Review
Chemistry, Multidisciplinary
Xiamin Cheng, Jing Gao, Yang Ding, Yao Lu, Qiancheng Wei, Dezhi Cui, Jiali Fan, Xiaoman Li, Ershu Zhu, Yongna Lu, Qiong Wu, Lin Li, Wei Huang
Summary: This review discusses the development of liposomes as versatile nano-carriers for drug delivery in order to overcome limitations of PDT and enhance therapeutic effects.
Review
Chemistry, Multidisciplinary
Yanhua Li, Xia Zhang, Xiaohan Liu, Wei Pan, Na Li, Bo Tang
Summary: Cancer immunotherapy utilizes the body's immune system to fight cancer, but direct injection of immunomodulators may lead to excessive immune response. Therefore, the development of intelligent stimuli-responsive nano immunomodulators is crucial for amplifying anti-tumor responses safely and effectively.
Article
Pharmacology & Pharmacy
Xueqi Lin, Xingdi Wu, Xiang Chen, Ben Wang, Wen Xu
Summary: This review introduces stimuli-responsive drug delivery systems in eyes, summarizes their design and mechanisms, and briefly discusses their advantages and limitations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biotechnology & Applied Microbiology
Neha Kaushik, Shweta B. Borkar, Sondavid K. Nandanwar, Pritam Kumar Panda, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Nanocarriers (NCs) have attracted significant attention for their structural ability, good biocompatibility, and biodegradability. The development of NCs with stimuli-responsive properties has become a hot topic among scientists. These NCs can deliver drugs to tumors by regulating their pH, temperature, and enzyme responsiveness, thereby improving the accuracy of drug delivery and minimizing side effects. Material carriers for chemotherapeutic medicines are discussed in this review, with a focus on their structural properties and targeting methods that enhance therapeutic efficacy and trigger metabolic pathways. Overall, the development of NCs that respond to endogenous and exogenous stimuli in tumor regions and the understanding of their mechanisms have great potential for advancing tumor therapy and precision diagnosis in the future.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Polymer Science
Sudipta Chatterjee, Patrick Chi-leung Hui
Summary: Thermo-responsive polysaccharides and protein-like materials have temperature-dependent sol-gel transitions, making them valuable for drug delivery and tissue engineering applications. Their biocompatibility, biodegradability, and non-toxicity make them ideal for such medical uses.
Review
Engineering, Environmental
Jingbo Yang, Haoxiang Zhang, Tianli Hu, Chenjie Xu, Lelun Jiang, Yu Shrike Zhang, Maobin Xie
Summary: Microneedles are minimally invasive tools that have gained increasing attention for their advantages such as pain-free, self-administration, and ease of disposal. This review summarizes the latest developments in microneedle technology and its advanced applications in biomedical field.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Medicine, Research & Experimental
Mohammad Arad Zandieh, Melika Heydari Farahani, Mahshid Daryab, Alireza Motahari, Sarah Gholami, Farshid Salmani, Fatemeh Karimi, Seyedeh Setareh Samaei, Aryan Rezaee, Parham Rahmanian, Ramin Khorrami, Shokooh Salimimoghadam, Noushin Nabavi, Rongjun Zou, Gautam Sethi, Mohsen Rashidi, Kiavash Hushmandi
Summary: The use of phytochemicals in cancer therapy has been accelerated due to tumor cell resistance to conventional chemotherapy drugs. However, the poor bioavailability and lack of specific accumulation at tumor sites pose challenges. The use of nanocarriers for targeted delivery of phytochemicals shows promise in improving pharmacokinetics and therapeutic indices. Stimuli-responsive nanostructures and surface functionalization with ligands further enhance the internalization and cytotoxicity of natural compounds in cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Polymer Science
Julia Radwan-Praglowska, Lukasz Janus, Marek Piatkowski, Aleksandra Sierakowska, Ernest Szajna, Dalibor Matysek, Dariusz Bogdal
Summary: Epilepsy is a common neurological disease that can have a significant negative impact on quality of life, especially when symptoms are drug-resistant. Cannabidiol, derived from Cannabis Sativa, offers new hope for epilepsy treatment, with potential benefits in increasing bioactivity through transdermal delivery.
