Article
Immunology
Huanhuan Cao, Yufei Huang, Chunxiu Zhong, Xingmei Liao, Wenjuan Tan, Siru Zhao, Liangxu Guo, Rong Fan
Summary: This study investigated the immune response and safety of inactivated SARS-CoV-2 vaccines among chronic hepatitis B (CHB) patients. It was found that cirrhotic patients had lower antibody titers and patients with abnormal liver function had a better antibody response. The vaccines were generally well tolerated in CHB patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Respiratory System
Chao Cao, Feng Qiu, Chengcheng Lou, Lingling Fang, Fang Liu, Jingjing Zhong, Weijie Sun, Weiping Ding, Xiaopin Yu, Qinhong Xu, Ran Wang, Liemin Ruan, Qifa Song
Summary: This retrospective cohort study examined the local and systemic reactions in patients with allergic disease who received inactivated SARS-CoV-2 vaccines. The study found that patients with allergic disease reported higher rates of pain at the injection site and systemic reactions compared to the control group. However, the administration of the vaccine was safe and well tolerated by all participants.
RESPIRATORY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Hui Xuan Lim, Masita Arip, Abdul Aziz Al-Fattah Yahaya, Seyed Davoud Jazayeri, Sibrandes Poppema, Chit Laa Poh
Summary: The SARS-CoV-2 infections, first detected in Wuhan in December 2019, led to a global pandemic in 2020 with more than 180 million cases and 3.9 million deaths. The rapid development of vaccine candidates has shown promising results, with some achieving over 90% efficacy in preventing COVID-19.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Biochemistry & Molecular Biology
Ni Tien, Yu-Chang Chang, Po-Ku Chen, Hui-Ju Lin, Shih-Hsin Chang, Joung-Liang Lan, Po-Ren Hsueh, Ching-Kun Chang, Der-Yuan Chen
Summary: This study evaluated the immunogenicity and safety of three types of vaccines in patients with immune-mediated inflammatory diseases (IMID) and healthcare workers (HCWs). The study found that mRNA-1273 or BNT162b2 vaccines had higher immunogenicity compared to the AZD1222 vaccine. Immunogenicity was enhanced after the second dose of any vaccine type in all IMID patients. Patients receiving abatacept/rituximab therapy had lower immunogenicity compared to those receiving other DMARDs. All three SARS-CoV-2 vaccines showed acceptable safety profiles, with injection site reactions being the common adverse events.
Review
Medicine, Research & Experimental
Jonathan L. Golob, Njira Lugogo, Adam S. Lauring, Anna S. Lok
Summary: Multiple vaccines targeting the SARS-CoV-2 surface glycoprotein have shown high efficacy in preventing symptomatic COVID-19, with success attributed to open science collaboration, harmonized clinical trials, and the altruism of study participants. Challenges remain in manufacturing and distributing vaccines, with a focus now shifting towards ensuring equitable global vaccination against COVID-19.
Article
Hematology
J. Erika Haydu, Jenny S. Maron, Robert A. Redd, Kathleen M. E. Gallagher, Stephanie Fischinger, Jeffrey A. Barnes, Ephraim P. Hochberg, P. Connor Johnson, R. W. Takvorian, Katelin Katsis, Daneal Portman, Jade Ruiters, Sidney Sechio, Mary Devlin, Connor Regan, Kimberly G. Blumenthal, Aleena Banerji, Allen D. Judd, Krista J. Scorsune, Brianne M. McGree, Maryanne M. Sherburne, Julia M. Lynch, James I. Weitzman, Matthew Lei, Camille N. Kotton, Anand S. Dighe, Marcela V. Maus, Galit Alter, Jeremy S. Abramson, Jacob D. Soumerai
Summary: This prospective study demonstrates that SARS-CoV-2 vaccination induces functional T-cell and antibody responses in patients with CLL. The serologic response to the vaccine is more common in treatment-naive patients. Most patients had functional spike-specific T-cell responses in interferon-gamma release assays.
