Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors

Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors

(2021) Takuya Kobayakawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins

(2021) Takuya Kobayakawa et al.   Biomolecules

Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation

(2020) Francesca Curreli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fostemsavir in Adults with Multidrug-Resistant HIV-1 Infection

(2020) Michael Kozal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment

(2020) Kohei Tsuji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bivalent HIV-1 fusion inhibitors based on peptidomimetics

(2020) Takuya Kobayakawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Potent leads based on CA-19L, an anti-HIV active HIV-1 capsid fragment

(2020) Kohei Tsuji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Soluble-type small-molecule CD4 mimics as HIV entry inhibitors

(2019) Takuya Kobayakawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands

(2019) Maxwell M. Sakyiamah et al.   BIOORGANIC & MEDICINAL CHEMISTRY

C34 Dimeric Derivatives Utilizing Disulfide Bridges as Novel HIV‐1 Fusion Inhibitors

(2019) Takuya Kobayakawa et al.   CHEMBIOCHEM

Discovery and Development of anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

(2019) Kenji Maeda et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120

(2017) Francesca Curreli et al.   JOURNAL OF MEDICINAL CHEMISTRY

A minimally cytotoxic CD4 mimic as an HIV entry inhibitor

(2016) Takaaki Mizuguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors

(2016) Nami Ohashi et al.   ChemMedChem

Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition

(2016) Bruno Melillo et al.   ACS Medicinal Chemistry Letters

Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

(2014) Joel R. Courter et al.   ACCOUNTS OF CHEMICAL RESEARCH

CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus to Vaccine-Elicited Antibodies

(2014) N. Madani et al.   JOURNAL OF VIROLOGY

Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products

(2013) Wataru Nomura et al.   ACS Chemical Biology

CD4 mimics as HIV entry inhibitors: Lead optimization studies of the aromatic substituents

(2013) Tetsuo Narumi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins

(2012) Tetsuo Narumi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase in Inhibition Potency

(2012) Wataru Nomura et al.   ChemMedChem

Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

(2012) Judith M. LaLonde et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Antiviral Activity of Entry Inhibitors That Target the CD4-Binding Site of HIV-1

(2012) Francesca Curreli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

(2012) Y. D. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamics-based drug design: strategies for inhibiting protein–protein interactions

(2011) Arne Schön et al.   Future Medicinal Chemistry

Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

(2010) Judith M. LaLonde et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products

(2010) Shintaro Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of the Dimerization State in Cells

(2010) Tomohiro Tanaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds

(2010) K. Yoshimura et al.   JOURNAL OF VIROLOGY

CD4 mimics targeting the mechanism of HIV entry

(2009) Yuko Yamada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120

(2008) Navid Madani et al.   STRUCTURE