Article
Immunology
Wanich Suksatan, Supat Chupradit, Alexei Valerievich Yumashev, Sahithya Ravali, Mohammed Nader Shalaby, Yasser Fakri Mustafa, Anatoley Kurochkin, Homayoon Siahmansouri
Summary: SARS-CoV-2 causing COVID-19 is associated with MIS-C, characterized by classic inflammation symptoms, multi-organ dysfunction, and fever with no specific treatment identified. MSCs show potential in reducing disease inflammation and severity, offering promise for treating MIS-C.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Einat Blumfield, Terry L. Levin, Jessica Kurian, Edward Y. Lee, Mark C. Liszewski
Summary: This study evaluated imaging findings of MIS-C associated with COVID-19 in 16 pediatric patients. The most common presenting symptoms were fever, vomiting, abdominal pain, rash, conjunctivitis, and diarrhea. Imaging studies showed cardiovascular abnormalities as well as solid visceral organ, gallbladder, and bowel abnormalities.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Review
Pediatrics
Alanood S. Algarni, Njoud M. Alamri, Noor Z. Khayat, Raghad A. Alabdali, Rawabi S. Alsubhi, Shahad H. Alghamdi
Summary: The study compares and evaluates current clinical practice guidelines for MIS-C from different institutions. The features of MIS-C patients are found to be consistent, which helps in managing symptoms and reducing mortality rates. The study also proposes a unified guideline for pharmacological treatment based on cross-comparison of different guidelines.
WORLD JOURNAL OF PEDIATRICS
(2022)
Article
Infectious Diseases
Istemi Serin, Nagehan Didem Sari, Murat Gunaltili, Ayse Karakilic, Begum Gulesir, Beyza Kal Kolik, Gulnihal Cevik, Hilal Sungurlu, Melike Keskin, Muhammed Baltik, Onurhan Cakmak, Tahir Alper Cinli
Summary: This study aimed to determine the effect of LDH/lymphocyte ratio (LLR) on the development of MIS-A. The results showed that LLR level can predict the development of MIS-A, and LLR above 0.32 can predict the mortality rate of MIS-A patients.
BMC INFECTIOUS DISEASES
(2022)
Review
Cardiac & Cardiovascular Systems
Shekhar Kunal, Pranav Ish, Pirabu Sakthivel, Nipun Malhotra, Kashish Gupta
Summary: MIS-A is a newly identified disease, predominantly affecting males with common symptoms of fever and skin rash. Cardiovascular system involvement is frequent, and treatment typically includes steroids and immunoglobulins. The average hospital stay is 11.67 days with a mortality rate of 5.1% during hospitalization.
Article
Biochemistry & Molecular Biology
Marcela Kreslova, Petr Jehlicka, Aneta Sykorova, Daniel Rajdl, Eva Klaskova, Pavel Prokop, Sabina Kapralova, Jan Pavlicek, Romana Kaslova, Alzbeta Palatova, Veronika Mohylova, Josef Sykora
Summary: The study observed evidence of endothelial dysfunction and altered endothelial biomarkers in patients after MIS-C. Serum cystatin C (Cys C) levels were identified as an independent indicator for endothelial dysfunction in MIS-C.
Article
Medicine, General & Internal
Abdullah Aldawas, Mateen Ishfaq
Summary: A novel coronavirus, COVID-19, emerged in late 2019 and quickly became a global pandemic. While COVID-19 in children is usually mild, rare cases have shown symptoms similar to incomplete Kawasaki disease or toxic shock syndrome. This condition is known as multisystem inflammatory syndrome in children (MIS-C). We report the case of a 12-year-old boy who presented with fever, skin rash, conjunctivitis, and multiorgan dysfunction, diagnosed as MIS-C with a positive COVID-19 polymerase chain reaction (PCR) test. The patient received treatment including intravenous immunoglobulin (IVIG) and showed improvement.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Figen Palabiyik, Nihal Akcay, Esra Sevketoglu, Nevin Hatipoglu, Emine Ergul Sari, Ercan Inci
Summary: The radiological findings in MIS-C in pediatric cases are correlated with the affected system, with no specific findings for this disease. While radiological findings are not the primary diagnostic tool, they can assist in evaluating the affected systems and guiding treatment.
