Article
Biochemistry & Molecular Biology
Sangita Bhattacharyya, Hindole Ghosh, Obdulia Covarrubias-Zambrano, Krishan Jain, K. Venkateswara Swamy, Anup Kasi, Ameer Hamza, Shrikant Anant, Michael VanSaun, Scott J. Weir, Stefan H. Bossmann, Subhash B. Padhye, Prasad Dandawate
Summary: Pancreatic ductal adenocarcinoma (PDAC) is the leading cause of cancer-related deaths in the US. The development of novel drugs with improved delivery is crucial due to factors such as genetic mutations, drug resistance, multiple signaling pathways, cancer stem cells (CSCs), and desmoplastic stroma. Curcumin shows promise in inhibiting PDAC, but its clinical applicability is limited by poor solubility and metabolic instability. A difluorinated curcumin analog (CDF) has been developed, which selectively accumulates in the pancreas and inhibits PDAC growth. Its inclusion complex with 2-hydroxy-propyl-beta-cyclodextrin (HCD) increases water solubility and hydrolytic stability, leading to improved therapeutic efficacy against PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zhi Xuan Low, Michelle Yee Mun Teo, Fariza Juliana Nordin, Firli Rahmah Primula Dewi, Vijayaraj Kumar Palanirajan, Lionel Lian Aun In
Summary: Curcumin (CUR) encapsulated within a beta-cyclodextrin (beta-CD) complex showed significantly improved water solubility and enhanced anticancer effects. The inclusion complex demonstrated reduced cancer cell migration and invasion rates, increased apoptosis rates, and inhibited colorectal cancer cell growth. Preliminary toxicity evaluation indicated the safety of this formulation for cancer therapy in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Junqiang Guo, Liwei Lin, Yuping Wang, Wang Zhang, Guowang Diao, Yuanzhe Piao
Summary: A water-soluble inclusion complex of DPG and beta-CDP, termed DPG-beta-CDP, was prepared and found to greatly enhance the water solubility of DPG, making it a promising candidate for water-soluble vulcanization accelerators.
Article
Pharmacology & Pharmacy
Hamdy Abdelkader, Adel Al Fatease, Zeinab Fathalla, Mai E. Shoman, Heba A. Abou-Taleb, Mohammed A. S. Abourehab
Summary: This study investigated four different cyclodextrins as inclusion complexes with curcumin using two preparation methods. The results showed that the curcumin: hydroxypropyl beta-cyclodextrin complex had a protective effect on breast cancer cells.
Article
Pharmacology & Pharmacy
Mahsa Shahriari, Prashant Kesharwani, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Cancer is a widespread disease with various treatment modalities and challenges. Chemotherapy has limitations due to toxicity and drug resistance. Curcumin, a natural compound with multiple therapeutic properties, has poor solubility and limited bioavailability. Cyclodextrin complexes of curcumin improve its properties, and beta-cyclodextrin is commonly used. This review focuses on comparing different curcumin-cyclodextrin formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Polymer Science
Jing Li, Fang Xu, Yujie Dai, Jiawen Zhang, Yuan Shi, Danning Lai, Natthida Sriboonvorakul, Jiamiao Hu
Summary: This paper summarizes the recent advances in cyclodextrin-based carriers for encapsulating curcumin (CUR), discussing the polymerization properties of CD self-assembly to enhance CUR encapsulation and the progress on stimuli-responsive CD carriers for controlled release of CUR. These studies lay an important foundation for the development of CUR-based precision therapy in clinical practice.
Article
Chemistry, Multidisciplinary
Modhusudan Mondal, Shatarupa Basak, Salim Ali, Debadrita Roy, Subhadeep Saha, Biswajit Ghosh, Narendra Nath Ghosh, Khusboo Lepcha, Kanak Roy, Mahendra Nath Roy
Summary: The co-evaporation approach was used to investigate the host-guest interaction between 6-mercaptopurine monohydrate (6-MP) and beta-cyclodextrin (beta-CD). The study found that the formed inclusion complex exhibited improved stability, solubility, cytotoxicity, and antibacterial activity compared to pure 6-MP.
