Phase I double-blind, placebo-controlled trial of dolcanatide (SP-333) 27 mg to explore colorectal bioactivity in healthy volunteers

Cyclic-GMP–Elevating Agents Suppress Polyposis in Apc Min Mice by Targeting the Preneoplastic Epithelium

(2018) Sarah K. Sharman et al.   Cancer Prevention Research

Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders

(2018) Scott A Waldman et al.   GUT

Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models

(2018) Illona-Marie Boulete et al.   WORLD JOURNAL OF GASTROENTEROLOGY

ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice

(2017) Peng Li et al.   Toxins

Congenital secretory diarrhoea caused by activating germline mutations inGUCY2C

(2015) Thomas Müller et al.   GUT

Meconium ileus in a Lebanese family secondary to mutations in the GUCY2C gene

(2014) Amanda Smith et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

(2012) William D Chey et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Meconium Ileus Caused by Mutations in GUCY2C, Encoding the CFTR-Activating Guanylate Cyclase 2C

(2012) Hila Romi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Familial Diarrhea Syndrome Caused by an ActivatingGUCY2CMutation

(2012) Torunn Fiskerstrand et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two Randomized Trials of Linaclotide for Chronic Constipation

(2011) Anthony J. Lembo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

(2010) Robert W. Busby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Taking a Lesson From Microbial Diarrheagenesis in the Management of Chronic Constipation

(2010) Adil E. Bharucha et al.   GASTROENTEROLOGY

The Hormone Receptor GUCY2C Suppresses Intestinal Tumor Formation by Inhibiting AKT Signaling

(2009) Jieru Egeria Lin et al.   GASTROENTEROLOGY

The Boston bowel preparation scale: a valid and reliable instrument for colonoscopy-oriented research

(2009) Edwin J. Lai et al.   GASTROINTESTINAL ENDOSCOPY

Association of GUCY2C Expression in Lymph Nodes With Time to Recurrence and Disease-Free Survival in pN0 Colorectal Cancer

(2009) Scott A. Waldman   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Colorectal Cancer Is a Paracrine Deficiency Syndrome Amenable to Oral Hormone Replacement Therapy

(2008) Peng Li et al.   CTS-Clinical and Translational Science