Review
Oncology
Fakhara Sabir, Mahira Zeeshan, Ushna Laraib, Mahmood Barani, Abbas Rahdar, Magali Cucchiarini, Sadanand Pandey
Summary: DNA-based smart nano-carriers can deliver drugs to tumor cells efficiently, enhancing treatment efficacy and minimizing damage to healthy cells. However, before clinical translation, challenges such as understanding in vivo parameters and drug delivery mechanisms must be addressed.
Article
Chemistry, Applied
Khadijeh Soleimani, Hossein Derakhshankhah, Mehdi Jaymand, Hadi Samadian
Summary: Natural gums can be utilized as stimuli-responsive DDSs for cancer treatment due to their beneficial characteristics, though they may require modification to overcome certain limitations. This review article aims to compile natural gums-based stimuli-responsive DDSs and briefly highlight different types of stimuli, fundamental features of natural gums, and chemical modification approaches.
CARBOHYDRATE POLYMERS
(2021)
Review
Pharmacology & Pharmacy
Avelino Corma, Pablo Botella, Eva Rivero-Buceta
Summary: This article introduces silica-based nanomedicines and their significant role in cancer treatment. Silica nanoparticles have been proposed as safe and effective vehicles for delivering antitumor drugs due to their stability, high surface area, and easy functionalization. These silica nanomedicines have specific mechanisms for intracellular drug release, allowing for precise control of drug discharge. By responding to endogenous and exogenous stimuli, these nanomedicines can achieve selective delivery to cancer cells.
Article
Engineering, Biomedical
Xuan Meng, Lin Wang, Ning Zhao, Delong Zhao, Yongli Shen, Yuan Yao, Wenjie Jing, Shuli Man, Yujie Dai, Yanjun Zhao
Summary: This study reports a hybrid nanocarrier that targets glycolysis and redox balance simultaneously for cancer therapy. The nanocarrier, composed of pH-and ATP-responsive ZIF-8 core and poloxamer 407 coating, delivers glucose oxidase and 3-bromopyruvate to liver hepatocellular carcinoma cells, effectively inhibiting cellular energy metabolism and reducing cell viability. This approach enriches the available strategies for anti-tumor treatment.
ACTA BIOMATERIALIA
(2023)
Review
Polymer Science
Siphokazi B. K. Dludla, Leshasha T. Mashabela, Brian Ng'andwe, Pedzisai A. Makoni, Bwalya A. Witika
Summary: The application of nanotechnology in ophthalmic drug delivery systems shows great potential to overcome barriers faced by traditional ophthalmic formulations. Stimuli-responsive nano drug carriers have attracted significant attention due to their unique functionalities and therapeutic efficacy, playing a crucial role in the treatment and alleviation of ocular diseases.
Review
Pharmacology & Pharmacy
Tao Sun, Chen Jiang
Summary: Drug delivery systems (DDS) triggered by local microenvironment represent the state-of-art of nanomedicine design, aiming to precisely recognize diseased sites, reduce side effects, and expand the therapeutic window. However, the design of DDS functioning at microcosmic levels is still challenging and underexploited.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Yuhan Xia, Zhiyuan Ma, Xuechen Wu, Huidan Wei, Han Zhang, Guang Li, Yuqi Qian, Mina Shahriari-Khalaji, Kai Hou, Ran Cao, Meifang Zhu
Summary: Sustainable and controllable drug transport is an efficient method for disease treatment. Chitosan hydrogel, characterized by high biocompatibility, good biodegradability, and low costs, has been widely used in biomedical fields. The abundant amino and hydroxyl groups in chitosan hydrogel allow it to interact with human tissues and enable drugs to pass through biological barriers. The multi-responsive nature of chitosan hydrogel, including pH, temperature, ions strength, and magnetic field, makes precise drug release possible. This review summarizes the synthesis methods, modification strategies, stimuli-responsive mechanisms, and recent progress of chitosan-based hydrogels in drug delivery, focusing on subcutaneous, oral, and facial administration. The challenges towards clinical application and future prospects are also discussed.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Long Binh Vong, Yuna Sato, Pennapa Chonpathompikunlert, Supita Tanasawet, Pilaiwanwadee Hutamekalin, Yukio Nagasaki
ACTA BIOMATERIALIA
(2020)
Article
Engineering, Biomedical
Qianglan Lu, Tong Lu, Min Xu, Lifang Yang, Yilin Song, Nan Li
Article
Engineering, Environmental
Wen Li, Siyu Wang, Chuchu Ren, Ping Liu, Qianglan Lu, Lifang Yang, Yilin Song, Min Xu, Fengping Tan, Meng Yu, Nan Li
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Thu-Ha Thi Nguyen, Nhu-Thuy Trinh, Han Ngoc Tran, Hao Thi Tran, Phong Quoc Le, Dai-Nghiep Ngo, Hieu Tran-Van, Toi Van Vo, Long Binh Vong, Yukio Nagasaki
Summary: The study developed silica-containing redox nanoparticles to improve the bioavailability of silymarin, demonstrating the potential for treating inflammatory bowel diseases (IBD).
