Article
Engineering, Biomedical
Ping Huang, Yao Yang, Wenyan Wang, Zimu Li, Nansha Gao, Hongzhong Chen, Xiaowei Zeng
Summary: We report a multifunctional nanoprodrug platform that combines ferroptosis, photothermal therapy, and immunotherapy to awaken immune responses and block the indoleamine 2,3-diox-ygenase (IDO) pathway, thereby overcoming the limitations of tumor immunotherapy. The platform improved the delivery efficiency of indoximod (IND) and strengthened immune response through the self-driven release of IND and the amplification of oxidative stress. This study provides a new perspective on immunotherapeutics for cancer treatment.
Review
Chemistry, Multidisciplinary
Yutian Xia, Jianzhong Zhang, Gang Liu
Summary: Apoptosis, as a fundamental process of cell death, has provided broad prospects for tumor treatment in nanomedicine. However, apoptosis resistance caused by various factors has led to therapeutic failure or tumor recurrence. Ferroptosis, a newly identified form of programmed cell death, offers a new approach to killing cancer cells beyond apoptosis. Combination therapy, which synergizes ferroptosis with apoptosis, has shown promising results in clinical applications. This review summarizes the latest research progress in combining ferroptosis with apoptosis for enhanced tumor therapeutic effects in nanomedicine and suggests a potential research focus for the future.
Review
Pharmacology & Pharmacy
Yang Wang, Tianfu Liu, Xiang Li, Hui Sheng, Xiaowen Ma, Liang Hao
Summary: Ferroptosis, combined with nanomaterials, shows great potential in cancer therapy. Current research is focused on developing ferroptosis-inducing nanomedicine and finding ways to improve and apply it in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Changwen You, Xingguang Li, Dongqiong Wang, Hongzhong Chen, Lei Liang, Yu Chen, Yanli Zhao, Huijing Xiang
Summary: An intelligent anticancer nanoplatform based on a Aza-boron-dipyrromethene dye was developed for ferroptosis augmented sonodynamic therapy. The platform induced cellular ferroptosis through cysteine starvation and enhanced sonodynamic therapy through the release of a sonosensitizer.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Inorganic & Nuclear
Woojung Yoo, Sunhong Min, Yu Shrike Zhang, Jinmyoung Joo, Heemin Kang, Dong-Hyun Kim
Summary: This review provides a comprehensive overview of recent advancements in photonic nanomaterials for image-guided ferroptosis cancer nanomedicine, offering insights into their strengths, constraints, and their potential as a future paradigm in cancer treatment.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Chemistry, Multidisciplinary
Ling-Xiao Zhao, Zhi-Qiang Gong, Qi Zhang, Da-Long He, Ri-Le Ge, Jin Meng, Hang Ren, Yong-Gang Fan, Zhan-You Wang
Summary: Glioblastoma, a highly malignant tumor, can be treated by inducing ferroptosis using graphdiyne-based nanoplatforms. These nanoplatforms can penetrate the blood-brain barrier and release the therapeutic drug in the tumor tissue, leading to inhibition of tumor growth and prolonged survival.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Materials Science, Multidisciplinary
Li-Han Liu, Xian-Zheng Zhang
Summary: The past decade has seen significant advances in the development of carrier-free nanomedicines, which are attractive due to their high biosafety, drug loading capacities, simple compositions, and simplified synthesis procedures. Extensive efforts have been made to expand the scope of carrier-free nanomedicines and improve their therapeutic performance through the exploration of new excipients, therapeutic agents, self-assembly methods, and mechanisms. This review summarizes the research progress and practical applications of carrier-free nanomedicines in cancer therapy.
