Journal
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
Volume 213, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cmpb.2021.106497
Keywords
subcortical vascular dementia; computational fluid dynamics; cerebrovascular hemodynamics
Categories
Funding
- National Natural Science Foundation of China [81830040, 82130042, 81661168015, 61703017, 81871447]
- National Key Research and Development Plan of China [2016YFC1306700]
- Science and Technology Program of Guangdong [2018B030334001]
- Program of Excellent Talents in Medical Science of Jiangsu Province [JCRCA2016006]
- Shenzhen Science and Technology Innovation Commission [ZDSYS201703031711426]
Ask authors/readers for more resources
The study utilized a computational fluid dynamics (CFD) approach to detect cerebral hemodynamics, revealing that SVaD patients had reduced outlets, CAV, and tCBF index, along with an increased tCVR index compared to CNCs. Fewer outlets and more WMH were identified as risk factors for SVaD, partially mediated by the tCBF index.
Background: Cerebral hemodynamic disorders are involved in the occurrence and progression of vascular dementia (VaD), but the methods to detect hemodynamics remainmultifarious and uncertain nowadays. We aim to exploit a computational fluid dynamics (CFD) approach by static and dynamic parameters, which can be used to detect individual cerebrovascular hemodynamics quantitatively. Methods: A patient-specific CFD model was constructed with geometrical arteries on the magnetic resonance angiography (MRA) and hemodynamic parameters on ultrasound Doppler, by which, the structural and simulated hemodynamic indexes could be obtained, mainly including the cerebral arterial volume (CAV), the number of visible arterial outlets, the total cerebral blood flow (tCBF) index and the total cerebrovascular resistance (tCVR) index. The hemodynamics were detected in subcortical vascular dementia (SVaD) patients ( n = 38) and cognitive normal controls (CNCs; n = 40). Results: Compared with CNCs, the SVaD patients had reduced outlets, CAV and tCBF index (all P < 0.001), increased volume of white matter hyperintensity (WMH) and tCVR index (both P < 0.01). The fewer outlets ( OR = 0.77), higher Hachinski ischemic score (HIS) ( OR = 3.65), increased tCVR index ( OR = 1.98) and volume of WMH ( OR = 1.12) were independently associated with SVaD. All hemodynamic parameters could differentiate the SVaD patinets and CNCs, especially the composite index calculated by outlets, tCVR index and HIS (AUC = 0.943). Fewer outlets and more WMH increased the odds of SVaD, which were partly mediated by the tCBF index (14.4% and 13.0%, respectively). Conclusion: The reduced outlets, higher HIS and tCVR index may be independent risk factors for the SVaD, and a combination of these indexes can differentiate SVaD patients and CNCs reliably. The tCBF index potentially mediates the relationships between hemodynamic indexes and SVaD. Although all simulated indexes only represented the true hemodynamics indirectly, this CFD model can provide patient specific hemodynamic alterations non-invasively and conveniently. (c) 2021 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available