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Long Binh Vong, Nhu-Thuy Trinh, Yukio Nagasaki
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Nanoscience & Nanotechnology
Khoa Minh Le, Nhu-Thuy Trinh, Vinh Dinh-Xuan Nguyen, Tien-Dat Van Nguyen, Thu-Ha Thi Nguyen, Toi Van Vo, Tuan Quoc Tran, Dai-Nghiep Ngo, Long Binh Vong
Summary: The study demonstrates that curcumin nanoparticles show significant antioxidant and anti-inflammatory effects, improving water solubility and bioavailability, making them a potential effective approach for treating chronic inflammation.
JOURNAL OF NANOMATERIALS
(2021)
Article
Engineering, Biomedical
Wen Li, Yilin Song, Xiaoyang Liang, Yue Zhou, Min Xu, Qiang Lu, Xinxing Wang, Nan Li
Summary: The strategy developed provides effective sonodynamic therapy under hypoxic microenvironment for the treatment of rheumatoid arthritis (RA), with promising prospects for highly efficient treatment.
Article
Materials Science, Biomaterials
Ngoc Xuan Dat Mai, Thu-Ha Thi Nguyen, Long Binh Vong, Minh-Huy Dinh Dang, Trang Thi Thu Nguyen, Linh Ho Thuy Nguyen, Hanh Kieu Thi Ta, Thi-Hiep Nguyen, Thang Bach Phan, Tan Le Hoang Doan
Summary: The biodegradable B-PMO nanoparticles, particularly the P4S synthesized in this study, exhibited high drug loading capacity and slow release profile, making it an excellent nanocarrier for therapeutic drugs. The incorporation of aromatic phenylene groups in the framework enhanced the interaction with cordycepin molecules, resulting in specific release behavior and minimal side effects. Moreover, P4S demonstrated complete biodegradability in a reducing environment within 14 days, with high drug loading and slower release compared to conventional materials like liposomes, gelatin nanoparticles, and hydrogels.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Biomedical
Nhu Nguyen-Trinh Quynh, Kim Xuyen Thi Trinh, Nhu-Thuy Trinh, Van Toi Vo, Nan Li, Yukio Nagasaki, Long Binh Vong
Summary: In this study, silica-installed ROS scavenging nanoparticles (siRNP) were used as a potential nanomedicine for the treatment of colon cancer. The incorporation of camptothecin (CPT) into the core of the nanoparticle significantly improved its solubility. The CPT@siRNP treatment showed enhanced anticancer activity against colorectal cancer cells, reduced cytotoxicity to normal endothelial cells, and suppressed intestinal side effects in a tumor-bearing mouse model.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Environmental
Yilin Song, Wen Li, Huaqing Jing, Xiaoyang Liang, Yue Zhou, Nan Li, Shiqing Feng
Summary: This study presents the design of a Z-scheme heterostructure sonosensitizer, which effectively separates electron-hole pairs and enhances redox potentials, thereby improving the efficiency of sonodynamic therapy. This novel sonosensitizer shows potential utility in the treatment of rheumatoid arthritis (RA).
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Tingting Wang, Guangxu Xiao, Qianglan Lu, Yue Zhou, Siyu Wang, Xiaoyang Liang, Yilin Song, Min Xu, Yan Zhu, Nan Li
Summary: This study proposes an innovative pharmacological strategy to enhance autophagy dysfunction by combining endoplasmic reticulum stress and lysosomal impairment. The results show that the synthesized nanobullets exhibit excellent therapeutic efficacy by inducing ER stress and impairing lysosomes, leading to autophagy dysfunction. This research provides a promising therapeutic nanoagent for effective tumor therapy.
