Chitosan-coated organosilica nanoparticles as a dual responsive delivery system of natural fragrance for axillary odor problem

Citronellol (CI)-loaded, chitosan (CS)-enclosed dendritic mesoporous organosilica nanoparticles (CI@DMONs@CS) are successfully fabricated. The synthesized CI@D-MONs@CS present spherical shape with the particle size of 424 +/- 24 nm in diameter and dendritic mesopores. CI loading ratio of CI@D-MONs@CS is about 12.42% from TGA analysis. CI release from CI@D-MONs@CS exhibits pH-redox dual responsiveness. More interesting, the axillary deodorant effect is investigated with Staphylococcus haemolyticus in an artificial sweat model. The results show that CI@D-MONs@CS present an excellent bacteria-killing effect and the smell of artificial sweat is greatly improved, avoiding the formation of undesirable odorant compounds from the bacteria. The obtained CI@D-MONs@CS is a potential carrier of natural fragrance or actives with dual responsive release. The application of CI@D-MONs@CS is a new and effective strategy to the axillary odor problem.

Automated summary

Citronellol-loaded, chitosan-enclosed dendritic mesoporous organosilica nanoparticles (CI@DMONs@CS) were successfully fabricated with dual responsive release, showing excellent bacteria-killing effect against Staphylococcus haemolyticus and improved smell of artificial sweat.