Decabromodiphenyl ether induces male reproductive toxicity by activating mitochondrial apoptotic pathway through glycolipid metabolism dysbiosis

Decabromodiphenyl ethane disturbs hepatic glycolipid metabolism by regulating the PI3K/AKT/GLUT4 and mTOR/PPARγ/RXRα pathway in mice and L02 cells

(2020) Yupeng Zhu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

BDE-209 and DBDPE induce male reproductive toxicity through telomere-related cell senescence and apoptosis in SD rat

(2020) Xiangyang Li et al.   ENVIRONMENT INTERNATIONAL

Zearalenone induces apoptosis of rat Sertoli cells through Fas-Fas ligand and mitochondrial pathway

(2019) Guodong Cai et al.   ENVIRONMENTAL TOXICOLOGY

Cardiovascular toxicity of decabrominated diphenyl ethers (BDE-209) and decabromodiphenyl ethane (DBDPE) in rats

(2019) Li Jing et al.   CHEMOSPHERE

Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation

(2019) Alicia Bort et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

(2019) Masaji Sakaguchi et al.   Nature Communications

Maternal BDE-209 exposure during lactation causes testicular and epididymal toxicity through increased oxidative stress in peripubertal mice offspring

(2019) Debarshi Sarkar et al.   TOXICOLOGY LETTERS

Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway

(2019) Fang Huang et al.   Biomed Research International

BDE-209 induces male reproductive toxicity via cell cycle arrest and apoptosis mediated by DNA damage response signaling pathways

(2019) Xiangyang Li et al.   ENVIRONMENTAL POLLUTION

Polybrominated diphenyl ethers in the environment and human external and internal exposure in China: A review

(2019) Yufeng Jiang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The hypothalamic neuropeptide orexin A– a possible regulator in glucose homeostasis and germ cell kinetics in adult mice testes

(2018) Deepanshu Joshi et al.   BIOCHIMIE

Legacy and emerging brominated flame retardants in China: A review on food and human milk contamination, human dietary exposure and risk assessment

(2018) Zhixiong Shi et al.   CHEMOSPHERE

Global occurrence of polybrominated diphenyl ethers and their hydroxylated and methoxylated structural analogues in an important animal feed (fishmeal)

(2018) Xiaomin Li et al.   ENVIRONMENTAL POLLUTION

A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass

(2018) Yinxin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PM 2.5 induces male reproductive toxicity via mitochondrial dysfunction, DNA damage and RIPK1 mediated apoptotic signaling pathway

(2018) Jin Zhang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Disruption of thyroid hormone levels by decabrominated diphenyl ethers (BDE-209) in occupational workers from a deca-BDE manufacturing plant

(2018) Tian Chen et al.   ENVIRONMENT INTERNATIONAL

Maternal BDE-209 exposure during lactation perturbs steroidogenesis, germ cell kinetics and THRα1 expression in testes of prepubertal mice offspring

(2018) Debarshi Sarkar et al.   FOOD AND CHEMICAL TOXICOLOGY

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

High glucose levels affect spermatogenesis: an in vitro approach

(2017) Renata S. Tavares et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

A national survey of tetrabromobisphenol-A, hexabromocyclododecane and decabrominated diphenyl ether in human milk from China: Occurrence and exposure assessment

(2017) Zhixiong Shi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Maternal exposure to polybrominated diphenyl ether (BDE-209) during lactation affects germ cell survival with altered testicular glucose homeostasis and oxidative status through down-regulation of Cx43 and p27Kip1 in prepubertal mice offspring

(2017) Debarshi Sarkar et al.   TOXICOLOGY

High-fat diet aggravates 2,2′,4,4′-tetrabromodiphenyl ether-inhibited testosterone production via DAX-1 in Leydig cells in rats

(2017) Zhan Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Determination of novel brominated flame retardants and polybrominated diphenyl ethers in serum using gas chromatography–mass spectrometry with two simplified sample preparation procedures

(2016) Le Gao et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Occurrence of polybrominated diphenyl ethers (PBDEs) in foodstuffs in Italy and implications for human exposure

(2016) Tania Martellini et al.   FOOD AND CHEMICAL TOXICOLOGY

Regulators in the apoptotic pathway during spermatogenesis: Killers or guards?

(2016) Ya-Ru Xu et al.   GENE

Effect of polybrominated diphenyl ether (BDE-209) on testicular steroidogenesis and spermatogenesis through altered thyroid status in adult mice

(2016) Debarshi Sarkar et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Childhood exposure to polybrominated diphenyl ethers and neurodevelopment at six years of age

(2016) Cécile Chevrier et al.   NEUROTOXICOLOGY

Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth

(2016) Peng Ru et al.   Cell Reports

MicroRNA expression profiles in testicular biopsies of patients with impaired spermatogenesis

(2016) P. Noveski et al.   Andrology

Consistent age-dependent declines in human semen quality: A systematic review and meta-analysis

(2015) Sheri L. Johnson et al.   AGEING RESEARCH REVIEWS

Human exposure to PBDE and critical evaluation of health hazards

(2015) Victoria Linares et al.   ARCHIVES OF TOXICOLOGY

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

(2015) Chunming Cheng et al.   CANCER CELL

Dysregulated glycolysis as an oncogenic event

(2015) Takumi Mikawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Apoptosis Regulation at the Mitochondrial Outer Membrane

(2013) Laura A. Gillies et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hormonal control of Sertoli cell metabolism regulates spermatogenesis

(2012) Marco G. Alves et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sterols in spermatogenesis and sperm maturation

(2012) Rok Keber et al.   JOURNAL OF LIPID RESEARCH

Metabolic regulation is important for spermatogenesis

(2012) Luís Rato et al.   Nature Reviews Urology

Bisphenol A impairs insulin signaling and glucose homeostasis and decreases steroidogenesis in rat testis: An in vivo and in silico study

(2011) Shereen Cynthia D’Cruz et al.   FOOD AND CHEMICAL TOXICOLOGY

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

Mechanisms involved in the neurotoxic effects of environmental toxicants such as polychlorinated biphenyls and brominated flame retardants

(2009) Frode Fonnum et al.   JOURNAL OF NEUROCHEMISTRY

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling