Article
Radiology, Nuclear Medicine & Medical Imaging
Jeanne B. Ackman, Wariya Chintanapakdee, Dexter P. Mendoza, Melissa C. Price, Michael Lanuti, Jo-Anne O. Shepard
Summary: The study evaluated the longitudinal change in appearance of thymic cysts at CT and MRI, finding that most cysts undergo changes in volume, density, and MRI signal over more than 5 years of follow-up.
Article
Medicine, General & Internal
Shuhei Doi, Masahiro Yanagawa, Takahiro Matsui, Akinori Hata, Noriko Kikuchi, Yuriko Yoshida, Kazuki Yamagata, Keisuke Ninomiya, Shoji Kido, Noriyuki Tomiyama
Summary: This study evaluated thymic epithelial tumors using three-dimensional iodine density histogram texture analysis on dual-energy CT and found that extracellular volume fraction (ECV) related to fibrosis can predict thymic carcinoma, while the iodine effect can predict high-risk thymoma.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Marco Chiappetta, Paolo Mendogni, Margherita Cattaneo, Jessica Evangelista, Piero Farina, Daniele Antonio Pizzuto, Salvatore Annunziata, Angelo Castello, Maria Teresa Congedo, Diomira Tabacco, Carolina Sassorossi, Massimo Castellani, Mario Nosotti, Stefano Margaritora, Filippo Lococo
Summary: Thymic epithelial tumours are rare and insidious malignancies that can be histologically classified into different WHO subtypes. (18)FDG PET/CT scan has been reported to play a remarkable role in predicting histology in these tumours. This narrative review summarizes the current evidence on this topic and discusses potential applications.
Review
Oncology
Krisztian Suveg, Paul Martin Putora, Markus Joerger, Thomas Iseli, Galina Farina Fischer, Karlheinz Ammann, Markus Glatzer
Summary: Surgery is the preferred treatment for TETs, with the role of postoperative radiotherapy still debated. The treatment approach varies for different stages of thymomas, with radiotherapy playing an important role in the management of unresectable locally advanced TETs.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Review
Cell Biology
Jan von der Thusen
Summary: The thymus can give rise to a wide variety of tumors, some of which are similar to tumors in other organs, while others are unique to the thymus. Differential diagnosis, prognosis, and treatment of thymic epithelial tumors can be determined by morphology, immunohistochemistry, and molecular diagnostics.
Article
Oncology
Joohee Lee, Young Seok Cho, Jhingook Kim, Young Mog Shim, Kyung-Han Lee, Joon Young Choi
Summary: This study retrospectively reviewed data from 83 patients with thymic epithelial tumors who underwent pretreatment F-18-FDG PET/CT, and found that SUVavg and Masaoka stage were independent prognostic factors for progression-free survival in thymic epithelial tumors.
Review
Oncology
Filippo Lococo, Marco Chiappetta, Elizabeth Katherine Anna Triumbari, Jessica Evangelista, Maria Teresa Congedo, Daniele Antonio Pizzuto, Debora Brascia, Giuseppe Marulli, Salvatore Annunziata, Stefano Margaritora
Summary: Thymic epithelial tumours are rare malignancies that can be distinguished into different subtypes and relapse risk classes. Surgery, often followed by induction therapy, is the preferred treatment option with long-term outcomes depending on disease stage and resection completeness. The use of F-18 FDG PET CT scan has shown promise in predicting malignancy grade, treatment response, disease stage, and future applications in thymic epithelial tumours.
Article
Radiology, Nuclear Medicine & Medical Imaging
Liangna Deng, Jingjing Yang, Mengyuan Jing, Bin Zhang, Tao Han, Yuting Zhang, Junlin Zhou
Summary: The study aimed to explore the importance of quantitative characteristics of spectral CT in differentiating between invasive thymic epithelial tumors (TETs) and mediastinal lung cancer. By analyzing 54 patients who underwent spectral CT, the study compared clinical findings and spectral CT parameters of both groups and evaluated the diagnostic efficacy and optimal cutoff values of the parameters. The results showed that spectral CT imaging has potential value in the differential diagnosis of invasive TETs and mediastinal lung cancer.
