Journal
CANCER CELL
Volume 40, Issue 1, Pages 20-22Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2021.12.011
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In their comprehensive study, the researchers provide proof of principle for the development and efficacy of peptide centric (PC)-CARs targeting the oncogenic immunopeptidome of neuroblastoma.
A critical barrier to CAR T cell therapy is the paucity of target antigens that are broadly and stably expressed exclusively in tumors. In their comprehensive multi-omics and pre-clinical study, Yarmarkovich et al. provide proof of principle for the development and efficacy of peptide centric (PC)-CARs targeting the oncogenic immunopeptidome of neuroblastoma.
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