Human milk oligosaccharides and infant gut microbiota: Molecular structures, utilization strategies and immune function

A general strategy for the structural determination of carbohydrates by multi-dimensional NMR spectroscopies

(2021) Qi Shi et al.   CARBOHYDRATE POLYMERS

Quantifying the human milk oligosaccharides 2’‐fucosyllactose and 3‐fucosyllactose in different food applications by high‐performance liquid chromatography with refractive index detection

(2020) Anne Støvlbæk Christensen et al.   JOURNAL OF FOOD SCIENCE

More than sugar in the milk: human milk oligosaccharides as essential bioactive molecules in breast milk and current insight in beneficial effects

(2020) Lianghui Cheng et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics

(2020) Bernard Berger et al.   mBio

Human milk oligosaccharides: Shaping the infant gut microbiota and supporting health

(2020) Clodagh Walsh et al.   Journal of Functional Foods

Association of Maternal Probiotic Supplementation With Human Milk Oligosaccharide Composition

(2019) Antti E. Seppo et al.   JAMA Pediatrics

Modulation of Intestinal Epithelial Glycocalyx Development by Human Milk Oligosaccharides and Non‐digestible Carbohydrates

(2019) Chunli Kong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Novel Genes and Metabolite Trends in Bifidobacterium longum subsp. infantis Bi-26 Metabolism of Human Milk Oligosaccharide 2′-fucosyllactose

(2019) Bryan Zabel et al.   Scientific Reports

Breast milk-derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem

(2019) Melissa A. E. Lawson et al.   ISME Journal

The effect of 2′-fucosyllactose on simulated infant gut microbiome and metabolites; a pilot study in comparison to GOS and lactose

(2019) Krista Salli et al.   Scientific Reports

Identification of carbohydrate peripheral epitopes important for recognition by positive-ion MALDI multistage mass spectrometry

(2019) Chuncui Huang et al.   CARBOHYDRATE POLYMERS

Microbial transmission from mother to child: improving infant intestinal microbiota development by identifying the obstacles

(2019) Emmy Van Daele et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Human Milk Oligosaccharides Differently Modulate Goblet Cells Under Homeostatic, Proinflammatory Conditions and ER Stress

(2019) Lianghui Cheng et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Two extracellular sialidases from Bifidobacterium bifidum promote the degradation of sialyl-oligosaccharides and support the growth of Bifidobacterium breve

(2018) Keita Nishiyama et al.   ANAEROBE

Immunological Effects of Human Milk Oligosaccharides

(2018) Vassilis Triantis et al.   Frontiers in Pediatrics

Sharing of human milk oligosaccharides degradants within bifidobacterial communities in faecal cultures supplemented with Bifidobacterium bifidum

(2018) Aina Gotoh et al.   Scientific Reports

Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens

(2018) Zhendong Li et al.   Frontiers in Cellular and Infection Microbiology

Innate Immunity of Neonates and Infants

(2018) Jack C. Yu et al.   Frontiers in Immunology

In vitro immunomodulatory effects of human milk oligosaccharides on murine macrophage RAW264.7 cells

(2018) Weiyue Zhang et al.   CARBOHYDRATE POLYMERS

Production of HMOs using microbial hosts — from cell engineering to large scale production

(2018) Katrine Bych et al.   CURRENT OPINION IN BIOTECHNOLOGY

Human milk oligosaccharides and infant gut bifidobacteria: Molecular strategies for their utilization

(2017) Pamela Thomson et al.   FOOD MICROBIOLOGY

Human milk oligosaccharide consumption by probiotic and human-associated bifidobacteria and lactobacilli

(2017) Taksawan Thongaram et al.   JOURNAL OF DAIRY SCIENCE

Human Milk Oligosaccharides Influence Intestinal Epithelial Cell Maturation In Vitro

(2017) Hannah D. Holscher et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Influence of Gestational Age, Secretor, and Lewis Blood Group Status on the Oligosaccharide Content of Human Milk