Article
Thermodynamics
Dzhovidon Kabirov, Teresa Silvestri, Marcella Niccoli, Tatiana Usacheva, Laura Mayol, Marco Biondi, Concetta Giancola
Summary: This study investigates the formation of inclusion complexes between the semisynthetic hydroxypropyl-beta-cyclodextrin (HPβCD) and CURC. Various experimental conditions were tested to evaluate the formation, stability, and efficacy of the complexes.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Chemistry, Applied
Danning Lai, Arong Zhou, Bee K. Tan, Yibin Tang, Siti Sarah Hamzah, Zhigang Zhang, Shaoling Lin, Jiamiao Hu
Summary: A novel photosensitizer, curcumin-ll-cyclodextrin complex, was prepared to enhance the water solubility of curcumin. The complex demonstrated effective photodynamic antibacterial activity against food-borne pathogens, generating ROS and causing cell damage. Microscopic analysis revealed cell deformation and structural damage of bacteria, with inactivation mechanisms involving DNA damage and protein degradation.
Article
Biochemistry & Molecular Biology
Ana-Maria Fernandez-Romero, Francesca Maestrelli, Sara Garcia-Gil, Elena Talero, Paola Mura, Antonio M. Rabasco, Maria Luisa Gonzalez-Rodriguez
Summary: The study aimed to prepare a CurCD hydrogel for treating inflammatory skin conditions, with results showing improved solubility and anti-inflammatory activity of Curcumin when complexed with cyclodextrin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anne Boyina Sravani, K. Mangala Shenoy, Baby Chandrika, B. Harish Kumar, Suvarna G. Kini, K. Sreedhara Ranganatha Pai, Shaila A. Lewis
Summary: The complex of curcumin with sulfobutyl ether-beta-cyclodextrin (SBE beta CD) demonstrates superior antimicrobial activity, making it a promising alternative for the treatment of urinary tract infections (UTIs) caused by Gram-negative bacteria E. coli.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Food Science & Technology
Jianping Chen, Jiarui Li, Tugui Fan, Saiyi Zhong, Xiaoming Qin, Rui Li, Jialong Gao, Yuanwei Liang
Summary: This study aimed to investigate the protective effects of the curcumin/cyclodextrin polymer (CUR/CDP) inclusion complex on hydrogen peroxide (H2O2)-induced LO2 cells damage. The results showed that CUR/CDP reversed the changes of cell damage indicators and inhibited cell apoptosis to alleviate liver injury, indicating its protective effect on LO2 cells' oxidative damage.
FOOD SCIENCE & NUTRITION
(2022)
Article
Chemistry, Physical
Shuang Gao, Jingyu Jiang, Xiaoming Li, Fei Ye, Ying Fu, Lixia Zhao
Summary: In this study, an inclusion complex of beta-cyclodextrin and difenoconazole was synthesized to enhance water solubility and antifungal activity. The complex showed increased water solubility and improved fungicidal effect against Gibberella sp., presenting a new formulation idea for the agricultural application of difenoconazole.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Applied
Hyun-Mo Jeong, Yeontaek Lee, Yu-Jeong Shin, Seung-Hye Woo, Ji-Soo Kim, Da-Woon Jeong, Sooyong Shin, Sung Ho Jeon, Jae-Hoon Shim
Summary: A novel encapsulation process based on the cyclization activity of CGTase was developed to encapsulate resveratrol in cyclodextrins, significantly increasing its water solubility. Experimental results showed that CA-RVT in aqueous solution exhibited similar activities as an equal amount of RVT in dimethyl sulfoxide.
Article
Biochemistry & Molecular Biology
Wanrong Song, Xizhao Chen, Chongshan Dai, Degui Lin, Xuelin Pang, Di Zhang, Gang Liu, Yipeng Jin, Jiahao Lin
Summary: This study successfully improved the bioavailability of curcumin by preparing different complexes of the compound, which is significant for its application.
Article
Chemistry, Analytical
Wang Zhang, Tao Xia, Xin Huo, Xusen Li, Sumin Park, Liwei Lin, Guowang Diao, Yuanzhe Piao
Summary: Porous carbon spheres (PCS) can be prepared using gamma-cyclodextrin as a carbon source, and when combined with conductive polymer polyaniline (PANI), a composite with improved electrochemical energy storage properties can be obtained.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Wang Zhang, Jin Yang, Xusen Li, Tianyu Chen, Sumin Park, Minjun Bae, Dayun Jung, Liwei Lin, Sun Ha Paek, Yuanzhe Piao
Summary: A pH-responsive curcuminoid delivery system based on supramolecular vesicles was successfully fabricated using a host-guest inclusion complex. The system exhibited well-defined supramolecular structure and significant pH-responsive behavior, showing promising anticancer ability in vitro.
