Review
Medicine, General & Internal
Alexandros A. Drosos, Eleftherios Pelechas, Paraskevi V. Voulgari
Summary: The progression of SARS-CoV-2 to critical illness is associated with an uncontrolled inflammatory response, known as a cytokine storm. Current therapeutic strategies aim to target viral entry and replication, as well as the inflammatory response.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas A. F. Kite, Peter F. Ludman, Chris P. Gale, Jianhua Wu, Adriano Caixeta, Jacques Mansourati, Manel Sabate, Pilar Jimenez-Quevedo, Luciano Candilio, Parham Sadeghipour, Angel M. Iniesta, Stephen P. Hoole, Nick Palmer, Albert Ariza-Sole, Alim Namitokov, Hector H. Escutia-Cuevas, Flavien Vincent, Otilia Tica, Mzee Ngunga, Imad Meray, Andrew Morrow, Md Minhaj Arefin, Steven Lindsay, Ghada Kazamel, Vinoda Sharma, Aly Saad, Gianfranco Sinagra, Federico Ariel Sanchez, Marek Roik, Stefano Savonitto, Marija Vavlukis, Shankar Sangaraju, Iqbal S. Malik, Sharon Kean, Nick Curzen, Colin Berry, Gregg W. Stone, Bernard J. Gersh, Anthony H. Gershlick
Summary: This study aimed to report the demographics, angiographic findings, and in-hospital outcomes of COVID-19 ACS patients and compare them with pre-COVID-19 cohorts. The study found that COVID-19-positive ACS patients experienced delayed presentation and had higher in-hospital mortality rates compared to the control subjects before the COVID-19 pandemic. Excessive rates of and mortality from cardiogenic shock were major contributors to the worse outcomes in COVID-19 positive STEMI patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Matteo Cameli, Maria Concetta Pastore, Giulia Elena Mandoli, Flavio D'Ascenzi, Marta Focardi, Giulia Biagioni, Paolo Cameli, Giuseppe Patti, Federico Franchi, Sergio Mondillo, Serafina Valente
Summary: The COVID-19 pandemic has posed major challenges to the global healthcare system, increasing clinical issues related to acute coronary syndromes and lowering hospitalization rates, which may lead to short- and long-term complications of myocardial infarction. Efforts are needed to address the impact of COVID-19 on the diagnosis and management of ACS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Editorial Material
Orthopedics
Alan L. Zhang
Summary: The QL block is a new technique for perioperative analgesia during hip arthroscopy. Although some studies have shown decreased opioid consumption and no increased motor weakness with QL block, others have reported contrasting results. Further research is needed for QL block and exploration of other nerve block options for hip arthroscopy patients.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Medicine, General & Internal
D. Araiza-Garaygordobil, C. Montalto, P. Martinez-Amezcua, A. Cabello-Lopez, R. Gopar-Nieto, R. Alabrese, A. Almaghraby, S. Catoya-Villa, M. Chacon-Diaz, C. C. Kaufmann, M. Corbi-Pascual, P. Deharo, M. El-Tahlawi, A. Elgohari-Abdelwahab, F. Guerra, M. Jarakovic, E. Martinez-Gomez, L. Moderato, S. Montero, P. Morejon-Barragan, A. M. Omar, P. Jorge-Perez, P. Przybylo, E. Selim, U. Y. Sinan, M. Stratinaki, O. Tica, M. Trepa, A. Uribarri, J. Uzokov, K. Wilk, K. Czerwinska-Jelonkiewicz, A. Sionis, M. Gierlotka, S. Leonardi, K. A. Krychtiuk, G. Tavazzi
Summary: The study found a significant decrease in the rate of ACS hospitalizations, an increase in total ischemic time, and a higher rate of mechanical complications associated with the COVID-19 pandemic on an international scale.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2021)
Article
Cell Biology
N. B. Amaral, T. S. Rodrigues, M. C. Giannini, M. I. Lopes, L. P. Bonjorno, P. I. S. O. Menezes, S. M. Dib, S. L. G. Gigante, M. N. Benatti, U. C. Rezek, L. L. Emrich-Filho, B. A. Sousa, S. C. L. Almeida, R. Luppino-Assad, F. P. Veras, A. H. Schneider, L. O. S. Leiria, L. D. Cunha, J. C. Alves-Filho, T. M. Cunha, E. Arruda, C. H. Miranda, A. Pazin-Filho, M. Auxiliadora-Martins, M. C. Borges, B. A. L. Fonseca, V. R. Bollela, C. M. Del-Ben, F. Q. Cunha, R. C. Santana, F. C. Vilar, D. S. Zamboni, P. Louzada-Junior, R. D. R. Oliveira
Summary: This study evaluated whether colchicine treatment was associated with the inhibition of NLRP3 inflammasome activation in patients with COVID-19. The results showed that colchicine reduced the need for supplemental oxygen and the length of hospitalization, and lowered the serum levels of Casp1p20 and IL-18 in the first two days of treatment.