Article
Chemistry, Multidisciplinary
Yang Zhang, Chao Liu, Jiaqi Wang, Shoujun Ren, Yilin Song, Peng Quan, Liang Fang
Summary: Transdermal drug delivery has advantages over other administration pathways, but faces challenges with conventional permeation methods. Ionic liquids have been extensively studied and applied in pharmaceutical drug delivery due to their unique properties. This review discusses the application of ionic liquids in transdermal delivery and their breakthroughs.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Medicinal
Minh-Dat Quoc Tang, Nhu-Thuy Trinh, Dung Vu, Thu-Ha Thi Nguyen, Hung Thanh Dong, Toi Van Vo, Long Binh Vong
Summary: This study designed non-silica and silica redox nanoparticles (RNPN and siRNP) with reactive oxygen species (ROS) scavenging features to encapsulate doxorubicin (DOX) and reduce its cytotoxicity. The results showed that DOX@RNPN and DOX@siRNP exhibited anticancer activity against liver cancer cells and breast cancer cells, while their cytotoxicity on normal cells was significantly reduced.
Article
Chemistry, Multidisciplinary
Qian Wu, Yubo Cui, Guifeng Xia, Jinlong Yang, Shuming Du, Xinhong Xiong, Li Yang, Dong Xu, Xu Deng, Jiaxi Cui
Summary: Passive daytime radiative cooling (PDRC) technology, while promising for global spacing cooling, faces limitations in practical application due to reduced cooling effectiveness caused by wear and dirt contamination. Researchers have developed a renewable armor structure using fluorinated hollow glass microspheres to enhance the anti-fouling and cooling properties of PDRC coatings. The coatings exhibit high solar reflectance and thermal emittance, leading to significant temperature reduction below ambient temperature.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Qiang Bei, Bei Zhang, Kaifeng Wang, Shiming Zhang, Guichuan Xing, Clement Cabanetos
Summary: The power conversion efficiency (PCE) of organic solar cells (OSCs) has reached 20% in recent years, thanks to the advantages of organic photoactive materials. Benzothiadiazole (BT) has attracted significant research attention as a building block of OSCs. OSCs based on BT structure have shown diversity, and the increasing PCE values indicate a promising future for OSCs. This review analyzes the progress made in the last decades, focusing on effective BT small-molecules and BT polymers for OSCs. The structure-property relationships, donor-acceptor matching criteria, and morphology control approaches are discussed. The remaining challenges and a personal perspective on the future advancement of OSCs are summarized.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Rong He, Dandan Tang, Ningge Xu, Heng Liu, Kun Dou, Xuejun Zhou, Fabiao Yu
Summary: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, with a high incidence in China and Southeast Asian countries. In this study, a novel near-infrared fluorescent probe, SNAFL-GSH, was designed and synthesized for the detection of glutathione (GSH). The probe showed selective detection of GSH and the ability to distinguish normal and cancer cells. It has great potential for application in the diagnosis and evaluation of NPC.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Lian Jin, Song Li, Yan Deng, Zhu Chen, Hui Chen, Yuanying Zhang, Rabia Usman, Nongyue He
Summary: This study isolated primary cells that can be stably passaged from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice and used an autonomously developed automated screening instrument for efficient nucleic acid aptamer screening. The obtained aptamers were affinity verified at the cellular level. The study also investigated the impact of cell growth environment difference on the recognition ability of aptamers and confirmed the targeting ability and drug loading ability of the aptamer.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhongshan Yang, Qiqi Zhang, Hui Song, Xin Chen, Jiwei Cui, Yanhui Sun, Lequan Liu, Jinhua Ye
Summary: Methane chemistry is a significant area of research in catalysis. Converting methane into value-added chemicals is desirable but challenging due to its high C-H bonding energy and lack of pi bonding or unpaired electrons. Photocatalytic partial oxidation of methane to liquid oxygenates is a promising technology for achieving high efficiency and selectivity under mild conditions. The choice and activation of oxidants are crucial for its performance.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lu Liu, Ziyi Liu, Jingnan Cui, Guiling Ning, Weitao Gong