Article
Medicine, General & Internal
Valentina Cossiga, Mario Capasso, Maria Guarino, Ilaria Loperto, Stefano Brusa, Francesco Maria Cutolo, Maria Rosaria Attanasio, Raffaele Lieto, Giuseppe Portella, Filomena Morisco
Summary: The low response to vaccines is a well-known problem in cirrhosis. We evaluated the safety and immunogenicity of booster doses in patients with chronic liver disease (CLD), comparing the humoral response in cirrhotic vs. non-cirrhotic patients, and the impact of different factors on immune response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Markus Cornberg, Maria Buti, Christiane S. Eberhardt, Paolo Antonio Grossi, Daniel Shouval
Summary: According to a recent estimate by the World Health Organization, the SARS-CoV-2 pandemic has affected nearly 100 million people globally, with patients with chronic liver diseases (CLD) at higher risk of infections. Vaccination against various pathogens, including SARS-CoV-2, is important for these patients, although impaired immune responses may affect the efficacy of immunization. The safety, immunogenicity, and efficacy of SARS-CoV-2 vaccines in patients with CLD, cirrhosis, hepatobiliary cancer, and liver transplant recipients still require further study.
JOURNAL OF HEPATOLOGY
(2021)
Article
Virology
Athanasios-Dimitrios Bakasis, Kleopatra Bitzogli, Dimitrios Mouziouras, Abraham Pouliakis, Maria Roumpoutsou, Andreas V. Goules, Theodoros Androutsakos
Summary: The study demonstrates that mRNA-based vaccines against SARS-CoV-2 are safe and effective in patients with liver diseases. However, PWLD receiving immunosuppressive treatment and those of advanced age should be closely monitored after vaccination.
Article
Biochemistry & Molecular Biology
Angela Choi, Matthew Koch, Kai Wu, Laurence Chu, LingZhi Ma, Anna Hill, Naveen Nunna, Wenmei Huang, Judy Oestreicher, Tonya Colpitts, Hamilton Bennett, Holly Legault, Yamuna Paila, Biliana Nestorova, Baoyu Ding, David Montefiori, Rolando Pajon, Jacqueline M. Miller, Brett Leav, Andrea Carfi, Roderick McPhee, Darin K. Edwards
Summary: The study demonstrates that both the mRNA-1273 COVID-19 vaccine and its variant-modified booster doses are safe and effective in improving neutralizing antibody titers against various virus variants.
Article
Immunology
Yuling Han, Jiaxin Yang, Danshuang He, Yang Feng, Xiaoman Liu, Yu Min, Shenghao Fan, Guobing Yin, Daixing Hu
Summary: This study assessed the safety and immunogenicity of SARS-CoV-2 vaccines in patients with thyroid cancer. The results showed that SARS-CoV-2 vaccines (CoronaVac, BBIBP-CorV, and ZF2001) are safe in thyroid cancer patients. However, the duration of immune response is shorter in these patients compared to healthy adults. Therefore, a booster vaccination may be recommended earlier for thyroid cancer patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jin Ge, Mark J. Pletcher, Jennifer C. Lai
Summary: The study used an electronic health record database to describe outcomes of SARS-CoV-2 infection in patients with chronic liver disease and cirrhosis, finding that patients with cirrhosis infected with SARS-CoV-2 had an increased risk of mortality.
Review
Immunology
Konstantina Toutoudaki, Melitini Dimakakou, Theodoros Androutsakos
Summary: This review discusses the safety and efficacy of anti-SARS-CoV-2 vaccination in patients with liver cirrhosis and the post-vaccination antibody responses. Overall, all vaccines appear to be extremely safe with few adverse events, and efficient in reducing hospitalization rates and COVID-19-related mortality. However, the T- and B-cell responses remain unclear, especially in patients with decompensated disease, as some studies show lower titers and rapid waning of anti-SARS-CoV-2 antibodies. The clinical impact of this finding is still undetermined.
