Review
Biochemistry & Molecular Biology
Jose Ignacio Erices, Carolina Bizama, Ignacio Niechi, Daniel Uribe, Arnaldo Rosales, Karen Fabres, Giovanna Navarro-Martinez, Angelo Torres, Rody San Martin, Juan Carlos Roa, Claudia Quezada-Monras
Summary: Glioblastoma (GBM) is a common and malignant brain cancer with poor prognosis. Its low effectiveness is attributed to tumor infiltration into healthy brain tissue, which depends on the interaction between GBM cells and the tumor microenvironment (TME). This review highlights the use of 3D patient-derived glioblastoma organoid cultures as a new platform for studying TME and invasiveness. It discusses the mechanisms involved in GBM-TME interaction and proposes potential prognostic biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Johannes Jun Wei Low, Siti Aishah Sulaiman, Nor Adzimah Johdi, Nadiah Abu
Summary: Glioblastoma is an aggressive type of brain cancer that poses challenges for treatment. Extracellular vesicles, nanosized vesicles secreted by cells, play important roles in immunomodulation. The extracellular vesicles secreted by tumor and immune cells participate in various immunomodulatory effects, affecting the survival and progression of the tumor in the brain.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Seiji Mabuchi, Tomoyuki Sasano
Summary: In uterine cervical and endometrial cancers, increased number of MDSCs is associated with advanced stage, poor survival, and resistance to chemotherapy or radiotherapy. Studies in murine models have shown the important roles of MDSCs in cancer progression. Treatment strategies targeting MDSCs may have growth-inhibitory effects and enhance the efficacy of existing anticancer treatments.
Article
Immunology
Mingyan Ding, Qiang Xu, Xiuying Jin, Zhezhu Han, Hao Jiang, Honghua Sun, Yongmin Jin, Zhengri Piao, Songnan Zhang
Summary: In this study, a risk score model based on genes in glioblastoma-derived exosomes was developed. It was found that the risk score could independently predict the prognosis of glioma patients, and there were significant differences in outcomes between high- and low-risk groups. Additionally, high-risk patients showed better responses to immunotherapy and various anti-cancer drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gloria Krapez, Katarina Kouter, Ivana Jovcevska, Alja Videtic Paska
Summary: Glioblastoma is the most common and aggressive brain tumor in the central nervous system, with poor patient survival and limited treatment options. In addition to gene mutations, the malignancy of the tumor is also influenced by its communication with the surrounding environment.
Article
Biochemistry & Molecular Biology
Yunhong Tian, Chunshan Liu, Zhiyong Li, Meiling Ai, Baiyao Wang, Kunpeng Du, Wei Liu, Hongmei Wang, Peng Yu, Chengcong Chen, Jie Lin, Anan Xu, Rong Li, Weijun Zhang, Yawei Yuan
Summary: This study found that radiation can enhance the expression of B7-H4 in exosomes, thereby promoting immunosuppression and tumor growth. This finding links radiation to anti-tumor immune responses and suggests that the combination of radiotherapy and anti-B7-H4 therapy may improve local tumor control. Exosomal B7-H4 may also serve as a potential tumor biomarker.
Review
Cell Biology
Guoqiang Chen, Lei Qiu, Jinghai Gao, Jing Wang, Jianhong Dang, Lingling Li, Zhijun Jin, Xiaojun Liu
Summary: In the past decade, research has shown the presence of innervation in gynecological cancers, indicating the role of neurotransmitters in cell proliferation and metastasis. Understanding these mechanisms could lead to potential clinical treatments using inexpensive beta-blockers and dopamine agonists, as well as providing new insights into targeting tumor innervation and neurotransmitters in the tumor microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Deyang Wu, Xiaowei Liu, Jingtian Mu, Jin Yang, Fanglong Wu, Hongmei Zhou
Summary: This article summarizes the important role of tumor-associated macrophages (TAMs) in tumor development, explores protein-dependent TAM target strategies, and discusses methods to manipulate TAMs to regulate the tumor microenvironment.
Article
Oncology
Nadiah Abu, Nurul Ainaa Adilah Rus Bakarurraini
Summary: The interdependency between cancer cells and immune cells is crucial to understanding cancer pathogenesis. Extracellular vesicles (EVs) released by both cancer and immune cells act as messengers in this process. Tumor-derived EVs have been found to interact with immune cells, especially T cells, while T cell-derived EVs also play immunomodulatory roles. This mini-review aims to explore the impact of tumor-derived EVs and T cell-derived EVs on cancer immunosuppression, highlighting the interplay between different types of EVs and their effects on tumor immunity. The role of EVs in various types of T cells, including CD8(+), CD4(+) Th17, and Treg cells, is also discussed. Furthermore, limitations and future directions regarding this research are addressed, contributing to a better understanding of the functions of these tiny mediators.
