Therapeutic supramolecular tubustecan hydrogel combined with checkpoint inhibitor elicits immunity to combat cancer

Supramolecular Design of Unsymmetric Reverse Bolaamphiphiles for Cell-Sensitive Hydrogel Degradation and Drug Release

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Self-assembling and self-formulating prodrug hydrogelator extends survival in a glioblastoma resection and recurrence model

(2020) Paula Schiapparelli et al.   JOURNAL OF CONTROLLED RELEASE

A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia

(2020) Nisarg J. Shah et al.   Nature Biomedical Engineering

Supramolecular prodrug hydrogelator as an immune booster for checkpoint blocker–based immunotherapy

(2020) Feihu Wang et al.   Science Advances

Supramolecular Tubustecan Hydrogel as Chemotherapeutic Carrier to Improve Tumor Penetration and Local Treatment Efficacy

(2020) Feihu Wang et al.   ACS Nano

Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel

(2020) Feihu Wang et al.   Nature Biomedical Engineering

Targeted antibody and cytokine cancer immunotherapies through collagen affinity

(2019) Jun Ishihara et al.   Science Translational Medicine

Fine-Tuning the Linear Release Rate of Paclitaxel-Bearing Supramolecular Filament Hydrogels through Molecular Engineering

(2019) Rami W. Chakroun et al.   ACS Nano

Interface-Enrichment-Induced Instability and Drug-Loading-Enhanced Stability in Inhalable Delivery of Supramolecular Filaments

(2019) Caleb F. Anderson et al.   ACS Nano

Rational design of multimodal therapeutic nanosystems for effective inhibition of tumor growth and metastasis

(2018) Feihu Wang et al.   Acta Biomaterialia

Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases

(2018) Chun Gwon Park et al.   Science Translational Medicine

Injectable, Tough Alginate Cryogels as Cancer Vaccines

(2018) Ting-Yu Shih et al.   Advanced Healthcare Materials

Elimination of established tumors with nanodisc-based combination chemoimmunotherapy

(2018) Rui Kuai et al.   Science Advances

NIR-light and GSH activated cytosolic p65-shRNA delivery for precise treatment of metastatic cancer

(2018) Feihu Wang et al.   JOURNAL OF CONTROLLED RELEASE

Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors

(2018) Daniel Y. Wang et al.   JAMA Oncology

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

(2018) Qian Chen et al.   Nature Nanotechnology

The future of immune checkpoint cancer therapy after PD-1 and CTLA-4

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Synergistic antitumor activity of a self-assembling camptothecin and capecitabine hybrid prodrug for improved efficacy

(2017) Wang Ma et al.   JOURNAL OF CONTROLLED RELEASE

Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy

(2017) Yuchen Fan et al.   NANO LETTERS

Injectable biomimetic liquid crystalline scaffolds enhance muscle stem cell transplantation

(2017) Eduard Sleep et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1 -mutated breast cancer

(2017) Emma Nolan et al.   Science Translational Medicine

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

(2017) Jianqin Lu et al.   Nature Communications

Gel phase formation in dilute triblock copolyelectrolyte complexes

(2017) Samanvaya Srivastava et al.   Nature Communications

Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents

(2017) Zhipeng Chen et al.   Theranostics

Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies

(2016) J. Naidoo et al.   ANNALS OF ONCOLOGY

MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth

(2016) Daniela Kalafatovic et al.   BIOMATERIALS

The Where, the When, and the How of Immune Monitoring for Cancer Immunotherapies in the Era of Checkpoint Inhibition

(2016) P. S. Hegde et al.   CLINICAL CANCER RESEARCH

Chemotherapy and immunotherapy: mapping the road ahead

(2016) Alistair M Cook et al.   CURRENT OPINION IN IMMUNOLOGY

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

Enzyme-Instructed Self-Assembly of Small d-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells

(2016) Jie Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial

(2016) Howard L Kaufman et al.   LANCET ONCOLOGY

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

(2016) Robert L. Ferris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Designing hydrogels for controlled drug delivery

(2016) Jianyu Li et al.   Nature Reviews Materials

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

(2015) Xuewen Du et al.   CHEMICAL REVIEWS

Drug-Triggered and Cross-Linked Self-Assembling Nanofibrous Hydrogels

(2015) Vivek A. Kumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK

(2015) Idit Sagiv-Barfi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Hydrogels and Scaffolds for Immunomodulation

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Linker-determined drug release mechanism of free camptothecin from self-assembling drug amphiphiles

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Supramolecular Nanostructures Formed by Anticancer Drug Assembly

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Tissues in Different Anatomical Sites Can Sculpt and Vary the Tumor Microenvironment to Affect Responses to Therapy

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Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Controlled release of dexamethasone from peptide nanofiber gels to modulate inflammatory response

(2012) Matthew J. Webber et al.   BIOMATERIALS

Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles

(2011) Aysegul Altunbas et al.   BIOMATERIALS

Multi-hierarchical self-assembly of a collagen mimetic peptide from triple helix to nanofibre and hydrogel

(2011) Lesley E. R. O'Leary et al.   Nature Chemistry

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

(2010) K. N. Sugahara et al.   SCIENCE

Injectable solid hydrogel: mechanism of shear-thinning and immediate recovery of injectable β-hairpin peptide hydrogels

(2010) Congqi Yan et al.   Soft Matter

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative

(2009) Yuan Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY