Review
Biochemistry & Molecular Biology
Pavel E. Z. Klier, Ryan Roo, Evan W. Miller
Summary: This article surveys recent advances in developing and deploying voltage-sensitive fluorescent indicators to interrogate organelle membrane potential in intact cells.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Andrey S. Klymchenko
Summary: Biomembranes, as lipid structures, play a crucial role in cellular processes. The development of chemical tools, such as fluorescent probes, for sensing and imaging biomembranes is a rapidly growing field. This Account focuses on advances in smart molecules for membrane targeting and sensing, with a particular emphasis on plasma membranes and organelles.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Dmytro Danylchuk, Pierre-Henri Jouard, Andrey S. Klymchenko
Summary: A series of solvatochromic probes have been designed for specific targeting of different organelles in live cells, allowing the detection of variations in lipid order and quantitative description of lipid order in each organelle. These probes revealed the characteristics of organelles under stress conditions, with mitochondria and lysosomes particularly sensitive to stress. The new probes provide a powerful toolbox for monitoring cellular response to physical and chemical stimuli at the level of individual organelle membranes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Subhadeep Das, Abhilasha Batra, Subhankar Kundu, Rati Sharma, Abhijit Patra
Summary: By employing time-resolved imaging and DC-Lyso fluorescent probe, we investigated the dynamic polarity of lysosomes in live cells and nematodes. DC-Lyso rapidly labels lysosomes and exhibits polarity-sensitive long lifetime. The changes in fluorescence lifetime of DC-Lyso suggest an increase in local polarity during lysosomal dynamics and interorganelle interactions.
Article
Chemistry, Analytical
Huamiao Zhang, Xiuquan He, Xuechen Li, Lifang Guo, Fangfang Meng, Rui Yang, Chuanya Li, Zhiqiang Liu, Xiaoqiang Yu
Summary: The novel permeability-controllable potentiometric fluorescent probes can visually discriminate near-zero and normal situations of cell membrane potential, using two fluorescent images with distinct differences to indicate the two situations point-to-point, thus avoiding complex operations and calibrations of conventional methods.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Hyo Won Lee, Vinayak Juvekar, Dong Joon Lee, Hwan Myung Kim
Summary: Biological events occur in specific cellular organelles to perform specialized roles in cells and collaborate with other organelles. Various methods have been used to study organelle dynamics, including two photon microscopy. This review focuses on the design strategies, photo-physical properties, and bioimaging applications of recent two-photon probes specifically localized in the endoplasmic reticulum, Golgi, lipid droplets, lysosomes, plasma membrane, and mitochondria. The summary is limited to research from 2017 onwards. © 2023 Elsevier B.V. All rights reserved.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Xiao-Xiao Chen, Felix Bayard, Nerea Gonzalez-Sanchis, Khurnia Krisna Puji Pamungkas, Naomi Sakai, Stefan Matile
Summary: Flipper probes have been introduced as small molecule fluorophores for imaging physical forces in living systems. The article describes their evolution in design and synthesis as well as their spectroscopic properties. Mechanosensitivity to image membrane tension in living cells is identified as their ideal origin. A variety of flippers have been developed for specific delivery and release in subcellular membranes, enabling super-resolution imaging and dual-sensing of membrane compression and hydration. The availability and broad use of flipper probes validate their power in translational supramolecular chemistry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Saki Matsumoto, Naoki Sugimoto
Summary: The canonical structure of nucleic acids is the right-handed double-helical B-form structure, but they can also form various non-canonical structures influenced by both sequence and surrounding environment. These non-canonical structures may exhibit diverse biological functions by changing their structures in response to specific cellular environments.
TOPICS IN CURRENT CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zheming Zhang, Shuxian Yang, Baoli Dong, Xiuqi Kong, Minggang Tian
Summary: In this study, a robust fluorescent probe was successfully constructed to selectively illuminate lipid droplets, mitochondria, and lysosomes with different emission colors. The interactions between these organelles were investigated, and the critical roles of lysosomes and lipid droplets in mitochondrial fission were revealed. Additionally, the probe enabled the identification of different stages of cell apoptosis through the fading of specific emission colors.
Article
Materials Science, Biomaterials
Yi Wang, Tong Lei, Jinghui Zhang, Lei Gong, Yanjie Yang, Xiaolin Ma, Yongqiang Wen, Hongwu Du, Dongdong Qi, Yongzhong Bian, Zhiqiang Liu, Jianzhuang Jiang
Summary: A new two-photon fluorescent viscosity rotor combining an electron-rich unit with an electron-deficient fluorophore was developed for ratiometric two-photon fluorescent detection of intracellular viscosity. The rotor showed sensitive fluorescence responses to changes in viscosity in a methanol/glycerol system, and also displayed good cell imaging performance and targeting ability in living cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Pavel E. Z. Klier, Anneliese M. M. Gest, Julia G. Martin, Ryan Roo, Marisol X. Navarro, Lauren Lesiak, Parker E. Deal, Neville Dadina, Jonathan Tyson, Alanna Schepartz, Evan W. Miller
Summary: This study presents the design, synthesis, and application of LUnAR RhoVR, an optical detector for monitoring membrane potential changes in the endoplasmic reticulum (ER) of living cells. By combining a fluorescence probe with molecules that target the ER, voltage changes in the ER can be accurately observed. The study validates the electroneutrality of calcium release and provides direct evidence of the ER potential response to plasma membrane potential changes. This research offers a new tool for exploring organelle physiology.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Javier Lopez-Andarias, Krikor Eblighatian, Quentin T. L. Pasquer, Lea Assies, Naomi Sakai, Sascha Hoogendoorn, Stefan Matile
Summary: Researchers have introduced photocleavable flipper probes that can release and label the most ordered regions of membranes upon irradiation. These probes provide spatiotemporal control for observing dynamic changes in membranes without chemical or physical interference, making them useful tools for biological research.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Javier Lopez-Andarias, Krikor Eblighatian, Quentin T. L. Pasquer, Lea Assies, Naomi Sakai, Sascha Hoogendoorn, Stefan Matile
Summary: Mechanosensitive flipper probes, such as PhotoFlippers, containing a photocleavable linker and an ultralong tether, are able to release and label the most ordered membrane accessible by intermembrane transfer upon irradiation. This spatiotemporal control is essential for accessing open, dynamic or elusive membrane motifs without chemical or physical interference. PhotoFlippers have been shown to be useful chemistry tools for studying changes in membrane tension, membrane trafficking, and membrane asymmetry in biological systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Francesca Piazzolla, Vincent Mercier, Lea Assies, Naomi Sakai, Aurelien Roux, Stefan Matile
Summary: Researchers have developed a rational strategy to target early endosomes using a substituted benzylamine with a higher pKa value as the head group of flipper probes. This allows for preserved mechanosensitivity and can be used to elucidate the mechanics of endocytosis in biology.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Xue Tian, Lloyd C. Murfin, Luling Wu, Simon E. Lewis, Tony D. James
Summary: Small-molecule based fluorescent probes play an increasingly important role in detecting and imaging biological signaling molecules due to their simplicity, high selectivity, and real-time analysis capabilities. Various sensing mechanisms, including FRET, ICT, PeT, ESIPT, AIE, as well as dual/triple sensing mechanisms, are highlighted, but challenges remain. Future development should focus on improving small-molecule fluorescent probes for biosensing applications.
