Review
Biotechnology & Applied Microbiology
Bhagwan Toksha, Vinay Alias Manish Sonawale, Abhishek Vanarase, Deepak Bornare, Shyam Tonde, Chinmay Hazra, Debasree Kundu, Ajinkya Satdive, Saurabh Tayde, Aniruddha Chatterjee
Summary: The largest and oldest agricultural industry is facing problems such as increasing demand for food and depletion of resources, leading to the widespread use of synthetic fertilizers. Nanotechnology has shown capabilities in improving plant nutrition and soil fertility with nanofertilizers, contributing to sustainable agriculture.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Horticulture
Alejandro Palacio-Marquez, Carlos A. Ramirez-Estrada, Nayeli Jazmin Gutierrez-Ruelas, Esteban Sanchez, Damaris L. Ojeda-Barrios, Celia Chavez-Mendoza, Juan P. Sida-Arreola
Summary: The individual application of zinc oxide nanoparticles and chitosan can improve crop growth and production, with higher effectiveness compared to conventional fertilizers. However, there is limited information on the foliar application of zinc oxide nanoparticles complexed with chitosan and their effects on crop physiology. Further research is needed to understand the physicochemical properties of these nanoparticles and their impact on plant physiology and biochemistry.
SCIENTIA HORTICULTURAE
(2021)
Article
Plant Sciences
Satyendra Pratap Singh, Chetan Keswani, Tatiana Minkina, Aurelio Ortiz, Estibaliz Sansinenea
Summary: Sustainable agriculture poses challenges to human health, particularly in terms of managing plant diseases caused by climate change and emerging pathogens. The use of environmentally friendly biopesticides/biofertilizers and nanomaterials shows promise in mitigating the impact of these challenges. Nanotechnology can reduce chemical use, nutrient loss, and increase crop yield through the use of nanofertilizers and nanopesticides. Nanosensors can monitor soil quality and maintain the health of agricultural plants. Despite ongoing large-scale production and field testing, information suggests that nano-agrochemicals improve uptake, efficiency, targeted delivery, and reduce leaching and pollution. This review summarizes the impact of nanotechnology in agriculture.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Review
Biochemistry & Molecular Biology
Chenxu Liu, Hui Zhou, Jie Zhou
Summary: Nanotechnology presents a promising approach to improving crop production, enhancing crop tolerance, and reducing environmental pollution. The use of nanomaterials in plant growth and crop production, such as nanofertilizers, nanopesticides, nanosensors, and nanobiotechnology, offers diverse applications to address agricultural challenges.
Review
Plant Sciences
Paola Fincheira, Gonzalo Tortella, Amedea B. Seabra, Andres Quiroz, Maria Cristina Diez, Olga Rubilar
Summary: Advancements in nanotechnology have positioned it as a crucial tool for enhancing agricultural production, with nanomaterials serving as efficient nutrients or carriers for controlled fertilizer release. Despite the potential benefits of nanofertilizers in improving plant growth and nutrition, their application in sustainable agriculture remains a significant challenge.
Article
Chemistry, Physical
Piotr Salachna, Malgorzata Mizielinska, Beata Ploszaj-Witkowska, Agnieszka Jaszczak
Summary: This study demonstrated that low rates of ZnO NPs are beneficial for red perilla production, serving as a biostimulant and nanofertilizer.
Article
Environmental Sciences
Prexha Kapoor, Rahul Kumar Dhaka, Pooja Sihag, Sheetal Mehla, Vijeta Sagwal, Yogita Singh, Sonu Langaya, Priyanka Balyan, Krishna Pal Singh, Baoshan Xing, Jason C. White, Om Parkash Dhankher, Upendra Kumar
Summary: Nutrient deficiency in food crops is a significant problem affecting human health, particularly in under privileged communities. The use of chemical fertilizers has limitations in delivering nutrients efficiently and poses risks to the environment and health. Utilizing nanofertilizers can address nutrient deficiency and improve food quality.
Review
Green & Sustainable Science & Technology
Peter Olutope Fayemi, Omolola Esther Fayemi, Luke Oluwaseye Joel, Michael Gbenga Ogungbuyi
Summary: The outbreak of the SARS-CoV-2 virus has caused significant disruptions to millions of people in 2020-2021, with concerns about susceptibility to infection and the communal nature of agrarians in the livestock industry. Identifying coronavirus variants and correlating exposure dynamics remains a challenge in the livestock industry.