MATERIALS & DESIGN
(2022)
Article
Materials Science, Multidisciplinary
Song Shan, Lifei Lin, Xin Huo, Liwei Lin, Wang Zhang
Summary: Ordered polymerization of polyaniline on porous carbon was achieved through cyclodextrin polymer functionalization. This functionalized material exhibited remarkable specific capacitance and high rate capability in a supercapacitor device, while maintaining good stability during cycling.
Article
Biochemistry & Molecular Biology
Junqiang Guo, Liwei Lin, Yuping Wang, Wang Zhang, Guowang Diao, Yuanzhe Piao
Summary: A water-soluble inclusion complex of DPG and beta-CDP, termed DPG-beta-CDP, was prepared and found to greatly enhance the water solubility of DPG, making it a promising candidate for water-soluble vulcanization accelerators.
Article
Multidisciplinary Sciences
Wang Zhang, Liwei Lin, Junqiang Guo, Ming Wu, Sumin Park, Hang Yao, Sun Ha Paek, Guowang Diao, Yuanzhe Piao
Summary: This study prepared DPG-HP-β-CD inclusion complex and applied it to the foaming process of NR latex, which significantly improved the mechanical properties of the latex foam, reduced the usage of DPG, and lowered toxicity and environmental hazards.
Article
Agricultural Engineering
Liwei Lin, Zhiqiang Zheng, Xusen Li, Sumin Park, Wang Zhang, Guowang Diao, Yuanzhe Piao
Summary: Waste NRLF scraps can be transformed into S and O-doped porous carbon materials with high specific surface area and interconnected micropores through a synthetic route. The resulting carbon material shows great potential for supercapacitor applications.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Hang Yao, Xiaohui Yuan, Zhonglian Wu, Sumin Park, Wang Zhang, Hui Chong, Liwei Lin, Yuanzhe Piao
Summary: A gelatin/sodium alginate-based hydrogel microsphere was synthesized with optimized reaction conditions. Macrophages (RAW246.7) and adipose mesenchymal stem cells (ADSC) were encapsulated in the microsphere to construct a 3D paracrine system for wound healing treatment. The microsphere exhibited excellent biocompatibility and positive regulation of cytokine expression, promoting macrophage phenotype transformation and anti-inflammatory performance. Compared to a 2D paracrine system, the 3D paracrine system showed more pronounced benefits in wound healing rate, indicating its potential as a robust wound healing dressing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Hang Yao, Ming Wu, Liwei Lin, Zhonglian Wu, Minjun Bae, Sumin Park, Shuli Wang, Wang Zhang, Jiefeng Gao, Dongan Wang, Yuanzhe Piao
Summary: The wound healing process is often hindered by bacterial infections, leading to impaired healing. The use of adhesive hydrogels with natural antibacterial agents as wound dressings has been recognized as an effective treatment. This review summarizes studies on ingredients, preparation methods, antibacterial mechanisms, and internal factors of adhesive hydrogels, providing insights and prospects for their biomedical applications and clinical research.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Multidisciplinary
Xusen Li, Liwei Lin, Tianyu Chen, Sumin Park, Minjun Bae, Youngseul Cho, Jeongyeon Lee, Wang Zhang, Yuanzhe Piao, Guowang Diao
Summary: In this study, a rapid and simple method for preparing porous carbon (PC) using microwave irradiation was proposed. Oxygen-rich PC was synthesized by irradiating potassium citrate and ZnCl2 in air. The use of ZnCl2 allowed for microwave absorption through dipole rotation, converting heat energy in the reaction system. Potassium salt etching was found to enhance the porosity of the PC. The resulting PC had a large specific surface area (902 m2/g) and exhibited significant specific capacitance (380 F/g) in the three-electrode system at 1 A/g. The assembled supercapacitor device based on PC-375W-0.4 showed energy and power densities of 32.7 W·h·kg-1 and 0.65 kW·kg-1, respectively, at a current density of 1 A/g. Even after 5000 cycles at a current density of 5 A/g, the PC retained 94% of its initial capacitance, demonstrating excellent cycle life.