ACADEMIC RADIOLOGY
(2021)
Article
Immunology
Tina Y. Poussaint, Kerri L. LaRovere, Jane W. Newburger, Janet Chou, Lise E. Nigrovic, Tanya Novak, Adrienne G. Randolph
Summary: A 12-year-old boy developed acute encephalopathy and other symptoms after receiving the COVID-19 vaccine, suggesting a potential immune-related reaction. After treatment, the boy recovered and his symptoms disappeared.
Article
Obstetrics & Gynecology
Moti Gulersen, Cara Staszewski, Evelina Grayver, Hima Tam Tam, Eric Gottesman, Donnie Isseroff, Burton Rochelson, Clarissa Bonanno
Summary: Multisystem inflammatory syndrome in adults associated with COVID-19 in pregnancy is a critical illness, presenting several weeks after initial infection. Treatment with intravenous immunoglobulin and corticosteroids was associated with a favorable outcome.
OBSTETRICS AND GYNECOLOGY
(2021)
Review
Infectious Diseases
Jennifer van Heerden, Jeremy Nel, Pramodhini Moodley, Preesha Govender, Jonathan Hooijer, Claudia Ickinger, Sa'ad Lahri, Elizabeth Louw, Helena Rabie, Denasha Reddy, Jacob Tsitsi, Michelle Venter, Arifa Parker
Summary: This study aimed to provide descriptive data on multisystem inflammatory syndrome temporally associated with COVID-19 in adults and adolescents from low- and middle-income countries. The study found that fever, gastrointestinal symptoms, cardiorespiratory abnormalities, and mucocutaneous findings were common in patients with MIS.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Gavriela Feketea, Vasiliki Vlacha, Ioana Corina Bocsan, Emilia Vassilopoulou, Luminita Aurelia Stanciu, Mihnea Zdrenghea
Summary: This article discusses the role of vitamin D in viral infections, as well as its association with MIS-C and Kawasaki disease. It emphasizes the importance of vitamin D levels in predicting the severity of MIS-C.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Tamas Constantin, Tamas Pek, Zsuzsanna Horvath, Diana Garan, Attila J. Szabo
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has had a significant impact globally, resulting in widespread illness and death. While children are less susceptible to infection and tend to have milder symptoms, they can still develop serious complications such as MIS-C. This review provides an overview of the epidemiology, immune pathology, and genetics of SARS-CoV-2 infection and MIS-C in children, with implications for personalized medicine and vaccination strategies.
INFLAMMOPHARMACOLOGY
(2023)
Editorial Material
Medicine, Research & Experimental
Dinah V. Parums
Summary: MIS-C is a rare multisystem inflammatory syndrome that occurs in children and adolescents following COVID-19 infection. The CDC and ACR have updated guidelines to address the characteristics of this syndrome. However, challenges persist due to the rapid emergence of new strains of the coronavirus.
MEDICAL SCIENCE MONITOR
(2021)
Article
Virology
Yan Zhao, Lijuan Yin, Jenil Patel, Lei Tang, Ying Huang
Summary: This study analyzed inflammatory markers in children with multisystem inflammatory syndrome (MIS-C) compared to those with COVID-19, showing significant differences in severity among MIS-C patients. The measurement of inflammatory markers may assist clinicians in accurately evaluating and diagnosing MIS-C and associated disorders.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Neil Murthy, Ryan Saelee, Bhavini Patel Murthy, Lu Meng, Lauren Shaw, Lynn Gibbs-Scharf, LaTreace Harris, Terence Chorba, Elizabeth Zell
Summary: In summer 2021, COVID-19 vaccination rates increased during the surge of the Delta variant, but remained lower in areas with previously low coverage. Efforts are needed to improve access to and confidence in COVID-19 vaccines in low-coverage areas.