Article
Immunology
Songyun Zhao, Qi Wang, Kaixiang Ni, Pengpeng Zhang, Yuan Liu, Jiaheng Xie, Wei Ji, Chao Cheng, Qiang Zhou
Summary: This study comprehensively explores the exosome-related features of GBM using single-cell RNA sequencing and spatial transcriptome RNA sequencing, revealing that malignant cells with higher exosome scores exhibit stronger communication with monocytes/macrophages. In terms of spatial data, highly scored malignant cells are concentrated in the tumor core region. Prognostic models constructed using ERGs can predict survival and immunotherapy outcomes in GBM patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Boyuan Huang, Jin Zhang, Wenjing Zong, Sisi Chen, Zhitao Zong, Xiaojun Zeng, Hongbo Zhang
Summary: Glioblastoma (GBM) is a common and lethal malignant tumor in the central nervous system. Conventional therapies have limited success due to the immunosuppressive tumor microenvironment. Immunotherapy has shown promise and is extensively studied for GBM treatment. This review discusses the features and functions of myeloid cells and current advances in immunotherapies for GBM.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Yinjiang Zhang, Hongyun Wei, Lu Fan, Mingyan Fang, Xu He, Binan Lu, Zongran Pang
Summary: The study found that CLEC4A and CLEC4L mRNA levels were significantly higher in HCC tissues compared to normal liver tissues, while CLEC4G/H1/H2/M expression levels were significantly lower. The expression of CLEC4H1 and CLEC4H2 was significantly associated with clinical stages, and the expression of other CLEC4s decreased with tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
In Kang, Yumin Kim, Heung Kyu Lee
Summary: Gamma delta T cells play important roles in tumor immunity and have potential applications in GBM treatment. However, limitations still exist and further research is needed. This review summarizes the effector functions of gamma delta T cells, current advances and limitations, and suggests future research directions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Xingkai Liu, Ping Zhang, Jing Xu, Guoyue Lv, Yan Li
Summary: Bioactive lipid molecules play important roles in linking obesity/metabolic syndrome and cancers. Controlling lipid metabolism can be a potential strategy for cancer prevention and therapy. Comprehensive understanding of the regulatory role of lipid metabolism in cellular entities and their tumor microenvironment will provide a new direction for further studies and development of novel anti-cancer strategies.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Jingdian Liu, Kai Zhao, Sisi Wu, Chaoxi Li, Chao You, Junwen Wang, Kai Shu, Ting Lei
Summary: As an adaptor protein, PDCD10 is involved in regulating diverse biological processes and has a dual role in cancers, either promoting or inhibiting tumor growth depending on cell/tissue specificity and different cellular interactors.
Article
Chemistry, Medicinal
Thiago M. de Aquino, Paulo H. B. Franca, Erica E. E. S. Rodrigues, Igor J. S. Nascimento, Paulo F. S. Santos-Junior, Pedro G. Aquino, Mariana S. Santos, Aline C. Queiroz, Morgana Araujo, Magna S. Alexandre-Moreira, Raiza R. L. Rodrigues, Klinger A. F. Rodrigues, Johnnatan D. Freitas, Jacques Bricard, Mario R. Meneghetti, Jean-Jacques Bourguignon, Martine Schmitt, Edeildo F. da Silva-Junior, Joao X. de Araujo-Junior
Summary: This study aimed to address the side effects and drug resistance issues in the treatment of leishmaniasis by designing and synthesizing different compounds and performing screening for their antileishmanial activity and cytotoxicity. The study found that certain compounds showed potential antileishmanial activity and inhibitory effects on trypanothione reductase of the amastigote forms.
MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Igor G. O. Lima, James R. S. Bispo, Adson Y. H. Agostinho, Aline C. De Queiroz, Magna Suzana A. Moreira, Michel Rodrigo Z. Passarini, Valeria M. De Oliveira, Lara D. Sette, Luiz Henrique Rosa, Alysson Wagner F. Duarte
Summary: This review explores the potential and unique characteristics of enzymes synthesized by Antarctic bacteria and fungi as potential drug producers, highlighting their importance in providing therapeutic efficacy, reducing side effects, and lowering production costs.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Cell Biology
Max Denisson Mauricio Viana, Alyne Almeida de Lima, Geraldo Jose da Silva Neto, Suellen Maria Albuquerque da Silva, Anderson Brandao Leite, Elane Conceicao dos Santos, Enio Jose Bassi, Eliane Aparecida Campesatto, Aline Cavalcanti de Queiroz, Eliezer Jesus Barreiro, Lidia Moreira Lima, Magna Suzana Alexandre-Moreira
Summary: Pain and inflammatory disorders are common health problems that can cause disabilities. LASSBio-596, a hybrid compound, has been found to have anti-inflammatory effects by modulating TNF-alpha and phosphodiesterases 4 and 5 in a pulmonary inflammatory model. Through various tests, it was demonstrated that LASSBio-596 can inhibit pain and inflammation, specifically reducing paw edema in arthritis and decreasing serum levels of TNF-alpha.
