Article
Biochemistry & Molecular Biology
Yunbao Pan, Xianghu Jiang, Liu Yang, Liangjun Chen, Xiaojiao Zeng, Guohong Liu, Yueting Tang, Chungen Qian, Xinming Wang, Fangming Cheng, Jun Lin, Xinghuan Wang, Yirong Li
Summary: Our study on COVID-19 convalescent individuals showed that the survival of neutralizing antibodies is significantly affected by IL-2, IL-8, and IFN-gamma responses, while the activation of T cells and NK cells stimulated by antigen peptide pools is correlated with the presence of neutralizing antibodies. These findings provide insights into protective immunity against SARS-CoV-2, the pathogenesis of COVID-19, and the development of an effective vaccine.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Medicine, Research & Experimental
Li Huang, Che Zhang, Xihui Zhou, Zhou Zhao, Weiping Wang, Weidong Leng, Xiao Su, Qizhou Lian
Summary: This study analyzed the characteristics and outcomes of patients with or without convalescent plasma (CP) transfusion for coronavirus disease-2019. The results showed that while CP transfusion was clinically safe, it did not provide significant clinical benefits for critically ill patients with more comorbidities at the late stage of disease during a 28-day observation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Jessica Seessle, Tim Waterboer, Theresa Hippchen, Julia Simon, Marietta Kirchner, Adeline Lim, Barbara Mueller, Uta Merle
Summary: Long COVID, defined as persistent symptoms after SARS-CoV-2 infection, can last for at least 1 year and significantly impact life quality. Neurocognitive symptoms, possibly related to autoimmunity indicated by elevated ANA titers, are more common in females and can persist even when SARS-CoV-2 antibody levels are not significantly different from patients without symptoms.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Virology
Fabrice Camou, Claire Tinevez, Mathilde Beguet-Yachine, Pantxika Bellecave, Diana Ratiarison, Camille Tumiotto, Xavier Lafarge, Olivier Guisset, Gaelle Mourissoux, Marie-Edith Lafon, Fabrice Bonnet, Nahema Issa
Summary: This study suggests that convalescent plasma therapy may be safe and efficient in treating critically ill patients with COVID-19, potentially improving clinical outcomes. More randomized controlled trials are needed to confirm these findings.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Maya Nitecki, Boris Taran, Itay Ketko, Gil Geva, Roey Yosef, Itay Toledo, Gilad Twig, Eva Avramovitch, Barak Gordon, Estela Derazne, Noam Fink, Ariel Furer
Summary: This study assessed the utility of self-reported symptoms in identifying positive COVID-19 cases among predominantly healthy young adults in a military setting. The results showed that loss of taste or smell, suspected exposure, and fever were consistently associated with positive test results in this population.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Frauke Muecksch, Helen Wise, Becky Batchelor, Maria Squires, Elizabeth Semple, Claire Richardson, Jacqueline McGuire, Sarah Clearly, Elizabeth Furrie, Neil Greig, Gordon Hay, Kate Templeton, Julio C. C. Lorenzi, Theodora Hatziioannou, Sara Jenks, Paul D. Bieniasz
Summary: Understanding the longitudinal trajectory of SARS-CoV-2 antibodies is crucial for diagnosis and immunity prediction. Different serological assays have varying suitability for surveillance and prediction of neutralization potency, with S-based assays better predicting neutralization levels over time.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Luther A. Bartelt, Alena J. Markmann, Bridget Nelson, Jessica Keys, Heather Root, Heather Henderson, JoAnn Kuruc, Caroline Baker, D. Ryan Bhowmik, Yixuan J. Hou, Lakshmanane Premkumar, Caleb Cornaby, John L. Schmitz, Susan Weiss, Yara Park, Ralph Baric, Aravinda M. de Silva, Anne Lachiewicz, Sonia Napravnik, David van Duin, David M. Margolis
Summary: In this study, it was found that among high-risk patients admitted for COVID-19, those who received CCP with nAb titers of >1:640 had earlier hospital discharge compared to those who received CCP with lower nAb titers, with no CCP-related adverse events. The significance of this research lies in identifying a dose response of CCP and clinical outcomes based on nAb titers. Although limited by a small study size, these findings support further investigation of high-nAb-titer CCP (>1:640) in the treatment of COVID-19.