Article
Plant Sciences
Geetika Guleria, Shweta Thakur, Mamta Shandilya, Sushma Sharma, Sapna Thakur, Susheel Kalia
Summary: The rapid population growth and environmental challenges in agriculture require innovative and sustainable solutions to meet the growing need for food worldwide. Recent nanotechnological advances have found broad applications in agriculture's protection and post-harvesting. Engineered nanomaterials play a vital role in plant regulation, seed germination, and genetic manipulation, ultimately leading to enhanced crop growth and production capacity in the food industry.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Agronomy
Fakir Mathlouthi, Roberto Ruggeri, Angelo Rossini, Francesco Rossini
Summary: This research compares the effect of a novel fertilization plan (T2) with a traditional fertilization pattern (T1) on the yield and protein content of bread wheat. The results suggest that the novel plan slightly increased yield and protein content, while decreasing plant height at harvest.
Article
Plant Sciences
Hani Saber Saudy, Goma Ahmed Abd El-Samad, Mohamed Esmail El-Temsah, Yasser Abd El-Gawad El-Gabry
Summary: This study aimed to investigate the response of various sesame genotypes to a nanostructure mixture of micronutrients. The Sohag1 genotype exhibited the most efficient utilization of Fe and Zn, leading to higher productivity and better nutrient uptake than other genotypes. The application of nano-mixture could be a promising solution for addressing micronutrient deficiency in sesame cultivation, especially under arid conditions like those in Egypt.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2022)
Article
Environmental Sciences
Subhash Babu, Raghavendra Singh, Devideen Yadav, Sanjay Singh Rathore, Rishi Raj, Ravikant Avasthe, S. K. Yadav, Anup Das, Vivek Yadav, Brijesh Yadav, Kapila Shekhawat, P. K. Upadhyay, Dinesh Kumar Yadav, Vinod K. Singh
Summary: The indiscriminate use of chemical fertilizers in agriculture has had a negative impact on ecosystem services and environmental quality. The development of alternative mechanisms, such as nanofertilizers, can enhance farm production and environmental sustainability. Nanofertilizers provide smart nutrient delivery to plants and have proven to be more effective than traditional chemical fertilizers in terms of crop productivity and environmental sustainability.
Review
Agronomy
Akila Wijerathna-Yapa, Ranjith Pathirana
Summary: Despite the Green Revolution's success in matching world food production with population growth, the UN's State of Food Security and Nutrition in the World 2022 Report reveals that hunger has increased, affecting 828 million people, with 29.3% of the global population being food insecure and 22% of children under five suffering from stunted growth. Poor diets and nutrient deficiencies have led to various diet-related non-communicable diseases. Furthermore, current agricultural systems have significant environmental and climate impacts. Climate change, pandemics, and conflicts also weaken food systems, aggravating global food insecurity. This review highlights the importance of implementing sustainable agricultural practices and policies to achieve food security and nutrition goals in the UN's 2030 Agenda for Sustainable Development.
Review
Biotechnology & Applied Microbiology
Boregowda Nandini, Kiran S. Mawale, Parvatam Giridhar
Summary: Nanotechnology has the potential to revolutionize agriculture and food production by reducing inputs, improving soil quality, managing plant diseases, and detecting diseases. This review highlights the promising impact of nanomaterials on plant health and their role in increasing agricultural production. Nanotechnology offers innovative solutions to overcome plant diseases and meet the growing need for food security.
Article
Multidisciplinary Sciences
Carlos Alberto Garza-Alonso, Antonio Juarez-Maldonado, Susana Gonzalez-Morales, Marcelino Cabrera-De la Fuente, Gregorio Cadenas-Pliego, America Berenice Morales-Diaz, Libia Iris Trejo-Tellez, Gonzalo Tortella, Adalberto Benavides-Mendoza
Summary: This study evaluated the applications of drench (D) and foliar (F) ZnO nanoparticles (NZnO) compared to ionic Zn2+ (ZnSO4) in lettuce. Results showed that NZnO promoted increases in biomass (14-52%), chlorophylls (32-69%), and antioxidant compounds such as phenolics, flavonoids, and vitamin C compared to Zn2+. A better response was found in the plants with foliar applications of NZnO equivalent to 50-75% of the total Zn2+ applied conventionally. These findings demonstrate the potential of NZnO in improving fertilizer efficiency and the quality of lettuce.
Review
Biochemistry & Molecular Biology
Sukhbir Singh, Neelam Sharma, Ishrat Zahoor, Tapan Behl, Anita Antil, Sumeet Gupta, Md Khalid Anwer, Syam Mohan, Simona Gabriela Bungau
Summary: The abundant synthesis and accretion of melanin inside skin can be caused by activation of melanogenic enzymes or increase in number of melanocytes. Melasma is defined as hyperpigmented bright or dark brown spots which are symmetrically distributed and have serrated and irregular borders. This review gives a brief overview regarding the Fitzpatrick skin phototype classification system, life cycle of melanin, mechanism of action of anti-hyperpigmenting drugs, and existing pharmacotherapy strategies for the treatment of melasma.
Review
Biochemistry & Molecular Biology
Aditi Sharma, Lalit Sharma, Shouvik Kumar Nandy, Nazrana Payal, Shivam Yadav, Celia Vargas-De-La-Cruz, Md. Khalid Anwer, Haroon Khan, Tapan Behl, Simona Gabriela Bungau
Summary: Due to genetic changes, cancer remains a major cause of death. Anticancer research faces challenges in targeting healthy cells while addressing the importance of target function. Cancer cells undergo various mutations and abnormalities that affect the efficacy of anticancer drugs. With low clinical success rates, finding alternative herbal-based therapies to attenuate resistance and protect against chemotherapy side effects is crucial. This review updates the understanding of common cancer types and presents key compounds that may enhance cancer treatment efficacy.
Review
Neurosciences
Vaibhav Jain, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Hafiz A. Makeen, Mohammed Albratty, Abdulkarim M. Meraya, Asim Najmi
Summary: Parkinson's disease is a neurodegenerative disorder characterized by loss of dopaminergic nerve cells due to oxidative stress. Symptoms include muscle stiffness, disturbed sleep, fatigue, and voice impairment. Recent studies have shown that certain cannabinoids act as antioxidants and may protect nerve cells from degeneration. Combining cannabinoids with existing drugs could potentially revolutionize the treatment of Parkinson's disease, offering new hope for patients suffering from this debilitating illness.
NEUROTOXICITY RESEARCH
(2023)
Review
Immunology
Anuja Singh, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Maaz Naqwi, Anil Mavi, Randhir Singh
Summary: This article discusses the potential and recent advancements in using stem cell-derived exosomes for the treatment of rheumatoid arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Review
Biology
Manuel Alexandru Gitea, Simona Gabriela Bungau, Daniela Gitea, Bianca Manuela Pasca, Anamaria Lavinia Purza, Andrei-Flavius Radu
Summary: Seeds from grapes are rich in biologically active compounds and can be used as a primary platform for natural extracts, innovative foods, medicines, and cosmetics. This paper focuses on the phytochemical composition, manufacturing processes, and health benefits of various grape seed oils extracted using different methods. However, the results vary across studies due to different factors and measurement units, making the communication of results challenging. The main topics covered are grape seed oil's lipophilic fatty acids, tocopherols, and phytosterols. In addition, affordable, energy-efficient, and environmentally friendly extraction methods should be developed to improve the oil's quality and biological activity for the management of various diseases.
Review
Biotechnology & Applied Microbiology
Safir Ullah Khan, Muhammad Imran Khan, Munir Ullah Khan, Noor Muhammad Khan, Simona Bungau, Syed Shams ul Hassan
Summary: Diseases affecting the brain and spinal cord are classified as central nervous system diseases. Most medications used for these diseases are unable to cross the blood-brain barrier, limiting their effectiveness. However, exosomes, due to their small size, high delivery efficiency, and compatibility, can cross the blood-brain barrier and serve as transporters for targeted drug administration. Further research and bioengineering modifications can enhance the properties and targeting abilities of exosomes, making them promising vectors for central nervous system diseases.
BIOENGINEERING-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Mehreen Ghufran, Mehran Ullah, Haider Ali Khan, Sabreen Ghufran, Muhammad Ayaz, Muhammad Siddiq, Syed Qamar Abbas, Syed Shams ul Hassan, Simona Bungau
Summary: During the SARS-CoV-2 outbreak, researchers extensively studied pharmacological strategies to decrease the viral load in severe patients. The M-pro protease, which is essential for viral replication, has been identified as a potential therapeutic target. To prevent further spread of the pandemic, scientists are actively searching for more efficient inhibitors against SARS-CoV-2.