Article
Immunology
Amy C. Sherman, Michael Desjardins, Chi-An Cheng, Bruce Bausk, Natalie Izaguirre, Guohai Zhou, Jonathan Krauss, Nicole Tolan, David R. Walt, Robert Soiffer, Vincent T. Ho, Nicolas C. Issa, Lindsey R. Baden
Summary: This study describes the humoral response and reactogenicity profile of the severe acute respiratory syndrome coronavirus 2 messenger RNA vaccine in allogeneic hematopoietic stem cell transplant recipients. The findings showed that 75.0% to 80.0% of HSCT recipients had a positive antibody response after vaccination, compared to 100% in the healthy cohort.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Daniel Arroyo-Sanchez, Oscar Cabrera-Marante, Rocio Laguna-Goya, Patricia Almendro-Vazquez, Octavio Carretero, Francisco Javier Gil-Etayo, Patricia Suarez-Fernandez, Pilar Perez-Romero, Edgard Rodriguez de Frias, Antonio Serrano, Luis M. Allende, Daniel Pleguezuelo, Estela Paz-Artal
Summary: Common Variable Immunodeficiency (CVID) patients show slower humoral and cellular responses to COVID-19 vaccination compared to healthy controls. Despite most CVID patients developing S1-specific antibodies and T cells after vaccination, neutralizing antibodies were only detected in half of the patients. Those with absent or discordant responses often had a history of autoimmunity or lymphoproliferation, while recent anti-B cell antibody therapy may also weaken the response. Further studies are necessary to assess the protective efficacy of COVID-19 vaccination in CVID patients, with consideration for a third dose to achieve full immune response.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Letter
Rheumatology
Hanlin Yin, Bei Liu, Qianqian Li, Qingran Yan, Liangjing Lu
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Chemistry, Organic
Siyuan Wang, Yunpeng Sun, Yaqi Li, Wenjun Xu, Qianqian Li, Yanbing Mu, Lingyi Kong, Jun Luo
Summary: In this study, seven lindenane-type sesquiterpenoid trimers were isolated from Chloranthus fortunei. Four of them were new compounds, while the other three were known analogues. Their structures and absolute configurations were determined using various analytical techniques. Compound 1 exhibited a unique feature of two lindenane units connected by a C-15-C-15' bond. Compound 2 had a 5/7/5-fused ring system, which was believed to be formed through keto-enol tautomerism and Cope rearrangement. Compounds 3-6 were derived from trishizukaol A (7) via vinylcyclopropane rearrangement. The biomimetic conversion from 7 to 3-6 was successfully achieved. Compound 1-7 showed anti-inflammatory activity with IC50 values ranging from 2.90 to 22.80 nmol/L.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Yu Huang, Chunyuan Liang, Yueling Cai, Yi Zhou, Bingkun Guo, Jipeng Cheng, Heguang Liu, Peng Wang, Qianqian Li, Anmin Nie, Hongtao Wang, Jinsong Wu, Tongyi Zhang
Summary: The fundamental reaction behaviors of nickel sulfide (NixSy) as lithium-ion battery anodes were investigated using in-situ TEM. Ni3S2 was found to be the electrochemically stable phase. During lithiation, NixSy nanoparticles evolved into a mixture of Ni nanocrystals embedded in Li2S matrix, forming a porous structure. In delithiation, the Ni3S2 phase recrystallized to form a compact and interconnected network. Carbon substrate improved the tolerance for size-dependent pulverization of NixSy nanoparticles. This work enhances the understanding of electrochemical reaction behavior and aids in the rational design of high-energy density battery anodes.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Wenkang Miao, Ronghui Hao, Jingzhou Wang, Zihan Wang, Wenxin Lin, Heguang Liu, Zhenjie Feng, Yingchun Lyu, Qianqian Li, Dongling Jia, Runhai Ouyang, Jipeng Cheng, Anmin Nie, Jinsong Wu
Summary: Non-noble metal catalysts have been successfully designed for the hydrogenation of CO2, with high conversion activity and stability. The reversible regeneration mechanism of catalytic activity has been revealed. This study is of great significance for rational structure design and improving catalyst performance.