JAPANESE JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiuling Shen, Xin Zhou, Yuan Yao, Xiangxi Meng, Yufei Song, Zhi Yang, Nan Li
Summary: The purpose of this study was to compare the abilities of [Ga-68]Ga-DOTA-FAPI-04 PET/CT and [F-18]FDG PET/CT to stratify the malignancy and invasiveness of thymic epithelial tumours (TETs). Clinical characteristics, CT features, and metabolic parameters of subjects with different pathological types and stages were compared. The results showed that [Ga-68]Ga-DOTA-FAPI-04 PET/CT was superior to [F-18]FDG PET/CT in differentiating thymomas from thymic carcinomas (TCs).
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Shuai Wang, Jiahao Jiang, Jian Gao, Gang Chen, Yue Fan, Bei Xu, Jihong Dong, Shisuo Du, Junzhen Liu, Jianyong Ding
Summary: This study aimed to explore the treatment of unresectable thymic epithelial tumors (TETs) through induction therapy followed by surgery. The results showed a high tumor response rate and resection rate. Multivariate analysis revealed that TNM stage, Masaoka stage, complete resection, and tumor response were significant independent prognostic factors. The study also found that different induction modalities and downstaging of tumor stage did not significantly affect survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chunhai Yu, Ting Li, Xiaotang Yang, Ruiping Zhang, Lei Xin, Zhikai Zhao, Jingjing Cui
Summary: In this study, a radiomics model based on contrast-enhanced CT scans was developed to differentiate various risk subgroups of thymic epithelial tumors. The model performed better when using an improved risk grouping approach.
BMC MEDICAL IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Zi-Ming Wang, Feng Li, Lara Sariguel, Dania Nachira, Diego Gonzalez-Rivas, Harun Badakhshi, Jens-C Rueckert, Calvin S. H. Ng, Mahmoud Ismail
Summary: Thymic epithelial tumours (TETs) are relatively rare cancers in the mediastinum. Lymph node metastasis (LNM) is an important factor affecting the prognosis of TETs. This study aimed to investigate the pattern of LNM in TETs and identify the factors associated with LNM. The results showed that the rate of LNM in thymoma, thymic carcinomas, and thymic neuroendocrine tumours was 6.8%, 30.2%, and 61.1%, respectively. Histology type and T stage were found to be independent factors correlated with LNM.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Multidisciplinary Sciences
Haiyang Dai, Bowen Lan, Shengkai Li, Yong Huang, Guihua Jiang, Junzhang Tian
Summary: This study aimed to determine the prognostic CT features in patients with untreated thymic epithelial tumors (TETs). It was found that vessel invasion and pericardial mass were independent predictors for poor outcomes in patients with thymic carcinoma, while pericardial mass was an independent predictor in high-risk thymoma. Features including lung invasion, great vessel invasion, lung metastasis, and distant organ metastasis indicated worse survival in thymic carcinoma, whereas lung invasion and pericardial mass indicated worse survival in high-risk thymoma. In conclusion, CT can serve as an important tool for predicting the prognosis and survival of patients with TETs.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Jiatong Li, Nan Cui, Zhiyun Jiang, Wei Li, Wei Liu, Shuai Wang, Kezheng Wang
Summary: Clinical feasibility nomograms were developed to differentiate between thymic epithelial tumors (TETs) and mediastinal lymphomas (MLs), aiming to minimize unnecessary thymectomy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Chengzhou Zhang, Qinglin Yang, Fan Lin, Heng Ma, Haicheng Zhang, Ran Zhang, Ping Wang, Ning Mao
Summary: The study developed a radiomics nomogram using CT images to distinguish between anterior mediastinal thymic cysts and thymic epithelial tumors. The nomogram outperformed other models and clinical judgment, with high accuracy in both training and validation cohorts, providing a valuable tool for clinical decision-making.
FRONTIERS IN ONCOLOGY
(2021)