Polymeric nanomedicine for overcoming resistance mechanisms in hedgehog and Myc-amplified medulloblastoma

ApoE mimetic peptide targeted nanoparticles carrying a BRD4 inhibitor for treating Medulloblastoma in mice

(2020) Qiyue Wang et al.   JOURNAL OF CONTROLLED RELEASE

Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy

(2018) Nagendra K. Chaturvedi et al.   Oncotarget

Dual-activity PI3K–BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis

(2017) Forest H. Andrews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Challenges and Recent Advances in Medulloblastoma Therapy

(2017) Vinod Kumar et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Erratum: Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma

(2017) Sonia Coni et al.   Scientific Reports

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Co-delivery of small molecule hedgehog inhibitor and miRNA for treating liver fibrosis

(2016) Virender Kumar et al.   BIOMATERIALS

Micelle Mixtures for Coadministration of Gemcitabine and GDC-0449 To Treat Pancreatic Cancer

(2016) Melek Karaca et al.   MOLECULAR PHARMACEUTICS

Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy

(2015) Elias E. Stratikopoulos et al.   CANCER CELL

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

(2015) Hayley J. Sharpe et al.   CANCER CELL

Molecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells

(2015) Verline Justilien et al.   CLINICAL CANCER RESEARCH

Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma

(2015) X Gai et al.   Cell Death & Disease

Brain-Penetrating Nanoparticles Improve Paclitaxel Efficacy in Malignant Glioma Following Local Administration

(2014) Elizabeth Nance et al.   ACS Nano

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Synthesis and Cancer Stem Cell-Based Activity of Substituted 5-Morpholino-7H-thieno[3,2-b]pyran-7-ones Designed as Next Generation PI3K Inhibitors

(2013) Guillermo A. Morales et al.   JOURNAL OF MEDICINAL CHEMISTRY

MAX and MYC: A Heritable Breakup

(2012) A. Cascon et al.   CANCER RESEARCH

Dissecting the genomic complexity underlying medulloblastoma

(2012) David T. W. Jones et al.   NATURE

A Dense Poly(Ethylene Glycol) Coating Improves Penetration of Large Polymeric Nanoparticles Within Brain Tissue

(2012) E. A. Nance et al.   Science Translational Medicine

Gene expression of growth signaling pathways is up-regulated in CD133-positive medulloblastoma cells

(2011) CHUNYU GU et al.   Oncology Letters

Synthesis and Characterization of Amphiphilic Lipopolymers for Micellar Drug Delivery

(2010) Feng Li et al.   BIOMACROMOLECULES

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD133+ cells from medulloblastoma and PNET cell lines are more resistant to cyclopamine inhibition of the sonic hedgehog signaling pathway than CD133− cells

(2010) Mónica Enguita-Germán et al.   TUMOR BIOLOGY

Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression

(2009) W D Thomas et al.   ONCOGENE