DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults

Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome

(2021) Ayala Tovy et al.   HAEMATOLOGICA

Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome

(2021) Amanda M. Smith et al.   Nature Communications

Tatton‐Brown‐Rahman syndrome: Six individuals with novel features

(2020) Tugce B. Balci et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Adolescent and young adult oncology—past, present, and future

(2019) Allison G. Close et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Acromegaly in the setting of Tatton-Brown-Rahman Syndrome

(2019) C. Hage et al.   Pituitary

Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies

(2017) Christopher B. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute myeloid leukaemia in a case with Tatton-Brown-Rahman syndrome: the peculiarDNMT3AR882 mutation

(2017) Iris H I M Hollink et al.   JOURNAL OF MEDICAL GENETICS

The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

(2017) Hamid Bolouri et al.   NATURE MEDICINE

Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers

(2015) Gaëlle Bougeard et al.   JOURNAL OF CLINICAL ONCOLOGY

Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability

(2014) Katrina Tatton-Brown et al.   NATURE GENETICS

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

(2011) Xiao-Jing Yan et al.   NATURE GENETICS

Genetic variation and the risk of acute lymphoblastic leukemia

(2010) Charles G. Mullighan   LEUKEMIA RESEARCH

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inherited susceptibility to pediatric acute lymphoblastic leukemia

(2009) Ross L Levine   NATURE GENETICS