Novel anion exchange membrane chromatography method for the separation of empty and full adeno‐associated virus

Separating Empty and Full Recombinant Adeno‐Associated Virus Particles Using Isocratic Anion Exchange Chromatography

(2020) Ryan Dickerson et al.   Biotechnology Journal

Adeno-associated viral vector serotype 9–based gene therapy for Niemann-Pick disease type A

(2019) Lluis Samaranch et al.   Science Translational Medicine

Analytical Strategies for Quantification of Adeno-Associated Virus Empty Capsids to Support Process Development

(2019) Xiaotong Fu et al.   Human Gene Therapy Methods

Developing an Anion Exchange Chromatography (AEX) Assay for Determining Empty and Full Capsid Contents in AAV6.2

(2019) Chunlei Wang et al.   Molecular Therapy-Methods & Clinical Development

Universal Method for the Purification of Recombinant AAV Vectors of Differing Serotypes

(2018) Shelley A. Nass et al.   Molecular Therapy-Methods & Clinical Development

A Direct Approach for Process Development Using Single Column Experiments Results in Predictable Streamlined Multi-Column Chromatography Bioprocesses

(2018) Aditya Utturkar et al.   Biotechnology Journal

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

(2017) Stephen Russell et al.   LANCET

Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors

(2017) Qizhao Wang et al.   Molecular Therapy-Methods & Clinical Development

Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector

(2016) Joshua C Grieger et al.   MOLECULAR THERAPY

Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1)

(2016) Taro Tomono et al.   Molecular Therapy-Methods & Clinical Development

Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors

(2015) Brenda Burnham et al.   Human Gene Therapy Methods

A simplified purification protocol for recombinant adeno-associated virus vectors

(2014) Mark Potter et al.   Molecular Therapy-Methods & Clinical Development

Empty virions in AAV8 vector preparations reduce transduction efficiency and may cause total viral particle dose-limiting side effects

(2014) Kai Gao et al.   Molecular Therapy-Methods & Clinical Development

Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys

(2013) F. Mingozzi et al.   Science Translational Medicine

Scalable Purification of Adeno-associated Virus Serotype 1 (AAV1) and AAV8 Vectors, Using Dual Ion-Exchange Adsorptive Membranes

(2009) Takashi Okada et al.   HUMAN GENE THERAPY