(2017) Clemens Kunz et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery

(2017) Derrick M Chu et al.   NATURE MEDICINE

Bifidobacterium bifidum Extracellular Sialidase Enhances Adhesion to the Mucosal Surface and Supports Carbohydrate Assimilation

(2017) Keita Nishiyama et al.   mBio

The intestinal barrier: a fundamental role in health and disease

(2017) Maaike Vancamelbeke et al.   Expert Review of Gastroenterology & Hepatology

Host-derived glycans serve as selected nutrients for the gut microbe: human milk oligosaccharides and bifidobacteria

(2016) Takane Katayama   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Fucosyllactose and L-fucose utilization of infant Bifidobacterium longum and Bifidobacterium kashiwanohense

(2016) Vera Bunesova et al.   BMC MICROBIOLOGY

Relative fermentation of oligosaccharides from human milk and plants by gut microbes

(2016) Jing Wang et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Exclusive breastfeeding duration and infant infection

(2016) M A Quigley et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Biotechnological production of fucosylated human milk oligosaccharides: Prokaryotic fucosyltransferases and their use in biocatalytic cascades or whole cell conversion systems

(2016) Barbara Petschacher et al.   JOURNAL OF BIOTECHNOLOGY

Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

(2016) Cesar G Victora et al.   LANCET

The Infant Microbiome

(2016) Irene Yang et al.   NURSING RESEARCH

A key genetic factor for fucosyllactose utilization affects infant gut microbiota development

(2016) Takahiro Matsuki et al.   Nature Communications

A novel gene cluster allows preferential utilization of fucosylated milk oligosaccharides in Bifidobacterium longum subsp. longum SC596

(2016) Daniel Garrido et al.   Scientific Reports

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Multiplatform characterization of dynamic changes in breast milk during lactation

(2015) Nicholas J. Andreas et al.   ELECTROPHORESIS

Human milk oligosaccharides in premature infants: absorption, excretion and influence on the intestinal microbiota

(2015) Mark A. Underwood et al.   PEDIATRIC RESEARCH

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria

(2015) Daniel Garrido et al.   Scientific Reports

Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants

(2015) Zachery T Lewis et al.   Microbiome

Breast Milk Oligosaccharides: Structure-Function Relationships in the Neonate

(2014) Jennifer T. Smilowitz et al.   Annual Review of Nutrition

Metabolism of Sialic Acid by Bifidobacterium breve UCC2003

(2014) Muireann Egan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cross-feeding by Bifidobacterium breve UCC2003 during co-cultivation with Bifidobacterium bifidum PRL2010 in a mucin-based medium

(2014) Muireann Egan et al.   BMC MICROBIOLOGY

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Correlation Between Intraluminal Oxygen Gradient and Radial Partitioning of Intestinal Microbiota

(2014) Lindsey Albenberg et al.   GASTROENTEROLOGY

Human Milk Oligosaccharides Influence Maturation of Human Intestinal Caco-2Bbe and HT-29 Cell Lines

(2014) Hannah D. Holscher et al.   JOURNAL OF NUTRITION

A unique gene cluster for the utilization of the mucosal and human milk-associated glycans galacto-N-biose and lacto-N-biose inLactobacillus casei

(2014) Gonzalo N. Bidart et al.   MOLECULAR MICROBIOLOGY

Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine

(2014) Y He et al.   Mucosal Immunology

Stool Microbiota and Vaccine Responses of Infants

(2014) M. N. Huda et al.   PEDIATRICS

Syntrophic exchange in synthetic microbial communities

(2014) M. T. Mee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variation in Consumption of Human Milk Oligosaccharides by Infant Gut-Associated Strains of Bifidobacterium breve

(2013) Santiago Ruiz-Moyano et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months

(2013) M. B. Azad et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Utilization of major fucosylated and sialylated human milk oligosaccharides by isolated human gut microbes

(2013) Zhuo-Teng Yu et al.   GLYCOBIOLOGY

13C-labeled oligosaccharides in breastfed infants' urine: Individual-, structure- and time-dependent differences in the excretion

