Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future

Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death

(2021) Pan Zheng et al.   NANO LETTERS

Copper‐Based Nanoscale Coordination Polymers Augmented Tumor Radioimmunotherapy for Immunogenic Cell Death Induction and T‐Cell Infiltration

(2021) Yuxiang Wang et al.   Small

A [Pt(cis-1,3-diaminocycloalkane)Cl2] analog exhibits hallmarks typical of immunogenic cell death inducers in model cancer cells

(2021) Vojtech Novohradsky et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Biomimetic gold nanocages for overcoming chemoresistance of osteosarcoma by ferroptosis and immunogenic cell death

(2021) Chong Zhang et al.   MATERIALS & DESIGN

Auranofin and Cold Atmospheric Plasma Synergize to Trigger Distinct Cell Death Mechanisms and Immunogenic Responses in Glioblastoma

(2021) Jinthe Van Loenhout et al.   Cells

PT-112 in advanced metastatic castrate-resistant prostate cancer (mCRPC), as monotherapy or in combination with PD-L1 inhibitor avelumab: Findings from two phase I studies.

(2020) Alan Haruo Bryce et al.   JOURNAL OF CLINICAL ONCOLOGY

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

(2020) Isaure Vanmeerbeek et al.   OncoImmunology

PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models

(2020) Takahiro Yamazaki et al.   OncoImmunology

Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy

(2020) Jing Gao et al.   ACTA PHARMACOLOGICA SINICA

A Photocaged, Water-Oxidizing, and Nucleolus-Targeted Pt(IV) Complex with a Distinct Anticancer Mechanism

(2020) Zhiqin Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MnO x Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect

(2020) Binbin Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PlatinER: a Highly Potent Anticancer Platinum(II) Complex that induces Endoplasmic Reticulum Stress‐driven Immunogenic Cell Death

(2020) Max Jing Rui Tham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immunogenic Cell Death of Breast Cancer Stem Cells by an Endoplasmic Reticulum‐Targeting Copper(II) Complex

(2020) Pooja Kaur et al.   CHEMBIOCHEM

Clinically Relevant Chemotherapeutics Have the Ability to Induce Immunogenic Cell Death in Non-Small Cell Lung Cancer

(2020) Tal Flieswasser et al.   Cells

Intratumoral Cancer Chemotherapy with a Carrier-Based Immunogenic Cell-Death Eliciting Platinum (IV) Agent

(2020) Chad Groer et al.   MOLECULAR PHARMACEUTICS

Rationally Designed Redox-Active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer

(2020) Sajal Sen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

(2020) Prathyusha Konda et al.   OncoImmunology

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

(2019) Reece G. Kenny et al.   CHEMICAL REVIEWS

Pt(IV) Bifunctional Prodrug Containing 2-(2-Propynyl)octanoato Axial Ligand: Induction of Immunogenic Cell Death on Colon Cancer

(2019) Maurizio Sabbatini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade

(2019) Fangyuan Zhou et al.   ADVANCED MATERIALS

Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors

(2019) Xiaopin Duan et al.   Nature Communications

Self‐Amplified Drug Delivery with Light‐Inducible Nanocargoes to Enhance Cancer Immunotherapy

(2019) Bing Feng et al.   ADVANCED MATERIALS

Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy

(2018) Junjie Wu et al.   CANCER LETTERS

Oxaliplatin disrupts pathological features of glioma cells and associated macrophages independent of apoptosis induction

(2018) Nathan B. Roberts et al.   JOURNAL OF NEURO-ONCOLOGY

Time-dependent shotgun proteomics revealed distinct effects of an organoruthenium prodrug and its activation product on colon carcinoma cells

(2018) Samuel M. Meier-Menches et al.   Metallomics

Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433

(2018) Susan Monro et al.   CHEMICAL REVIEWS

CBP501 induces immunogenic tumor cell death and CD8 T cell infiltration into tumors in combination with platinum, and increases the efficacy of immune checkpoint inhibitors against tumors in mice

(2017) Keiichi Sakakibara et al.   Oncotarget

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

(2017) Abhishek D. Garg et al.   OncoImmunology

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Anticancer metal drugs and immunogenic cell death

(2016) Alessio Terenzi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes

(2015) Daniel Yuan Qiang Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immunogenic cell death

(2015) Abhishek D. Garg et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

(2014) Encouse B Golden et al.   OncoImmunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Inducers of immunogenic cancer cell death

(2013) Aleksandra M. Dudek et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Crosstalk between ER stress and immunogenic cell death

(2013) Oliver Kepp et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance

(2013) Laurence Zitvogel et al.   IMMUNITY

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy

(2012) Yi Luo et al.   EUROPEAN JOURNAL OF CANCER

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

(2012) L. Menger et al.   Science Translational Medicine

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress

(2010) I Martins et al.   ONCOGENE

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE