interfaces has high thera-peutic potential. However, discovering such molecules is challenging. Most protein-protein binding affinity is attributed to a small set of amino acids found in protein interfaces known as hot spots. Recent studies demonstrate that drug-like small molecules specifically may bind to hot spots. Therefore, hot spot prediction is crucial. As experimental data accumulates, artificial intelligence begins to be used for computational hot spot prediction. First, we review machine learning and deep learning for computational hot spot prediction and then explain the significance of hot spots toward drug design.
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