Comments on DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders

I read with interest the article DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders recently published in Chemico-Biological Interactions. The authors suggested that acetaminophen, one of the most used drugs worldwide, alkylates DNA at therapeutic doses and is genotoxic. Given the implications of this statements for public health, it is important for the reader to hear a different perspective that is based on the entire literature on this subject. Everything considered, there is no credible evidence that acetaminophen is a genotoxic hazard or a carcinogen at therapeutic doses.

Automated summary

A recent article published in Chemico-Biological Interactions discusses the DNA-binding activities of compounds and claims that acetaminophen, a widely used drug, has genotoxic effects at therapeutic doses. However, based on the entire literature on this subject, there is no credible evidence supporting the claim that acetaminophen is genotoxic or a carcinogen at therapeutic doses.