Article
Chemistry, Multidisciplinary
Wang Zhang, Zhiqiang Zheng, Liwei Lin, Xi Zhang, Minjun Bae, Jeongyeon Lee, Ju Xie, Guowang Diao, Hyung-Jun Im, Yuanzhe Piao, Huan Pang
Summary: A microwave method using graphene oxide (GO) is proposed to design cyclodextrin-based metal-organic framework (CD-MOF)/GO composites with controlled crystal size. The CD-MOF/GOs possess high adsorption performance and good electrochemical properties, making them promising for energy storage devices.
Article
Chemistry, Multidisciplinary
Wang Zhang, Junqiang Guo, Tianyu Chen, Sumin Park, Minjun Bae, Youngseul Cho, Guowang Diao, Liwei Lin, Yuanzhe Piao
Summary: In this study, cyclodextrin polymer-functionalized polyaniline/hollow carbon sphere composites were prepared by an in-situ polymerization strategy, which improved the growth of polymers and enhanced the capacitance performance.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qian Wu, Yubo Cui, Guifeng Xia, Jinlong Yang, Shuming Du, Xinhong Xiong, Li Yang, Dong Xu, Xu Deng, Jiaxi Cui
Summary: Passive daytime radiative cooling (PDRC) technology, while promising for global spacing cooling, faces limitations in practical application due to reduced cooling effectiveness caused by wear and dirt contamination. Researchers have developed a renewable armor structure using fluorinated hollow glass microspheres to enhance the anti-fouling and cooling properties of PDRC coatings. The coatings exhibit high solar reflectance and thermal emittance, leading to significant temperature reduction below ambient temperature.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Qiang Bei, Bei Zhang, Kaifeng Wang, Shiming Zhang, Guichuan Xing, Clement Cabanetos
Summary: The power conversion efficiency (PCE) of organic solar cells (OSCs) has reached 20% in recent years, thanks to the advantages of organic photoactive materials. Benzothiadiazole (BT) has attracted significant research attention as a building block of OSCs. OSCs based on BT structure have shown diversity, and the increasing PCE values indicate a promising future for OSCs. This review analyzes the progress made in the last decades, focusing on effective BT small-molecules and BT polymers for OSCs. The structure-property relationships, donor-acceptor matching criteria, and morphology control approaches are discussed. The remaining challenges and a personal perspective on the future advancement of OSCs are summarized.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Rong He, Dandan Tang, Ningge Xu, Heng Liu, Kun Dou, Xuejun Zhou, Fabiao Yu
Summary: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, with a high incidence in China and Southeast Asian countries. In this study, a novel near-infrared fluorescent probe, SNAFL-GSH, was designed and synthesized for the detection of glutathione (GSH). The probe showed selective detection of GSH and the ability to distinguish normal and cancer cells. It has great potential for application in the diagnosis and evaluation of NPC.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Lian Jin, Song Li, Yan Deng, Zhu Chen, Hui Chen, Yuanying Zhang, Rabia Usman, Nongyue He
Summary: This study isolated primary cells that can be stably passaged from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice and used an autonomously developed automated screening instrument for efficient nucleic acid aptamer screening. The obtained aptamers were affinity verified at the cellular level. The study also investigated the impact of cell growth environment difference on the recognition ability of aptamers and confirmed the targeting ability and drug loading ability of the aptamer.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhongshan Yang, Qiqi Zhang, Hui Song, Xin Chen, Jiwei Cui, Yanhui Sun, Lequan Liu, Jinhua Ye
Summary: Methane chemistry is a significant area of research in catalysis. Converting methane into value-added chemicals is desirable but challenging due to its high C-H bonding energy and lack of pi bonding or unpaired electrons. Photocatalytic partial oxidation of methane to liquid oxygenates is a promising technology for achieving high efficiency and selectivity under mild conditions. The choice and activation of oxidants are crucial for its performance.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lu Liu, Ziyi Liu, Jingnan Cui, Guiling Ning, Weitao Gong