BIOENGINEERING-BASEL
(2023)
Review
Immunology
Safir Ullah Khan, Munir Ullah Khan, Muhammad Azhar Ud Din, Ibrar Muhammad Khan, Muhammad Imran Khan, Simona Bungau, Syed Shams ul Hassan
Summary: Over the past decade, it has been increasingly recognized that tumor-infiltrating myeloid cells, including tumor-associated macrophages (TAMs), play a crucial role in promoting tumor development, invasion, and metastasis. TAMs are the most common type of immune cells in many malignancies and contribute to the establishment of an immune-suppressive tumor microenvironment (TME). The presence of pro-tumoral TAMs hinders the effectiveness of conventional therapies and even innovative immunotherapies based on immune-checkpoint suppression. Understanding the metabolic changes and functional plasticity of TAMs in the complex TME is important for developing targeted tumor immunotherapy and more effective treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Aditi Sharma, Chakshu Sharma, Om Praksah Shah, Sridevi Chigurupati, Bhaskaran Ashokan, Semmal Syed Meerasa, Summya Rashid, Tapan Behl, Simona Gabriela Bungau
Summary: Postmenopausal osteoporosis, a prevalent disorder in older women, is characterized by a decrease in bone mineral density and increased risk of fractures. Insufficiency of estrogen hormone leads to postmenopausal osteoporosis. Hormone replacement therapy is the most effective treatment, but it carries the risk of breast cancer and cardiovascular disorders. This review compiles recent information on herbal and natural compounds used to treat and prevent postmenopausal osteoporosis, discussing their origin, chemical constituents, and molecular mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Alexa Florina Bungau, Andrei Flavius Radu, Simona Gabriela Bungau, Cosmin Mihai Vesa, Delia Mirela Tit, Laura Maria Endres
Summary: Acne vulgaris is a common skin condition caused by excessive sebum secretion, abnormal keratinization, bacterial colonization, and inflammation. Recent research suggests a link between acne vulgaris and metabolic syndrome, characterized by obesity, insulin resistance, hypertension, and dyslipidemia. The excessive production of reactive oxygen species and chronic inflammation play crucial roles in the pathophysiology of both conditions. This review focuses on the molecular implications of inflammatory, hormonal, and environmental factors in the acne-metabolic syndrome correlation and outlines the current understanding of phytotherapeutic approaches as adjuvant strategies. However, future large-scale studies are needed to establish new algorithms for managing patients with these conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Muhammad Tahir Aqeel, Nisar-ur Rahman, Arif-ullah Khan, Muhammad Tariq Khan, Zaman Ashraf, Syed Shams ul Hassan, Simona Gabriela Bungau, Muhammad Majid
Summary: This study assessed the therapeutic potential of five 2-methoxy phenol derivatives as antioxidants, anti-inflammatory agents, and vasorelaxants. The results showed that T2 exhibited significant antioxidant and vasorelaxant effects, with favorable pharmacokinetic properties, making it a promising lead compound for further investigation in cardiovascular disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Green & Sustainable Science & Technology
Manuel Alexandru Gitea, Daniela Gitea, Delia Mirela Tit, Simona Gabriela Bungau, Mihaela Alexandra Bogdan, Andrei-Flavius Radu, Francisc Vasile Dulf, Manuela Bianca Pasca
Summary: This study evaluated the physico-chemical and bioactive properties of grape seed oil (GSO) obtained from two grape varieties. The results showed that GSO has high antioxidant activity and is rich in polyunsaturated fatty acids and total polyphenols.
Article
Materials Science, Biomaterials
Neelam Sharma, Neha Tiwary, Tapan Behl, Sukhbir Singh, Sumeet Gupta, Md. Khalid Anwer, Celia Vargas-De-La-Cruz, Shivam Yadav, Simona Gabriela Bungau
Summary: Genistein, a type of isoflavone, has a wide range of therapeutic effects in the treatment of various diseases, including cardiovascular disease, diabetes, depression, and cancer. It inhibits cancer growth by regulating cell cycle and cell death signaling pathways, has antidiabetic activity through promoting cell proliferation and survival, and exerts cardioprotective effects through antioxidant and antihypertensive activities.
Article
Biotechnology & Applied Microbiology
Flaviu Bodea, Simona Gabriela Bungau, Andrei Paul Negru, Ada Radu, Alexandra Georgiana Tarce, Delia Mirela Tit, Alexa Florina Bungau, Cristian Bustea, Tapan Behl, Andrei-Flavius Radu
Summary: Ophthalmic disorders cover a wide range of diseases that affect the eye's structures and functions. The management of these disorders is crucial, but there are several unmet needs, including outcome measures in clinical trials, minimally invasive glaucoma surgery, and comprehensive bibliometric assessments. This study utilized molecular docking analysis, ligand virtual screening, and bibliometric analysis to address these needs and identify potential compounds for glaucoma management and evaluate the current knowledge in therapeutic approaches to ocular diseases.
BIOENGINEERING-BASEL
(2023)