Cellular interactions in resident memory T cell establishment and function

Tissue resident memory T cells (T-RM) are enriched in nonlymphoid tissues and represent a formidable barrier against invading pathogens and tumors. T-RM are armed with deployment ready effector molecules which combined with their frontline location allows them to be early organizing centers of our immune defense. Despite their autonomous nature, T-RM rely on careful collaboration with other immune and non-immune cells located within the barrier organ to exert their superior protective role. Here, we highlight recent studies focusing on cellular interactions that regulate T-RM establishment and function. A deeper understanding of these processes is instrumental in designing new means to target T-RM for desirable outcomes in infectious diseases, cancers and autoimmunity.

Automated summary

This article highlights recent studies on cellular interactions that regulate the establishment and function of tissue resident memory T cells (T-RM). A deeper understanding of these processes is instrumental in designing new means to target T-RM for desirable outcomes in infectious diseases, cancers, and autoimmunity.