INFLAMMATION RESEARCH
(2023)
Article
Rheumatology
Richard O. Akintayo, Akpabio A. Akpabio, Asgar A. Kalla, Dzifa Dey, Angela N. Migowa, Hakeem Olaosebikan, Rachid Bahiri, Yasser El Miedany, Djohra Hadef, Wafa Hamdi, Omondi Oyoo, Samy Slimani, Abubakar Yerima, Yassmin Taha, Adewale O. Adebajo, Olufemi O. Adelowo, Mohammed Tikly, Imad Ghozlani, Kawther Ben Abdelghani, Nermeen A. Fouad, Doaa Mosad, Dalia El Mikkawy, Mohamed Hassan Abu-Zaid, Rasha A. Abdel-Magied
Summary: The study found that the COVID-19 pandemic has led to shifts in rheumatology practices in Africa towards more virtual consultations, revealing regional disparities in the availability of local protocols and registries.
Review
Medicine, General & Internal
Fabiola Atzeni, Ignazio Francesco Masala, Javier Rodriguez-Carrio, Roberto Rios-Garces, Elisabetta Gerratana, Laura La Corte, Manuela Giallanza, Valeria Nucera, Agostino Riva, Gerard Espinosa, Ricard Cervera
Summary: This article reviews drugs used in the treatment of COVID-19 patients, recommending the consideration of immunomodulatory drugs in severe cases, although clinical outcomes are still suboptimal. Early detection and treatment combined with a multidisciplinary approach may aid in better recovery of patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Devang Sanghavi, Pankaj Bansal, Ikwinder Preet Kaur, Mohsin Sheraz Mughal, Chandana Keshavamurthy, Austin Cusick, Jennifer Schram, Siva Naga S. Yarrarapu, Abhishek R. Giri, Nirmaljot Kaur, Pablo Moreno Franco, Andy Abril, Fawad Aslam
Summary: Based on this systematic review, colchicine is not recommended as a treatment for COVID-19. Further high-quality and multi-center randomized controlled trials are required to assess the actual impact of this drug in COVID-19.
ANNALS OF MEDICINE
(2022)
Article
Virology
Maria Saenz-Aldea, Angel Salgado-Barreira, Margarita Taracido Trunk, Maria Pineiro-Lamas, Maria T. T. Herdeiro, Manuel Portela-Romero, Marc Saez, Adolfo Figueiras
Summary: This study aimed to assess the effect of colchicine on the risk of hospitalization due to COVID-19 and its effect on susceptibility to and severity of the virus in patients with COVID-19. The study found that, after adjustment, colchicine had no impact on the risk of hospitalization, susceptibility, or severity of COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Medicine, General & Internal
Maureen Yin, Laura Marrone, Christian G. Peace, Luke A. J. O'Neill
Summary: Severe COVID-19 is associated with hyperinflammation and dysregulated cytokine release, which is caused by intense and rapid stimulation of the innate immune response. The NLRP3 inflammasome plays a crucial role in this inflammatory response, leading to the release of proinflammatory cytokines and cell death. Clinical trials are underway to target NLRP3 for the treatment of severe COVID-19.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Editorial Material
Rheumatology
Paula Alba Moreyra, Francis Berenbaum, Debashish Danda, Bettina Groetsch, Simon R. Stones, Sowmya Viswanathan
Summary: In this viewpoint, six rheumatology researchers at different career stages and from different regions discuss the challenges of conducting research during the COVID-19 pandemic. They also reflect on how the pandemic has changed their attitudes towards research and their plans for the future.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Niall Patrick Connolly, Andrew Simpkin, Darren Mylotte, James Crowley, Stephen O'Connor, Khalid AlHarbi, Thomas Kiernan, Sacchin Arockiam, Patrick Owens, Amal John, Gavin J. Blake, Sean Fitzgerald, Diarmaid Cadogan, Liesbeth Rosseel
Summary: During the COVID-19 outbreak in 2020 in Ireland, there was a significant decrease in PCI procedures for the treatment of ACS, especially for non-ST-elevation ACS and STEMI. Patients should be encouraged to seek medical attention promptly when experiencing cardiac symptoms to prevent adverse outcomes.
Article
Medicine, General & Internal
Domingo A. Pascual-Figal, Aychel E. Roura-Piloto, Encarnacion Moral-Escudero, Enrique Bernal, Helena Albendin-Iglesias, M. Teresa Perez-Martinez, Jose Antonio Noguera-Velasco, Iria Cebreiros-Lopez, Alvaro Hernandez-Vicente, David Vazquez-Andres, Carmen Sanchez-Perez, Amjad Khan, Fatima Sanchez-Cabo, Elisa Garcia-Vazquez
Summary: In the COL-COVID study, colchicine treatment did not improve the clinical status or inflammatory response in hospitalized COVID-19 patients compared to standard treatment. However, it may have a preventive effect on further clinical deterioration.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Uwe Zeymer, Vusal Ahmadli, Steffen Schneider, Karl Werdan, Michael Weber, Sven Hohenstein, Gerhard Hindricks, Steffen Desch, Andreas Bollmann, Holger Thiele
Summary: This study aimed to comprehensively describe hospital admissions and in-hospital mortality during the first wave of the COVID-19 pandemic in all German federal states. The results showed a significant reduction in admissions for NSTEMI and STEMI, while the quality of in-hospital care and in-hospital mortality were not affected.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