Article
Multidisciplinary Sciences
Da Wang, Jia Yu, Xiaobin Yin, Sen Shao, Qianqian Li, Yanchao Wang, Maxim Avdeev, Liquan Chen, Siqi Shi
Summary: A p-type alloying strategy involving three stages has been proposed to design a 2H-V1.75Cr0.25S4 cathode with a record energy density of 554.3 Wh kg(-1) and interfacial compatibility with sulfide solid-state electrolyte. This material could overcome the reliance on scarce or high-cost transition metals (e.g. Co and Ni) in current commercial cathodes.
NATIONAL SCIENCE REVIEW
(2023)
Article
Pharmacology & Pharmacy
Lu Zhang, Xiaolei Zhou, Bowen Liu, Xuhe Shi, Xianmeng Li, Feifei Xu, Xueli Fu, Xue Wang, Kai Ye, Tianzhi Jin, Huimin Sun, Qianqian Li, Weiying Zhang, Lihong Ye
Summary: In this study, it was found that HBXIP promotes tumor cell migration and invasion by directly interacting with and phosphorylating NMHC-IIA. Furthermore, the anti-hyperlipidemic drug BZF inhibits breast cancer metastasis by suppressing PKCAII-mediated NMHC-IIA phosphorylation. These findings provide new insights into the regulatory mechanism of tumor metastasis and the development of anti-metastatic drugs for breast cancer.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Physical
Ronghui Hao, Wenkang Miao, Qiling Xiao, Zihan Wang, Wanyin Xu, Tianzhong Wang, Qianqian Li, Peng Wang, Anmin Nie, Hongtao Wang
Summary: This study reports the oxidation pathways of TiN with different grain sizes through careful atomic structure characterization. Nano-sized TiN single crystal undergoes a two-step phase transformation, while micron-sized TiN single crystal or polycrystals directly convert to rutile TiO2 upon oxidation. N2 nanobubbles are generated in the micron-sized TiN oxidation process, which preferentially embed inside of rutile TiO2 grain boundaries for single crystals and the oxide/nitride interface for polycrystals. The oxidation induces great volume expansion in all types of TiN, but only micron-sized single crystals are fractured and pulverized dramatically, impairing the mechanical properties.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Medicinal
Wang Hua, Xiaoli Wang, Qianqian Li, Yaqi Li, Letian Cui, Yongyi Li, Lingyi Kong, Jun Luo
Summary: Seven rare noreudesmane sesquiterpenoids, including three trinoreudesmanes, three 13-noreudesmanes, and one spirovetivane-type sesquiterpenoid, were isolated from the fruits of Dysoxylum densiflorum, along with two known analogues. Their planar structures were elucidated by various spectroscopic techniques, and their absolute configurations were determined by X-ray diffraction, CD exciton chirality method, and ECD calculation. All compounds were evaluated for their anti-inflammatory activity on LPS-induced RAW 264.7 cells and IL-1 beta inhibitory activity.
Review
Chemistry, Applied
Xiangquan Zeng, Weibo Jiang, He Li, Qianqian Li, Jozef L. Kokini, Zhenjiao Du, Yu Xi, Jian Li
Summary: Nowadays, food hydrogels are widely used in food processing to deliver functional components. Mesona chinensis Benth polysaccharides (MCBP), the main compounds of Mesona chinensis Benth, have been developed as stabilizers, coagulants, and binders in the food industry. However, MCBP needs to interact with other biomacromolecules to form hydrogels due to the insufficient viscosity of single MCBP solution. Researchers have prepared novel composite hydrogels by interacting MCBP with different polysaccharides. The addition of these polysaccharides significantly affects the properties of MCBP, such as pasting, gelling, textural, rheological, thermal, retrogradation, color, optical, and in vitro digestible properties. The physicochemical properties of composite hydrogels are greatly influenced by treatments like heat, urea, alkali, and salt ions, which affect the interactions between two polysaccharides. Overall, MCBP shows great potential for the development of novel functional hydrogels in the future.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Physical
Weiwei Chang, Tao Luo, Tianxiang Zhu, Qianqian Li, Bo Lu, Zhen-Yan Deng, Yi Liu, Takahiro Maruyama, Xinluo Zhao
Summary: The smallest carbon nanowires, LLCCs@SWCNTs, were successfully mass produced, allowing for the study of their Raman scattering behaviors at various temperatures. The intensity and peak positions of the Raman scattering spectra were found to change with temperature, indicating tunability of the crystal and electronic structures. This work provides insights into the Raman process and fundamental properties of LLCCs@SWCNTs, with potential applications in nanoscale temperature monitoring.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Polymer Science
Li-Ying Ren, Qian-Qian Li, Yu-Xia Zhang
Summary: EDOT-based conjugated microporous polymers (CMPs) were efficiently synthesized via one-step direct arylation polymerization using simple EDOT as a linker and commercially available aryl bromides as the knots. This strategy allows the use of simple thiophene derivatives as building blocks for synthesizing thiophene-based CMPs of different structures, avoiding the synthesis of complex thiophene derivatives. The resulting EDOT-based CMPs exhibited high quenching constants and were successfully applied as fluorescent sensors for various compounds.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Engineering, Multidisciplinary
Peng Wang, YiCheng Lin, Yu Cao, HaoRan Zhao, QianQian Li, HongTao Wang
Summary: In this work, the complete martensitic transformation of non-equiatomic HEA is reproduced via atomic simulations with a novel interatomic potential. The physical parameters of interatomic potential are verified to agree well with experimental measurements and first-principles calculations. The study reveals two basic transition models for martensitic transformation in TRIP-DP-HEA and elucidates the pathway with the gliding of Shockley partial dislocations.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)
Article
Agricultural Engineering
Qianqian Li, Chaoyang Zhang, Huawei Wang, Shengfan Chen, Wei Liu, Yi Li, Jianxun Li
Summary: It is important to evaluate vine tea comprehensively by considering both high content quality-related compounds and trace-level volatile compounds. NIR and GC-MS technologies were used for grade discrimination, and machine learning methods of random forest and PLS-DA were employed to construct a tea grade discrimination platform. The results showed that the mid-level fusion combined with random forest achieved impressive performance in terms of balanced matrix, efficient features, and discriminant ability.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Medicine, Research & Experimental
Rong Wang, Jingkun Qu, Xueping Tang, Jiaxin Zhang, Ante Ou, Qianqian Li, Guihua Chen, Caihong Zheng, Bahtiyor Muhitdinov, Yongzhuo Huang
Summary: A lactoferrin-modified gambogic acid liposomal delivery system was developed to enhance the treatment efficacy of colorectal cancer by improving tumor delivery and drug solubility.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Ye Wu, Li Fu, Qianqian Li, Xiang Gao, Yingjun Zhang, Chuanfei Jin, Feiqing Ding, Sheng Hong, Hui Cai, Yiliang Li
Summary: Alzheimer's disease is a neurodegenerative disease and the leading cause of dementia. Despite being discovered over 100 years ago and extensively studied, there is still much to learn about the exact biological changes that lead to the disease, the most effective methods for early diagnosis, and successful therapeutic interventions to slow or halt its progression. This article provides a brief overview of the disease progression, risk factors, pathogenesis, as well as current strategies for early diagnosis and treatment.
ADVANCED THERAPEUTICS
(2023)
