Journal
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Volume 45, Issue 1, Pages 97-105Publisher
SPRINGER
DOI: 10.1007/s00449-021-02643-2
Keywords
K-doped ZnO nanoparticles; Macrophages J774 cell; Safety; Bioethics principles
Funding
- Behbahan Faculty of Medical Sciences [400016]
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In this study, potassium-doped zinc oxide nanoparticles were green-synthesized using pine pollen extracts based on bioethics principles. The results showed that K-doped ZnO NPs demonstrated higher toxicity on cancer cell lines compared to pure ZnO NPs, while having less cytotoxicity on normal macrophage cells.
In this study, potassium-doped zinc oxide nanoparticles (K-doped ZnO NPs) were green-synthesized using pine pollen extracts based on bioethics principles. The synthesized NPs were analyzed using X-ray diffraction (XRD), inductively coupled plasma atomic emission spectroscopy (ICP-AES), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDXA), and transmission electron microscopy (TEM). The cytotoxicity of these nanoparticles (NPs) on normal macrophage cells and cancer cell lines was evaluated. In the same concentrations of K-doped ZnO and pure ZnO NPs, K-doped ZnO NPs demonstrated higher toxicity. The results confirmed that the doped potassium could increase cytotoxicity. The IC50 of K-doped ZnO NPs, pure ZnO NPs, and the examined control drug were 497 +/- 15, 769 +/- 12, and 606 +/- 19 mu g/mL, respectively. Considering the obtained IC50 of K-doped ZnO NPs, they were more toxic to the cancer cell lines and had less cytotoxicity on normal macrophage cells.
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