Article
Dentistry, Oral Surgery & Medicine
Daniela Paola Santos de Paula Souza, Lorena dos Reis Pereira Queiroz, Marcela Goncalves de Souza, Sabrina Ferreira de Jesus, Emisael Stenio Batista Gomes, Rogerio Trancoso Vitorino, Sergio Henrique Sousa Santos, Lucyana Conceicao Farias, Alfredo Mauricio Batista de Paula, Marcos Flavio Silveira Vasconcelos D'Angelo, Carlos Alberto de Carvalho Fraga, Andre Luiz Sena Guimaraes
Summary: By analyzing differentially expressed genes, we found that CSTA, FGFR2, MMP19, OLR1, PCSK1, RAMP2, and CGB5 are associated with a low survival rate in OSCC and may serve as potential prognostic factors for OSCC survival.
Article
Pharmacology & Pharmacy
Joao Paulo Noe, Jamylle Nunes De Souza-Ferro, Erica Erlanny Da Silva-Rodrigues, Edeildo Ferreira Da Silva-Junior, Magna Suzana Alexandre-Moreira, Joao Xavier De Araujo-Junior, Emiliano Barreto
Summary: In this study, a compound called LQM10 was found to have antinociceptive and anti-inflammatory effects in mice. LQM10 reduced nociceptive behavior in certain pain models and inhibited inflammatory responses in carrageenan-induced pleurisy. These results suggest that LQM10 has potential as a treatment for pain and inflammation by acting on peripheral mechanisms and reducing leucocyte migration and proinflammatory mediators.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Parasitology
Lilyana Waleska Nunes Albuquerque, Shakira Cavalcante de Albuquerque Ferreira, Marcio Thomaz dos Santos Varja, Amanda Evelyn da Silva, Alysson Wagner Fernandes Duarte, Glauber T. Silva, Magna Suzana Alexandre-Moreira, Aline Cavalcanti de Queiroz
Summary: This study conducts a patent prospection of immunodiagnostic methods for human tegumentary leishmaniasis in the last 10 years, focusing on those with high sensitivity and specificity, and simple usability. Eleven patents were found that satisfy the search criteria, with six of them being registered in 2017. Most patents were registered in Brazil. The obtained information covers the main characteristics of the evaluated immunodiagnostic methods. Moreover, no patent for immunodiagnostic methods was found in the last three years, raising concerns about the present and future trends of leishmaniasis diagnosis.
Article
Microbiology
Layssa de Melo Carlos, Karine Fernandes Camacho, Alysson Wagner Duarte, Valeria M. de Oliveira, Marcela Boroski, Luiz Henrique Rosa, Rosemary Vieira, Arthur A. Neto, Julia Ronzella Ottoni, Michel R. Z. Passarini
Summary: Microorganisms in the cold Antarctic environment have the potential to produce ligninolytic enzymes that can be used in bioremediation. This study characterized bacteria and fungi from marine sediment samples from King George and Deception Islands in Antarctica, which may be affected by hydrocarbon pollution and able to produce enzymes for bioremediation processes. Certain isolates showed tolerance to diesel oil and gasoline, as well as enzymatic activities for dye degradation. Taxonomic characterization identified two isolates (Psychrobacter sp. BAD17 and Cladosporium sp. FAR18) with better biotechnological results, exhibiting pyrene tolerance and laccase enzymatic activity. These findings suggest that bacteria and fungi in sediments under potential hydrocarbon pollution can be used to bioremediate cold environments contaminated with petroleum derivatives and dyes.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Microbiology
Jessica B. Silva, Victor B. Centurion, Alysson W. F. Duarte, Rodrigo M. Galazzi, Marco A. Z. Arruda, Adilson Sartoratto, Luiz H. Rosa, Valeria M. Oliveira
Summary: This study investigated the genetic potential of Antarctic soil microorganisms for hydrocarbon degradation, and found that the abundant hydrocarbon-degrading genes in Antarctic sediments were mainly affiliated with Proteobacteria and Actinobacteria. The study also revealed that hydrocarbon input in Antarctic soils may come from both anthropogenic and natural sources.
FEMS MICROBIOLOGY ECOLOGY
(2022)
Review
Multidisciplinary Sciences
Mauricio B. Silva, Alexya O. Feitosa, Igor G. O. Lima, James R. S. Bispo, Ana Caroline M. Santos, Magna S. A. Moreira, Paulo E. A. S. Camara, Luiz Henrique Rosa, Valeria M. Oliveira, Alysson W. F. Duarte, Aline C. Queiroz
Summary: Antimicrobial resistance is a global public health issue, and the exploration of Antarctic organisms could be a valuable source of new antimicrobial compounds. Despite the limited number of patent documents currently available, there is a wide variety of antimicrobial compounds present in Antarctic biota, which show potential for combating important human pathogens.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