Summary: The development of new metal-free heterogeneous catalysts has been the subject of extensive research. In this study, a new Troger's base (TB)-derived porous organic polymer (POPs) was designed and prepared by integrating multifunctional monomers. The resulting polymer, which combines the advantages of pillar[5]arene macrocycle and TB moiety, exhibited enhanced catalytic performance in Knoevenagel condensation and CO2 conversion, serving as an effective metal-free catalyst. This work provides a new strategy for fabricating metal-free heterogeneous catalysts based on macrocyclic POPs.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leyong Zhou, Changyin Yang, Weitao Dou, Tongxia Jin, Haibo Yang, Lin Xu
Summary: This review summarizes the application of micro/nanofluidic techniques in constructing supramolecular assemblies of different scales, and highlights the advantages of these techniques over conventional synthesis methods. Furthermore, it emphasizes the potential of micro/nanofluidic systems in improving our understanding of supramolecular self-assembly processes.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Yanchao Jin, Suixiaochen Chen, Peiwen Huang, Xiongjian Chen, Chun-Yan Lin, Li-Ping Li, Xiao Chen, Rui Ding, Jianxi Liu, Riyao Chen
Summary: In this study, magnesium and coconut shell carbon were used to disinfect water by adsorbing copper(II) and converting dissolved oxygen to hydrogen peroxide through Mg corrosion. The copper was enriched on the carbon surface and efficiently catalyzed the hydrogen peroxide to inactivate E.coli. The process showed promising disinfection performance both in laboratory experiments and real wastewater treatment.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Haihong Lai, Zehong Chen, Hao Zhuo, Yijie Hu, Xuan Zhao, Jiwang Yi, Hongzhi Zheng, Ge Shi, Yifan Tong, Ling Meng, Xinwen Peng, Linxin Zhong
Summary: By altering the pyrolysis route of cellulose nanofiber, the structural defects of carbon aerogels can be reduced, leading to improved compressibility and stress retention, as well as higher stress sensor sensitivity and temperature coefficient.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lina Guo, Jinsong Ding, Wenhu Zhou
Summary: Bacteria-based tumor therapy has resurfaced due to the revolution of tumor immunotherapy, offering unique solutions for traditional tumor treatments. Bacteria with active tropism can selectively colonize tumor sites and suppress tumor growth through various mechanisms, making them attractive tools for tumor treatment. This critical review introduces recent advances in bacteria-based tumor therapy, including bacterial properties, their benefits for tumor therapy, anti-tumor mechanisms, challenges, and future perspectives.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lan Liang, Chuanbin Wang, Xukai Lu, Yunan Sun, Beibei Yan, Ning Li, Guanyi Chen, Li'an Hou
Summary: This study investigates the interactions between phenol and benzaldehyde in the ECH process through experiments and theoretical calculations. The results show that phenol can accelerate the conversion of benzaldehyde, while benzaldehyde inhibits the conversion of phenol. The research provides a theoretical basis for the application of ECH in practical bio-oil upgrading.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Pengcheng Fan, Yuhao He, Junan Pan, Ning Sun, Qiyu Zhang, Chen Gu, Kang Chen, Weinan Yin, Longlu Wang
Summary: This study focuses on the recent progress in hydrogen evolution reaction (HER) based on photothermal effect. It introduces the main pathways of photothermal conversions applied in H2 evolution, summarizes the functions of the photothermal effect, and presents a method to improve the catalytic system through thermal means. The study also discusses the challenges and outlook in this promising area.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leiduo Lai, Hongyu Zhou, Yichen Hong, Mengfan Luo, Yang Shi, Heng Zhang, Zhaokun Xiong, Gang Yao, Bo Lai
Summary: In this study, a facile ammonia reduction strategy was proposed and a novel FeVO3-x catalyst was synthesized for the activation of peroxymonosulfate (PMS) to degrade the pharmaceutical carbamazepine (CBZ). The results showed that the system could rapidly degrade CBZ and generate various active species involved in the degradation process.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Tangxin Xiao, Xiuxiu Li, Liangliang Zhang, Kai Diao, Zheng-Yi Li, Xiao-Qiang Sun, Leyong Wang
Summary: This study presents the construction of a supramolecular light harvesting system based on sequential energy transfer. The system demonstrates tunable fluorescence emission through self-assembly of polymers into nanoparticles, achieving efficient two-step light harvesting.
CHINESE CHEMICAL LETTERS
(2024)