Journal
CHEMOSPHERE
Volume 287, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2021.132269
Keywords
Ambient pollutants; IVC-Based real-ambient air exposure system; Nasal mucosa microbiota; Opportunistic pathogen
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Funding
- National Natural Science Foundation of China [91643111, 91743114]
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This study investigated the impact of exposure to real-ambient air pollutants on nasal mucosa microbiota composition. The findings showed that exposure to PM2.5 and O-3 altered the bacterial diversity and abundance of opportunistic pathogens in nasal microbiota, with a possible seasonal influence.
Studies have indicated that ambient pollutant exposure correlates with nasal disease, in which nasal mucosa microbiota play a crucial role. However, the association between exposure to real-ambient air pollutants and the composition of nasal mucosa microbiota has not been well studied. This study aimed to explore the composition of nasal mucosa microbiota after exposure to real-ambient air pollutants with a special system. We monitored PM2.5, O-3, etc. in the system and confirmed PM2.5 and O-3 were the main pollutants. SD rats were exposed to the system for 16 weeks in summer or 22 weeks in autumn-winter. The concentrations of PM2.5 were 24.00 mu g/m(3) in the Summer stage and 22.21 mu g/m(3) in the autumn-winter stage. The O-3 concentrations were 25.46 and 13.55 mu g/ m(3), respectively. Exposure altered bacterial beta diversity in the summer stage. There were 4 and 3 different bacteria at the king, order, family and genus levels between the two groups at the two stages, respectively. The abundance of opportunistic pathogens changed, Pseudomonas decreased in summer stage, and Bifidobacterium increased in the autumn-winter stage. The influence of the season on the nasal mucosa microbiota was analyzed. The alpha diversity of the autumn-winter stage was higher than that of the summer stage. LEfSe analysis revealed 34 differential bacterial taxa at the king, order, family and genus level in the two control groups and 31 of the two exposure groups, which were not the same as the bacteria between the control groups and exposure groups. We found that PM2.5 combined with O-3 exposure was associated with the composition of the nasal mucosa microbiota and the abundance of opportunistic pathogens, in which season likely impacted the microbiota.
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