PROGRESS IN MATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yi Zheng, Xin Li, Caihong Dong, Li Ding, Hui Huang, Tianhu Zhang, Yu Chen, Rong Wu
Summary: The study demonstrates an ultrasound-augmented nanocatalytic ferroptosis strategy that reverses tumor chemotherapeutic resistance and induces synergistic ferroptosis/apoptosis therapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Xinyu Zhang, Yanling Ma, Jipeng Wan, Jia Yuan, Diqing Wang, Weiyi Wang, Xiao Sun, Qingwei Meng
Summary: This review provides a comprehensive overview of recent developments of biomimetic nanomaterials in ferroptosis-related cancer nanomedicine, discussing the definition and characteristics of ferroptosis and its applications in chemotherapy, radiotherapy, and immunotherapy. The review highlights the advantages and limitations of representative biomimetic nanomedicines including biomembranes, proteins, amino acids, polyunsaturated fatty acids, and biomineralization-based ferroptosis nano-inducers.
FRONTIERS IN CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Lei Luo, Yiming Qi, Hong Zhong, Shinan Jiang, Hu Zhang, Hao Cai, Yahui Wu, Zhongwei Gu, Qiyong Gong, Kui Luo
Summary: In this study, a redox-responsive polymeric prodrug was synthesized by RAFT polymerization for precise delivery of combinational therapeutic agents. The prodrug exhibited a chemo-photodynamic therapeutic effect to kill breast cancer cells and showed a remarkable in vivo anticancer efficacy. The findings suggest that the redox-responsive polymeric prodrug has great potential as an anti-cancer agent for combinational therapy.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Changyu Cao, Nan Yang, Yan Su, Zheye Zhang, Chenxi Wang, Xuejiao Song, Peng Chen, Wenjun Wang, Xiaochen Dong
Summary: In this study, a nanozyme resembling cytochrome c oxidase was demonstrated for nanocatalytic cancer therapy. By loading a bioreductive predrug, it simultaneously achieved starvation, ferroptosis, and chemical therapy, resulting in significant tumor elimination and increased survival rate in tumor-bearing mice.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Medicinal
Haibo Zhao, Jing Yu, Renshuai Zhang, Pengwei Chen, Hongfei Jiang, Wanpeng Yu
Summary: The chemotherapeutic drug doxorubicin (DOX) is widely used for treating various cancers, but it has some disadvantages such as off-target toxicity and hydrophobicity. DOX treatment can enhance tumor antigen presentation and activate dendritic cells, as well as facilitate immune-mediated clearance of tumor cells. Despite advances in nanotechnology and biomaterials, the effective delivery of DOX drug molecules remains challenging. This review summarizes recent progress in DOX prodrug-based nanomedicines and provides insights for future development and clinical applications.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Jooho Park, Yong-Kyu Lee, In-Kyu Park, Seung Rim Hwang
Summary: Photodynamic therapy (PDT) using oxygen, light, and photosensitizers is a promising approach for cancer treatment. Current progress involves enhancing accumulation of photosensitizers in tumor sites using nanocarriers and future research directions include improving drug localization and optimizing treatment outcomes.
Article
Cell Biology
Yang Wu, Helena Kram, Jens Gempt, Friederike Liesche-Starnecker, Wei Wu, Juergen Schlegel
Summary: This study investigated the connection between ALDH1 and ferroptosis in glioblastoma cells. The results showed that high expression of ALDH1a3 is associated with sensitivity to ferroptosis induction. Inhibition of ALDH1a3 protected tumor cells from ferroptotic cell death. The findings suggest that ferroptosis induction could be a promising clinical approach for targeting the highly aggressive cell population of glioblastoma stem cells (GSC).
Article
Chemistry, Multidisciplinary
Na Yu, Xi Zhang, Haiping Zhong, Jingqing Mu, Xingwei Li, Tao Liu, Xiaoguang Shi, Xing-Jie Liang, Shutao Guo
Summary: In this study, we constructed two sub-20-nm nanomedicines to enhance chemotherapy for pancreatic ductal adenocarcinoma (PDAC). The nanomedicines exhibited excellent compatibility and improved pharmacokinetic profiles, leading to high tumor accumulation. Pretreatment with one of the nanomedicines restored stromal homeostasis and facilitated the distribution and penetration of the other nanomedicine, resulting in tumor regression.