Review
Chemistry, Inorganic & Nuclear
Pegah Hajivand, Johannes Carolus Jansen, Emilio Pardo, Donatella Armentano, Teresa F. Mastropietro, Amirreza Azadmehr
Summary: VOCs in human breath can be used as biomarkers for diseases, and MOFs have been extensively studied as gas sensors for VOCs. This review provides a comprehensive summary of the latest MOF-derived composites used as VOCs biomarkers' sensors, and discusses the structural and functional characteristics of MOFs, sensing properties, and the potential of bio-MOFs in VOCs sensing.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shudi Liu, Liangwei Zhang, Heejeong Kim, Jinyu Sun, Juyoung Yoon
Summary: Chromium is a strategic and critical transition metal element with extensive applications. Efficient detection methods, such as fluorescence and colorimetry, have been developed for monitoring its concentrations. However, existing reviews on fluorescent probes for chromium lack comprehensive coverage. This review aims to consolidate information and promote the development of novel fluorescent probes for chromium detection.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour
Summary: Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Priyadarshi Roy Chowdhury, Himani Medhi, Krishna G. Bhattacharyya, Chaudhery Mustansar Hussain
Summary: This review critically analyzes the production of waste-derived layered double hydroxides (LDH) and their utility in electrochemical water splitting for the generation of green hydrogen as sustainable energy. It highlights the importance of waste-derived LDH and discusses the challenges and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rajamanickam Sivakumar, Nae Yoon Lee
Summary: This article reviews the progress in imaging reactive oxygen, nitrogen, and sulfur species (RONSS) using luminescent metal complex-based probes. This technology is selective and sensitive, which is of great significance for studying the impact of RONSS in cells and tissues and preventing diseases.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Xinyang Li, Binbin Ding, Pan Zheng, Ping'an Ma, Jun Lin
Summary: The main goal of immunotherapy is to enhance the response and cytotoxicity of tumor-specific T cells by turning cold tumors into hot tumors. However, metabolic reprogramming in the tumor microenvironment can depress the cytotoxicity of T cells and hinder the effectiveness of immunotherapy. This review discusses the role of metabolic reprogramming in the interplay between cancer cells and immune cells in the tumor microenvironment and explores the use of nanomaterials to modulate metabolic pathways and improve immunotherapy outcomes.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Reza Abedi-Firoozjah, Hadiseh Ebdali, Mahya Soltani, Parastoo Abdolahi-Fard, Mahshid Heydari, Elham Assadpour, Maryam Azizi-Lalabadi, Fuyuan Zhang, Seid Mahdi Jafari
Summary: With the increasing awareness of food safety, there is a growing demand for efficient and affordable sensing methods for the detection of pathogens and toxins in food products. Nanosensors offer promising solutions with their quick and reliable detection capabilities, although challenges remain in their fabrication and practical application.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Li Li, Yang-Tao Yu, Ning-Ning Zhang, Shu-Hao Li, Jian-Ge Zeng, Yang Hua, Hong Zhang
Summary: This article summarizes recent advances in POM-based hybrid photochromic materials (PCHPMs), including structure types, new photochromic mechanisms, and applications. It can provide valuable guidance for researchers investigating POM-based hybrid photochromic materials.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Chien Ing Yeo, Clariss Hui Peng Goh, Edward R. T. Tiekink, Jactty Chew
Summary: This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Sangharaj Diyali, Nilankar Diyali, Bhaskar Biswas
Summary: This study discusses the recent progress in the design and development of catalysts, focusing on the factors influencing overpotential, catalytic rate, and stability, as well as the mechanisms of the hydrogen evolution reaction in acidic and alkaline media. Moreover, it outlines the challenges in future design of robust and active electrocatalysts.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shaik Gouse Peera, Rahul S. Menon, Sumanta Kumar Das, Akram Alfantazi, K. Karuppasamy, Chao Liu, Akhila Kumar Sahu
Summary: Doped carbon materials, especially F-doped carbon catalysts, have gained significant attention as metal-free catalysts for oxygen reduction reactions and as corrosion-resistant supports for Pt and non-Pt nanoparticles. F-doped carbon materials possess unique properties and greatly improve the activity and durability of the ORR compared to N-doped carbon materials. The high electronegativity of F-doping can efficiently modify the electronic band structure of carbon materials, favoring the ORR. This review systematically discusses the effect of F-doping/F co-doping on the electrocatalytic reduction of O2 in acidic and alkaline conditions, the stability and durability of fuel cell catalysts, and provides guidelines for working with F-doped carbons. Future research directions on F-doped carbons are also proposed to bridge the gap between laboratory-scale assessments and commercial applications.
COORDINATION CHEMISTRY REVIEWS
(2024)