Degrading FLT3-ITD protein by proteolysis targeting chimera (PROTAC)

Novel PROTACs for degradation of SHP2 protein

(2021) Mengzhu Zheng et al.   BIOORGANIC CHEMISTRY

In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP

(2020) Dongwei Kang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

PROTAC Technology: Opportunities and Challenges

(2020) Hongying Gao et al.   ACS Medicinal Chemistry Letters

PROTAC: A promising technology for cancer treatment

(2020) Xin Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges

(2020) Shenxin Zeng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer

(2019) Xin Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene−d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities

(2019) Nguyen Dinh Thanh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of Pyrrolo[2,3-d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia

(2019) Xue Yuan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction

(2019) Xing Qiu et al.   ORGANIC LETTERS

Click chemistry-assisted synthesis of novel aminonaphthoquinone-1,2,3-triazole hybrids and investigation of their cytotoxicity and cancer cell cycle alterations

(2019) Maryam Gholampour et al.   BIOORGANIC CHEMISTRY

Targeted protein degradation: elements of PROTAC design

(2019) Stacey-Lynn Paiva et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation

(2019) Meiyang Xi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity

(2019) Hao Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dual FLT3 inhibitors: Against the drug resistance of acute myeloid leukemia in recent decade

(2019) Ting Yuan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders

(2019) Shang Su et al.   JOURNAL OF MEDICINAL CHEMISTRY

PROTACs as Potential Therapeutic Agents for Cancer Drug Resistance

(2019) Xiuyun Sun et al.   BIOCHEMISTRY

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs

(2019) Hongying Gao et al.   ACS Medicinal Chemistry Letters

Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases

(2019) Ferenc Baska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

MDM2- and FLT3-inhibitors in the treatment of FLT3-ITD acute myeloid leukemia, specificity and efficacy of NVP-HDM201 and midostaurin

(2018) Katja Seipel et al.   HAEMATOLOGICA

Ubiquitination: Friend and foe in cancer

(2018) Mohammed A. Mansour   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MDM2- and FLT3-inhibitors in the treatment of FLT3-ITD acute myeloid leukemia, specificity and efficacy of NVP-HDM201 and midostaurin

(2018) Katja Seipel et al.   HAEMATOLOGICA

Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion

(2018) George M. Burslem et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation

(2017) Ryan P. Wurz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?

(2017) Ian Churcher   JOURNAL OF MEDICINAL CHEMISTRY

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)

(2017) Matthias Schiedel et al.   JOURNAL OF MEDICINAL CHEMISTRY

FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions

(2017) Maria Larrosa-Garcia et al.   MOLECULAR CANCER THERAPEUTICS

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Advances of azide-alkyne cycloaddition-click chemistry over the recent decade

(2016) Maya Shankar Singh et al.   TETRAHEDRON

G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia

(2014) H. K. Lee et al.   BLOOD