Article
Obstetrics & Gynecology
Michael Richley, Rashmi R. Rao, Yalda Afshar, Jenny Mei, Thalia Mok, Tara Vijayan, Stacey Weinstein, Christine U. Pham, Jason Madamba, Christina S. Shin, Deborah Suda, Christina S. Han
Summary: This study presents a retrospective case series of pregnant patients who received monoclonal antibody treatment for COVID-19, and the results suggest that pregnant patients who received treatment generally had favorable outcomes.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Virology
Ali S. Omrani, Ahmed Zaqout, Anas Baiou, Joanne Daghfal, Naser Elkum, Rand A. Alattar, Dana Bakdach, Hatem Abusriwil, Abdalrahman M. Mostafa, Bassem Alhariri, Naseem Ambra, Mohamed Khatib, Ali M. Eldeeb, Zeyd Merenkov, Zeinab Fawzi, Saloua M. Hmissi, Ali A. Hssain, Peter V. Coyle, Hussam Alsoub, Muna A. Almaslamani, Abdullatif Alkhal
Summary: A study compared critically ill COVID-19 patients who received standard care with those who also received convalescent plasma therapy, finding no clinical benefits associated with convalescent plasma. There were no significant differences in 28-day mortality rates and viral clearance rates between the two groups, and randomized trials are needed to confirm these findings.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Critical Care Medicine
Elliott Bennett-Guerrero, Jamie L. Romeiser, Lillian R. Talbot, Tahmeena Ahmed, Linda J. Mamone, Sunitha M. Singh, Janet C. Hearing, Huda Salman, Dishaw D. Holiprosad, Alex T. Freedenberg, Jason A. Carter, Nicholas J. Browne, Megan E. Cosgrove, Margaret E. Shevik, Laura M. Generale, Margaret A. Andrew, Sharon Nachman, Bettina C. Fries
Summary: This study found that administration of convalescent plasma to hospitalized patients with coronavirus disease 2019 infection did not improve outcomes, despite convalescent plasma having high neutralizing activity and increasing antibodies to severe acute respiratory syndrome coronavirus 2.
CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Evan M. Bloch, Daniele Focosi, Shmuel Shoham, Jonathon Senefeld, Aaron A. R. Tobian, Lindsey R. Baden, Pierre Tiberghien, David J. Sullivan, Claudia Cohn, Veronica Dioverti, Jeffrey P. Henderson, Cynthia So-Osman, Justin E. Juskewitch, Raymund R. Razonable, Massimo Franchini, Ruchika Goel, Brenda J. Grossman, Arturo Casadevall, Michael J. Joyner, Robin K. Avery, Liise-anne Pirofski, Kelly A. Gebo
Summary: This viewpoint provides expert guidance on the use of convalescent plasma for treating immunocompromised patients with COVID-19, including indications, dosage, frequency/schedule, and duration of treatment. English summary rating: 8/10
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Daniele Focosi, Fabrizio Maggi, Massimo Franchini, Adriano Aguzzi, Maria Lanza, Alessandro Mazzoni, Francesco Menichetti
Summary: This study focuses on separating study design variables that could affect the clinical outcome of COVID-19 convalescent plasma therapy. Neglecting variables such as pretransfusion antibody testing in recipients, dose adjustments, and antibody affinity measurements has impacted the outcomes of the majority of clinical trials to date. Understanding and addressing these variables is crucial for the design of future CCP clinical trials to improve clinical outcomes and reduce risks of immune evasion.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Medicine, General & Internal
Savino Sciascia, Chelsea Bentow, Massimo Radin, Alice Barinotti, Irene Cecchi, Silvia Foddai, Dario Roccatello, Michael Mahler
Summary: This study aimed to explore the use of saliva as an alternative matrix for the detection of autoantibodies. By using a novel and highly sensitive method, the study found a high level of correlation between saliva and serum results, and participants clearly preferred saliva sampling.
Article
Nursing
Juan Li, Zhen Yang, Jie Zhang, An-ni Wang, Xiao Wang, Li-li Dong, Fu-sheng Wang, Rui-hong Wei, Yi-fei Li, Jing-ping Zhang
Summary: This study found that a minority of patients with mild symptoms of coronavirus disease 2019 in China were still experiencing psychological symptoms, with women, those in the initial stages of hospitalization, and those with current physical symptoms being at higher risk. Healthcare providers are advised to be particularly vigilant in screening and providing targeted psychological care for these high-risk groups.
JOURNAL OF ADVANCED NURSING
(2021)
Article
Multidisciplinary Sciences
Felix Dewald, Martin Pirkl, Martha Paluschinski, Joachim Kuehn, Carina Elsner, Bianca Schulte, Jacqueline Knuefer, Elvin Ahmadov, Maike Schlotz, Goeksu Oral, Michael Bernhard, Mark Michael, Maura Luxenburger, Marcel Andree, Marc Tim Hennies, Wali Hafezi, Marlin Maybrit Mueller, Philipp Kuempers, Joachim Risse, Clemens Kill, Randi Katrin Manegold, Ute von Frantzki, Enrico Richter, Dorian Emmert, Werner O. Monzon-Posadas, Ingo Graeff, Monika Kogej, Antonia Buening, Maximilian Baum, Finn Teipel, Babak Mochtarzadeh, Martin Wolff, Henning Gruell, Veronica Di Cristanziano, Volker Burst, Hendrik Streeck, Ulf Dittmer, Stephan Ludwig, Joerg Timm, Florian Klein
Summary: Determining SARS-CoV-2 immunity is crucial for assessing COVID-19 risk and the effectiveness of prevention strategies. In a study of 1,411 patients in Germany, it was found that 95.6% had Spike-IgG antibodies and 24.0% had Nucleocapsid-IgG antibodies. Neutralizing activity against different variants was observed, but it was significantly lower against BA.4/5 and BQ.1.1 compared to Wu01. The study highlights the importance of improving vaccine uptake to reduce the risk of immune evasive variants.
NATURE COMMUNICATIONS
(2023)
