A phase I, first‐in‐human, randomized dose‐escalation study of anti‐activated factor XII monoclonal antibody garadacimab

Predicting bioavailability of monoclonal antibodies after subcutaneous administration: Open innovation challenge

(2020) Manuel Sánchez-Félix et al.   ADVANCED DRUG DELIVERY REVIEWS

A hypothesized role for dysregulated bradykinin signaling in COVID‐19 respiratory complications

(2020) Joseph A. Roche et al.   FASEB JOURNAL

Hereditary Angioedema

(2020) Paula J. Busse et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression

(2020) Mary Kathryn Bohn et al.   PHYSIOLOGY

Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation

(2018) Helen Cao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Coagulation factor XII regulates inflammatory responses in human lungs

(2017) Christina Hesse et al.   THROMBOSIS AND HAEMOSTASIS

Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations

(2016) Steven de Maat et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III

(2015) Jenny Björkqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

Factor XII: a novel target for safe prevention of thrombosis and inflammation

(2015) E. Kenne et al.   JOURNAL OF INTERNAL MEDICINE

A Factor XIIa Inhibitory Antibody Provides Thromboprotection in Extracorporeal Circulation Without Increasing Bleeding Risk

(2014) M. Larsson et al.   Science Translational Medicine

Hereditary angioedema: a bradykinin-mediated swelling disorder

(2013) Jenny Björkqvist et al.   THROMBOSIS AND HAEMOSTASIS

In vivo roles of factor XII

(2012) T. Renne et al.   BLOOD

Recommendations for the validation of immunoassays used for detection of host antibodies against biotechnology products

(2008) Gopi Shankar et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Exploratory assessment of dose proportionality: review of current approaches and proposal for a practical criterion

(2008) Jürgen Hummel et al.   PHARMACEUTICAL STATISTICS

Pasteurized C1 inhibitor concentrate in hereditary angioedema: pharmacology, safety, efficacy and future directions

(2007) Konrad Bork   Expert Review of Clinical Immunology