Summary: The development of new metal-free heterogeneous catalysts has been the subject of extensive research. In this study, a new Troger's base (TB)-derived porous organic polymer (POPs) was designed and prepared by integrating multifunctional monomers. The resulting polymer, which combines the advantages of pillar[5]arene macrocycle and TB moiety, exhibited enhanced catalytic performance in Knoevenagel condensation and CO2 conversion, serving as an effective metal-free catalyst. This work provides a new strategy for fabricating metal-free heterogeneous catalysts based on macrocyclic POPs.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leyong Zhou, Changyin Yang, Weitao Dou, Tongxia Jin, Haibo Yang, Lin Xu
Summary: This review summarizes the application of micro/nanofluidic techniques in constructing supramolecular assemblies of different scales, and highlights the advantages of these techniques over conventional synthesis methods. Furthermore, it emphasizes the potential of micro/nanofluidic systems in improving our understanding of supramolecular self-assembly processes.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Yanchao Jin, Suixiaochen Chen, Peiwen Huang, Xiongjian Chen, Chun-Yan Lin, Li-Ping Li, Xiao Chen, Rui Ding, Jianxi Liu, Riyao Chen
Summary: In this study, magnesium and coconut shell carbon were used to disinfect water by adsorbing copper(II) and converting dissolved oxygen to hydrogen peroxide through Mg corrosion. The copper was enriched on the carbon surface and efficiently catalyzed the hydrogen peroxide to inactivate E.coli. The process showed promising disinfection performance both in laboratory experiments and real wastewater treatment.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Haihong Lai, Zehong Chen, Hao Zhuo, Yijie Hu, Xuan Zhao, Jiwang Yi, Hongzhi Zheng, Ge Shi, Yifan Tong, Ling Meng, Xinwen Peng, Linxin Zhong
Summary: By altering the pyrolysis route of cellulose nanofiber, the structural defects of carbon aerogels can be reduced, leading to improved compressibility and stress retention, as well as higher stress sensor sensitivity and temperature coefficient.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lina Guo, Jinsong Ding, Wenhu Zhou
Summary: Bacteria-based tumor therapy has resurfaced due to the revolution of tumor immunotherapy, offering unique solutions for traditional tumor treatments. Bacteria with active tropism can selectively colonize tumor sites and suppress tumor growth through various mechanisms, making them attractive tools for tumor treatment. This critical review introduces recent advances in bacteria-based tumor therapy, including bacterial properties, their benefits for tumor therapy, anti-tumor mechanisms, challenges, and future perspectives.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lan Liang, Chuanbin Wang, Xukai Lu, Yunan Sun, Beibei Yan, Ning Li, Guanyi Chen, Li'an Hou
Summary: This study investigates the interactions between phenol and benzaldehyde in the ECH process through experiments and theoretical calculations. The results show that phenol can accelerate the conversion of benzaldehyde, while benzaldehyde inhibits the conversion of phenol. The research provides a theoretical basis for the application of ECH in practical bio-oil upgrading.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Pengcheng Fan, Yuhao He, Junan Pan, Ning Sun, Qiyu Zhang, Chen Gu, Kang Chen, Weinan Yin, Longlu Wang
Summary: This study focuses on the recent progress in hydrogen evolution reaction (HER) based on photothermal effect. It introduces the main pathways of photothermal conversions applied in H2 evolution, summarizes the functions of the photothermal effect, and presents a method to improve the catalytic system through thermal means. The study also discusses the challenges and outlook in this promising area.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leiduo Lai, Hongyu Zhou, Yichen Hong, Mengfan Luo, Yang Shi, Heng Zhang, Zhaokun Xiong, Gang Yao, Bo Lai
Summary: In this study, a facile ammonia reduction strategy was proposed and a novel FeVO3-x catalyst was synthesized for the activation of peroxymonosulfate (PMS) to degrade the pharmaceutical carbamazepine (CBZ). The results showed that the system could rapidly degrade CBZ and generate various active species involved in the degradation process.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Tangxin Xiao, Xiuxiu Li, Liangliang Zhang, Kai Diao, Zheng-Yi Li, Xiao-Qiang Sun, Leyong Wang
Summary: This study presents the construction of a supramolecular light harvesting system based on sequential energy transfer. The system demonstrates tunable fluorescence emission through self-assembly of polymers into nanoparticles, achieving efficient two-step light harvesting.
CHINESE CHEMICAL LETTERS
(2024)