Article
Medicine, Research & Experimental
Benlin Wang, Haoyuan Li, Qingyu Yao, Yulin Zhang, Xiaodong Zhu, Tongliang Xia, Jian Wang, Gang Li, Xingang Li, Shilei Ni
BIOMEDICINE & PHARMACOTHERAPY
(2016)
Review
Chemistry, Multidisciplinary
Xiao Fu, Leticia Hosta-Rigau, Rona Chandrawati, Jiwei Cui
Article
Clinical Neurology
Chuanwei Wang, Yulin Zhang, Jiangang Wang, Shilei Ni
WORLD NEUROSURGERY
(2019)
Article
Chemistry, Physical
Xiao Fu, Haifeng Sun, Guiqiang Zhang, Kaijie Zhao, Yuan Tian, Zhiliang Gao, Jiwei Cui, Qun Yu
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2020)
Article
Immunology
Yang Kong, Zi-Chao Feng, Yu-Lin Zhang, Xiao-Fei Liu, Yuan Ma, Zhi-Min Zhao, Bin Huang, An-Jing Chen, Di Zhang, Frits Thorsen, Jian Wang, Ning Yang, Xin-Gang Li
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Yulin Zhang, Xiao Fu, Junsheng Jia, Tobias Wikerholmen, Kaiyan Xi, Yang Kong, Junpeng Wang, Haijun Chen, Yuan Ma, Zhiwei Li, Chuanwei Wang, Qichao Qi, Frits Thorsen, Jian Wang, Jiwei Cui, Xingang Li, Shilei Ni
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Xiao Fu, Guiqiang Zhang, Yulin Zhang, Haifeng Sun, Shuang Yang, Shilei Ni, Jiwei Cui
Summary: The study demonstrated the one-pot synthesis of poly(ethylene glycol) mediated ZIF-8 NPs for the co-delivery of an anticancer drug and a cell-penetrating peptide to improve therapeutic efficacy. These pH-responsive NPs showed stability at neutral pH and released the encapsulated drugs at acidic pH, enhancing their cytotoxicity. This strategy provides a new perspective for the design of drug delivery systems and offers more opportunities for biomedical applications.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Yulin Zhang, Yang Kong, Yuan Ma, Shilei Ni, Tobias Wikerholmen, Kaiyan Xi, Feihu Zhao, Zhimin Zhao, Junpeng Wang, Bin Huang, Anjing Chen, Zhong Yao, Mingzhi Han, Zichao Feng, Yaotian Hu, Frits Thorsen, Jian Wang, Xingang Li
Summary: The research identified COPZ1 as a therapeutic target candidate for GBM due to its role in dysregulating iron metabolism, leading to increased tumor grade and poor prognosis. Suppression of COPZ1 through siRNA knockdown inhibited proliferation and tumor growth of GBM cells both in vitro and in vivo, suggesting COPZ1/NCOA4/FTH1 axis as a potential novel therapeutic target for human GBM.
Article
Nanoscience & Nanotechnology
Guiqiang Zhang, Xiao Fu, Haifeng Sun, Peiyu Zhang, Shumei Zhai, Jingcheng Hao, Jiwei Cui, Ming Hu
Summary: The study presents a one-step assembly method for vaccine particles using PEG-mediated ZIF-8 NPs, which improves stability, dispersity, and protection of encapsulated antigens and nucleic acids, enhancing antigen uptake and immune cell activation while retaining bioactivity. This technology shows promise for effective and cold chain-independent vaccination against diseases.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Songqi Wang, Yulin Zhang, Fengying Sun, Kaiyan Xi, Zhenwei Sun, Xiaoyue Zheng, Fengzhen Guo, Hanlin Zhong, Mengmeng Yang, Yuting Shao, Bin Huang, Ming Dong, Shilei Ni, Lei Sun
Summary: Diabetic wounds have a complex microenvironment. The EGAP@HG nanoparticle can improve the treatment of diabetic wounds by promoting cell proliferation, exerting anti-inflammatory and antioxidant effects, and killing bacteria to promote wound healing.
MATERIALS & DESIGN
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.