PUBLIC HEALTH REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Kimberly E. Bonner, Kushagra Vashist, Neetu S. Abad, Jennifer L. Kriss, Lu Meng, James T. Lee, Elisabeth Wilhelm, Peng-Jun Lu, Rosalind J. Carter, Kwanza Boone, Brittney Baack, Nina B. Masters, Debora Weiss, Carla Black, Qian Huang, Sitaram Vangala, Christina Albertin, Peter G. Szilagyi, Noel T. Brewer, James A. Singleton
Summary: This study examined the associations between behavioral and social drivers of vaccination with COVID-19 vaccine uptake in U.S. adults and their prevalence by region. The study found that greater anticipated regret, risk perception, and confidence in vaccine safety and importance were the factors most strongly associated with vaccine uptake.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Immunology
Anna R. Yousaf, Amber Kunkel, Joseph Y. Abrams, Ami B. Shah, Teresa A. Hammett, Kathryn E. Arnold, Yajira L. Beltran, Federico R. Laham, Carol M. Kao, David A. Hunstad, Laila Hussaini, Nadine Baida, Luis Salazar, Maria A. Perez, Christina A. Rostad, Shana Godfred-Cato, Angela P. Campbell, Ermias D. Belay
Summary: This study described the characteristics associated with COVID-19 vaccination, vaccine adverse events, and vaccine attitudes in children with a history of MIS-C or COVID-19. The results showed that COVID-19 vaccination was well tolerated in children with prior MIS-C or COVID-19, and parents/guardians regarded their children's doctors as a trusted source of information for COVID-19 vaccines.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Lu Meng, Nina B. Masters, Peng-Jun Lu, James A. Singleton, Jennifer L. Kriss, Tianyi Zhou, Debora Weiss, Carla L. Black
Summary: By the end of 2021, 15% of U.S. adults remained unvaccinated against COVID-19, and vaccination initiation rates had stagnated. Researchers used unsupervised machine learning to identify and compare clusters of unvaccinated respondents based on behavioral and social factors. The study identified three subgroups of unvaccinated adults and provided insights for tailoring messaging and policy interventions.
PREVENTIVE MEDICINE
(2023)
Correction
Infectious Diseases
Anne M. Kjemtrup, Kerry Padgett, Christopher D. Paddock, Sharon Messenger, Jill K. Hacker, Tina Feiszli, Michael Melgar, Marco E. Metzger, Renjie Hu, Vicki L. Kramer
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Immunology
Michael Melgar, Joseph Y. Abrams, Shana Godfred-Cato, Ami B. Shah, Amit Garg, Andrew Strunk, Mangala Narasimhan, Jonathan Koptyev, Alexandra Norden, David Musheyev, Fahmida Rashid, Rachel Tannenbaum, Rosa M. Estrada-Y-Martin, Bela Patel, Siddharth Karanth, Chad J. Achenbach, Gavin T. Hall, Sara M. Hockney, Matthew Caputo, Lilian M. Abbo, Laura Beauchamps, Stephen Morris, Renzo O. Cifuentes, Annabelle de St Maurice, Douglas S. Bell, Kavitha K. Prabaker, Fernando J. Sanz Vidorreta, Evan Bryant, David K. Cohen, Rohith Mohan, Christopher P. Libby, Spencer SooHoo, Tristel J. Domingo, Angela P. Campbell, Ermias D. Belay
Summary: This retrospective cohort study compared the clinical manifestations and treatments of MIS-A patients with COVID-19 patients. The findings showed that MIS-A patients were more likely to have gastrointestinal symptoms and chest pain, had a higher mortality rate, and required longer hospitalization, more intensive care, and mechanical ventilation compared to COVID-19 patients.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Critical Care Medicine
Hugo Boechat Andrade, Ivan Rocha Ferreira da Silva, Rodolfo Espinoza, Mayara Secco Torres da Silva, Pedro Henrique Nascimento Theodoro, Marcel Treptow Ferreira, Jesus Soares, Ermias D. Belay, James J. Sejvar, Fernando Augusto Bozza, Jose Cerbino-Neto, Andre Miguel Japiassu
Summary: This study compared the performance of specialized infectious diseases ICUs with other ICUs in the treatment of community-acquired central nervous system infections (CNSI), and found that CNSI patients had lower mortality and resource use rates when treated in specialized infectious diseases ICUs.
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
J. Danielle Sharpe, Kelly Charniga, Katrina M. Byrd, Ruth Stefanos, Linda Lewis, Jessica Watson, Amanda Feldpausch, Jessica Pavlick, Julie Hand, Theresa Sokol, Emma Ortega, Preeti Pathela, Robin R. Hennessy, Melissa Dulcey, Lisa McHugh, Michael Pietrowski, Dana Perella, Seema Shah, Azarnoush Maroufi, Melanie Taylor, Anna Cope, Ermias D. Belay, Sascha Ellington, Andrea M. McCollum, Leah Zilversmit Pao, Sarah Anne J. Guagliardo, Patrick Dawson
Summary: The extent to which the 2022 mpox outbreak has affected individuals without recent history of male-to-male sexual contact is not clear, but findings suggest that sexual activity remains an important route of mpox exposure among patients who do not report such contact.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)
Article
Public, Environmental & Occupational Health
Emily Wong, Kira Barbre, Ryan E. Wiegand, Hannah E. Reses, Heather Dubendris, Megan Wallace, Philip Dollard, Jonathan Edwards, Minn Soe, Lu Meng, Andrea Benin, Jeneita M. Bell
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)
Article
Public, Environmental & Occupational Health
Krishna Kiran Kota, Harrell Chesson, Jaeyoung Hong, Carla Zelaya, Ian H. Spicknall, Aspen P. Riser, Elizabeth Hurley, Dustin W. Currie, R. Ryan Lash, Neal Carnes, Jeniffer Concepcion-Acevedo, Sascha Ellington, Ermias D. Belay, Jonathan Mermin
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)
Article
Public, Environmental & Occupational Health
Krishna Kiran Kota, Jaeyoung Hong, Carla Zelaya, Aspen P. Riser, Alexia Rodriguez, Daniel L. Weller, Ian H. Spicknall, Jennifer L. Kriss, Florence Lee, Peter Boersma, Elizabeth Hurley, Peter Hicks, Craig Wilkins, Harrell Chesson, Jeniffer Concepcion-Acevedo, Sascha Ellington, Ermias Belay, Jonathan Mermin
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)
Article
Immunology
Eleanor S. Click, Donald Malec, Jennifer R. Chevinsky, Guoyu Tao, Michael Melgar, Jennifer E. Giovanni, Adi Gundlapalli, S. Deblina Datta, Karen K. Wong
Summary: Using electronic health information, we compared pre- and post-COVID-19 diagnostic codes to identify symptoms that had higher encounter incidence in the post-COVID-19 period as sequelae. This method can be used for hypothesis generation and ongoing monitoring of sequelae of COVID-19 and future emerging diseases.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Jeneita Bell, Lu Meng, Kira Barbre, Emily Haanschoten, Hannah E. Reses, Minn Soe, Jonathan Edwards, Jason Massey, Gnanendra Reddy Tugu Yagama Reddy, Austin Woods, Matthew J. Stuckey, David T. Kuhar, Kayla Bolden, Heather Dubendris, Emily Wong, Theresa Rowe, Megan C. Lindley, Elizabeth J. Kalayil, Andrea Benin
Summary: This analysis examines the influenza and COVID-19 vaccination coverage among healthcare personnel (HCP) working in acute care hospitals and nursing homes during the 2022-23 influenza season. The study found that influenza vaccination coverage was 81.0% among HCP in acute care hospitals and 47.1% among those in nursing homes. Up-to-date COVID-19 vaccination coverage was 17.2% among HCP in acute care hospitals and 22.8% among those in nursing homes. The study emphasizes the need for evidence-based strategies to improve vaccination coverage among HCP and suggests tailored strategies to reach all HCP with recommended vaccines.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)
Article
Public, Environmental & Occupational Health
Hoody Lymon, Lu Meng, Hannah E. Reses, Kira Barbre, Heather Dubendris, Shanjeeda Shafi, Ryan Wiegand, Gnanendra Reddy Tugu Yagama Reddy, Austin Woods, David T. Kuhar, Matthew J. Stuckey, Megan C. Lindley, Lori Haas, Iram Qureshi, Emily Wong, Andrea Benin, Jeneita M. Bell
Summary: Vaccination coverage among healthcare personnel increased before the COVID-19 pandemic but decreased during the pandemic. Further measures are needed to improve vaccination coverage and identify reasons for the decline.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)
Article
Public, Environmental & Occupational Health
Fiona P. Havers, Michael Whitaker, Michael Melgar, Bhoomija Chatwani, Shua J. Chai, Nisha B. Alden, James Meek, Kyle P. Openo, Patricia A. Ryan, Sue Kim, Ruth Lynfield, Yomei P. Shaw, Grant Barney, Brenda L. Tesini, Melissa Sutton, H. Keipp Talbot, Kristen P. Olsen, RSV NET Surveillance Team
Summary: This analysis examined the characteristics of adults aged >= 60 years who were hospitalized with laboratory-confirmed RSV infection. The study found that age, underlying medical conditions, and severe outcomes were associated with RSV infection in older adults. These findings highlight the importance of considering age, long-term care facility residence, and underlying medical conditions in shared clinical decision-making for RSV vaccination in adults aged >= 60 years.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)