(2013) Viktoria Dotz et al.   GLYCOBIOLOGY

Consumption of human milk glycoconjugates by infant-associated bifidobacteria: mechanisms and implications

(2013) D. Garrido et al.   MICROBIOLOGY-SGM

Proteomic Analysis of Bifidobacterium longum subsp. infantis Reveals the Metabolic Insight on Consumption of Prebiotics and Host Glycans

(2013) Jae-Han Kim et al.   PLoS One

Release and utilization of N-acetyl-d-glucosamine from human milk oligosaccharides by Bifidobacterium longum subsp. infantis

(2012) Daniel Garrido et al.   ANAEROBE

Human milk oligosaccharides: Every baby needs a sugar mama

(2012) L. Bode   GLYCOBIOLOGY

The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota

(2012) Zhuo-Teng Yu et al.   GLYCOBIOLOGY

Bifidobacteria Isolated From Infants and Cultured on Human Milk Oligosaccharides Affect Intestinal Epithelial Function

(2012) Maciej Chichlowski et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Comprehensive Profiles of Human Milk Oligosaccharides Yield Highly Sensitive and Specific Markers for Determining Secretor Status in Lactating Mothers

(2012) Sarah M. Totten et al.   JOURNAL OF PROTEOME RESEARCH

Structure-Function Relationships of Human Milk Oligosaccharides

(2012) Lars Bode et al.   Advances in Nutrition

Bifidobacterial Enzymes Involved in the Metabolism of Human Milk Oligosaccharides

(2012) Motomitsu Kitaoka   Advances in Nutrition

Bifidobacterium longum subsp. infantis ATCC 15697 α-Fucosidases Are Active on Fucosylated Human Milk Oligosaccharides

(2011) David A. Sela et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacteroides in the Infant Gut Consume Milk Oligosaccharides via Mucus-Utilization Pathways

(2011) Angela Marcobal et al.   Cell Host & Microbe

Physiology of Consumption of Human Milk Oligosaccharides by Infant Gut-associated Bifidobacteria

(2011) Sadaki Asakuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Infant-associated Bacterial Commensal Utilizes Breast Milk Sialyloligosaccharides

(2011) David A. Sela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prebiotic Oligosaccharides Reduce Proinflammatory Cytokines in Intestinal Caco-2 Cells via Activation of PPARγ and Peptidoglycan Recognition Protein 3

(2011) Marwa Zenhom et al.   JOURNAL OF NUTRITION

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

Preterm Milk Oligosaccharides During the First Month of Lactation

(2011) O. Gabrielli et al.   PEDIATRICS

Oligosaccharide Binding Proteins from Bifidobacterium longum subsp. infantis Reveal a Preference for Host Glycans

(2011) Daniel Garrido et al.   PLoS One

Genetic variation of FUT2 in a Vietnamese population: identification of two novel Se enzyme-inactivating mutations

(2011) Mikiko Soejima et al.   TRANSFUSION

Genomics and ecological overview of the genus Bifidobacterium

(2010) Francesca Turroni et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Consumption of Human Milk Oligosaccharides by Gut-Related Microbes

(2010) Angela Marcobal et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Diet, gut microbiota and immune responses

(2010) Kendle M Maslowski et al.   NATURE IMMUNOLOGY

Succession of microbial consortia in the developing infant gut microbiome

(2010) J. E. Koenig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides

(2010) David A. Sela et al.   TRENDS IN MICROBIOLOGY

Distribution of In Vitro Fermentation Ability of Lacto-N-Biose I, a Major Building Block of Human Milk Oligosaccharides, in Bifidobacterial Strains

(2009) J.-z. Xiao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bifidobacterium bifidum Lacto-N-Biosidase, a Critical Enzyme for the Degradation of Human Milk Oligosaccharides with a Type 1 Structure

(2008) J. Wada et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structural and Thermodynamic Analyses of Solute-binding Protein fromBifidobacterium longumSpecific for Core 1 Disaccharide and Lacto-N-biose I

(2008) Ryuichiro Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY